Digital Commons Network^™

Antithrombotic Efficacy And Bleeding Risks Of Vaccine-Induced Immune Thrombotic Thrombocytopenia Treatments, Halina H.L. Leung, Zohra Ahmadi, Brendan Lee, John Casey, Sumita Ratnasingam, Steven E. Mckenzie, Jose Perdomo, Beng H. Chong

Cardeza Foundation for Hematologic Research

Current guidelines for treating vaccine-induced immune thrombotic thrombocytopenia (VITT) recommend nonheparin anticoagulants and IV immunoglobulin (IVIg). However, the efficacy of these treatments remains uncertain due to case studies involving small patient numbers, confounding factors (eg, concurrent treatments), and a lack of animal studies. A recent study proposed danaparoid and heparin as potential VITT therapies because of their ability to disrupt VITT IgG-platelet factor 4 (PF4) binding. Here, we examined the effects of various anticoagulants (including unfractionated [UF] heparin, danaparoid, bivalirudin, fondaparinux, and argatroban), IVIg, and the FcγRIIa receptor-blocking antibody, IV.3. Our investigation focused on VITT IgG-PF4 binding, platelet activation, thrombocytopenia, …

Atypical Presentation Of Spindle Cell Lipoma In A Young Male With A History Of Malignant Melanoma, Ty Theriot, John David Cattar, Lacey Falgout, Nicholas Culotta, Christopher Haas

School of Medicine Faculty Publications

Spindle cell lipoma (SCL) is a benign adipocytic tumor usually found in the subcutis of the posterior neck, upper back, and shoulder, predominantly in middle-aged males. This case report describes an atypical presentation of SCL in a 26-year-old male with a history of malignant melanoma. The patient presented with an erythematous plaque with central hyperpigmentation on the right upper arm, an uncommon location and presentation for SCL. Histopathological examination revealed an atypical myxoid spindle cell neoplasm with CD34 positivity and an overlying mildly atypical compound melanocytic nevus. The unusual clinical and histological features, combined with the patient's melanoma history, complicated …

Gut Microbiota Profiling In Injection Drug Users With And Without Hiv-1 Infection In Puerto Rico, Nirosh Aluthge, Seidu Adams, Carmen A. Davila, Nova R. Gocchi Carrasco, Kathy S. Chiou, Roberto Abadie, Sydney J. Bennett, Kirk Dombrowski, Angel M. Major, Aníbal Valentín-Acevedo, John T. West, Charles Wood, Samodha C. Fernando

School of Medicine Faculty Publications

INTRODUCTION: The full extent of interactions between human immunodeficiency virus (HIV) infection, injection drug use, and the human microbiome is unclear. In this study, we examined the microbiomes of HIV-positive and HIV-negative individuals, both drug-injecting and non-injecting, to identify bacterial community changes in response to HIV and drug use. We utilized a well-established cohort of people who inject drugs in Puerto Rico, a region with historically high levels of injection drug use and an HIV incidence rate disproportionately associated with drug use. METHODS: Using amplicon-based 16S rDNA sequencing, we identified amplicon sequence variants (ASVs) that demonstrated significant variations in the …

Clinical Practice Guideline End Of Shift Handover Toolkit, Sasha Samaroo-Burgos

Walden Dissertations and Doctoral Studies

The DNP project is a Clinical Practice Guideline (CPG) to guide nurses in performing end-of-shift reports at a Medical Center in the West Indies. The gap in practice identified is that nurses perform end-of-shift reporting without using a standardized document. This affects patient safety because the absence of a structured handover process disrupts the continuity of patient care and the transmission of vital patient data. The nurse administrator and general manager reported that many adverse events at the facility were related to miscommunication of information among nurses. The purpose of the project was to develop a CPG that nurses will …

Experiences Of Newly Graduated Registered Nurses’ Successful Transition Into Practice In Their First Year, Angelica Calvillo

Walden Dissertations and Doctoral Studies

The transition into nursing practice can be described as a phase that significantly impacts nurses’ professional development, quality of care, and attrition rates. Newly graduated registered nurses’ experiences during the transition into practice may be challenging and stressful, affect job satisfaction, attrition rates, and burnout. The purpose of this interpretive descriptive qualitative study, guided by Duchscher’s transition theory, was to describe the experiences of newly graduated registered nurses who report a successful transition into clinical practice in their first year postgraduation to identify what factors contribute to their success and retention. Nine newly graduated registered nurses, with 9-12 months of …

The Effect Of Call Center Agent Burnout On Employee Engagement, Shyriah M. Marshall

Walden Dissertations and Doctoral Studies

Call center organizations have become important contact centers for various fields to conduct customer service. Within the automotive industry, call centers are used for emergency roadside assistance. The customer service representatives who are responsible for handling roadside assistance may be managing various issues, including burnout, which may carry over into their performance and ability to properly service customers. The relationships between burnout and employee engagement for inbound emergency roadside assistance agents were not well understood. The purpose of this study was to examine the relationship between customer service representatives’ level of burnout and employee engagement. A quantitative, cross-sectional research design …

Perceptions Of Experiences Of Formerly Incarcerated Individuals On Community Reentry Programs To Reduce Recidivism, Kelly Sieger

Walden Dissertations and Doctoral Studies

This study was conducted to identify the perceptions of experiences of formerly incarcerated individuals who have been actively involved in community-based reentry programming (CBRP). Utilizing a qualitative interview approach with previously incarcerated persons, the study’s focus was to identify the differences in literature, lived experiences, and the connection between CBRP and recidivism through the perceptions of formerly incarcerated persons who have completed CBRP. A key goal was to identify difficulties in the reentry process through the perception of lived experience and offer suggestions for improvements through the lens of actuarial justice. Using a qualitative, phenomenological approach, data was collected through …

Understanding Mechanisms For Coastal Marsh Sustainability In A Changing Climate, Ashley R. Booth

LSU Doctoral Dissertations

In the Chenier Plain of Louisiana and Texas, coastal marshes are subject to high rates of relative sea level rise (RSLR), restricted sedimentation, and declining elevation attributed to subsidence and decades of intensive management. These marshes were created via mineral sedimentation but now largely accrete via organic matter accumulation. This organic matter accumulation (OMA) – or the balance between plant productivity and decomposition – is essential for maintaining elevation and thus long-term sustainability. However, management for elevation is complicated by a poor understanding of how abiotic factors like flooding and salinity impact processes driving OMA and elevation. To better understand …

The Link November 26, 2024, Access To Justice Institute

The Link Newsletter

No abstract provided.

Characterising The Anxiogenic Network From Functional Connectivity Analysis Of The Co2 Challenge Model, Daniel Graham, Santra Mathew, Jonathan Marsden, Alastair D Smith, Gary Smerdon, Stephen D Hall

School of Psychology

The CO2 challenge model (CCM) is a gas inhalation paradigm that provides precisely controlled anxiety induction in experimental settings. Despite its potential as an experimental model of anxiety, our understanding of the neural effects of the CCM is incomplete. This study employs resting-state functional magnetic resonance imaging (rs-fMRI) to explore functional connectivity (FC) changes underlying the CCM. Following a preliminary CO2 tolerance assessment, participants completed an MRI session that included three rs-fMRI scans: during inhalation of control air (pre and post), and during a 6% CCM exposure. Here, we confirm that 6% CCM is a tolerable anxiogenic model in the …

Brief Of Banking And Administrative Law Scholars As Amici Curiae In Support Of Appellants/Cross-Appellees, Jeffrey Lubbers

Amicus Briefs & Court Filings

Amici have a strong interest in how this Court’s decision will affect the fields of banking and administrative law and the enforcement of banking regulation. Amici seek to assist this Court in resolving questions of law that arise in the core of their professional expertise and scholarship, namely the scope of the Seventh Amendment as applied to the Federal Deposit Insurance Corporation’s authority to regulate and adjudicate unsafe or unsound practices in the operation of banks.

High Diagnostic Accuracy Of Arterial Phase Ct In Differentiating Pheochromocytoma In Good/Poor Washout Adrenal Masses, Aditya Phadte, Brijesh Krishnappa, Saba Samad Memon, Virendra Patil, Anurag Lila, Padma Vikram Badhe, Vijaya Sarathi, Gwendolyn Fernandes, Sameer Rege, Gagan Prakash, Santosh Menon, Manjiri Karlekar, Rohit Barnabas, Nalini Shah, Hemangini Thakkar, Tushar Bandgar

Faculty, Staff and Student Publications

Introduction: Differentiating pheochromocytomas from other adrenal masses based on computed tomography (CT) characteristics remains challenging, particularly in lipid-poor lesions with variable washout patterns. This study evaluated CT features for distinguishing pheochromocytomas in good and poor washout subcohorts.

Methods: We prospectively analyzed 72 patients with unilateral lipid-poor adrenal masses. CT protocol included basal, bolus-tracked arterial, early venous (45 seconds postarterial), and delayed (15 minutes postarterial) phases. Masses were categorized into good and poor washout groups. Histopathology provided the final diagnosis. CT characteristics and calculated indices were compared between pheochromocytomas and other masses in each washout category.

Results: The cohort included pheochromocytomas …

Real-World Impact Of Emicizumab And Immunosuppression On Acquired Hemophilia A: A Multicenter Us Cohort, Jacqueline N Poston, Cassandra Bryan, Annette Von Drygalski, Kadhim Al Banaa, Jenny Y Zhou, Aric Parnes, Evan C Chen, Osman Khan, Patrick Ellsworth, Lorraine Cafuir, Christopher Walsh, Miguel A Escobar, James F Wu, Lynn M Malec, Craig M Kessler, Maissaa Janbain, Rebecca Kruse-Jarres

Faculty, Staff and Student Publications

Acquired hemophilia A (AHA) is an autoimmune bleeding disorder that is caused by factor VIII (FVIII) autoantibodies with high morbidity and mortality due to bleeding and complications from immunosuppression (IST). To address the real-world implications of the FVIII mimetic antibody, emicizumab, and the role of IST, we retrospectively collected de-identified data on 62 patients with AHA who were treated off-label with emicizumab for a median of 10 weeks at 12 US-based hemophilia treatment centers. Most patients (95.2%) had acute bleeding at diagnosis, and 62.9% had partial or no control of bleeds despite the use of hemostatic agents at the time …

Septal Wall Synthesis Is Sufficient To Change Ameba-Like Cells Into Uniform Oval-Shaped Cells In Escherichia Coli L-Forms, Masafumi Hayashi, Chigusa Takaoka, Koichi Higashi, Ken Kurokawa, William Margolin, Taku Oshima, Daisuke Shiomi

Faculty, Staff and Student Publications

A cell wall is required to control cell shape and size to maintain growth and division. However, some bacterial species maintain their morphology and size without a cell wall, calling into question the importance of the cell wall to maintain shape and size. It has been very difficult to examine the dispensability of cell wall synthesis in rod-shaped bacteria such as Escherichia coli for maintenance of their shape and size because they lyse without cell walls under normal culture conditions. Here, we show that wall-less E. coli L-form cells, which have a heterogeneous cell morphology, can be converted to a …

Neurohospitalist Core Competencies, Jana J Wold, Jetter Robertson, Jerome A Jeevarajan, Molly G Knox, Prateek Thatikunta, Guillermo E Solorzano, Kristin Galetta, Shefali Dujari, Tarini Goyal, Matthew E Ehrlich, Jonathan P Donnelly, Elizabeth Marriott, Vishal A Mandge, Roshni S Dhoot, Matthew W Luedke, Matthew B Maas, Margaret Y Yu, Michel Toledano, Rafid Mustafa, Jamie L Palaganas, Kathryn Kvam, Rachelle Dugue, Ethan Meltzer, Lahoud Touma, Maulik P Shah, Vanja C Douglas, Karen Orjuela, Brian J Scott, Joshua P Klein, David J Likosky, Jennifer R Simpson, Megan B Richie, Carolin Dohle, Jane G Morris, Carl A Gold

Faculty, Staff and Student Publications

The Neurohospitalist Core Competencies comprise a set of competency-based learning objectives that encapsulate the knowledge, skills, and attitudes of neurohospitalitists who specialize in the care of hospitalized patients with neurologic conditions. These competencies serve to characterize the rapidly expanding field of neurohospitalist medicine. The 27 chapters are divided into 3 sections entitled: neurological conditions, clinical interventions and interpretation of ancillary studies, and neurohospitalist role in the healthcare system. Each individual learning objective in the chapters describes a specific concept with an action verb to illustrate the behavior that the neurohospitalist exhibits. The individual neurohospitalist may not exhibit mastery in each …

The Akwesasne Black Hole: America’S Hidden Border Crisis, Anthony Puntasecca

University of Miami Inter-American Law Review

No abstract provided.

Intelligent Transportation System With 5g Vehicle-To-Everything (V2x): Architectures, Vehicular Use Cases, Emergency Vehicles, Current Challenges, And Future Directions, Vaishali Pawar, Nilima Zade, Deepali Vora, Vaishali Khairnar, Aurenice M. Oliveira, Ketan Kotecha, Ambarish Kulkarni

Michigan Tech Publications

In recent years, connected vehicle technologies emerged to provide a safer and more connected environment for transportation systems, which has further evolved into cellular vehicle-to-everything (C-V2X) technology. The current study contributes in the direction of future research of smart India @2047 in connected vehicles. The study presents the diverse aspects of 5G V2X as a comprehensive overview of Vehicle-to-Everything (V2X) technology that covers the significant scope of V2X technology, including its development, components, functionality, use cases, and future potential. It is observed that few surveys are available that cover limited aspects of 5G V2X communication technologies, with one or two …

Sustainable Environmental Technologies: Recent Development, Opportunities, And Key Challenges, Prafulla Kumar Sahoo, Rupali Datta, Mohammad Mahmudur Rahman, Dibyendu Sarkar

Michigan Tech Publications

No abstract provided.

Network Differentiation And Identification Of Singletons In Gaussian Networks Under The Bayesian Framework, James Olusegun Adefisoye

Electronic Theses and Dissertations Archive

This dissertation explores Bayesian approaches for network analysis in the context of epigenetic modifications, specifically focusing on Deoxyribonucleic acid methylation (DNA-m) at cytosine-phosphate-guanine (CpG) sites. DNA-m is a key epigenetic modification associated with diseases and infections. Recent research suggests that analyzing joint activities across multiple CpG sites could provide more powerful insights, which can be achieved using network-based approaches, such as Gaussian networks. The first project introduces a Bayesian variable selection method for detecting singletons and reconstructing networks that incorporate singleton status. Singletons, or isolated nodes, can lead to false connections and biased interpretations. The proposed method effectively detects singletons, …

Habit Coach: Customising Rag-Based Chatbots To Support Behavior Change, Arian Fooroogh Mand Arabi, Cansu Koyuturk, Michael O'Mahony, Raffaella Calati, Dimitri Ognibene

Conference papers

This paper presents the iterative development of Habit Coach, a GPT-based chatbot designed to support users in habit change through personalized interaction. Employing a user-centered design approach, we developed the chatbot using a Retrieval-Augmented Generation (RAG) system, which enables behavior personalization without retraining the underlying language model (GPT-4). The system leverages document retrieval and specialized prompts to tailor interactions, drawing from Cognitive Behavioral Therapy (CBT) and narrative therapy techniques. A key challenge in the development process was the difficulty of translating declarative knowledge into effective interaction behaviors. In the initial phase, the chatbot was provided with declarative knowledge about CBT …

Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – October 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

October 2024 Berkeley Pit Migratory Waterfowl Protection Monthly Report, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Perceptions Of Experiences Of Formerly Incarcerated Individuals On Community Reentry Programs To Reduce Recidivism, Kelly Sieger

Walden Dissertations and Doctoral Studies

This study was conducted to identify the perceptions of experiences of formerly incarcerated individuals who have been actively involved in community-based reentry programming (CBRP). Utilizing a qualitative interview approach with previously incarcerated persons, the study’s focus was to identify the differences in literature, lived experiences, and the connection between CBRP and recidivism through the perceptions of formerly incarcerated persons who have completed CBRP. A key goal was to identify difficulties in the reentry process through the perception of lived experience and offer suggestions for improvements through the lens of actuarial justice. Using a qualitative, phenomenological approach, data was collected through …

Strategies To Enhance Financial Efficiency Of Small Businesses During Protracted Periods Of Economic Disruptions, Paul Juren Cunningham

Walden Dissertations and Doctoral Studies

Small business leaders without effective business strategies are at a higher risk of business failure. In fact, the majority of minority-operated businesses will fail within the first five years of operation because they lack sustainable business strategies. Grounded in the competitive advantage theory, the purpose of this qualitative pragmatic inquiry study was to explore and identify effective strategies small minority-operated trucking business leaders could use to financially sustain their businesses during protracted periods of economic disruption. Participants were six business leaders of minority-operated trucking businesses who successfully sustained their businesses during protracted periods of economic disruption. Data were collected using …

Social Support, Employee Engagement, And Turnover Intention Of Hybrid Working Leaders In The Pharmaceutical Industry, Victoria Terrell

Walden Dissertations and Doctoral Studies

Retaining leaders in the U.S. pharmaceutical industry is a challenge, and leadership attrition can negatively impact a company. Following the COVID-19 pandemic, hybrid work arrangements are used to retain leaders in the U.S. pharmaceutical industry, yet challenges exist with social support and employee engagement within hybrid work. The purpose of this quantitative, correlational study was to examine the relationships, if any, between social support, employee engagement, and turnover intentions among hybrid working leaders in the U.S. pharmaceutical industry. The job demands-resources model and the social exchange theory provided the study’s foundation. The study sample consisted of 245 leaders in middle-management …

Perceptions Of Experiences Of Formerly Incarcerated Individuals On Community Reentry Programs To Reduce Recidivism, Kelly Sieger

Walden Dissertations and Doctoral Studies

This study was conducted to identify the perceptions of experiences of formerly incarcerated individuals who have been actively involved in community-based reentry programming (CBRP). Utilizing a qualitative interview approach with previously incarcerated persons, the study’s focus was to identify the differences in literature, lived experiences, and the connection between CBRP and recidivism through the perceptions of formerly incarcerated persons who have completed CBRP. A key goal was to identify difficulties in the reentry process through the perception of lived experience and offer suggestions for improvements through the lens of actuarial justice. Using a qualitative, phenomenological approach, data was collected through …

Comparing Neoantigen Cancer Vaccines And Immune Checkpoint Therapy Unveils An Effective Vaccine And Anti-Trem2 Macrophage-Targeting Dual Therapy, Sunita Keshari, Alexander S Shavkunov, Qi Miao, Akata Saha, Tomoyuki Minowa, Martina Molgora, Charmelle D Williams, Mehdi Chaib, Anna M Highsmith, Josué E Pineda, Sayan Alekseev, Elise Alspach, Kenneth H Hu, Marco Colonna, Kristen E Pauken, Ken Chen, Matthew M Gubin

Faculty, Staff and Student Publications

The goal of therapeutic cancer vaccines and immune checkpoint therapy (ICT) is to promote T cells with anti-tumor capabilities. Here, we compared mutant neoantigen (neoAg) peptide-based vaccines with ICT in preclinical models. NeoAg vaccines induce the most robust expansion of proliferating and stem-like PD-1+TCF-1+ neoAg-specific CD8 T cells in tumors. Anti-CTLA-4 and/or anti-PD-1 ICT promotes intratumoral TCF-1- neoAg-specific CD8 T cells, although their phenotype depends in part on the specific ICT used. Anti-CTLA-4 also prompts substantial changes to CD4 T cells, including induction of ICOS+Bhlhe40+ T helper 1 (Th1)-like cells. Although neoAg vaccines or ICTs expand iNOS+ macrophages, neoAg vaccines …

Association Between Various Types Of Corticosteroids And Mortality For Severe Community-Acquired Pneumonia In Adults: A Systematic Review And Network Meta-Analysis, Peng Wang, Jun Wan, Qiaoyu You, Yuxin Zheng, Wenhao Xu, Jialing He, Liyuan Peng, Cuyubamba Dominguez Jorge Luis, Yuning Feng, Ping Xu, Xinrong Li, Weelic Chong, Yang Hai, Lu Jia, Fang Fang, Yu Zhang

Department of Medical Oncology Faculty Papers

OBJECTIVE: This study aims to conduct a systematic review and network meta-analysis to evaluate the efficacy and safety of specific corticosteroids, including but not limited to hydrocortisone, methylprednisolone, prednisolone, and dexamethasone, in the treatment of severe community-acquired pneumonia (SCAP). Efficacy will be assessed using specific outcomes, such as 30-day mortality and the requirement for mechanical ventilation. Safety evaluations will include adverse events like gastrointestinal bleeding and healthcare-associated infections. The study seeks to address the gaps identified in the latest guidelines regarding the optimal use of different corticosteroid types and to provide recommendations for clinical practice.

DATA SOURCES: This study conducted …

Breaking Down Barriers To Opioid Use Treatment: The Beacon Act Clinic At Uab, Staff

Browse All News

No abstract provided.

Trials And Tribulations Of Cell Therapy For Heart Failure, An Update On Ongoing Trials, Staff

Browse All News

No abstract provided.