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2024

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Contentment And Control: The Stonega Coke & Coal Company & Pioneering Welfare Capitalism In Southwest Virginia, Christopher Lloyd Tomlinson Jan 2024

Contentment And Control: The Stonega Coke & Coal Company & Pioneering Welfare Capitalism In Southwest Virginia, Christopher Lloyd Tomlinson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Founded in 1902, the Stonega Coke & Coal Company was the largest coal operator in Virginia throughout the twentieth century, becoming even larger through its merger with the Westmoreland Coal Company in 1964. Over the course of this long history, the company used a brand of welfare capitalism aimed at keeping miners and their families satisfied enough with their living and working conditions that the workers would develop a sense of loyalty to the company. Management at SC&C termed these practices “contentment sociology.” While many coal operators began shifting away from such practices during the New Deal, SC&C maintained and …


Dance Intervention For Stroke Rehabilitation: Restoring Occupational Performance Through Creative Movement, Olivia Paige Allen Jan 2024

Dance Intervention For Stroke Rehabilitation: Restoring Occupational Performance Through Creative Movement, Olivia Paige Allen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Thousands of individuals are affected by cerebral vascular accidents, (CVA), also known as strokes in the United States each year, (CDC, 2023). Cerebral vascular accidents are one of the leading causes of death among the elderly population in the U.S. each year, (NIH et al., 2023). The deficits caused by a CVA can be global, from hemiparetic limbs and sensory loss to psychosocial impacts on an individual and their support system. In occupational therapy, the goal is to regain as much function and independence as possible for the individual who has experienced a CVA. Although many evidence-based intervention tools are …


A Practice Improvement Project Improving Tobacco And Nicotine Dependence Treatment Education In A Doctor Of Nursing Practice Program, Kanchan Bhattarai Jan 2024

A Practice Improvement Project Improving Tobacco And Nicotine Dependence Treatment Education In A Doctor Of Nursing Practice Program, Kanchan Bhattarai

Nursing

Tobacco use is a global epidemic and the leading cause of preventable mortality and morbidity in the United States (Centers for Disease Control and Prevention [CDC], 2022h). Approximately 5.4 million people die annually due to tobacco-related illnesses. About 70% of tobacco users visit primary care clinics annually and even brief advice from clinicians can improve cessation rates ( United States Department of Health and Human Services [USDHHS], 2020). However, four out of nine adult smokers who visited healthcare providers did not receive any advice or counseling on quitting smoking. Lack of training and confidence were identified as a barrier among …


Zoo Communication: A Study Of Stewardship With Animal Conservation In Zoos Across The United States, Abby Rachelle Lester Jan 2024

Zoo Communication: A Study Of Stewardship With Animal Conservation In Zoos Across The United States, Abby Rachelle Lester

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis investigates the communication strategies employed by zoo professionals to promote engagement and advanec animal conservation education. Through in-depth interviews with zoo experts, the stidy explores the intricate connections between communication practices and stewardship princliples within zoo facilities. Findings from this study contribute to the understanding of effective communication in the realm of animal conservation, with implications for both zoo practitioners and conservation educators. The study delves into the effective strategies for identifying and fostering relationships with environmental stewards, alongside encouraging their involvement in zoo-based animal conservation initiatives. The theoretical implications highlight gaps in existing models, emphasizing the need …


You Belong With Me: What Communication Professionals Can Learn From Swifties, Rachel Belle Johnson Jan 2024

You Belong With Me: What Communication Professionals Can Learn From Swifties, Rachel Belle Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pop powerhouse Taylor Swift has managed to create a dedicated fanbase that has the power to disrupt national sporting leagues and boost the American economy. Her Swifties are an exemplar in the world of fandom. Taylor Swift’s online interactions with fans, especially in the early days of her career, are partially responsible for her success in creating and maintaining this fanbase. Using principles of social informational processing theory (SIPT), this research examines what aspects of Taylor Swift’s computer-mediated communication with fans have fostered such intense feelings of community in her fandom of Swifties. Using in-depth interviews to explore the relationships …


Pediatric Preparedness In A Rural Health System, Sarah Nielsen Jan 2024

Pediatric Preparedness In A Rural Health System, Sarah Nielsen

Nursing

Pediatric emergencies present significant challenges and emotional strain in healthcare settings. In critical access hospitals, the provision of safe, effective, and high-quality emergency response for pediatric cases is especially demanding. Many rural hospitals have infrequent exposure to pediatric emergency care, which can contribute to a lack of confidence when caring for this population. Diminished confidence in pediatric skills and procedures has been linked with a reduction in overall patient safety. Research on pediatric emergency preparedness in rural settings outlines the need for further multi-faceted education to achieve increased provider comfort and preparedness. The practice improvement project aimed to understand health …


Ask The Duke, Why: How Fabrications Can Undermine Impact In Shakespeare’S Measure For Measure, Spencer D. Hansen Jan 2024

Ask The Duke, Why: How Fabrications Can Undermine Impact In Shakespeare’S Measure For Measure, Spencer D. Hansen

Graduate Theses, Dissertations, and Problem Reports (ETD)

The following document recounts the observations and consequences that result from my attempts at justifying the actions of Duke Vincentio in Shakespeare’s Measure for Measure. By following my experience through the duration of West Virginia University’s 2023 production of Measure for Measure, I examine the ramifications of justifying the Duke’s actions and the potentially harmful consequences such justifications could create with regard to the play’s reception. Additionally, this text outlines performance techniques, audience responses, rehearsal strategies, and progressive interpretations for one of Shakespeare’s most challenging characters in one of his most divisive plays.


The Impact Of Occupational Therapy In Lactation Services, Sarah Adrienne Mcaninch Jan 2024

The Impact Of Occupational Therapy In Lactation Services, Sarah Adrienne Mcaninch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many benefits to breastfeeding exist for both mothers and infants, yet exclusive breastfeeding rates remain low across the nation. These benefits include decreased chance of infections for infants, low infant mortality, and decreased chances of breast and ovarian cancers for mothers (Binns et al., 2016; CDC, 2023). Education strategies have recently become imperative for health organizations to help mothers sustain their ability to breastfeed within the recommended six-month timeframe. Current literature on education supports that women who receive education at some point in their lactation journey are more likely to reach the six-month period and have more confidence in their …


Eating Concerns And Self-Injury Among Collegiate Populations: A Comparison Of Sexual Orientation Groups, Matthew Kasopsky Jan 2024

Eating Concerns And Self-Injury Among Collegiate Populations: A Comparison Of Sexual Orientation Groups, Matthew Kasopsky

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examined the prevalence of eating concerns and nonsuicidal self-injurious behaviors (NSSIB) in college students seeking services at college and university counseling centers (UCCs), focusing on whether sexual minority students experience these issues at higher rates than their heterosexual peers. Eating concerns and NSSIB are understudied among sexual minority individuals. Previous research has demonstrated that through prejudice, stigma, and social stress, sexual minority individuals may be at a higher risk of developing mental health concerns and conditions than their heterosexual counterparts. The present study used a cross-sectional design to examine data from a sample of collegiate clients nationwide. Data …


Healthcare Professionals' Education Regarding Human Trafficking Identification And Resources, Madeline Iversen Jan 2024

Healthcare Professionals' Education Regarding Human Trafficking Identification And Resources, Madeline Iversen

Nursing

Human trafficking is one of the largest illegal industries with over 40 million adults and children enslaved worldwide. The psychological and physical consequences of human trafficking are high and may impact a victim for their entire life. Approximately 88% of human trafficking victims report receiving medical care during their time captured, and a majority of these victims seek care in the emergency department (ED). Only 11% of healthcare professionals (HCPs) report receiving education on human trafficking. The purpose of this project was to determine if education regarding human trafficking influences HCPs including, nurses, physicians, nurse practitioners (NPs), physician assistants (PAs), …


Visit North Carolina: Trail Accessibility, Hannah Caitlyn Guschel Jan 2024

Visit North Carolina: Trail Accessibility, Hannah Caitlyn Guschel

Graduate Theses, Dissertations, and Problem Reports (ETD)

This paper focuses on the perceived barriers to travel from marketing material for individuals with disabilities compared to those without disabilities and the direct impact on leisurely travel participation, particularly in outdoor spaces. Employing a cross-sectional study design encompassing both quantitative and qualitative data collection methods, this research investigates the experiences and transparency of trail accessibility in the state of North Carolina. Quantitative data were gathered through trail assessment accessibility checklists, while qualitative insights were obtained via in-depth interviews. The findings reveal an improved understanding of accessibility and the application of an accessibility checklist. Moreover, the study underscores the importance …


An Inquiry Into The Accessibility Of Campus Recreation For College Students With Disabilities, Kayla B. Abrahamson Jan 2024

An Inquiry Into The Accessibility Of Campus Recreation For College Students With Disabilities, Kayla B. Abrahamson

Graduate Theses, Dissertations, and Problem Reports (ETD)

University recreation centers are identified as the main sources of physical activity for college students. However, an estimated 68% of college students with disabilities (SWD) use their campus recreational facilities less than five times per year (Yoh et al., 2008). Structural and programmatic accessibility barriers may account for low facility use and corresponding low physical activity levels among college SWD. An accessibility assessment of facilities and programming is warranted to identify priority areas for barrier removal. This collective case study evaluates the accessibility of three campus recreation facilities at 4-year public universities in the southeast U.S. Adopting a mixed-method approach, …


Developing The 21st Century Piano Studio, Brianna Mae Eddy Jan 2024

Developing The 21st Century Piano Studio, Brianna Mae Eddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explores the needs of the contemporary piano studio, including business policies, the use of technologies, mental health and neurodivergence in students, and the influence and use of social media. Focused on the needs of both the private-studio piano teacher and traveling piano teacher, the paper offers insight into studio ownership and management with an emphasis on providing experiences that meet the needs of contemporary students. The paper includes a brief history of private piano instruction as well as information for developing studio policies, business issues related to current tax requirements and forms, and resources for financial and general …


Effect Of Haemonchus Contortus Excretory/Secretory Protein On Differences In Host Neutrophil Migration, Hannah Grace Teddleton Jan 2024

Effect Of Haemonchus Contortus Excretory/Secretory Protein On Differences In Host Neutrophil Migration, Hannah Grace Teddleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

An excretory/secretory (E/S) product, common to many helminths, is neutrophil inhibitory factor (NIF) which negatively affects neutrophil migration and activity. Due to differences in neutrophil accumulation between parasite resistant St. Croix STC and parasite susceptible Suffolk (SUF) sheep, we hypothesized that Hc-NIF may inhibit migration of SUF and not STC neutrophils. Previous studies have demonstrated that Hc produces NIF but is not commercially available. To test our hypothesis, neutrophils were cultured from STC and SUF sheep in the presence of Ancylostoma caninum-derived NIF (Ac-NIF) and measure chemotaxis to Interleukin-8 (IL-8), HcLA or H. contortus third-stage excretory/secretory (E/S) products. Neutrophils were …


Machine Learning And Rna Bioinformatics, Jason Rafe Miller Jan 2024

Machine Learning And Rna Bioinformatics, Jason Rafe Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

The applied science of bioinformatics encompasses computational analysis of molecular biology data. Advances in genomics and DNA sequencing technology have enabled computational analysis of ribonucleic acids (RNAs), which play diverse and critical roles in most cells. To assist the study of human RNA, we trained machine learning models on RNA nucleotide sequences, devoid of domain knowledge. We built models that distinguish long non-coding lncRNA from protein-coding mRNA, and models that predict the cytoplasmic vs. nuclear preferences of lncRNAs. In a review of published lncRNA subcellular localization classifiers, we show that the commonly used validation protocol generates optimistic performance measures, and …


Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky Jan 2024

Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The Occupational Therapists working within the burn unit at West Penn Hospital assess and treat patients utilizing the biomechanical approach FOR, as well as the support from MOHO and PEOP. The patients seen within the burn unit encompass a variety of injuries and occupational deficits that require an individualized and holistic approach to care.

Purpose: The purpose of the contracture management project is to provide an interdisciplinary approach to improve carryover and patient care within and out of the hospital.

Theoretical framework: The contracture management project is guided using the biomechanical frame of reference as well as supporting constructs …


Data-Driven Approaches For Achieving Carbon Neutrality: Predictive Models For Reducing Co2 Emissions And Enhancing Industrial Sustainability, Farzana Islam Jan 2024

Data-Driven Approaches For Achieving Carbon Neutrality: Predictive Models For Reducing Co2 Emissions And Enhancing Industrial Sustainability, Farzana Islam

Graduate Theses, Dissertations, and Problem Reports (ETD)

In response to the escalating challenges posed by climate change and industrial inefficiency, this thesis presents a comprehensive investigation aimed at advancing the predictive modeling of global CO2 emissions and enhancing operational efficiency in steel manufacturing through Electric Arc Furnace (EAF) temperature optimization. Leveraging a rich dataset sourced from the World Development Indicators database alongside a meticulously curated dataset specific to EAF operations, our study applies an innovative blend of econometric and machine learning techniques, including Pooled Ordinary Least Squares (Pooled OLS), Random Effects (RE), Fixed Effects (FE), and Seasonal Autoregressive Integrated Moving Average with Exogenous Variables (SARIMAX) models. The …


Developmentally Appropriate Care In The Neonatal Intensive Care Unit (Nicu), Ashten Cenkus Jan 2024

Developmentally Appropriate Care In The Neonatal Intensive Care Unit (Nicu), Ashten Cenkus

Graduate Theses, Dissertations, and Problem Reports (ETD)

As specialized healthcare professionals educated in developmental care, occupational therapy practitioners (OTPs) have a role in educating, coaching, and assessing the needs of infants, their families, and the staff in the NICU. These high-risk and medically fragile infants require specialized care that considers the incorporation of neurodevelopment, neurobehavioral regulation, sensory stimulation, and motor development through supportive and appropriate interventions. A project addressing these needs across 14 weeks was implemented as part of an Occupational Therapy Doctoral (OTD) capstone experience at WVU Medicine Children’s in Morgantown, West Virginia. This project examined the results of the NICU staff's confidence, knowledge, and awareness …


Machine Learning Maintenance Costs Prediction Model For Heavy-Duty Alternative Fuel And Diesel Vehicles, Esteban Fernandez Villar Jan 2024

Machine Learning Maintenance Costs Prediction Model For Heavy-Duty Alternative Fuel And Diesel Vehicles, Esteban Fernandez Villar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Medium- and Heavy-Duty Vehicles (MHDVs) are essential to global logistics and transportation. Around 77% of these vehicles are diesel-powered due to its powertrain mechanical characteristics that make them reliable and energy efficient. However, the environmental implications of diesel combustion, particularly its direct contribution to air pollution and greenhouse gas (GHG) emissions, have increased the interest in alternative fuel vehicles (AFVs). These alternatives include Natural Gas (NG), Propane, Hybrid Electric Vehicles (HEVs), and Battery Electric Vehicles (BEVs), each presenting unique benefits and challenges in terms of required fueling infrastructure, energy efficiency, environmental impact, and total cost of operation (TCO). Maintenance costs …


Assessment Of Instrument Exploring Underwear Preferences Of Incontinent Geriatric Women In Assisted Living, Cassandra M. Stewart Jan 2024

Assessment Of Instrument Exploring Underwear Preferences Of Incontinent Geriatric Women In Assisted Living, Cassandra M. Stewart

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urinary incontinence is a urologic condition commonly occurring in geriatric individuals and often results in disability. This affects not only physical functioning, but also psychological and emotional implications. Prior research focused on prevention and using smart technology to improve the current products available to help manage urinary incontinence. Little research has been completed to examine the preferences of geriatric individuals and assess what they are looking for in incontinence products. The purpose of the study was to create an instrument to assess the individual preferences of older adults for these products in a community living environment. Research questions included: (1) …


Puberty-Associated Changes In Kiss1r, Mc3r, And Mc4r In The Ewe, Ashleigh Caitlyn Thomson Jan 2024

Puberty-Associated Changes In Kiss1r, Mc3r, And Mc4r In The Ewe, Ashleigh Caitlyn Thomson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The neural mechanisms that control the onset of puberty are not completely understood. In livestock, the onset of puberty relies on an increase in gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH). Kisspeptin, neurokinin B, and dynorphin neurons (KNDy) and their receptors, Kiss1r, NK3R, and KOR, respectively, are important regulators of puberty. Previous data from our laboratory has shown that KNDy neurons may be responding to other inputs, including the melanocortin system, that will affect the timing of puberty. Given this, we examined kisspeptin receptor (Kiss1r) mRNA expression in GnRH neurons as well as examining melanocortin 3 and 4 receptor …


Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin Jan 2024

Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Child abuse is a significant public health concern that impacts children worldwide. Efforts to connect at-risk parents with prevention and intervention programs require the use of high-quality measures that evaluate child abuse potential. Researchers frequently use the Child Abuse Potential Inventory (Milner, 1986) and the Brief Child Abuse Potential Inventory (BCAP; Ondersma et al., 2005) which contain Validity indices that evaluate response patterns such as social desirability responding. The measure developers recommended that abuse risk scores from invalid profiles be disregarded in clinical and research settings; however, little is known about factors that may relate to invalid responses and whether …


S(+)-Propylnorapomorphine Hydrochloride Alters Mutant Huntingtin Aggregation And Membrane Interactions, Gabriella M. Pettipas Jan 2024

S(+)-Propylnorapomorphine Hydrochloride Alters Mutant Huntingtin Aggregation And Membrane Interactions, Gabriella M. Pettipas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from an abnormally long CAG repeat in the huntingtin gene. This results in an expanded polyglutamine (polyQ) domain in the huntingtin protein (htt) that directly leads to self-assembly of huntingtin (htt) into a variety of aggregate species that underlie cellular toxicity. Interaction of protein aggregates with a variety of lipid membranes has been linked to disease pathology. Here, the ability of a small molecule S(+)-propylnorapomorphine (NM) hydrochloride to modulate htt-exon1(46Q) aggregation and interactions with lipid membranes was determined. ThT assays were performed to quantify fibril formation of htt in the …


Formulation, Sensory Evaluation, And Physicochemical Assessment Of And Consumer Behavior Toward Novel Energy Bars, Ian Phillip Israelsen Jan 2024

Formulation, Sensory Evaluation, And Physicochemical Assessment Of And Consumer Behavior Toward Novel Energy Bars, Ian Phillip Israelsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objectives of this study were to 1) formulate a novel energy bar containing significant macronutrients and calories per serving with favorable ratings from consumers; 2) analyze responses to a consumer preference survey and sensory evaluation of novel energy bars compared to a commercially available energy bar. For the first study, fourteen iterations of an energy bar were synthesized with differing protein sources (whey, soy, pea, hemp), and characteristic variations (nougat, chocolate truffle, peanut butter, double-date caramel). A shortbread base, date caramel, and chocolate coating were included in every bar. Sensory evaluations determined that the most liked variation overall was …


Kinetic Study Of Oh Radical Reactions With Cyclopentenone Derivatives, Patrick Kipkoech Rutto Jan 2024

Kinetic Study Of Oh Radical Reactions With Cyclopentenone Derivatives, Patrick Kipkoech Rutto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Conjugated a, b-unsaturated carbonyl compounds like cyclopentenone play a significant role in various environmental processes. These compounds are formed in combustion and Earth’s atmosphere from the oxidation of cyclic ketones such as cyclopentanone. Once formed under oxidative conditions, cyclopentenone may react with presence of free radicals like OH in the atmosphere molecules to form vinoxy type resonantly stabilized radicals. The presence of free radicals species like OH, O2 in the atmosphere can react with these molecules resulting into intermediate products that dissociate to give final products. Experimental and theoretical investigations in the reactions of cyclopentenone derivatives with these small free …


Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi Jan 2024

Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Big game hunting is an important source of revenue and recreation in the United States. Of big game species, white-tailed deer (Odocileus virginianus) are the most heavily pursued. White-tailed deer are a widespread generalist species, capable of existing at high densities. Hunting is often used as the primary method of managing deer populations, particularly in the eastern United States, where there is a lack of large predators. When populations reach high densities, there can be negative effects on the environment and conflicts with humans. Managers must consider both creating adequate hunting opportunities and reducing negative impacts when managing …


Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas Jan 2024

Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Communicating the importance of rules and warnings to visitors of recreational parks through signage can be difficult. However, it is one of the most important things to keep visitors safe. Oftentimes, these signs use fear of punishment or injury to discourage certain behaviors. According to studies following the Extended Parallel Processing Model (EPPM), using threats can backfire and cause visitors to use maladaptive fear responses to counteract a threat message if the content is too extreme or too psychologically close. Humor is a versatile tool that can be used to grab attention, temper perceptions, and influence decision-making. Comedians like Jon …


Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey Jan 2024

Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Systemic chemotherapy is a cornerstone of cancer treatment, but it often leads to significant side effects, which may impact patients' quality of life and lead to increased acute healthcare utilization. Although patients are typically informed of potential symptoms and advised to seek care as needed, many struggle to understand and manage symptoms effectively. Patient-reported outcomes (PROs) have been shown to improve symptom monitoring, decrease symptom burden, and reduce emergency department visits and hospital admissions. Electronic patient-reported outcomes (ePROs), in particular, offer timely and accessible symptom tracking, though their effectiveness has largely been evaluated within urban clinical trial settings and …


An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell Jan 2024

An Appalachian Perspective On Suicide: A Focus On West Virginia’S Unique Context, Erin Delaney Caswell

Graduate Theses, Dissertations, and Problem Reports (ETD)

INTRODUCTION: The Appalachian region, spanning 13 states from New York to northern Mississippi, experiences the suicide rates in the United States (U.S.), underscoring a public health crisis exacerbated by persistent socioeconomic challenges. West Virginia (WV), the only state entirely within Appalachia, serves as a focal point for understanding the broader suicide crisis in the region, as WV has the highest suicide rates in the region. Moreover, the state has several unique socioeconomic factors, like increased poverty, lower educational attainment, limited access to healthcare, and a high prevalence of chronic pain and substance that may contribute to elevated rates of suicide. …


Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks Jan 2024

Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nearly all neurodegenerative diseases (NDs) and some eye diseases are characterized by the presence of misfolded and aggregated proteins. The ubiquitin proteasome system (UPS) is responsible for degrading the majority of proteins including misfolded and aggregated proteins. However, in NDs the performance of the UPS is impaired, and this impairment partially comes from these protein aggregates inhibiting the proteasome. This inhibition leads to an accumulation of protein aggregates, more proteasomal inhibition, and fewer chaperones for newly synthesized proteins, triggering a collapse in proteostasis, which is thought to contribute to the pathogenesis of NDs. Consequently, stimulating proteasome function is being investigated …