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2024

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Health Insurance And Differences In Infant Mortality Rates In The Us, Desalyn L. Johnson, Waldemar A. Carlo, A K M Rahman, Rachel Tindal, Sarah G. Trulove, Mykaela J. Watt Jan 2024

Health Insurance And Differences In Infant Mortality Rates In The Us, Desalyn L. Johnson, Waldemar A. Carlo, A K M Rahman, Rachel Tindal, Sarah G. Trulove, Mykaela J. Watt

UAB Huntsville Research Day - All Presentations

2024 research poster


The Impact Of Socioeconomic Status On Cervical Spondylotic Myelopathy Presentation, Evan Gross, Yifei Sun, Nicholas Laskay, Mohammad Hamo, Sasha Howell, James Mooney Jan 2024

The Impact Of Socioeconomic Status On Cervical Spondylotic Myelopathy Presentation, Evan Gross, Yifei Sun, Nicholas Laskay, Mohammad Hamo, Sasha Howell, James Mooney

UAB Huntsville Research Day - All Presentations

2024 research poster


Establishing Collaborations In Global Neurosurgery: The Role Of Intersurgeon, Pedram Maleknia, Nathan A. Shlobin, James M. Johnston, Gail Rousseau Jan 2024

Establishing Collaborations In Global Neurosurgery: The Role Of Intersurgeon, Pedram Maleknia, Nathan A. Shlobin, James M. Johnston, Gail Rousseau

UAB Huntsville Research Day - All Presentations

2024 research poster


Predictors Of Neutropenia Secondary To Ganciclovir Exposure During Treatment Of Congenital Cytomegalovirus Disease, Javier K. Nishikawa, Immaculada Aban, Edward Acosta, Pablo J. Sanchez, David W. Kimberlin Jan 2024

Predictors Of Neutropenia Secondary To Ganciclovir Exposure During Treatment Of Congenital Cytomegalovirus Disease, Javier K. Nishikawa, Immaculada Aban, Edward Acosta, Pablo J. Sanchez, David W. Kimberlin

UAB Huntsville Research Day - All Presentations

2024 research poster


The Effectiveness Of Dental Pulp Stem Cells-Derived Exosomes For Direct Pulp Capping: In Vitro Study, Dina A. Hammouda, Alaa M. Mansour, Mohammed E. Grawish, Ahmed R. Zaher Jan 2024

The Effectiveness Of Dental Pulp Stem Cells-Derived Exosomes For Direct Pulp Capping: In Vitro Study, Dina A. Hammouda, Alaa M. Mansour, Mohammed E. Grawish, Ahmed R. Zaher

Mansoura Journal of Dentistry

Objective: This in vitro investigation's goal was to ascertain how well dental pulp stem cell exosomes (DPSC-exo) modulate endogenous dental pulp stem cells (DPSCs) and direct their navigation toward mineralized tissue regeneration, either alone or in conjunction with mineral trioxide aggregate (MTA). Materials and methods: For this investigation, DPSCs were harvested using rat incisors. To extract exosomes from DPSCs, an ultracentrifugation method was employed. Flow cytometry was used for the characterization of DPSCs-exo, and transmission electron microscopy (TEM) was used to measure their size. DPSCs were incubated in standard culture media and split up into three groups. The first one …


Biocompatibility Evaluation Of Edta And Chitosan Nanoparticles Gel Forms: In Vivo Histopathological Study, Alaa H. Youssef, Doaa A. Labah, Abeer A. Elgendy, Amany E. Badr Jan 2024

Biocompatibility Evaluation Of Edta And Chitosan Nanoparticles Gel Forms: In Vivo Histopathological Study, Alaa H. Youssef, Doaa A. Labah, Abeer A. Elgendy, Amany E. Badr

Mansoura Journal of Dentistry

Objectives: The purpose of this study was to evaluate and compare biocompatibility of gel form chelating agents (EDTA and chitosan NPS) after implantation of polyethylene tubes in rats. Materials and methods: Twenty albino rats were included in this study. Three horizontal incisions were performed on dorsal surface of each rat to receive three polyethylene tubes as subcutaneous implants; two of them filled with tested materials and one empty tube served as control. After 2 and 4 weeks of subcutaneous implantation, 10 rats were sacrificed and implanted polyethylene tubes with surrounding tissues were dissected with 1 cm safety margin. The specimens …


Osteocalcin As A Gingival Crevicular Fluid Biomarker For Periodontitis Among Egyptian Population Sample- Controlled Clinical Trial, Mohamed Al Bahrawy, Sahar Abdel Rauf, Eman M. Abdulhady Jan 2024

Osteocalcin As A Gingival Crevicular Fluid Biomarker For Periodontitis Among Egyptian Population Sample- Controlled Clinical Trial, Mohamed Al Bahrawy, Sahar Abdel Rauf, Eman M. Abdulhady

Mansoura Journal of Dentistry

Objectives This clinical trial aimed to evaluate osteocalcin levels in healthy and diseased periodontium and to correlate the changes in its levels with the changes in the clinical and radiographic parameters before and after treatment. Subject & Methods Double blind clinical trial, 40 patients divided into 3 groups; 15 patients diagnosed as periodontitis stage III grade B, 15 patients diagnosed as periodontitis stage III grade C, 10 healthy cases as control. Clinical parameters namely plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL), radiographic examination, beside gingival crevicular fluid (GCF) samples collection for osteocalcin (OC) …


A Comparison Between Three Conservative Treatment Modalities For Anterior Disc Displacement Of The Temporomandibular Joint, Mirna A. Anis, Mohamed Shady, Manar Mansour, Ashraf A. Gebreel Jan 2024

A Comparison Between Three Conservative Treatment Modalities For Anterior Disc Displacement Of The Temporomandibular Joint, Mirna A. Anis, Mohamed Shady, Manar Mansour, Ashraf A. Gebreel

Mansoura Journal of Dentistry

Objective: The purpose of this study was to compare the effects of three types of conservative treatment modalities (maxillary anterior repositioning splint, low-level laser therapy and infra-red led on the temporomandibular joint and masticatory muscles) for temporomandibular disorder. Materials and methods: A total of 30 patients diagnosed with anterior disk displacement with Reduction, underwent examination using magnetic resonance imaging. The participants were randomly assigned according to treatment modalities into three groups (n=10): maxillary anterior repositioning splint, low-level laser therapy and infra-red led. Clinical evaluation was performed at the baseline and after a six-month follow-up period utilizing the Helkimo Clinical Dysfunction …


Tensile Bond Strength Of Machinable Ceramics Bonded To Dentin Using Pre-Heated Resin Composite, Flowable Composite And Resin Cement: A Laboratory Trial, Reham K. Elnagar, Radwa I. Eltoukhy, Salah H. Mahmoud Jan 2024

Tensile Bond Strength Of Machinable Ceramics Bonded To Dentin Using Pre-Heated Resin Composite, Flowable Composite And Resin Cement: A Laboratory Trial, Reham K. Elnagar, Radwa I. Eltoukhy, Salah H. Mahmoud

Mansoura Journal of Dentistry

Objective: To evaluate tensile bond strength of machinable ceramics bonded to dentin using pre-heated and flowable resin composites compared to self-adhesive resin cement. Materials and methods: Thirty mid-coronal dentin surfaces were assigned into 3 equal groups (n=10) according to luting agent: pre-heated resin composite, flowable composite and self-adhesive resin cement. Zirconia overlays were fabricated and cemented to the dentin surfaces. After storing in water for 24 hours, each tooth was subjected to the tensile test. A one-way ANOVA test was used to tabulate and statistically analyze the retrieved data (P


The Impact Of Social Media On Charitable Giving For Nonprofit Organization, Namchul Shin Jan 2024

The Impact Of Social Media On Charitable Giving For Nonprofit Organization, Namchul Shin

Journal of International Technology and Information Management

Research has extensively studied nonprofit organizations’ use of social media for communications and interactions with supporters. However, there has been limited research examining the impact of social media on charitable giving. This research attempts to address the gap by empirically examining the relationship between the use of social media and charitable giving for nonprofit organizations. We employ a data set of the Nonprofit Times’ top 100 nonprofits ranked by total revenue for the empirical analysis. As measures for social media traction, i.e., how extensively nonprofits draw supporters on their social media sites, we use Facebook Likes, Twitter Followers, and Instagram …


How Does Digitalisation Transform Business Models In Ropax Ports? A Multi-Site Study Of Port Authorities, Yiran Chen, Anastasia Tsvetkova, Kristel Edelman, Irina Wahlström, Marikka Heikkila, Magnus Hellström Jan 2024

How Does Digitalisation Transform Business Models In Ropax Ports? A Multi-Site Study Of Port Authorities, Yiran Chen, Anastasia Tsvetkova, Kristel Edelman, Irina Wahlström, Marikka Heikkila, Magnus Hellström

Journal of International Technology and Information Management

This article investigates the relationship between digitalisation and business model changes in RoPax ports. The study is based on six RoPax ports in Northern Europe, examining their digitalisation efforts and the resulting changes in their business models, leading to further digital transformation. The paper offers insights by reviewing relevant literature on digitalisation’s role in business model innovation and its application in ports. The findings reveal that digitalisation supports relevant business model changes concerning port operation integration within logistics chains, communication, documentation flow, and cargo flow optimisation. However, exploring digitalisation’s potential for diversifying value propositions is still limited. Most digitalisation efforts …


An Empirical Study To Understand The Role Of Institution-Based Trust And Its Antecedents In Iot Adoption By Individuals, Anupam Kumar Nath, Amit Kumar Nath Jan 2024

An Empirical Study To Understand The Role Of Institution-Based Trust And Its Antecedents In Iot Adoption By Individuals, Anupam Kumar Nath, Amit Kumar Nath

Journal of International Technology and Information Management

ABSTRACT

The Internet of Things (IoT) enables the connection between humans, physical objects, and cyber objects, resulting in monitoring, automation, and decision-making capabilities. This connection can be complex and lead to uncertainty for individuals before adopting IoT technology. To address this, we conducted research on the role of Institution-based trust in the context of IoT adoption. Our model for IoT adoption is based on existing literature and includes the components of Institution-based trust and its antecedents. Through empirical testing, we confirmed that Institution-based trust positively affects IoT adoption at the individual level. Additionally, we found that User confirmation/disconfirmation and familiarity …


Key Issues Of Predictive Analytics Implementation: A Sociotechnical Perspective, Leida Chen, Ravi Nath, Nevina Rocco Jan 2024

Key Issues Of Predictive Analytics Implementation: A Sociotechnical Perspective, Leida Chen, Ravi Nath, Nevina Rocco

Journal of International Technology and Information Management

Developing an effective business analytics function within a company has become a crucial component to an organization’s competitive advantage today. Predictive analytics enables an organization to make proactive, data-driven decisions. While companies are increasing their investments in data and analytics technologies, little research effort has been devoted to understanding how to best convert analytics assets into positive business performance. This issue can be best studied from the socio-technical perspective to gain a holistic understanding of the key factors relevant to implementing predictive analytics. Based upon information from structured interviews with information technology and analytics executives of 11 organizations across the …


Does Personality Traits And Security Habits Influence Security Of Personal Identification Numbers? The Context Of Mobile Money Services In Tanzania., Daniel Ntabagi Koloseni Jan 2024

Does Personality Traits And Security Habits Influence Security Of Personal Identification Numbers? The Context Of Mobile Money Services In Tanzania., Daniel Ntabagi Koloseni

Journal of International Technology and Information Management

Security is an important ingredient in financial transactions; as such, it is imperative that attention should be paid to enhancing the security habits and user behaviours of mobile payment services. Establishing a link between security habits, personality characteristics, and security behaviours provides a new dimension to studying security behaviours regarding mobile money services. Therefore, this study investigates how personality traits affect security behaviours and habits and how security habits mediate the link between personality traits and PIN security practices. The study found that conscientiousness, openness to experience, extroversion and security habits influence PIN security practices, while conscientiousness, agreeableness, and neuroticism …


Media And Internet Censorship In India: A Study Of Its History And Political-Economy, Ramesh Subramanian Jan 2024

Media And Internet Censorship In India: A Study Of Its History And Political-Economy, Ramesh Subramanian

Journal of International Technology and Information Management

The Indian Constitution, which came into force on January 26, 1950, guarantees various fundamental rights, such as the freedom of speech and expression, freedom of religion, rights to form association, as well as rights to privacy. Yet, since the adoption of the Constitution, the Indian citizen has been subject to varying degrees of media censorship and surveillance. This paper seeks to delve into the historical evolution of media and Internet censorship and surveillance in India. It shows how media censorship of varying types have existed since the British colonists introduced restrictive laws in order to expand and control the native …


Activities Tailoring Within Agile Scrum Roles: A Case Of Nigerian Healthcare Information Systems Development, Yazidu Salihu, Julian Bass, Gloria Iyawa Jan 2024

Activities Tailoring Within Agile Scrum Roles: A Case Of Nigerian Healthcare Information Systems Development, Yazidu Salihu, Julian Bass, Gloria Iyawa

Journal of International Technology and Information Management

Developing quality agile healthcare information systems requires understanding regulatory compliance and evolving healthcare needs through activities tailored within agile scrum roles. Agile scrum, a widely adopted philosophy, offers significant advantages in managing software development processes. This research explores how activities within the agile scrum roles are tailored to agile healthcare information systems development within the Nigerian context. This study adopted a qualitative case study methodology and interviewed 12 agile practitioners developing healthcare information systems within Nigeria using semi-structured open-ended interview guide questions. The practitioners were selected based on a snowballing process, a sunset of purposive sampling techniques from our network …


A Validation Of Wepp Water Quality Routines In Uniform And Nonuniform Agricultural Hillslopes, Ryan P. Mcgehee, Dennis C. Flanagan, Bernard A. Engel, John E. Gilley Jan 2024

A Validation Of Wepp Water Quality Routines In Uniform And Nonuniform Agricultural Hillslopes, Ryan P. Mcgehee, Dennis C. Flanagan, Bernard A. Engel, John E. Gilley

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Nutrients in agricultural runoff may cause offsite environmental impacts. The objective of this investigation was to examine nutrient transport by overland sheet flow on sites containing swine slurry. Data examined in this study was collected during field rainfall simulation tests conducted on cropland sites in southeast Nebraska, USA. Inflow was added to the top of experimental plots in four successive increments to simulate runoff rates occurring at greater downslope distances. Runoff rates on the experimental sites ranged from 2.3 to 21.2 L min 1 and maximum equivalent downslope distances varied from 5 to 108 m. Phosphorus (P) and nitrogen (N) …


A Case Study Of Hospital Contraceptive Waste Management Practices In Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Anambra State, Yanmeer S. Tyotswam, Rosebella Iseme, Eliphas G. Makunyi Jan 2024

A Case Study Of Hospital Contraceptive Waste Management Practices In Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Anambra State, Yanmeer S. Tyotswam, Rosebella Iseme, Eliphas G. Makunyi

Population Health, East Africa

Background: Effective management of hospital waste is a critical component of a hospital’s infection control program and is central to occupational safety for healthcare workers. Thus, this study focused on the assessment of hospital contraceptive waste management practices at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH) Awka, Anambra state, Nigeria.

Methods: A cross sectional analytical study was carried out among healthcare workers selected using multistage sampling technique in 6 categories of healthcare workers in COOUTH. Data was collected using a pre-tested semi-structured interviewer-administered questionnaire and a World Health Organization (WHO) checklist and analyzed using statistical package for the …


Medical Expenditures And The Measurement Of Poverty In The United States, Luke Petach, David Wyant Jan 2024

Medical Expenditures And The Measurement Of Poverty In The United States, Luke Petach, David Wyant

Faculty Scholarship

Using data from the Medical Expenditure Panel Survey (MEPS) we estimate the fraction of the US population that is health poor. A person is health poor if their income prior to paying health insurance premiums and out-of-pocket healthcare costs is above the poverty line, but their income net-of-premiums and out-of-pocket healthcare costs is below the poverty line. Because resources used to finance health insurance premiums and out-of-pocket costs are (A) lexicographically preferred and (B) cannot be used to maintain an individual’s standard of living, they should be excluded from official poverty estimates. Approximately 1% to 2% of the US population …


A Proposal For The Use Of A Fixed Low-Energy Selective Laser Trabeculoplasty For Open Angle Glaucoma, Zachary Sacks, L. Jay Katz, Gus Gazzard, Sarah H. Van Tassel, Eytan Z. Blumenthal, Fabian S. Lerner, Augusto Azuara-Blanco, Gregory John Roy Spooner, Yoram Solberg, Thomas Samuelson, Michael Belkin Jan 2024

A Proposal For The Use Of A Fixed Low-Energy Selective Laser Trabeculoplasty For Open Angle Glaucoma, Zachary Sacks, L. Jay Katz, Gus Gazzard, Sarah H. Van Tassel, Eytan Z. Blumenthal, Fabian S. Lerner, Augusto Azuara-Blanco, Gregory John Roy Spooner, Yoram Solberg, Thomas Samuelson, Michael Belkin

Wills Eye Hospital Papers

Selective laser trabeculoplasty (SLT) has been in routine clinical use for over 20 years with millions of patients successfully treated and a low rate of clinically significant complications. The procedure requires the clinician to manually position the laser beam on the trabecular meshwork using a gonioscopy lens and to titrate the SLT laser energy based on the amount of pigmentation in the angle, as well as the observation of small bubbles produced by the laser effect. We propose that SLT energy titration is unnecessary either to achieve intraocular pressure (IOP) reduction or to minimize potential side effects. Ample evidence to …


Challenges Of Implementing Integrated Project Delivery In The Construction Industry In Egypt, Ayman Ahmed Ezzat Othman, Doaa Refahy, Ashraf Nessim Jan 2024

Challenges Of Implementing Integrated Project Delivery In The Construction Industry In Egypt, Ayman Ahmed Ezzat Othman, Doaa Refahy, Ashraf Nessim

Architectural Engineering

No abstract provided.


In This Issuesystematic Revieworiginal Article Jan 2024

In This Issuesystematic Revieworiginal Article

Saudi Medical Journal

No abstract provided.


War And Health Crisis In Gaza, Fahdah Alokaily Jan 2024

War And Health Crisis In Gaza, Fahdah Alokaily

Saudi Medical Journal

No abstract provided.


The Importance Of The Erythrocyte Distribution Width/Albumin Ratio In Patients With Chronic Obstructive Pulmonary Disease Exacerbation, Berrin Z. Eraslan, Sümeyye K. Cengiz, Seda B. Sagmen, Kübra Z. Yalçınkaya, Nesrin Kıral, Sevda Cömert Jan 2024

The Importance Of The Erythrocyte Distribution Width/Albumin Ratio In Patients With Chronic Obstructive Pulmonary Disease Exacerbation, Berrin Z. Eraslan, Sümeyye K. Cengiz, Seda B. Sagmen, Kübra Z. Yalçınkaya, Nesrin Kıral, Sevda Cömert

Saudi Medical Journal

Objectives: To investigate the relationship of the erythrocyte distribution width (RDW)/albumin ratio on hospital length of stay (LOS) and prognosis in patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbation. Methods: Patients hospitalized in our clinic for COPD exacerbation were retrospectively analyzed. Demographic characteristics, comorbidities, pulmonary function tests, arterial blood gas, history of hospitalization due to exacerbation in the last year, LOS, C-reactive protein, RDW, albumin, platelet counts, and 30-day mortality status were recorded. Significant cut-off RDW/albumin ratio values that could predict hospitalization for 10 days or more were analyzed. Results: A total of 58 patients were included in our …


Impact Of Pulmonary Infection After Radical Esophagectomy On Serum Inflammatory Markers, Pulmonary Function Indices, And Prognosis, Wu Wang, Tianbao Yang, Jinbiao Xie, Shijie Huang Jan 2024

Impact Of Pulmonary Infection After Radical Esophagectomy On Serum Inflammatory Markers, Pulmonary Function Indices, And Prognosis, Wu Wang, Tianbao Yang, Jinbiao Xie, Shijie Huang

Saudi Medical Journal

Objectives: To analyze the influence of pulmonary infection after radical esophagectomy on serum inflammatory markers, pulmonary function, and prognosis. Methods: We enrolled 278 esophageal cancer patients who underwent radical esophagectomy. Patients were split into the infected (n=51) and uninfected groups (n=227). The inflammatory parameters, complications, and prognosis were compared. Results: In the infected group, interleukin (IL)-6 was 16.19±2.63 ng/L, tumor necrosis factor-α was 19.64±3.07 µg/L, and IL-1β was 22.49±5.13 ng/L at 7 days postoperatively; white blood cell counts was 12.65±2.14 ×10 9 /L, percentage of neutrophils (NEU%) was 67.04±10.48%, and platelet (PLT) counts was 249.82±63.26 ×10 9 /L; the increasing …


Treatment Of Non-Displaced Intracapsular Femoral Neck Fractures With Dynamic Hip And Cannulated Screws Resulting In Avascular Necrosis: A Comparative Study Of Complications, Hashem A. Bukhary, Fahd I. Aljuaid, Khalid M. Alhomayani, Abdulelah A. Saati, Amaal M. Aldosari, Wateen A. Hammadi, Hamed S. Qutbuddeen, Abdulhafiz A. Wazuddin, Haneen A. Hammadi, Amjad M. Jawhari Jan 2024

Treatment Of Non-Displaced Intracapsular Femoral Neck Fractures With Dynamic Hip And Cannulated Screws Resulting In Avascular Necrosis: A Comparative Study Of Complications, Hashem A. Bukhary, Fahd I. Aljuaid, Khalid M. Alhomayani, Abdulelah A. Saati, Amaal M. Aldosari, Wateen A. Hammadi, Hamed S. Qutbuddeen, Abdulhafiz A. Wazuddin, Haneen A. Hammadi, Amjad M. Jawhari

Saudi Medical Journal

Objectives: To compare the complications associated with cannulated hip screws (CHS) and dynamic hip screws (DHS) techniques. Methods: In this multicenter retrospective chart study, we reviewed the records and data of all patients operated upon by DHS or CHS for treatment of Garden type I and type II intracapsular non-displaced femoral neck fracture from January 2017 to December 2022. Patients with incomplete files or follow-ups of less than one year were excluded from the study. Results: The study enrolled 85 patients, 35 males, and 50 females, with a mean age of 72±5.4 for males and 70.6±7.6 for females. A total …


The Prevalence Of Extracranial Carotid Atherosclerosis Detected Via Ultrasound Imaging: A Single-Centre Study In Jeddah, Saudi Arabia, Salahaden R. Sultan Jan 2024

The Prevalence Of Extracranial Carotid Atherosclerosis Detected Via Ultrasound Imaging: A Single-Centre Study In Jeddah, Saudi Arabia, Salahaden R. Sultan

Saudi Medical Journal

Objectives: To assess the prevalence of carotid atherosclerosis in Jeddah, Saudi Arabia. Methods: Data on patients who underwent carotid ultrasound examinations between 2017-2021 were collected retrospectively from the archive of King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Patient characteristics, blood lipid profiles, and plaque features were extracted from the medical records and ultrasound images. Descriptive data were presented as percentages. Results: In total, 1334 patients were reviewed. Of these, 13.5% had carotid plaques and were included in the analysis. The mean patient age was 69.8±10.4 years, and 76.1% were men. The prevalence of hypertension was 62.7% and the prevalence of …


Over 40 Million Health Professionals Demand Bold Health And Climate Action At Cop28 Jan 2024

Over 40 Million Health Professionals Demand Bold Health And Climate Action At Cop28

Saudi Medical Journal

No abstract provided.


Magnetic Sensors: Principles, Methodologies, And Applications, Mohamed Morsy Jan 2024

Magnetic Sensors: Principles, Methodologies, And Applications, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.


Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications. A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer., Shahin Sayed, Chowdhury Arif Jahangir, David Page, Glenn Broeckx, Claudia Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge Reis-Filho, Amy Ly, Paul Harms Jan 2024

Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications. A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer., Shahin Sayed, Chowdhury Arif Jahangir, David Page, Glenn Broeckx, Claudia Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge Reis-Filho, Amy Ly, Paul Harms

Pathology, East Africa

Recent advances in thefield of immuno-oncology have brought transformative changes in the management ofcancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis andtreatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged aspotent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, therebyexpanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing thephenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinicallyrelevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential toguide appropriate treatment …