Digital Commons Network^™

Jaha At Scientific Sessions 2023: Moving Toward Social Justice In Cardiovascular Health In The United States, Carissa M. Baker-Smith, Salina P. Waddy, Sara Hassani, Mahasin Mujahid, Tochi Okwuosa, Emmanuel Peprah, Bernadette Boden-Albala

Department of Medicine Faculty Papers

Attention to social justice is essential to improving cardiovascular health outcomes. In the absence of social justice, equitable cardiovascular health is impossible. This viewpoint provides a brief synopsis of the 2023 Journal of the American Heart Association (JAHA)–sponsored session titled “Moving Towards Social Justice in Cardiovascular Health.” We define social justice and summarize the burden of cardiovascular disease inequity in the United States. We also highlight strategies for achieving social justice, including addressing workforce diversity, integrating social determinants into cardiovascular research, designing cardiovascular interventions to close the equity gap, and improving inclusivity in cardiovascular disease trials.

Understanding Contributing Factors To Injury Severity And Improper Driver Actions In Work Zone Crashes And Evaluating Smart Work Zone Applications For Safety Improvement, Rakesh Rangaswamy

USF Tampa Graduate Theses and Dissertations

A work zone can be described as a roadway designated for construction, maintenance, or other activities that temporarily disrupt the normal traffic flow. Due to this disrupts in traffic conditions, work zones may bring sudden shifts in driving experience, depending on the sort of work zone present, creating unpredictable maneuvers, and putting both motorists and workers at risk. To understand these issues, this study uses work zone accident data obtained from Florida and uses several methodological techniques, including the mixed logit model with variance and mean heterogeneity, temporal instability test, log-likelihood test, out-of-sample analysis, and ANOVA test.

Firstly, this study …

Are Biobased Microfibers Less Harmful Than Conventional Plastic Microfibers: Evidence From Earthworms, W. Courtene-Jones, F. De Falco, F. Burgevin, R. D. Handy, R. C. Thompson

School of Geography, Earth and Environmental Sciences

Biobased plastics are sometimes promoted as “environmentally friendly” compared to their conventional petrochemical-based counterparts, but their ecotoxicity is only partially understood. Biobased fibers are widely used in clothing and wet wipes and can accumulate in soils through the application of biosolid fertilizers. This study examined the lethal thresholds and sublethal toxicity of chemically characterized, additive-free, biobased (viscose and lyocell) compared to petrochemical-based (polyester) fibers on the key ecosystem engineer, Esenia fetida. Viscose and lyocell had LC₂₀ values of 14.00 and 22.66 mg·L^-1, respectively, and no observed effect concentrations (NOEC) of 0-2.8 mg·L^-1 (72 h, OECD TG207 …

What Influences Women's Participation In The Private Sector Workforce In Oman?, Rakesh Belwal, Shweta Belwal, Suhaila Alhashemi

Plymouth Business School

Purpose: Women’s employment has been a contentious issue in the Arab world. However, in today’s changing work conditions, workplaces, and the growth in education, women have increasingly occupied higher-level roles, and their presence in diverse industries has expanded. The study takes a holistic approach to female labor force participation (FLFP) in Oman, encompassing various theories and factors influencing women’s engagement in private sector jobs. Design/methodology/approach: The research employed an exploratory design followed by a qualitative analysis based on a constructivist grounded theory approach. The study involved 170 semi-structured face-to-face interviews with women workers in Oman’s private sector. It explored work–family …

Preservice Teachers’ Perceptions Of Their Level Of Preparedness To Support Students Who Encounter Adverse Childhood Experiences, Lanicia P. Marshall

USF Tampa Graduate Theses and Dissertations

This study aimed to explore preservice teachers’ perceptions of their preparedness to support students who have been exposed to or/are currently encountering adverse childhood experiences. Adverse childhood experiences (ACEs) are a form of trauma and are very likely to occur among students. Due to students spending a significant amount of time in classroom settings, teachers are the first to identify possible issues that can interfere with academic performance. The present study was built upon the few studies that have focused on preservice teachers and their perceptions of preparedness to support students experiencing ACEs. Data were collected using an online survey …

Il-37 Suppresses Cns Autoimmunity By Increasing The Frequency Of Treg Cells And Reducing Cd4 + T Cell-Derived Il-10 Production, Reza Yazdani, Hamed Naziri, Gholamreza Azizi, Bogoljub Ciric, Mozhde Askari, Amir Moghadam-Ahmadi, Jaya Aseervatham, Guang-Xian Zhang, Mohamad Rostami

Department of Neurology Faculty Papers

BACKGROUND: Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels of IL-37. However, it is unknown whether IL-37 has an inhibitory effect on ongoing autoimmune neuroinflammation, thus offering a potential MS therapy.

AIM: Here, we examined the effect of IL-37 in an experimental autoimmune encephalomyelitis (EAE) model after disease onset to determine if it was protective.

FINDINGS: IL-37-treated mice developed a less severe disease than control mice, with reduced demyelination as determined by increased expression of myelin basic protein. …

Endovascular Treatment Of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score, Ameer E Hassan, Nils H Petersen, Johanna T Fifi, Amer Malik, James E Siegler, Thanh N Nguyen, Sunil A Sheth, Guillermo Linares, Nazli Janjua, Jazba Soomro, Darko Quispe-Orozco, Marta Olivé-Gadea, Wondewossen G Tekle, Syed F Zaidi, Sara Y Sabbagh, Tiffany Barkley, Ayush Prasad, Reade A De Leacy, Mohamad Abdalkader, Sergio Salazar-Marioni, Weston Gordon, Charoskhon Turabova, Aaron Rodriguez-Calienes, Mahmoud Dibas, Maxim Mokin, Dileep R Yavagal, Albert J Yoo, Amrou Sarraj, Tudor G Jovin, Santiago Ortega-Gutierrez

Faculty, Staff and Student Publications

Background: Recent trials confirmed the efficacy and safety of endovascular thrombectomy in patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS); however, evidence in tandem lesions is limited. This study evaluates endovascular thrombectomy safety and efficacy in patients with acute large-vessel occlusion with tandem lesions, stratified by baseline ASPECTS.

Methods and results: We conducted a retrospective analysis of data from 16 centers. Inclusion criteria included the following: age ≥18 years, anterior circulation tandem lesions, endovascular thrombectomy < 24 hours of symptom onset, and ≥70% internal carotid artery stenosis/occlusion. Patients were categorized into low (0-5) and high (6-10) ASPECTS. Inverse probability of treatment weighting matching was used to balance the groups. Primary outcomes included the following: 90-day modified Rankin Scale (mRS) score 0 to 2 and symptomatic intracranial hemorrhage. Secondary outcomes included the following: ordinal mRS, mRS 0 to 3, modified Thrombolysis in Cerebral Infarction ≥2b and 2c-3, petechial hemorrhage, parenchymal hematoma (1/2), early neurologic improvement, and mortality. Of 691 patients, 44 had ASPECTS 0 to 5 and 505 had ASPECTS 6 to 10. Patients with low ASPECTS had lower odds of 90-day mRS 0 to 2 (adjusted odds ratio [OR], 0.48; P=0.036) and higher odds of symptomatic intracranial hemorrhage (adjusted OR, 3.78; P=0.014). Additional significant differences were found in mRS shift, …

Intrinsic Motivation And Career Satisfaction Among Immigrant Health Care Workers, Michelle Marie Henderson-Darling

Walden Dissertations and Doctoral Studies

Caribbean immigrants are vital to the U.S. health care workforce, yet they face barriers that often hinder their career satisfaction and well-being. This qualitative study aimed to explore how intrinsic motivations, specifically competence, autonomy, and relatedness, shape the career experiences of Caribbean immigrants in health care. Using self-determination theory as the theoretical framework, this study addressed the research question of how these intrinsic motivations shape immigrant experiences in the U.S. health care sector. Data were collected from 10 Caribbean immigrants who were naturalized U.S. citizens using semistructured, audio-recorded interviews. The data were thematically analyzed to detect patterns and themes. The …

Human Studies Of The Efficacy And Safety Of Stem Cells In The Treatment Of Diabetic Peripheral Neuropathy: A Systematic Review And Meta-Analysis, Seyed Danial Alizadeh, Shima Jahani, Mohammad Rezaei Zadeh Rukerd, Reza Tabrizi, Rasoul Masoomi, Seyedeh Zahra Banihashemian, Mahgol Sadat Hassan Zadeh Tabatabaei, Zahra Ghodsi, Ahmad Pour-Rashidi, James Harrop, Vafa Rahimi-Movaghar

Department of Neurosurgery Faculty Papers

OBJECTIVE: To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN).

METHODS: A comprehensive literature review was performed across multiple databases, including Ovid MEDLINE ALL, Embase via Ovid SP, Scopus, Web of Science Core Collection, and Cochrane CENTRAL, up to January 31, 2024. Keywords and controlled vocabularies related to diabetic neuropathy and stem cell therapy were used. Inclusion criteria encompassed all controlled trials examining stem cell therapy for DPN, excluding animal or in vitro studies, review papers, conference abstracts, and editor letters. Data extraction and risk of bias assessment were independently performed …

Uab Biologist To Co-Lead A Five-Year Nih Grant To Investigate Social Impacts On Lifespan, Staff

Browse All News

No abstract provided.

Delta-Like Ligand 3 (Dll3) Landscape In Pulmonary And Extra-Pulmonary Neuroendocrine Neoplasms, Alejandra G Serrano, Pedro Rocha, Cibelle Freitas Lima, Allison Stewart, Bingnan Zhang, Junya Fujimoto, Wei Lu, Khaja Khan, Beate Sable, Aaron R Ellison, Ignacio I Wistuba, Kyle F Concannon, Daniel M Halperin, Czerniak Bogdan, Kanishka Sircar, Miao Zhang, Kasey Cargill, Qi Wang, Ana Aparicio, Alexander Lazar, Sharia Hernandez, Jeannelyn Estrella, Preetha Ramalingam, Adel El-Naggar, Neda Kalhor, Carl M Gay, Lauren Averett Byers, Luisa M Solis Soto

Faculty, Staff and Student Publications

Delta-like Ligand 3 (DLL3) targeting therapies are promising in small cell lung cancer (SCLC) treatment. However, DLL3 expression in SCLC and other neuroendocrine neoplasms (NEN) is heterogeneous and not well characterized. We describe the landscape of DLL3 at the mRNA and protein levels across SCLC, large cell neuroendocrine carcinoma (LCNEC), and non-small cell lung cancer. Additionally, we explore its expression in extra-pulmonary NEN (EP-NEN) using a standardized DLL3 IHC assay. DLL3 expression is enriched in SCLC, LCNEC along with combined histology lung cancers. Moreover, we find a wide range of DLL3 expression in high-grade EP-NEN. We describe heterogenous DLL3 expression …

Adjuvant Radiation Therapy In Desmoplastic Melanoma: A Scoping Review, Christina Setareh Sharafi, B Ashleigh Guadagnolo, Kelly C Nelson, Devarati Mitra

Faculty, Staff and Student Publications

Desmoplastic melanoma (DM) is an uncommon subtype of cutaneous melanoma that presents distinct diagnostic and treatment challenges. This review aims to explore the role of adjuvant radiation therapy (RT) in managing DM. To evaluate this question, we reviewed relevant published reports on DM and its treatment and synthesized these findings. It was found that the clinical behavior of DM varies significantly based on its classification as either "pure" DM (pDM, ≥90% desmoplastic features) or mixed DM (mDM, ≤90% desmoplastic features). Patients with pDM have a uniquely high risk of local recurrence but a relatively lower likelihood of nodal disease. Recent …

Frontline Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia Treatment And The Emerging Role Of Blinatumomab, Elias J Jabbour, Hagop M Kantarjian, Nicola Goekbuget, Bijal D Shah, Sabina Chiaretti, Anita W Rijneveld, Shaun Fleming, Aaron C Logan, Josep M Ribera, Tobias F Menne, Khalid Mezzi, Faraz Zaman, Kelly Velasco, Nicolas Boissel

Faculty, Staff and Student Publications

This narrative review seeks to summarize chemotherapeutic regimens commonly used for patients with newly diagnosed Philadelphia (Ph) chromosome-negative B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in the frontline setting and to describe the latest clinical research using the bispecific T-cell-engaging immunotherapy blinatumomab in the first-line treatment setting. Current standard-of-care chemotherapeutic backbones for newly diagnosed Ph-negative BCP-ALL are based on the same overarching treatment principle: to reduce disease burden to undetectable levels and maintain lasting remission. The adult treatment landscape has progressively evolved following the adoption of pediatric-inspired regimens. However, these intense regimens are not tolerated by all, and high-risk patients still …

Efficacy Of High-Definition Transcranial Alternating Current Stimulation (Hd-Tacs) At The M1 Hotspot Versus C3 Site In Modulating Corticospinal Tract Excitability, Gerard Francisco

Faculty, Staff and Student Publications

Previous studies have shown that beta-band transcranial alternating current stimulation (tACS) applied at the M1 hotspot can modulate corticospinal excitability. However, it remains controversial whether tACS can influence motor unit activities at the spinal cord level. This study aims to compare the efficacy of applying tACS over the hotspot versus the conventional C3 site on motor unit activities and subsequent behavioral changes. This study used a randomized crossover trial design, where fifteen healthy participants performed a paced ball-squeezing exercise while receiving high-definition tACS (HD-tACS) at 21 Hz and 2 mA for 20 min. HD-tACS targeted either the flexor digitorum superficialis …

Advancements In Autophagy Modulation For The Management Of Oral Disease: A Focus On Drug Targets And Therapeutics, Md Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta, Nazeeba Siddika, Muhammad Saad Shaikh, Muhammad Sohail Zafar, Bonglee Kim, Ehsanul Hoque Apu

School of Medicine Publications

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, and thereby cell survival. Oral health is an essential component of integrated well-being, and it is critical for developing therapeutic interventions to understand the molecular mechanisms underlying the maintenance of oral homeostasis. However, because of the complex dynamic relationship between autophagy and oral health, associated treatment modalities have not yet been well elucidated. Determining how autophagy affects oral health at the molecular level may enhance the understanding of prevention and treatment of targeted oral diseases. At the molecular level, hard and soft oral tissues …

Body Condition Scoring For Sheep, Abigail Johnson, Reganne K. Briggs, Chad Page

All Current Publications

Body condition scoring is a helpful tool for sheep producers to use to evaluate the status of their flock. This fact sheet illustrates how to condition score sheep and the importance of condition scoring on production.

Fact Sheet For Parents: What You Need To Know About Adderall, Aaron Hunt, Gabriela Murza, Alyssa Ferrin

All Current Publications

This fact sheet provides information about what Adderall is used for, how it can be misused, and what parents can do to talk to their kids about appropriate use.

Samd7 Represses Short-Wavelength Cone Genes To Preserve Long-Wavelength Cone And Rod Photoreceptor Identity, Leo I Volkov, Yohey Ogawa, Ramiz Somjee, Hannah E Vedder, Hannah E Powell, Deepak Poria, Sam Meiselman, Vladimir J Kefalov, Joseph C Corbo

2020-Current year OA Pubs

The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell-type-specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional corepressor

Disordered Proteins Interact With The Chemical Environment To Tune Their Protective Function During Drying, Shraddha Kc, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby

2020-Current year OA Pubs

The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this sensitivity. One context in which IDPs play important roles that are concomitant with massive changes to the intracellular environment is during desiccation (extreme drying). The ability of organisms to survive desiccation has long been linked to the accumulation of high levels of cosolutes such as trehalose or sucrose as well as the enrichment of IDPs, such as late embryogenesis abundant (LEA) proteins or cytoplasmic abundant heat-soluble (CAHS) proteins. …

Electrical Impedance Tomography Monitoring In Adult Icu Patients: State-Of-The-Art, Recommendations For Standardized Acquisition, Processing, And Clinical Use, And Future Directions, Gaetano Scaramuzzo, Bhushan H Katira, Et Al.

2020-Current year OA Pubs

Electrical impedance tomography (EIT) is an emerging technology for the non-invasive monitoring of regional distribution of ventilation and perfusion, offering real-time and continuous data that can greatly enhance our understanding and management of various respiratory conditions and lung perfusion. Its application may be especially beneficial for critically ill mechanically ventilated patients. Despite its potential, clear evidence of clinical benefits is still lacking, in part due to a lack of standardization and transparent reporting, which is essential for ensuring reproducible research and enhancing the use of EIT for personalized mechanical ventilation. This report is the result of a four-day expert meeting …

Ethical Issues In Implementation Science: Perspectives From A National Heart, Lung, And Blood Institute Workshop, Neal W Dickert, Donna Spiegelman, Jennifer S Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M Kahn, Nancy E Kass, Scott Y H Kim, Meeta P Kerlin, Aisha T Langford, James V Lavery, Daniel D Matlock, Kathleen N Fenton, George A Mensah

Center for Medical Ethics and Health Policy Staff Publications

Ethical issues arise in the context of implementation science that may differ from those encountered in other research settings. This report, developed out of a workshop convened by the Center for Translation Research and Implementation Science within the United States National Heart, Lung, and Blood Institute, identifies six key themes that are important to the assessment of ethical dimensions of implementation science. First, addressing ethical challenges in implementation science does not require new ethical principles, commitments, or regulations. However, it does require understanding of the specific contexts arising in implementation research related to both study design and the intervention being …

Childless Mothers: Lived Experiences Of Black Mothers Who Lost An Only Child, Arielle Jordan

Walden Dissertations and Doctoral Studies

This qualitative study, grounded in hermeneutic phenomenology, explores the experiences of Black mothers who have lost their only child, addressing a topic often overlooked in counseling training programs. Many counselor educators and supervisors are unprepared to train counselors on how best to support these mothers through their unique grief journeys. This study outcomes fill that gap by providing a deeper understanding of their experiences, intending to shape better counseling practices. The central question guiding this research is: What are the lived experiences of Black mothers who have survived the loss of their only child? To answer this, in-depth interviews were …

Teaching Motivational Interviewing To Staff In A Mental Health Clinic To Improve Retention Rates Among The Homeless, Barry Godwin, Chinemerem Uzoechi

Walden Dissertations and Doctoral Studies

Summary Poor treatment retention rates are significant problems in mental health, with adverse outcomes being more profound for vulnerable populations, such as individuals experiencing homelessness. The current project was vital because the lack of engaging strategies in working with individuals experiencing homelessness contributes to high rates of treatment dropout. The purpose of the project was to equip mental health clinical staff with knowledge and skills in motivational interviewing (MI) to use MI in clinical settings to improve treatment retention for homeless populations. The practice-focused question that guided the project was: For staff in a mental health clinic, will training on …

African American Children’S Risk Of Long Covid-19 Syndrome Based On Daily Intake Of Fruits And Vegetables, Christopher Joseph Waskewich

Walden Dissertations and Doctoral Studies

Although the Covid-19 pandemic emerged in 2020, limited information about how the virus affects adolescents regarding long-term health risks is available. This quantitative study focused on the effect of U.S. adolescents' daily diet, race/ethnicity, levels of income, access to health care, age, and comorbidities on the risks of long Covid-19 syndrome. The constructs of the health belief model were used to understand the impact of those variables. The results of the online survey (n=298) with the parents of adolescent children (ages 11-17) from New York City found that adolescents whose daily vegetable consumption was more than the daily recommendations had …

Perceptions Of Women With Cardiovascular Disease Who Chose Conservative Therapy Over Advanced Therapy, Vanessa Pugh

Walden Dissertations and Doctoral Studies

Cardiovascular disease is the leading cause of death for women. Women with cardiovascular diseases are less likely to receive the available advanced therapies such as defibrillators, pacemakers, and left ventricular assist devices as part of their cardiovascular care plan when compared to their male counterparts. Kelly’s theory of personal constructs and his11 corollaries were used as the theoretical foundation for this basic qualitative study to help explore and understand the perceptions of women who chose a conservative therapy instead of a more advanced therapy for their cardiovascular disease. Social media platforms and snowballing technique were used to recruit the six …

Helping Our Graduate Students Soar: Promoting Scholarship And Populating Our Institutional Repository, Elaine Wells

Journal of Graduate Librarianship

The author describes how a requirement that our graduate students deposit theses and dissertations into our institutional repository (SOAR) helped to build our online scholarship, educate and strengthen graduate students’ identities as scholars, and forge relationships with the library. Taking advantage of the synergy brought about by a new open access policy, a robust digital repository, and library staff committed to advancing accessible scholarly works, we developed ways to educate, encourage, and promote our newest scholars. Based upon our success thus far, we will develop workshops and tutorials that will be extended to junior faculty to advance their scholarly success.

Sims Rn Role In The Emergency Care Center - A New Approach To Delivering Quality Care, Jo Zarnegar

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.

To Develop/Implement An Evidence Based Order Set For Maternity Patients With Potential Opioid Use Disorder (Oud), Katrina Munoz

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.

Millennial Nurses Experience High Burnout And Turnover Risk During A Pandemic, Dana N Rutledge, Elizabeth Winokur, Sarah Douville

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.

Road To Beacon Gold, Annika Daphne Bilog, Rhonda Tristan-Evans, Cecille Lamorena

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.