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2024

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Iniciación Deportiva En El Taekwondo, Bezerra Rodrigues Diogo, Eduar Alonso Ceballos Bernal Nov 2024

Iniciación Deportiva En El Taekwondo, Bezerra Rodrigues Diogo, Eduar Alonso Ceballos Bernal

Ciencias del Deporte y la Educación Física

El taekwondo es una de las artes marciales tradicionales de Corea del Sur —más sistemática y científica—, porque no solo enseña las habilidades físicas de la pelea, sino que es una disciplina que realza el espíritu y la vida de quien lo practica a través del entrenamiento del cuerpo y de la mente. Hoy, se ha convertido en un deporte global, que ha gana fama internacional y se encuentra dentro de los deportes oficiales de los Juegos Olímpicos.

La práctica del taekwondo demostró ser más que un simple deporte, pues es un arte marcial que combina defensa y desarrollo personal, …


Resilience And Positive Feedbacks: Water Quality Management And Eelgrass Health In Great Bay Estuary, Nh/Me “So What” Report, Anna Mikulis, Chris Peter, Cory Riley, David M. Burdick, Kalle Matso, Kelle Loughlin, Lynn Vaccaro, Miguel Leon, Thomas Gregory, Thomas C. Lippmann, William H. Mcdowell Nov 2024

Resilience And Positive Feedbacks: Water Quality Management And Eelgrass Health In Great Bay Estuary, Nh/Me “So What” Report, Anna Mikulis, Chris Peter, Cory Riley, David M. Burdick, Kalle Matso, Kelle Loughlin, Lynn Vaccaro, Miguel Leon, Thomas Gregory, Thomas C. Lippmann, William H. Mcdowell

PREP Reports & Publications

This report provides a high-level summary of the project and its implications. With a focus on lessons learned, the report distills why and how the project's results are important for future eelgrass management. Geared toward broader audiences, this report can be used for public education and engagement with eelgrass management.


The Impact Of Family Dynamics On Suicidal Ideation And Substance Use: Examining Lived Experiences Of Persons Who Use Drugs (Pwuds), John Mark F. Dela Cruz, Melhammid C. Tomawis, Tristan I. Filipinas, Joni Ruth T. Pacong, Maria Felicitas M. Mamauag Nov 2024

The Impact Of Family Dynamics On Suicidal Ideation And Substance Use: Examining Lived Experiences Of Persons Who Use Drugs (Pwuds), John Mark F. Dela Cruz, Melhammid C. Tomawis, Tristan I. Filipinas, Joni Ruth T. Pacong, Maria Felicitas M. Mamauag

Social Transformations Journal of the Global South

Suicide remains a pressing global public health issue, especially among vulnerable populations such as Persons Who Use Drugs (PWUD). Guided by the integrated motivational-volitional (IMV) model of suicidal behavior and the transactional theory of stress and coping, this study explores the lived experiences of Filipino PWUDs with suicidal ideation, focusing on family dynamics—parental relationships, caregiving, cohesion, and adaptability. The study uses Interpretative Phenomenological Analysis (IPA) to analyze in depth interviews with six (6) PWUDs in rehabilitation at the Department of Health - Drug Abuse Treatment and Rehabilitation Center, Agusan del Sur, Philippines. Results show that parental separation, neglect, and low …


The Impact Of Special Economic Zones On Intra-Regional Income Inequality In The Philippines, Raphael Jose M. Habana, Wonseok Choi Nov 2024

The Impact Of Special Economic Zones On Intra-Regional Income Inequality In The Philippines, Raphael Jose M. Habana, Wonseok Choi

Social Transformations Journal of the Global South

In the Philippines, alleviating income inequality has remained a persistent development challenge for the government. In this context, Special Economic Zones (SEZs) have emerged as potent policy tools to make economic growth more geographically equal and to raise incomes of workers in the regions. The Philippines currently has around 400 SEZs in various iterations (e.g., Tourism Enterprise Zones, privately operated SEZs, freeport areas, etc.), which create jobs and attract investments across regions. While existing literature extensively covers the link between SEZs and job creation, foreign direct investment, and other economic growth metrics, there is a notable research gap regarding the …


Finding Them Before They Find Us: Solving The Emerging Infectious Disease Crisis, Daniel R. Brooks Nov 2024

Finding Them Before They Find Us: Solving The Emerging Infectious Disease Crisis, Daniel R. Brooks

MANTER: Journal of Parasite Biodiversity

The human population grows daily, it’s on the move, and it’s carving a deep technological footprint on our planet. We alter landscapes and perturb ecosystems, inserting ourselves and other species into novel regions of the world, leading to potentially irreversible changes in the biosphere. This is not news. More than 75 years ago, Charles Elton, one of the founders of modern ecology, wrote, “We must make no mistake; we are seeing one of the greatest historical convulsions in the world’s fauna and flora.” We are also in the midst of a public health and epidemiological crisis. Climate change alters movements …


Family Perceptions Of Palliative Care For Advanced-Stage Cancer Patients At Home, Mariam Dasat, Sigit Mulyono, Uswatul Khasanah, Stepanus Maman Hermawan Nov 2024

Family Perceptions Of Palliative Care For Advanced-Stage Cancer Patients At Home, Mariam Dasat, Sigit Mulyono, Uswatul Khasanah, Stepanus Maman Hermawan

Jurnal Keperawatan Indonesia

Family assistance with palliative care for advanced cancer patients is very important in optimizing patients’ quality of life. The purpose of this study was to explore family perceptions of palliative service provision to advanced cancer patients at home. The study adopted a qualitative research design with a phenomenological approach based on in-depth interviews with six participants. The main theme that emerged was family perceptions of participation in palliative care programs for cancer patients at home. There were three subthemes: family administering additional treatment, the patient being resigned to and accepting their condition, and the patient being helped by treatment. The …


“We Will Fight For Them”: The Defense Of The ´Isolated´ Piriti People By The Waimiri Atroari, Amazonas And Roraima, Brazil, Silvia Melo Futada, Walter Nicanor Fontoura Blos, Antônio Carlos Andrade Do Nascimento, Marcelo De Sousa Cavalcante, Glenn H. Shepard Jr, Waimiri Atroari Community Association (Acwa) Nov 2024

“We Will Fight For Them”: The Defense Of The ´Isolated´ Piriti People By The Waimiri Atroari, Amazonas And Roraima, Brazil, Silvia Melo Futada, Walter Nicanor Fontoura Blos, Antônio Carlos Andrade Do Nascimento, Marcelo De Sousa Cavalcante, Glenn H. Shepard Jr, Waimiri Atroari Community Association (Acwa)

Tipití: Journal of the Society for the Anthropology of Lowland South America

The Pirititi are a little known ´isolated´ Indigenous group occupying a highly threatened territory on the border between Amazonas and Roraima states in Brazil who have rejected all previous attempts at contact and encounter. The Waimiri Atroari previously had conflicts with the Pirititi, who occupy a contiguous area, but over the past decade have taken it upon themselves to defend the Pirititi and their territory, relying mostly on their own resources. Given the slow pace of official Brazilian governmental responses to land invasions and other threats to the Pirititi, the Waimiri Atroari have become the main protagonists of protection and …


Uneven Burdens: The Intersection Of Brownfields, Pollution, And Socioeconomic Disparities In New Jersey, Usa, Shih-Chieh Chien, Charles Knoble Nov 2024

Uneven Burdens: The Intersection Of Brownfields, Pollution, And Socioeconomic Disparities In New Jersey, Usa, Shih-Chieh Chien, Charles Knoble

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Brownfields, abandoned or underutilized lands having the potential for contamination due to industrial activities, pose health risks to nearby residents and raise environmental justice (EJ) concerns. This study examines the relationship between brownfield distribution and socioeconomic factors in New Jersey, a state with over 700 brownfield sites, using correlation, spatial autoregression, and instrumental variable regression methods. Results show that brownfields are associated with higher combined EJ stressors, indicating compounding environmental pollution and health risks in affected areas. Brownfields are disproportionately correlated with lower household income, higher rates of uninsured individuals, lower educational attainment, and a greater percentage of people of …


Repurposed Energy, Alexandra B. Klass, Hannah Wiseman Nov 2024

Repurposed Energy, Alexandra B. Klass, Hannah Wiseman

Articles

Wildfires, weather extremes, and other conditions induced partially by climate change add urgency to the project of accelerating the clean energy transition from fossil fuels to zero-carbon energy infrastructure. Yet the hurdles to accomplishing such a massive industrial-scale transition are daunting. Indeed, large renewable energy generation projects regularly face denials or project-killing delays across the United States. This Article proposes a national policy to channel the bulk of new clean energy projects to targeted categories of both rural lands and urban, post-industrial lands that we define collectively as “repurposed energy” sites. Such lands will consist of marginal farmland, abandoned coal …


Revitalizing While Transmitting: Conversations Around “Natural Birth”Practices With Kichwa Midwives In Ecuador’S Napo Region, Laura Rival Nov 2024

Revitalizing While Transmitting: Conversations Around “Natural Birth”Practices With Kichwa Midwives In Ecuador’S Napo Region, Laura Rival

Tipití: Journal of the Society for the Anthropology of Lowland South America

Despite its relevance for analyzing many distinctive native imaginaries and societal values, childbirth remains a relatively neglected theme within Amazonianist scholarship. Yet, birthing can be shown to structure contemporary struggles around kinship, politics, economics, and the place of transformation in social life. This article proposes to examine a Kichwa organization (AMUPAKIN) through an experimental anthropological lens. By putting childbirth at the center of its political struggle, AMUPAKIN seeks to keep Kichwa knowledge/power alive. The goal of the organization is that each child born the Kichwa way will be able to live a good life in multicultural contexts. The article documents …


Assessing Knowledge And Preventive Practices Regarding Infectious Diseases Among Healthcare Workers In Hail City, Saudi Arabia, Sandro Costanilla Villareal Nov 2024

Assessing Knowledge And Preventive Practices Regarding Infectious Diseases Among Healthcare Workers In Hail City, Saudi Arabia, Sandro Costanilla Villareal

Jurnal Keperawatan Indonesia

Studies suggest that there may be gaps in knowledge and compliance with infection control measures among healthcare workers in Saudi Arabia. This study aimed to determine the knowledge of, and preventive measures employed by the healthcare workers in Hail City, Saudi Arabia, regarding infectious diseases. A cross-sectional design was employed, and the study participants were 265 healthcare workers aged 18 or older who were currently employed at government hospitals, involved in patient care or essential healthcare services, and fluent in English. Healthcare workers on leave, with cognitive impairments, with language barriers, or who refused to participate in the study were …


Pharmacy Alumna Honors Grandparents With Scholarship, Tina H. Hahn Nov 2024

Pharmacy Alumna Honors Grandparents With Scholarship, Tina H. Hahn

University of Mississippi News

OXFORD, Miss. – Nancy Kelty Stengel, a 1970 University of Mississippi pharmacy graduate, was heavily influenced by her maternal grandparents to stay in school, and she is expressing her gratitude by building a scholarship endowment in their names.


Opa1 And Disease-Causing Mutants Perturb Mitochondrial Nucleoid Distribution, J. Macuada, I. Molina-Riquelme, G. Vidal, N. Pérez-Bravo, C. Vásquez-Trincado, G. Aedo, D. Lagos, P. Yu-Wai-Man, R. Horvath, T. J. Rudge, B. Cartes-Saavedra, V. Eisner Nov 2024

Opa1 And Disease-Causing Mutants Perturb Mitochondrial Nucleoid Distribution, J. Macuada, I. Molina-Riquelme, G. Vidal, N. Pérez-Bravo, C. Vásquez-Trincado, G. Aedo, D. Lagos, P. Yu-Wai-Man, R. Horvath, T. J. Rudge, B. Cartes-Saavedra, V. Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Optic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness. Cells from ADOA patients show impaired mitochondrial fusion, cristae structure, bioenergetic function, and mitochondrial DNA (mtDNA) integrity. The mtDNA encodes electron transport chain subunits and is packaged into nucleoids spread within the mitochondrial population. Nucleoids interact with the IMM, and their distribution is tightly linked to mitochondrial fusion and cristae shaping. Yet, little is known about the physio-pathological relevance of nucleoid distribution. We studied the effect of OPA1 and ADOA-associated mutants on …


Impacts Of Terrorism In Education Sector Due To Internal Displacement: Case Study Cabo Delgado- Mozambique From 2017 To 2022, Isaque Joaquim Nov 2024

Impacts Of Terrorism In Education Sector Due To Internal Displacement: Case Study Cabo Delgado- Mozambique From 2017 To 2022, Isaque Joaquim

Journal of Terrorism Studies

The study aims to analyze the impacts of internal displacement in the education sector due to terrorist conflict ongoing in the northern region of Mozambique (Cabo Delgado). The internally displaced people (IDPs) in Mozambique establish themselves within the country. They abdicate their normal life and adapt themselves to the means of subsistence, and most of the time with little support from the government which does not ensure a dignified life in basic needs: education, health, and protection. This situation has been happening in the northern province of Mozambique, where access to education is deficient, mainly in rural areas. Thus, the …


Terrorist Financing In The Digital Age: An Analysis Of Crypto Currencies And Online Crowd Funding, Eziho Promise Ogele Nov 2024

Terrorist Financing In The Digital Age: An Analysis Of Crypto Currencies And Online Crowd Funding, Eziho Promise Ogele

Journal of Terrorism Studies

This study examines the potential risks of emerging payment technologies and value transfer systems in facilitating terrorist activities. Through an analysis of publications, blogs, and websites associated with terrorist groups and their supporters, the research reveals a growing interest in leveraging cryptocurrencies like Bitcoin and online crowdfunding platform to support funding, planning, and implementation of terror attacks. While concrete evidence of large-scale cryptocurrency use by terrorist groups is limited, there are indications of links to several terror attacks globally. This study demonstrates the potential for cryptocurrencies to facilitate clandestine activities, utilizing a document published by ISIS that outlines instructions undetected. …


Exploring The Use Of Music In Deradicalization, Pulung Agustanto, Arthur Josias Simon Runturambi, Puspitasari . Nov 2024

Exploring The Use Of Music In Deradicalization, Pulung Agustanto, Arthur Josias Simon Runturambi, Puspitasari .

Journal of Terrorism Studies

This study seeks to explore music as an alternative method to enrich the variety of deradicalization programs in the framework of counterterrorism. The use of ethnic and local culture-based music is not only intended to prevent radicalism but also as an instrument of recovery therapy for terrorism prisoners in correctional institutions (Lapas). The offer of the programmatic agenda departs from the assumption that deradicalization so far still lacks a cultural approach. Moreover, the archipelago has a variety of music from various ethnicities, for example Javanese music, Sundanese music, Balinese music, Ambon music, and others that are rich in spiritual and …


Addressing The Gap: A Need For A Gender-Based Approach In Indonesia’S Deradicalization Program, Raneeta Mutiara Nov 2024

Addressing The Gap: A Need For A Gender-Based Approach In Indonesia’S Deradicalization Program, Raneeta Mutiara

Journal of Terrorism Studies

An effective deradicalisation program is the key to combating violent extremism and reducing potential harm to society from radical ideologies. A gender-based approach to tackling violent extremism among women has received esteemed recognition from the governments of many countries. Various international organizations and scholarly institutes have also approved the advantages of this method. This work aims to find and address the gap in the current deradicalization program in Indonesia for future development in both academic and practical areas of this subject matter. An integrative literature review is used as a method that involves synthesizing previous research and integrating empirical findings …


Unraveling The Conflict-Ridden Weave: The Regional Security Of The Sahel Region Amidst Wagner Group’S Presence, Ghifarie Aulia Ramadhany, Mohammad Apridio Salahuddin Hakim, Abel Josafat Manullang Nov 2024

Unraveling The Conflict-Ridden Weave: The Regional Security Of The Sahel Region Amidst Wagner Group’S Presence, Ghifarie Aulia Ramadhany, Mohammad Apridio Salahuddin Hakim, Abel Josafat Manullang

Journal of Terrorism Studies

Mercenaries or guns for hire have been a considerable force to reckon with in the international system. Their involvement in the conflicts of all scales have their share of contribution to the eventual outcome of the conflict. Such is the case of the Wagner Group. As a non-state actor, the Wagner Group has engendered numerous tempests across the world, one of them is the Sahel region. Their presence in the Sahel region has been a focal point of disputes within the international community. Against that backdrop, the paper seeks to shed light on how the regional security complex of the …


Impact Of Chatgpt And Large Language Models On Radiology Education: Association Of Academic Radiology-Radiology Research Alliance Task Force White Paper, David H. Ballard, Alexander Antigua-Made, Emily Barre, Elizabeth Edney, Emile B. Gordon, Linda Kelahan, Taha Lodhi, Jonathan G. Martin, Melis Ozkan, Kevin Serdynski, Bradley Spieler, Daphne Zhu, Scott J. Adams Nov 2024

Impact Of Chatgpt And Large Language Models On Radiology Education: Association Of Academic Radiology-Radiology Research Alliance Task Force White Paper, David H. Ballard, Alexander Antigua-Made, Emily Barre, Elizabeth Edney, Emile B. Gordon, Linda Kelahan, Taha Lodhi, Jonathan G. Martin, Melis Ozkan, Kevin Serdynski, Bradley Spieler, Daphne Zhu, Scott J. Adams

School of Medicine Faculty Publications

Generative artificial intelligence, including large language models (LLMs), holds immense potential to enhance healthcare, medical education, and health research. Recognizing the transformative opportunities and potential risks afforded by LLMs, the Association of Academic Radiology-Radiology Research Alliance convened a task force to explore the promise and pitfalls of using LLMs such as ChatGPT in radiology. This white paper explores the impact of LLMs on radiology education, highlighting their potential to enrich curriculum development, teaching and learning, and learner assessment. Despite these advantages, the implementation of LLMs presents challenges, including limits on accuracy and transparency, the risk of misinformation, data privacy issues, …


Jean Langdon: Transformations And Perspectives From Half A Century Of Research About Shamanism, Isabel Santana De Rose Nov 2024

Jean Langdon: Transformations And Perspectives From Half A Century Of Research About Shamanism, Isabel Santana De Rose

Tipití: Journal of the Society for the Anthropology of Lowland South America

This text reviews some of Jean Langdon’s most important classical and contemporary writings about shamanism, highlighting her key contributions to the area, as well as her relevance to the anthropology of health and Indigenous health policies. The paper also reflects on Langdon’s influence in the discussions surrounding gender and female agency in ethnographies of lowland South America. Jean Langdon was one of the pioneers in the revival of the research on shamanism in the 1980s. During a period when male anthropologists largely dominated studies on this topic, she highlighted the complexity and diversity of Indigenous shamanisms, proposing that they should …


Interview With Magaly Rodriguez (2024-11-30) Nov 2024

Interview With Magaly Rodriguez (2024-11-30)

Latino Virginia Oral History Project

Magaly Rodriguez, un immigrante de Bolivia, compartir sus familias historia con la migración de Bolivia a los Estados Unidos y cómo se adpataron a la sociedad estadounidense. Magaly compartió la lucha de la salud de su mamá y como le sistema de salud en los Estados Unidos ayudaron bastante. Ella reflexionó en el tiempo de la pandemia y como afectaron su familia y la comunidad Latina. Habló sobre política con respecto a la deportación de Latinos. Magaly expresó su agradecimiento de los oportunidades y recursos en la Estados Unidos.

Magaly Rodriguez, an immigrant from Bolivia, shared her family's story of …


Innovations In Additive Manufacturing For Socket Fabrication: An Overview, Linda Ziyadatul Faiza, Wahyu Caesarendra, Wahyu Dwi Lestari Nov 2024

Innovations In Additive Manufacturing For Socket Fabrication: An Overview, Linda Ziyadatul Faiza, Wahyu Caesarendra, Wahyu Dwi Lestari

Journal of Mechanical Engineering Science and Technology (JMEST)

Additive Manufacturing (AM) has transformed the prosthetics industry, particularly in socket production, which plays a critical role in the comfort, fit, and functionality of prosthetic limbs. This article examines the latest advancements in AM technologies and their applications in socket fabrication. Key techniques like stereolithography (SLA), selective laser sintering (SLS), and fused deposition modeling (FDM) have facilitated the production of highly personalized, lightweight, and durable prosthetic sockets. These methods not only improve design precision but also allow for the use of biocompatible, flexible materials, enhancing both comfort and functionality. Digital design tools have streamlined the production process, reducing lead times …


Structural Simulation Of Wheelchair Ramp Using Finite Element Method, Bhre Wangsa Lenggana, Agung Nugroho, Ubaidillah Ubaidillah Nov 2024

Structural Simulation Of Wheelchair Ramp Using Finite Element Method, Bhre Wangsa Lenggana, Agung Nugroho, Ubaidillah Ubaidillah

Journal of Mechanical Engineering Science and Technology (JMEST)

Wheelchairs are essential mobility aids for people with disabilities, but they are often limited to flat surfaces and cannot overcome height differences. Portable ramps are an effective solution to overcome this limitation. This research aims to simulate and analyze the structure of a portable ramp for wheelchairs. Simulations were conducted using finite element method analysis software to assess the portable ramp's von Mises stress, deformation, and safety factor in various loading positions. Finite element method (FEM) analysis software was utilized to evaluate key mechanical properties, including von Mises stress, deformation, and safety factor, under different loading conditions and positions. The …


Antibiotic Use In Rural Kenyan Livestock. Project Dataset., Michael Dillon, Lucy Obolensky, Esbon Wambugu, Edna Kubai, Iain Doig, Miriam Beattie Nov 2024

Antibiotic Use In Rural Kenyan Livestock. Project Dataset., Michael Dillon, Lucy Obolensky, Esbon Wambugu, Edna Kubai, Iain Doig, Miriam Beattie

Faculty of Health Datasets

Antimicrobial resistance (AMR) is an escalating global health threat, with the greatest risk observed in low to middle-income countries (LMICs), particularly in the global south. The World Health Organisation advocates for a One Health approach to address AMR, promoting collaboration across sectors, including in agriculture. This study aimed to enhance understanding of antimicrobial use and stewardship within pastoralist communities in northern Kenya, where there is limited information. Dataset Description: This dataset consists of four PDF files that collate anonymised qualitative and quantitative interview responses from four regions in Kenya: 1. Leparua 2. Mutunyi 3. Naibor 4. Ngare Ndare The questionnaire …


The Relationship Of Online Learning And Information Technology With Cognitive, Affective, And Psychomotor Abilities, Sidik Awaludin, Usman Chatib Warsa, Soetrisno Soemardjo, Elly Nurachmah, Arum Atmawikarta, Dwi Novitasari Nov 2024

The Relationship Of Online Learning And Information Technology With Cognitive, Affective, And Psychomotor Abilities, Sidik Awaludin, Usman Chatib Warsa, Soetrisno Soemardjo, Elly Nurachmah, Arum Atmawikarta, Dwi Novitasari

Jurnal Keperawatan Indonesia

The COVID-19 pandemic had a significant impact on education in nursing programs. Changes in the learning system were followed by changes in learning methods and information technology as a means of support. In fact, mastery of learning methods and information technology support is still not optimal. To improve students’ cognitive, affective, and psychomotor capacities, lecturers must grasp numerous learning approaches and information technology. This study aimed to examine the relationship of mastery of online learning methods and information technology assistance with nursing students’ cognitive, emotional, and psychomotor capacities in Indonesia. The design of this study was a cross- sectional internet-based …


Mammalian Mitochondrial Inorganic Polyphosphate (Polyp) And Cell Signaling: Crosstalk Between Polyp And The Activity Of Ampk, Renata T. Da Costa, Anna Nichenko, Matheus M. Perez, Malgorzata Tokarska-Schlattner, Sheida Kavehmoghaddam, Vedangi Hambardikar, Ernest R. Scoma, Erin L. Seifert, Uwe Schlattner, Joshua C. Drake, Maria E. Solesio Nov 2024

Mammalian Mitochondrial Inorganic Polyphosphate (Polyp) And Cell Signaling: Crosstalk Between Polyp And The Activity Of Ampk, Renata T. Da Costa, Anna Nichenko, Matheus M. Perez, Malgorzata Tokarska-Schlattner, Sheida Kavehmoghaddam, Vedangi Hambardikar, Ernest R. Scoma, Erin L. Seifert, Uwe Schlattner, Joshua C. Drake, Maria E. Solesio

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

UNLABELLED: Inorganic polyphosphate (polyP) is an evolutionary and ancient polymer composed by orthophosphate units linked by phosphoanhydride bonds. In mammalian cells, polyP shows a high localization in mammalian mitochondria, and its regulatory role in various aspects of bioenergetics has already been demonstrated, via molecular mechanism(s) yet to be fully elucidated. In recent years, a role for polyP in signal transduction, from brain physiology to the bloodstream, has also emerged.

OBJECTIVE: In this manuscript, we explored the intriguing possibility that the effects of polyP on signal transduction could be mechanistically linked to those exerted on bioenergetics.

METHODS: To conduct our studies, …


Analysis Of 1386 Epileptogenic Brain Lesions Reveals Association With Dyrk1a And Egfr, Christian M Boßelmann, Costin Leu, Tobias Brünger, Lucas Hoffmann, Sara Baldassari, Mathilde Chipaux, Roland Coras, Katja Kobow, Hajo Hamer, Daniel Delev, Karl Rössler, Christian G Bien, Thilo Kalbhenn, Tom Pieper, Till Hartlieb, Kerstin Becker, Lisa Ferguson, Robyn M Busch, Stéphanie Baulac, Peter Nürnberg, Imad Najm, Ingmar Blümcke, Dennis Lal Nov 2024

Analysis Of 1386 Epileptogenic Brain Lesions Reveals Association With Dyrk1a And Egfr, Christian M Boßelmann, Costin Leu, Tobias Brünger, Lucas Hoffmann, Sara Baldassari, Mathilde Chipaux, Roland Coras, Katja Kobow, Hajo Hamer, Daniel Delev, Karl Rössler, Christian G Bien, Thilo Kalbhenn, Tom Pieper, Till Hartlieb, Kerstin Becker, Lisa Ferguson, Robyn M Busch, Stéphanie Baulac, Peter Nürnberg, Imad Najm, Ingmar Blümcke, Dennis Lal

Faculty, Staff and Student Publications

Lesional focal epilepsy (LFE) is a common and severe seizure disorder caused by epileptogenic lesions, including malformations of cortical development (MCD) and low-grade epilepsy-associated tumors (LEAT). Understanding the genetic etiology of these lesions can inform medical and surgical treatment. We conducted a somatic variant enrichment mega-analysis in brain tissue from 1386 individuals who underwent epilepsy surgery, including 599 previously unpublished individuals with ultra-deep ( > 1600x) targeted panel sequencing. Here we confirm four known associations (BRAF, SLC35A2, MTOR, PTPN11), support eight associations without prior statistical support (FGFR1, PIK3CA, AKT3, NF1, PTEN, RHEB, KRAS, NRAS), and identify novel associations for two genes, …


Final Report - Qa/Qc Guidelines On Drone-Based Remote Sensing For Bridge Element Inspection, Genda Chen, Woubishet Z. Taffese, Ritesh Sharma, Zhenhua Shi Nov 2024

Final Report - Qa/Qc Guidelines On Drone-Based Remote Sensing For Bridge Element Inspection, Genda Chen, Woubishet Z. Taffese, Ritesh Sharma, Zhenhua Shi

Project IM-4

Remote sensing of elevated infrastructure via robotic platforms has recently gained increasing interest in bridge inspection. Such automated bridge inspection can not only overcome accessibility and safety challenges but also improve objectivity and consistency of the measured data compared to current visual inspection practices. With the advent of advanced technologies, quality assurance (QA) and quality control (QC) for robot-based bridge inspection become imperative. This study aims (1) to understand actionable inspection activities and procedures in route planning, sensor preparation and measurement, ground truth selection, and statistical analysis; (2) to outline assessment matrices and best practices for drone-based images to achieve …


Crosstalk Of Pyroptosis And Cytokine In The Tumor Microenvironment: From Mechanisms To Clinical Implication, Hua Wang, Tao Wang, Shuxiang Yan, Jinxin Tang, Yibo Zhang, Liming Wang, Haodong Xu, Chao Tu Nov 2024

Crosstalk Of Pyroptosis And Cytokine In The Tumor Microenvironment: From Mechanisms To Clinical Implication, Hua Wang, Tao Wang, Shuxiang Yan, Jinxin Tang, Yibo Zhang, Liming Wang, Haodong Xu, Chao Tu

Faculty, Staff and Student Publications

In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellular constituents within the TME, including immune cells, cancer-associated fibroblasts, and cancer cells themselves. These cytokines facilitate intricate communication networks that significantly influence tumor initiation, progression, metastasis, and immune suppression. Pyroptosis contributes to TME remodeling by promoting the release of pro-inflammatory cytokines and sustaining chronic inflammation, impacting processes such as immune escape and angiogenesis. However, challenges remain due to the complex …


Development Of A New Peyronie’S Disease Self-Assessment Screening App, Gregory A Broderick, Jesse N Mills, Lisa Bathish, Christopher Davis, Mohit Khera Nov 2024

Development Of A New Peyronie’S Disease Self-Assessment Screening App, Gregory A Broderick, Jesse N Mills, Lisa Bathish, Christopher Davis, Mohit Khera

Faculty, Staff and Students Publications

Peyronie's disease (PD) is an underdiagnosed and undertreated fibroproliferative disorder associated with the formation of plaques that results in penile curvature and discourages some men from seeking medical consultation. The PD self-assessment app, a digital application (app), was developed to increase PD awareness, provide men with a self-screening and educational tool for PD, and help eliminate barriers to seeking consultation with a physician. Prior to deployment, 4 board-certified urologists provided qualitative reviews on the app's usability and utility as a screening tool. The PD self-assessment app features a questionnaire that addresses penile curvature, challenges with penetration, partner distress, and the …