Digital Commons Network^™

Protocol For A Pilot Clinical Trial Of The Senolytic Drug Combination Dasatinib Plus Quercetin To Mitigate Age-Related Health And Cognitive Decline In Mental Disorders [Version 2; Peer Review: 1 Approved, 2 Approved With Reservations], Abigail Schweiger, Breno Diniz, Ginger Nicol, Julie Schweiger, Andes E Dasklakis-Perez, Eric J Lenze

2020-Current year OA Pubs

BACKGROUND: Major depressive disorder (MDD) and schizophrenia are linked to accelerated aging leading to reduced lifespan, health span and cognitive decline. Cellular senescence, in which cells lose proliferative capacity and develop a senescence-associated secretory phenotype (SASP), plays a role in this process. Emerging research suggests that the senolytic regimen of dasatinib+quercetin (D+Q) reduces senescent cells, potentially mitigating age-related health and cognitive decline. This pilot study aims to assess the feasibility and safety of D+Q in older adults with schizophrenia, schizoaffective disorder, and treatment-resistant depression (TRD).

METHODS: This single-center study will recruit 30 participants total aged 50 years or older with …

Tourette Syndrome Research Highlights From 2023 [Version 2; Peer Review: 3 Approved], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Nanette Mol Debes, Simon Morand-Beaulieu, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.

La Fin Du Droit National A L'Interruption Volontaire De Grossesse Aux Etats-Unis: Quels Enseignements Pour L'Etude Comparative Des Droits?, Elisabeth Zoller

Articles by Maurer Faculty

No abstract provided.

Deals In The Heartland: Renewable Energy Projects, Local Resistance, And How Law Can Help, Christiana Ochoa, Kacey Cook, Hanna Weil

Articles by Maurer Faculty

This Article offers proposals for better engagements, relationships, and deals with local communities contemplating wind farms. Because the rapid expansion of wind energy to date has exhausted the first-mover rural communities, the promise of wind energy depends on reluctant rural communities that may require the legal, relational, and policy innovations proposed herein if they are to grant their consent to future wind farms and participate in the renewable energy transformation. The proposals herein are the result of empirical research exploring how occupants of rural spaces have reacted to wind developer’s strategies in their communities and how local communities have employed …

Broadening The Community, Strengthening The Movement: An Introduction To The Innocence Project "Just Data" 2024 Scholarship Issue, Vanessa Meterko, Jaime S. Henderson, Ngozi Ndulue, Tebah Browne, Valena Beety

Articles by Maurer Faculty

This special issue of The Wrongful Conviction Law Review features a collection of seven research papers presented at the Innocence Project’s 2023 Just Data: Advancing the Innocence Movement conference. This annual event, organized by the Innocence Project and partners in the larger Innocence Network, brings together a diverse group of scholars and advocates, including those who have been wrongfully convicted themselves, to share the latest social science, discuss emerging issues, and make connections to inform our collective work and promote new applied research. Social science research, often conducted quietly and behind the scenes, is critical to data-driven litigation and policy …

Silencing The Sex Worker, Yvette Butler

Articles by Maurer Faculty

This Article argues that sex workers are silenced when they attempt to contribute to lawmaking processes. As a result, they are unable to contribute their knowledge in a meaningful way. The consequence is that laws reflect only one perspective of life in the sex trades: the prostitution abolitionist position that all sex work is inherently a form of violence against women. Without the ability to help shape this narrative, sex workers will continue to be silenced by the allegation that they are a danger to the feminist movement, courts will make harmful rulings, and legislatures will continue to enact laws …

Misery, Melancholy, And Misfortune: A Migrant Case Study, Jayanth K. Krishnan

Articles by Maurer Faculty

There is an ongoing crisis of despair involving migrants from abroad who are seeking refuge in one of the world’s longest-standing, post-World War II democracies—India. There are roughly 4.9 million noncitizen migrants in India, with most coming from Bangladesh, Myanmar, Nepal, Pakistan, and Sri Lanka. Because these migrants often live in the shadows, they are frequently deprived of fundamental human rights.

On the one hand, it may seem surprising that this population remains so vulnerable. After all, India’s Supreme Court has been a leading institutional light in safeguarding the rights of many marginalized groups. Supreme courts in other countries point …

Blunt Speech Rights, Nicholas Almendares

Articles by Maurer Faculty

There is a lot to be said about the Supreme Court’s decision in 303 Creative LLC. In the wake of the decision there will be a range of commentaries like those presented in this Issue. I want to draw attention to a particular aspect of the opinion, part of a broader trend in the Court’s First Amendment jurisprudence, towards blunt, sweeping rules. By a blunt rule, I mean a simple, coarse one that lacks nuance or distinctions. Blunt rules, by their nature, tend to be sweeping: nuance, that is, distinguishing cases based on various factors, limits the scope of a …

The Sec And "Major Questions Doctrine" Questions, Donna M. Nagy

Articles by Maurer Faculty

Nearly two years ago, in the wake of the Supreme Court’s formal adoption of what it termed the “major questions doctrine,” the Wall Street Journal reported a prediction that “‘every corporate securities lawyer in America is going to now fashion their arguments against SEC rulemaking to force-fit it into [that doctrine].’” As articulated by the sharply divided 6- 3 majority in West Virginia v. EPA, major questions doctrine (MQD) analysis is warranted in certain “extraordinary cases” involving a “transformative expansion” in a federal agency’s regulatory authority that is premised on “a merely plausible textual basis for the agency action.” Extraordinariness, …

Expecting Medication Surveillance, Jennifer D. Oliva

Articles by Maurer Faculty

In response to federal financial incentives and mandates, all fifty states, the District of Columbia, and three U.S. territories administer electronic prescription drug monitoring programs (PDMPs). Federal and state policymakers justified the implementation and enhancement of ubiquitous prescription drug monitoring by contending that expansive state drug surveillance was a necessary weapon in the war against the American drug overdose crisis. As is often the case with tools designed for law enforcement surveillance, however, PDMPs have proven susceptible to mission creep. Although pioneer PDMPs were paper-based systems that limited their surveillance to a narrow class of heavily regulated controlled substances, modern …

Characterization And Z-Score Calculation Of Cardiovascular Magnetic Resonance Imaging Parameters In Patients After The Fontan Operation: A Fontan Outcome Registry Using Cardiovascular Magnetic Resonance Examinations Study, Tarek Alsaied, Manish Aggarwal, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cardiac magnetic resonance (CMR) offers valuable hemodynamic insights post-Fontan, but is limited by the absence of normative single ventricle data. The Fontan Outcomes Registry using CMR Examinations (FORCE) is a large international Fontan-specific CMR registry. This study used FORCE registry data to evaluate expected CMR ventricular size/function and create Fontan-specific z-scores adjusting for ventricular morphology (VM) in healthier Fontan patients.

METHODS: "Healthier" Fontan patients were defined as patients free of adverse outcomes, who are New York Heart Association class I, have mild or less valve disease, and < 30% aortopulmonary collateral burden. General linear modeling was performed on 70% of the dataset to create z-scores for volumes and function. Models were tested using the remainder (30%) of the data. The z-scores were compared between children and adults. The z-scores were also compared between "healthier" Fontan and patients with adverse outcomes (death, listing for transplantation, or multiorgan disease).

RESULTS: The "healthier" Fontan population included 885 patients (15.0 ± 7.6 years) …

How Does Marijuana Affect Reproductive Health?, Miriam Blatner

The Science Journal of the Lander College of Arts and Sciences

Marijuana use has become prevalent worldwide, especially amongst men and women of reproductive age. Marijuana acts on Cannabinoid receptors, which are a part of the Endocannabinoid system. CB1 and CB2 receptors are most found in humans. Activation of Cannabinoid receptors in males cause a reduction in healthy sperm parameters and inhibits the acrosomal reaction, and therefore minimizes fertility potential. Researchers have not yet discovered any significant interactions between marijuana and the female reproductive system. There has also been limited evidence displaying the effects that marijuana has on pregnancy and breastfeeding of infants. Nevertheless, physicians have recommended against marijuana use while …

Full Issue: Volume 17, Number 2, Spring 2024

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 17, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2024.

Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller

The Science Journal of the Lander College of Arts and Sciences

Cystic fibrosis is a genetic disease with over 2,000 reported mutation varieties. It affects a chloride channel called CFTR, which by the transmembrane transport of chlorine, maintains an apical membrane electrolyte equilibrium in luminal epithelial cells. Its malfunction results in cystic fibrosis which causes excess mucus in various organs and is associated with respiratory complications and salty sweat. Treatment of cystic fibrosis has primarily taken two approaches: a mutation-specific method, targeted at a particular mutation to restore its function, and a mutation-non-specific method, which modulates intracellular barriers to CFTR trafficking or cellular repression of mutant protein function. This paper presents …

Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko

The Science Journal of the Lander College of Arts and Sciences

This study delves into small intestinal bacterial overgrowth (SIBO), exploring its origins, diagnosis, and treatment methods. The research illuminates the complexities of SIBO, a condition characterized by an abnormal surge of bacteria in the small intestine. Factors contributing to SIBO include impaired motility, anatomical abnormalities, and digestive system dysfunctions. Diagnosing SIBO proves challenging due to its nonspecific symptoms which often overlap with other conditions like irritable bowel syndrome (IBS). Various diagnostic approaches, including lactulose breath testing, blood tests, stool analysis, and imaging, aim to identify SIBO and its underlying causes. Treatment involves dietary modifications—such as low FODMAP, biphasic, or fast …

Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer

The Science Journal of the Lander College of Arts and Sciences

Male pattern baldness affects nearly 50% of the world’s male population. It is associated with physiological conditions such as cardiovascular disease as well as psychological issues with self-image and self-esteem. Although surgical treatments exist, they are associated with risks and complications. Various non-surgical treatment modalities for male pattern baldness are available for patients. Topical and oral formulations of minoxidil, finasteride, and dutasteride can be used, in addition to low level light therapy (LLLT) and platelet rich plasma (PRP) therapy. As many treatment options exist, it may be challenging for patients to decide which to choose. Although there have been few …

What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?, Shirah Balakhane

The Science Journal of the Lander College of Arts and Sciences

The historical understanding of Recurrent Aphthous Stomatitis (RAS), also known as canker sores, has evolved. This paper aims to collect data that determines the underlying factors that can cause RAS and highlights treatments or preventive measures one should take. RAS is a common mucosal disease of the mouth that affects healthy people and presents atypically in immunocompromised people. Geographical, age, and gender-related factors can all affect the prevalence. RAS still has no known cause; however, several systemic, local, immunologic, genetic, dietary, allergy, and microbiological factors—including immunosuppressive medications and stress—have been suggested as potential culprits. Using topical and systemic medicines, the …

The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh

The Science Journal of the Lander College of Arts and Sciences

Electronic cigarettes, which became available for purchase in the United States in 2007, were initially touted as a harmless aid for smoking cessation. However, recent research into the impact of electronic cigarettes on the human body has shown potential deleterious effects. This paper aims to examine the effects electronic cigarette usage has on the oral cavity. The methods to compile research involved reading through many peer-reviewed articles to analyze the most current information on the topic. The findings indicate several potentially adverse effects on the oral cavity including oral cancer, periodontitis, dental caries, xerostomia, facial fractures, failed dental implants, and …

Is Manual Therapy An Effective Modality Of Physical Therapy?, Caryn Karfunkel

The Science Journal of the Lander College of Arts and Sciences

Physical therapy provides relief to patients with musculoskeletal disorders who experience pain and have difficulty functioning. Manual therapy is one of the therapeutic modalities of physical therapy, and helps treat patients through utilizing human touch and pressure. This paper analyzes studies that aim to understand the reasoning behind manual therapy’s effectiveness as a physical therapy modality, questioning whether its benefits are primarily biomechanical or psychological. The research was conducted by analyzing relevant literature on academic databases on topics such as pain, physical therapy, manual therapy, and human touch. The findings reveal that manual therapy is an effective modality of physical …

Ethanol-Containing Mouthwash: Is It Safe? Exploring The Potential Risks And Benefits, Michoel Adler

The Science Journal of the Lander College of Arts and Sciences

This thesis investigates the safety of ethanol-containing mouthwash, focusing on the risks and benefits associated with the ethanol in mouthwash and its metabolic product, acetaldehyde. While ethanol is an effective antimicrobial agent, its carcinogenic and cytotoxic effects raise some concerns. This paper examines ethanol and acetaldehyde exposure, its toxicity, and its effects on oral health. Existing studies have found risks associated with ethanol exposure and have not found decreased effectiveness in ethanol-free mouthwash controlling oral bacteria. Further research is needed to determine the exact risks associated with ethanol-containing mouthwash and should focus on identifying the most effective and safest combination …

Is It Possible For Glp-1ras To Combat Type 2 Diabetes And Its Comorbidities?, Michael Weingarten

The Science Journal of the Lander College of Arts and Sciences

Type 2 Diabetes Mellitus is a prevalent metabolic disorder characterized by insulin resistance and pancreatic beta-cell dysfunction, leading to chronic hyperglycemia and comorbidities such as obesity and cardiovascular disease. Traditional treatments focus on glycemic control, but often fail to address the broader spectrum of related conditions. This study investigates the potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to combat type 2 diabetes and its comorbidities through their diverse mechanisms of action. GLP-1RAs not only improve glycemic control by enhancing insulin secretion and inhibiting glucagon release, but also promote weight loss, reduce inflammation, and lower cardiovascular risk. The efficacy of GLP-1RAs …

Overview Of Weight Loss Medications, Malky Mandel

The Science Journal of the Lander College of Arts and Sciences

Obesity is a complex medical condition that is multifactorial in origin. About one-third of adults in the United States are obese, and another third are overweight (Ogden et al., 2007). Obesity is associated with a multitude of comorbidities, such as cardiovascular disease, diabetes mellitus, and osteoarthritis (Lim, Boster, 2023). Additionally, obesity may cause psychological disorders due to social prejudice and discrimination toward obese people (Wadden et al. 2002). Economically, obesity is also a tremendous financial burden (Tremmel et al. 2017). It is estimated that the overall cost of obesity-related illness in the US is nearly $500 billion (Cawley et al., …

What Is The Best Way To Combat The Symptoms Of Knee Osteoarthritis?, Anna Reich

The Science Journal of the Lander College of Arts and Sciences

Osteoarthritis is a debilitating disease that a significant percentage of adults contend with. This degenerative joint disease causes the breakdown of tissue at the joint, which leads to symptoms of pain, decreased function, and limited range of motion. There are various methods of combating these symptoms. Treatment options include basic lifestyle modifications and other nonpharmacological methods, oral and topical drugs, intraarticular injections, and surgery. There are benefits and risks, as well as a lack of effectiveness associated with these treatments. The purpose of this paper is to determine whether there is an optimal treatment for this disease. Based on the …

Classification Of Ipsc-Derived Cultures Using Convolutional Neural Networks To Identify Single Differentiated Neurons For Isolation Or Measurement, Purva Patel, Lina K. Mohammad Ali, Uma Kaushik, Malllory Wright, Kaylee Green, Jason E. Waligorski, Colin L. Kremitzki, Graham W. Bachman, Serena N. Elia, William J. Buchser

2020-Current year OA Pubs

No abstract provided.

The Association Of Dementia Risk Symptoms And Functional Activity In Adults With Down Syndrome, Selena E Washington, Amy E Bodde, Brian C Helsel, Rebecca M Bollinger, Nora Smith, Lauren T Ptomey, Beau Ances, Susan L Stark

2020-Current year OA Pubs

INTRODUCTION: Adults with Down syndrome (DS) have an increased risk of Alzheimer's disease (AD) dementia, often showing neuropathological indicators by age 40. Physical function and activities of daily living (ADLs) are understudied areas of function that may inform dementia risk. We investigated associations among age, physical function (gait/balance, grip strength, and lower extremity strength), ADLs, and dementia risk symptoms in adults with DS. We hypothesized that compromised physical function and lower independence with ADLs would be associated with an informant/caregiver-reported measure of dementia risk symptoms.

METHODS: A secondary analysis for this cross-sectional study was completed using data from two academic …