Digital Commons Network^™

Evaluation Of The Effectiveness Of The Implementation Of A New Workflow Process On The Incidence Of High Blood Culture Contamination (Bcc) Rates In The Emergency Department, Angelita Rodgers

Walden Dissertations and Doctoral Studies

The purpose of this Doctor of Nursing Practice Project was to evaluate the effectiveness of a quality improvement (QI) initiative to reduce blood culture contamination (BCC) rates in the emergency department (ED) of a large healthcare organization in the southeastern United States. Evidence-base sources indicated that high blood culture contamination (BCC) rates compromised diagnostic accuracy, leading to unnecessary treatments, increased hospital stays, and elevated healthcare costs. The project was guided by the evidence-based practice question: “How does the implementation of a new workflow process influence the incidence of high blood culture contamination (BCC) rates in the emergency department?” To address …

The Grizzly, November 21, 2024, Kate Horan, Nathaniel Nerone, Zach Cosme, Sophia Kumar, Ashley Adam, Hadley Whitman, Malachi Kea

Ursinus College Grizzly Newspaper, 1978 to Present

What's in a Baden? • Vector Trainings and the Scramble Before Registration • Wind Ensemble Holiday Concert • Coffee Beans n' Bears • In Our Lavender Lifetimes • A Professor, Advisor, and Icon • Men's Basketball Out to Strong Start • Determined to Dominate: Jaheim Oates' Story

Genetic Risk Stratification And Outcomes Among Treatment-Naive Patients With Aml Treated With Venetoclax And Azacitidine, Hartmut Döhner, Keith W Pratz, Courtney D Dinardo, Andrew H Wei, Brian A Jonas, Vinod A Pullarkat, Michael J Thirman, Christian Récher, Andre C Schuh, Sunil Babu, Xiaotong Li, Grace Ku, Zihuan Liu, Yan Sun, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A Pollyea

Faculty, Staff and Student Publications

The European LeukemiaNet (ELN) acute myeloid leukemia (AML) genetic risk classification systems are based on response to intensive chemotherapy; their ability to discriminate outcomes in older patients treated with venetoclax-azacitidine may be suboptimal. This pooled analysis of the phase 3 VIALE-A trial (NCT02993523) and phase 1b study (NCT02203773) examined prognostic stratification according to the 2017 and 2022 ELN risk classifications and derived new molecular signatures differentiating venetoclax-azacitidine-treated patients based on overall survival (OS). Overall, 279 patients treated with venetoclax-azacitidine and 113 patients treated with placebo-azacitidine were analyzed. The ELN 2017 or 2022 prognostic criteria classified most …

Medilink: A Secure Blockchain Framework For Multi-Institutional Healthcare, Jorge Castillo, Qian Chen

Informatics and Engineering Systems Faculty Publications

The use of Electronic Medical Records (EMRs) in the healthcare industry has proven to be critical for storing highly sensitive information. Disseminating and protecting healthcare data poses major challenges for the current healthcare information system. Blockchain technology provides solutions to these challenges with its inherited properties, such as decentralization, immutability, and transparency. This provides a unique opportunity to improve data sharing among stakeholders. We propose MediLink, a blockchain-based framework for secure collaborative medical storage. MediLink is designed to (1) protect EMR data from cyber attacks, (2) share healthcare information of patients with different stakeholders, and (3) enable the Internet of …

Firearm Access, Carriage And Use In An Ethnically Diverse Sample Of Young Adults In Texas, Usa, Yu Lu, Elizabeth Baumler, Annalyn Saludares Demello, Leila Wood, Hillary Mcguire, Jeff R Temple

Faculty, Staff and Student Publications

Background Despite the high rates of firearm ownership and firearm-related injuries and mortalities in Southern US states, understandings on the factors contributing to these are lacking.

Methods Using wave 10 (2021) data from a longitudinal study, we examined firearm-related experiences among 636 ethnically diverse young adults (mean age=26 years; 62% female) in Texas, USA.

Results Just over half of participants had ready access to firearms, with 22.3% having carried a firearm outside of their home, 4.9% having been threatened with a firearm by a romantic partner and 4.4% by a non-romantic partner. More firearm access and carriage were reported in …

Quaker Campus, November 21, 2024 (Vol. 23, Issue 7), Whittier College

Quaker Campus

No abstract provided.

Optimal Management Of Patients With Moderate-To-Severe Inflammatory Bowel Disease, Tugrul Purnak, Atilla Ertan

Faculty, Staff and Student Publications

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and often debilitating condition requiring complex and individualized management. Over the past few decades, advancements in understanding IBD pathophysiology have led to a transformative shift in therapeutic approaches. This article provides a comprehensive overview of the evolution of IBD treatments, from early symptom-focused therapies to modern biologics, small molecule agents, and emerging treatment strategies. We discuss therapeutic goals centered on achieving clinical remission, endoscopic/mucosal healing, and enhancing patient quality of life. Additionally, we explore the rationale for the early and personalized use of biologic therapies …

Birth Privilege As White Privilege, Jennifer Scuro Phd

Philosophy: Faculty Publications

In The Pregnancy ≠ Childbearing Project: A Phenomenology of Miscarriage (2017), I argued the need to ‘disentangle the plot’ of pregnancy as it has a naturalised and uncritical access to heteronormative gender privilege. In this paper, with the premise that, ‘whiteness is property,’ as argued by Cheryl Harris in 1993, I extend this work to how birthing is only a story for the white entitled few, and as an entitlement, is tied to the making and preserving of the ‘nuclear family’ and ‘family values.’ As this history of birth privilege as white privilege is also a trauma history, I include …

Determining The Role Of The Histone Demethylase Kdm5b In Microglial Reactivity To Ethanol, Jessica Wohlfahrt

USF Tampa Graduate Theses and Dissertations

Through their involvement in various processes such as phagocytosis of foreign materials and damaged cellular debris, regulatory factor release, and surveillance, the macrophages of the brain, microglia, maintain homeostasis within the central nervous system. These diverse microglial functions therefore require transition to a range of phenotypic states. The epigenetic regulation of this activity, especially through trimethylation of lysine 4 on histone H3, and its regulator, lysine demethylase (KDM)5B, is an emerging research area. KDM5B has been implicated in several diseases including cancer, inflammatory disorders, and alcohol use disorder (AUD), the latter being the focus of this dissertation project. Deep proteomic …

Teen Dating Violence And The Covid-19 Pandemic: Trends From A Longitudinal Study In Texas, Leila Wood, Elizabeth Baumler, Morgan E Pettyjohn, Jeff R Temple

Faculty, Staff and Student Publications

Purpose: Teen dating violence (TDV) is a global public health and safety issue causing health impacts to youth people. This study aimed to examine: (1) the impact of the pandemic on TDV victimisation rates and (2) socioecological factors associated with sustained risk for TDV victimisation during the first year of COVID-19.

Methods: Data are from an ongoing randomised controlled trial of a TDV prevention programme in Texas (n=2768). We conducted annual assessments in 2019-2021. We used regression modelling to assess demographic, individual, peer and family factors associated with TDV risks.

Results: TDV rates declined from 11.9% in 2019 to 5.2% …

Faculty Senate Agenda, Georgia Southern University, Faculty Senate

Faculty Senate Agendas

No abstract provided.

Faculty Senate Minutes, Georgia Southern University, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Advanced Magnetic Sensing Technologies For Enhanced Biodetection And Healthcare Monitoring, Kee Young Hwang

USF Tampa Graduate Theses and Dissertations

The development of biosensing systems that leverage the unique properties of magnetic nanoparticles and the high sensitivity of magnetic sensors for detecting biomolecules and cancer cells has been an active area of research. However, challenges remain in detecting and differentiating the magnetic signals of biomarkers made from nanoparticles that have similar sizes but distinct magnetic properties. Additionally, overcoming the reduction in detection sensitivity caused by non-magnetic coatings on magnetic nanoparticles remains a key hurdle. Concurrently, there is a pressing need to develop advanced magnetic sensor technologies that can enhance existing healthcare monitoring systems and enable more precise, real-time diagnostics.This dissertation …

Coping With And Surviving Domestic Violence Among African American Women In A Rural Community, Kimberly Evonne Wimbush

Walden Dissertations and Doctoral Studies

Domestic violence (DV) or intimate partner violence is a widespread public health problem in the United States that knows no boundaries. Previous researchers have found that in the United States, African American women experience more severe effects from DV than women in other ethnic groups. The purpose of this generic qualitative study was to identify the coping strategies used by African American women who have survived DV living in rural areas where there are limited professional resources. Premises from the superwoman schema and adult resilience theory guided this research. Semistructured audio-recorded interviews, conducted via Zoom and face-to-face, were used to …

Dog Sniffing Biomechanic Responses In An Odor Detection Test Of Odorants With Differing Physical Properties, Lydia Burnett, Nicholas Hebdon, Pete A. Stevens, Monica Moljo, Lindsay D. Waldrop, Lauryn Degreeff

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Dogs are utilized in forensic science for their extensive scent detection capabilities. They are often considered the “gold standard” in field detection for targets such as illicit drugs and explosives. Despite their prevalence in the field, relatively little is known about how dogs interact with and transport volatile organic compounds through their olfactory system. In this study, two groups of dogs were utilized – Sport detection dogs (n=19) that participate in the National Association of Canine Scent Work and have achieved advanced standing through training and successful search competitions and law enforcement explosive detection dogs (n=8) which were included for …

Unravelling The Erythropoietin Heterodimeric Complex: In Silico Analysis Of Complex Assembly And Binding Interface, Atiya Habib, Urooj Qureshi, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

Erythropoietin (Epo), a glycosylated protein categorized as a member of the cytokine family, is responsible for the modulation of erythrogenesis. Besides this, the nonhaematopoietic effects of Epo are associated with tissue-protective activity via an antiapoptotic pathway. This function of Epo is linked with its heterodimeric form, i.e. EpoR/βcR belonging to the cytokine family as well. Both receptors are dissected into three domains: extracellular (also known as ligand-binding domain), transmembrane and cytoplasmic domain. The transmembrane and cytoplasmic domains are assumed to play a paramount role in dimerization and tissue protection. However, the tertiary structure of cytoplasmic domains of both …

Chloronitramide Anion Is A Decomposition Product Of Inorganic Chloramines, Julian L. Fairey

Civil Engineering Faculty Publications and Presentations

Editor’s summary

Uab Adds New Meg Technology To Enhance Research And Clinical Care For Epilepsy And Other Brain Diseases, Staff

Browse All News

No abstract provided.

Effects Of Surface Treatment On Adhesive Performance Of Composite-To-Composite And Composite-To-Metal Joints, Nikhil Paranjpe, Md. Nizam Uddin, Akm S. Rahman, Ramazan Asmatulu

Publications and Research

This study deals with the long-running challenge of joining similar and dissimilar materials using composite-to-composite and composite-to-metal joints. This research was conducted to evaluate the effects of surface morphology andsurfacetreatments onthemechanicalperformanceofadhesively bonded joints used for the aircraft industry. A two-segment, commercially available, toughened epoxy was chosen as the adhesive. Unidirectional carbon fiber prepreg and aluminum 2021-T3 alloys were chosen for the composite and metal panels, respectively. Surface treatment of the metal included corrosion elimination followed by a passive surface coating of Alodine®. A combination of surface treatment methods was used for the composite and metal specimens, including detergent cleaning, plasma …

Genetic Risk Classification For Adults With Aml Receiving Less-Intensive Therapies: The 2024 Eln Recommendations, Hartmut Döhner, Courtney D Dinardo, Frederick R Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L Ebert, Pierre Fenaux, Lucy A Godley, Robert P Hasserjian, Richard A Larson, Ross L Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M Stein, Martin S Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H Wei, Bob Löwenberg

Faculty, Staff and Student Publications

The European LeukemiaNet (ELN) genetic risk classifications were developed based on data from younger adults receiving intensive chemotherapy. Emerging analyses from patients receiving less-intensive therapies prompted a proposal for an ELN genetic risk classification specifically for this patient population.

November 21, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Mode Of Injury And Level Of Synovitis Alter Inflammatory Chondrocyte Gene Expression And Associated Pathways, Megan L Libke, Daniel J Cunningham, Bridgette D Furman, John S Yi, Jonathan M Brunger, Virginia B Kraus, Farshid Guilak, Amy L Mcnulty, Steven A Olson

2020-Current year OA Pubs

Although various joint injuries result in post-traumatic osteoarthritis (PTOA), differences in chondrocyte response to specific injuries, such as blunt compression or fracture, are unclear. Furthermore, the role of underlying joint inflammation, or synovitis, is often not considered. We investigated how injury mechanisms and underlying synovitis affect chondrocyte gene expression using osteochondral injury models with synovial co-culture. We hypothesized that the state of synovitis as well as the mechanism of biomechanical cartilage injury differentially alter the gene expression of chondrocytes and that these responses are regulated by the pro-inflammatory cytokine interleukin 1 (IL-1). The mechanism of injury and level of synovial …

Sertraline Modulates Hippocampal Plasticity Via Sigma 1 Receptors, Cellular Stress And Neurosteroids, Yukitoshi Izumi, Angela M Reiersen, Eric J Lenze, Steven J Mennerick, Charles F Zorumski

2020-Current year OA Pubs

In addition to modulating serotonin transport, selective serotonin reuptake inhibitors (SSRIs) have multiple other mechanisms that may contribute to clinical effects, and some of these latter actions prompt repurposing of SSRIs for non-psychiatric indications. In a recent study of the SSRIs fluvoxamine, fluoxetine and sertraline we found that, unlike the other two SSRIs, sertraline acutely inhibited LTP at a low micromolar concentration through inverse agonism of sigma 1 receptors (S1Rs). In the present studies, we pursued mechanisms contributing to sertraline modulation of LTP in rat hippocampal slices. We found that sertraline partially inhibits synaptic responses mediated by N-methyl-D-aspartate receptors (NMDARs) …

Qualitative Assessment Of Proposed Visual Key Information Pages For Informed Consent, Krista E. Cooksey, Eliana Goldstein, Clara Lee, Jessica Mozersky, Kimberly A. Kaphingst, Victor Catalan Gallegos, Mary C. Politi

2020-Current year OA Pubs

No abstract provided.

Effectiveness And Safety Of Irreversible Electroporation When Used For The Ablation Of Stage 3 Pancreatic Adenocarcinoma: Initial Results From The Direct Registry Study, Robert C G Martin, Rebekah Ruth White, Malcolm M Bilimoria, Michael D Kluger, David A Iannitti, Patricio M Polanco, Chet W Hammil, Sean P Cleary, Robert Evans Heithaus, Theodore Welling, Carlos H F Chan

2020-Current year OA Pubs

BACKGROUND/OBJECTIVES: Overall survival for patients with Stage 3 pancreatic ductal adenocarcinoma (PDAC) remains limited, with a median survival of 12 to 15 months. Irreversible electroporation (IRE) is a local tumor ablation method that induces cancerous cell death by disrupting cell membrane homeostasis. The DIRECT Registry study was designed to assess the effectiveness and safety of IRE when combined with standard of care (SOC) treatment for Stage 3 PDAC versus SOC alone in a real-world setting after at least 3 months of induction chemotherapy; Methods: Patients with Stage 3 PDAC treated with IRE plus SOC or SOC alone were prospectively enrolled …

Smartphone Haptics Can Uncover Differences In Touch Interactions Between Asd And Neurotypicals, Ivonne Monarca, Franceli L. Cibrian, Isabel López Hurtado, Monica Tentori

Engineering Faculty Articles and Research

Utilizing touch interactions from smartphones for gathering data and identifying digital markers for screening and monitoring neurological disorders, such as Autism Spectrum Disorder (ASD), is an emerging area of research. Smartphones provide multiple benefits for this kind of study, including unobtrusive data collection via built-in sensors, integrated haptic feedback systems, and the capability to create specialized applications. Acknowledging the significant yet understudied presence of tactile processing differences in individuals with ASD, we designed and developed Feel and Touch, a mobile game that leverages the haptic capabilities of smartphones. This game provides vibrotactile feedback in response to touch interactions and collects …

A Cyber Security Look At The Imo Mass Regulations, Kimberly Tam

School of Engineering, Computing and Mathematics

The International Maritime Organisation (IMO) held its second session on Maritime Autonomous Surface Ships (MASS) in April 2023. This chapter looks at the outputs of that discussion and discusses the potential cyber-physical implications and directions based on this most recent session. This cyber security lens will cover a wide range of topics such as cyber physical security, where cyber security can have a physical effect on operations and safety, as well as socio-technical cyber attacks and risks such as misinformation. This chapter will also have a wide lens in terms by looking at a wide threat landscape in the Maritime …

Strategic Interventions In Clinical Randomized Trials For Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld) And Obesity In The Pediatric Population: A Systematic Review With Meta-Analysis And Bibliometric Analysis, Isabel Omaña-Guzmán, Anthony Alanis, David Martinez, Joshua Membreno, Hector Rivera-Marrero, Alisha Valdez, Kathleen V. Carter, Beatriz Tapia, Leonel Vela, Juan Lopez-Alvarenga

School of Medicine Publications

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent hepatic condition linked to metabolic alterations. It gradually causes liver damage and potentially progresses to cirrhosis. Despite its significance, research, especially in the pediatric population, is limited, leading to contradictory findings in diagnosis and treatment. This meta-analysis aims to synthesize existing literature on therapeutic interventions for MASLD in children and adolescents.

Methods

A comprehensive search of randomized controlled clinical trials yielded 634 entries from PubMed, Scopus, and Web of Science up to 2023. Interventions included medications, behavioral modifications, dietary changes, probiotics, supplements, …

Understanding The Teen Brain And Building Strong Relationships: A Foundation For Supporting Healthy Decisions, Josie Hatch, Ashley Yaugher, Christina Pay, Cris Meier

All Current Publications

This fact sheet overviews the importance of strong caregiver relationships with youth to support healthy decision-making.

Comparison Of The Bristol Stool Scale And Modified Version For Children: Use By Providers Vs Children, Bruno P Chumpitazi, Danita I Czyzewski, Meagan S Mcmullen, Rebecca Berger, Clarissa A Gonzalez, Amber L Cunha, Robert J Shulman

Faculty, Staff and Students Publications

Introduction: Accurate report of stool form is essential to diagnosis and assessment of treatment response. The modified Bristol Stool Form Scale for Children (mBSFS-C) classifies stool form into 5 types and is reliable and valid. However, a direct comparison of provider's and children's ratings using the mBSFS-C vs the traditional BSFS that uses 7 stool form types has not been done.

Methods: Pediatric gastroenterology providers and children rated the same 35 stool photographs, reflecting diverse stool forms, using both scales. The order of photograph presentation and scale use were randomized. For each photograph, the most common rating (modal rating) was …