Digital Commons Network^™

Moose Movement In An Urbanizing Landscape, Lucian R. Mcdonald

All Graduate Theses and Dissertations, Fall 2023 to Present

Humans disturb the environment in specific places and at specific times. As wildlife learn to navigate these disturbances, they react as they would to the risk of predation. Wildlife biologists can identify where and when these disturbances will lead wildlife to congregate by comparing geospatial data, such as metrics that represent vegetation, topography, or other environmental conditions, to known locations of the animal(s) in question. In Chapter I, I discuss the impact of human disturbances, like urbanization and roads, on wildlife behavior. In Chapter II, I compare the risk of moose-vehicle collisions (MVCs) to moose selection of urbanized landscapes to …

Barriers And Drivers To Bus Electrification: The Transit Agency's Perspective, Aleks C. Paskett

All Graduate Theses and Dissertations, Fall 2023 to Present

Battery-electric buses (BEBs) have become increasingly common in recent years, as transit agencies around the world seek to reduce their carbon emissions. Although many agencies and governments have set ambitious climate goals pushing for increased adoption of BEBs, some agencies face difficulty transitioning their fleets to this technology. This study seeks to understand the challenges faced by these agencies, as well as their motivations for adopting BEBs. Researchers conducted a series of interviewers with twelve transit leaders representing ten transit agencies who were leading BEB adoption programs, asking questions about their experiences trying to implement this technology. The interviewees stated …

Development Of A Multidimensional Index Of Fall Risk For Older Adults: The Cache County Study, Alexandra G. Hammond

All Graduate Theses and Dissertations, Fall 2023 to Present

One out of four adults over the age of 65 are estimated to fall each year in the U.S. alone, with that number expected to rise to 52 million falls per year by the year 2030. Improving accuracy for identification of older adults at a higher risk of falling is increasingly important and may be integral in informing the distribution of limited resources and assist in preventing falls in older adults. This project examined the relationship between previously identified risk factors and fall risk to create multidimensional fall risk indexes for older adults, specific for each sex.

Factors best associated …

From Pasture To Plate: Striking An Omega Balance Between Grass-Fed And Grain-Fed Beef Ribeyes - Fatty Acid Composition, Minerals, Soil, And Forage Analysis, Travis Earl Statham

All Graduate Theses and Dissertations, Fall 2023 to Present

Most beef cattle in the US are feedlot-finished where intensive feeding of grains is used to increase weight and yield; however, a minority are raised in grass-fed operations that use exclusive pasture, rangeland, and hay for feeding, possibly leading to benefits for the land, soil, ecosystems, forages, and the meat itself. These operations use a variety of methods, and the goal of this was to recognize differences in the soil and forage metrics to help understand the resulting meat fatty acid composition and mineral content. We collected these samples from 78 sets of farmers while testing 25 sets of grain-fed …

Physical Activity In Play Environments Inclusively Designed For Children With And Without Disabilities, Mckall E. Vigil

All Graduate Theses and Dissertations, Fall 2023 to Present

This study examines physical activity within inclusively designed play environments for children with and without disabilities. The purpose of this study is to determine to what extent children in the third grade with and without disabilities differ in physical activity across various behavior settings of an inclusively designed play environment. Of the 50 third-grade students, 34 participated in eight weeks of observations conducted during lunch recess. Accelerometers and GPS units were utilized to collect data during the observations. The majority of settings on this playground were identified as inclusive. Children with disabilities didn’t engage in organized games as often as …

Adolescent Mental Health And Social Media: The Roles Of Psychosocial Development And Online Interaction, Mark L. Ferguson

All Graduate Theses and Dissertations, Fall 2023 to Present

Social media has become an integral part of adolescent life, and its effects on adolescents’ mental health has been studied for over twenty years. However, the research approaches used to discover connections between adolescent social media use and their mental health have been diverse, and findings have varied over time. This study sought to explore the potential relationships between adolescent social media use and mental health by including several different variables that aren’t typically accounted for in the same study, such as attachment to parents and peers, internal psychological development, emotional intensity towards social media use, and how adolescents feel …

Spatial Transcriptomics Reveals Discrete Tumour Microenvironments And Autocrine Loops Within Ovarian Cancer Subclones, Elena Denisenko, Leanne De Kock, Adeline Tan, Aaron B. Beasley, Maria Beilin, Matthew E. Jones, Rui Hou, Dáithí Ó Muirí, Sanela Bilic, G. Raj K. A. Mohan, Stuart Salfinger, Simon Fox, Khaing P. W. Hmon, Yen Yeow, Youngmi Kim, Rhea John, Tami S. Gilderman, Emily Killingbeck, Elin S. Gray, Paul A. Cohen, Yu Yu, Alistair R. R. Forrest

Research outputs 2022 to 2026

High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here, we use spatial transcriptomics to identify HGSOC subclones and study their association with infiltrating cell populations. Visium spatial transcriptomics reveals multiple tumour subclones with different copy number alterations present within individual tumour sections. These subclones differentially express various ligands and receptors and are predicted to differentially associate with different stromal and immune cell populations. In one sample, CosMx single molecule imaging reveals subclones differentially associating with immune cell populations, fibroblasts, …

Comparative Analysis Of Household Food And Nutrition Security In Selected Philippine Urban And Rural Households During The Covid-19 Pandemic, Jay-Al Reyes, Julieta Delosreyes

The Philippine Agricultural Scientist

This study analyzed the food and nutrition security of selected urban and rural households in Pili, Camarines Sur, Philippines during the COVID-19 pandemic. It determined the prevalence of food insecurity among the selected urban and rural households, analyzed the determinants of food insecurity in these households, determined the prevalence of malnutrition, and assessed the relationship between the households’ food security and nutrition security. Primary data from a survey of 185 urban and rural households and secondary data from the Electronic Operation Timbang Plus (e-OPT) Tool were used to determine the prevalence of food insecurity using the Food Insecurity Experience Scale …

Bioactivity And Synergism Of Tagpo (Ardisia Tomentosa) Molluscicidal Extracts, Darwin C. Gomez, Grechelle Socias, Rosemarie Galanza, Florlyn C. Gayas Ma., Fe T. Piedad, Brian John Sarno

The Philippine Agricultural Scientist

Population control of golden apple snails (GAS, Pomacea canaliculata) is beneficial in rice farming; however, the associated control measures can be expensive and time-consuming. Currently, farmers use synthetic molluscicides such as niclosamide to control GAS infestation, but this has some drawbacks. For example, niclosamide has broad toxicity to non-target organisms and negatively affects the growth of rice seedlings. Plant extracts with potent bioactivity and low toxicity to non-target organisms are attractive alternatives to synthetic molluscicides. In this study, the bioactivity of the crude fruit extract of tagpo (Ardisia tomentosa) was assessed against GAS and tilapia (Oreochromis niloticus) fries. The potential …

Field Assessment Of Fertilization, Nursery, And Crop Management Practices Among Tomato (Solanum Lycopersicum L.) Growers In The Ilocos Provinces, Philippines, Annalissa Aquino, Sancho Bon, Angelica Guanlao, Ann Mylalulex Magnaye, Filomena Sta Cruz, Pompe C. Sta. Cruz

The Philippine Agricultural Scientist

Growth and yield of many economically important vegetables like tomatoes are heavily influenced by crop management practices, particularly fertilizer application, irrigation scheme, and pest management. To attain maximum tomato yields and increase farmers’ profits, these crop production components must be optimized in local farm levels. Before optimization measures can be conducted, baseline information on prevailing practices needs to be evaluated. To assess the nutrient management and other crop production practices of tomato farmers in the Ilocos provinces, Philippines, on-farm surveys were conducted in 16 and 18 barangays planting fresh-type and processing-type tomatoes, respectively. The study involved a total of 88 …

Channel Dynamics In Response To Compounding Hydrogeomorphic Disturbances In A Steep Burned Watershed, Paxton Ridgway

All Graduate Theses and Dissertations, Fall 2023 to Present

Wildfires significantly increase sediment input to rivers through various pathways, including post-fire debris flows. Understanding how mountain rivers respond to these sediment inputs is crucial for predicting and managing downstream impacts on infrastructure, water security, and aquatic habitats. While the causes and characteristics of post-fire debris flows have been extensively studied, the morphological changes in downstream fluvial channels remain poorly understood. This study uses scripted spatial analysis toolsets, high-resolution pre- and post-fire DEMs, repeat cross-sectional surveys, time-lapse footage, and pebble counts to document channel responses to sediment supply in a burned steep mountain stream in the upper Colorado River Basin, …

Westward Words: An Exploration Of Western Beats And Their Legacy, Brenna Jones

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis examines the art, poetry, and experiences of western Beats or Beatniks. Also known as the Beat Generation, this literary movement is traditionally associated with East Coast writers. However, a prominent Beat culture was also present on the West Coast throughout the 1950s and 1970s. The thesis explores how the West influenced the literature and art produced by Beats during this time.

Examining Support By Residents For Community Scale Wildfire Mitigation Strategies In The Wasatch Front, Conner R. Smith

All Graduate Theses and Dissertations, Fall 2023 to Present

Current development trends along the Wasatch Front are causing a greater threat of wildfires to the Utahns who reside there. Research indicates that although studies meant to examine wildfire mitigation strategy preferences do exist, their findings are not applicable to the Wasatch Front. This thesis addresses the lack of applicable data and the resultant lack of understanding of the Wasatch Front residents' preferences. In my project specifically, I will be looking at what wildfire mitigation strategies, at the community scale, residents of the Wasatch Front prefer. Additionally, I will be comparing the preferences of residents living in areas with above …

Cellulose–Starch Composite Aerogels As Thermal Superinsulating Materials, Safoura Ahmadzadeh, Angelina Sagardui, David Huitink, Jingyi Chen, Ali Ubeyitogullari

Chemistry & Biochemistry Faculty Publications and Presentations

The demand for sustainable packaging materials is rapidly increasing due to growing environmental concerns over the impact of plastic waste. In this study, biodegradable, porous, lightweight, and high-surface-area microcrystalline cellulose–starch (MCC-S) hybrid aerogels were synthesized via supercritical carbon dioxide (SC–CO₂) drying. The samples were generated using five different MCC-S weight ratios and characterized for their morphology, crystallinity, and structural and thermal properties. When MCC and S were used together, aerogels with superior properties were obtained compared to those made from each component individually. Specifically, the 1:2 MCC-S aerogel exhibited the highest porosity (97%), the lowest density (0.058 g/cm …

Ai Regulation Has Its Own Alignment Problem: The Technical And Institutional Feasibility Of Disclosure, Registration, Licensing, And Auditing, Neel Guha, Christie M. Lawrence, Lindsey A. Gailmard, Kit T. Rodolfa, Faiz Surani, Rishi Bommasani, Inioluwa Deborah Raji, Mariano-Florentino Cuéllar, Colleen Honigsberg, Percy Liang, Daniel E. Ho

Faculty Scholarship

Calls for regulating artificial intelligence (“AI”) are widespread, but there remains little consensus on both the specific harms that regulation can and should address and the appropriate regulatory actions to take. Computer scientists propose technical solutions that may be infeasible or illegal; lawyers propose regulation that may be technically impossible; and commentators propose policies that may backfire. AI regulation, in that sense, has its own alignment problem, in which proposed interventions are often misaligned with societal values.This Article assesses the alignment and technical and institutional feasibility of four dominant proposals for AI regulation in the United States: disclosure, registration, licensing, …

Human Capital Disclosure & Corporate Governance: The New Evidence, George S. Georgiev

Articles

This Article explores the evolution of human capital disclosure-firm-supplied information about various workforce-related matters-as a factor in contemporary corporate governance. Regulatory and nonregulatory developments from recent years have upended longstanding practices and generated extensive new evidence. Most notably, the Securities and Exchange Commission (SEC) adopted a human capital management ("HCM") disclosure mandate in 2020, which, though long overdue, was criticized from the outset for its modest scope and lax design. In the meantime, courts have taken a renewed interest in board of directors' oversight responsibilities in a number of areas, including HCM, while labor's power has unexpectedly increased in some …

Jak2-V617f Mutation Among Blood Donors: A Meta-Analysis, Mada H. Alsharif, Eman M. Mansory, Amjad A. Alharazi, Maha A. Badawi

Saudi Medical Journal

Objectives: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial. Evidence on managing these donors is limited. Methods: We performed a literature search using EMBASE and MEDLINE from inception until August 2023, including studies on the prevalence of JAK2 mutation or PV among blood donors. Eligible studies examined blood donors in hospital or community settings, had a sample size of at least 20 …

Post-Thyroidectomy Hypoparathyroidism: A Clinical Surgical Dilemma, Saad M. Alqahtani

Saudi Medical Journal

ABSTRACT Thyroid dysfunction directly affects human health and overall well-being; various approaches are available for the treatment of thyroid diseases, including conservative measures and surgical interventions. Despite advancements in conservative treatment, surgery remains the preferred option. Hypoparathyroidism is the primary cause of hospitalization after thyroidectomy, leading to cost-related concerns and a detrimental impact on patients’ overall quality of life. Postoperative hypoparathyroidism can result in hypocalcemia, and these are challenging conditions that must be identified promptly to prevent immediate and long-term complications. This article focused on the presentation, risk factors, and management of hypoparathyroidism to increase awareness of the risks associated …

Differentiating Mycosis Fungoides Lesions From Their Mimickers Clinically And Histologically: A Single Tertiary Center Retrospective Analysis In Saudi Arabia, Fatimah M. Budair, Ahmed A. Alsayyah, Omar M. Alakloby

Saudi Medical Journal

Objectives: To identify the clinical and histological features of MF that can assist in distinguishing MF from MF-mimicking cases. Although mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma, clinicopathological correlations are required to establish an accurate diagnosis, which are currently lacking. Methods: This retrospective observational study evaluated the clinical presentations, characteristics, and histological features of 56 patients with suspected MF who presented to our clinic between January 2018 and August 2022. Immunohistochemistry was performed, and the loss of CD5 and CD7 T-cells and T-cell receptor rearrangement was evaluated. Results: Overall, 34 patients were diagnosed with MF, …

Assessing The Accuracy And Efficiency Of Chat Gpt-4 Omni (Gpt-4o) In Biomedical Statistics: Comparative Study With Traditional Tools, Anusha S. Meo, Narmeen Shaikh, Sultan A. Meo

Saudi Medical Journal

ABSTRACT Objectives: To assess the accuracy of ChatGPT-4 Omni (GPT-4o) in biomedical statistics. The recent novel inauguration of Artificial Intelligence ChatGPT-Omni (GPT-4o), has emerged with the potential to analyze sophisticated and extensive data sets, challenging the expertise of statisticians using traditional statistical tools for data analysis. Methods: This study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, in May 2024. Three datasets in a raw Excel file format were imported onto Statistical Package for the Social Sciences (SPSS) version 29 for data analysis. Based on this analysis, a script of 9 questions …

Equitable Thriving: A Lifecourse Approach To Maternal And Child Health Justice, Yael Cannon

Georgetown Law Faculty Publications and Other Works

Black women are at least three times more likely to die due to a pregnancy-related cause than White women. Grave racial disparities also abound in severe maternal morbidity, or significant unexpected health consequences of labor and delivery. The Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization, eliminating the constitutional right to abortion, has only further restricted reproductive healthcare options and raised concerns that these disparities will grow even starker. Black, Indigenous, and Latine infants and children also experience unjust—and avoidable—health inequities. As a general matter, people of color are sicker across their lifespans and die younger in …

Violence In The Administrative State, Emily R. Chertoff

Georgetown Law Faculty Publications and Other Works

Drawing on an original, interview-based case study of Immigration and Customs Enforcement (ICE) and a synthesis of six decades of social science literature, this Article offers a theory of physical violence in the administrative state that challenges foundational assumptions about administrative law. Approximately one-fifth of federal employees work for administrative agencies that police, fight wars, enforce immigration law, or incarcerate people—in other words, agencies that use force to execute the laws. These agencies are saturated with administrative law that obligates front-line administrators to confer due process, give notice, behave non-arbitrarily, and comply with law. Yet this law often fails to …

The Nursing Human Capital Value Model, Olga Yakusheva, Kathryn A. Lee, Marianne Weiss

College of Nursing Faculty Research and Publications

Nursing's economic value is presently framed within the dominant “outcomes-over-cost” value framework. Within this context, organizations employing nurses often use nursing budget reductions as a cost-minimization strategy, with the intent of retaining high quality outcomes. However, persistent issues such as nurse understaffing, burnout, and turnover threaten healthcare systems' capacity to deliver the quality, equitable, affordable patient care that the public requires. In this paper, we propose a new conceptual model and definition of nursing's economic value. The model development is guided by the convergence of three classic economic frameworks: human capital theory, production theory, and value theory. Grounded in these …

Measles Cases Surge Worldwide, Infecting 10.3 Million People In 2023

Saudi Medical Journal

No abstract provided.

Prevention Is Better Than Cure: Rethinking Court Behaviour And Design, De Maartje Visser

Research Collection Yong Pung How School Of Law

Using a relational dynamics perspective, this commentary considers how to buttress courts' ability to practice their role as guardians of the constitution. It suggests that we should pay more attention to empowering the general public to provide meaningful social support for courts through constitutional literacy efforts. Such literacy efforts should focus on the place of the court within the separation of powers and the value of judicial independence. At the same time, it may be prudent to redact the list of tasks given to constitutional courts and divest responsibility for some activities to other institutions.

Disputing Personal Data In The Eu-China Comprehensive Agreement On Investment, Mark Mclaughlin

Research Collection Yong Pung How School Of Law

This chapter analyses the emerging data realms in China and the European Union against the backdrop of the Comprehensive Agreement on Investment (CAI). It examines the link between data protection and investment flows and undertakes a comparative analysis of the PIPL and GDPR. Moreover, this chapter will also analyse the Digital Silk Road in promoting China’s model of data sovereignty. While early trade and investment agreements did not consider data relevant for the regulation of cross-border commerce, modern treaties are increasingly cognisant of rules for data protection. As such, the data-related provisions of the CAI will be placed in the …

“Split My Award With Whom?” A Case For Plaintiff Incentive Awards And Plaintiff-Attorney Fee Splitting In Class Action Lawsuits, Ilana Kruchenetskaya

Cardozo Law Review

Named plaintiffs are the heart of class action lawsuits—without them, there is no class action. To motivate these individuals to be the face of the class and compensate them for their role in the litigation process, courts typically approve named plaintiff incentive awards when such awards are included in settlement offers. Recently, however, the Eleventh Circuit held that these awards are prohibited under purported Supreme Court precedent from the late 1800s. This decision undermines the future of class actions by removing any incentive individuals may have in taking on the extra work and scrutiny of bringing a class action lawsuit. …

Subcutaneous Ocrelizumab In Multiple Sclerosis: Results Of The Phase 1b Ocarina I Study, Scott D Newsome, Robert T Naismith, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Subcutaneous ocrelizumab is being developed to provide treatment flexibility and additional choice to patients with multiple sclerosis. OCARINA I (NCT03972306) is an open-label, multicenter, Phase 1b, dose-finding study to investigate the pharmacokinetics, safety, tolerability, and immunogenicity of subcutaneous ocrelizumab and to select a dose for the Phase 3 OCARINA II study (NCT05232825).

METHODS: Patients with relapsing or primary progressive multiple sclerosis (aged 18-65 years; Expanded Disability Status Scale score 0.0-6.5) were enrolled into two groups: previously treated with intravenous ocrelizumab (Group A) or naïve to ocrelizumab (Group B). Patients received single ascending doses of subcutaneous ocrelizumab up to 1200 …

Mucosal Single-Cell Profiling Of Crohn's-Like Disease Of The Pouch Reveals Unique Pathogenesis And Therapeutic Targets, Siyan Cao, Khai M Nguyen, Kaiming Ma, Xiaotang Du, Xiuli Liu, Alina Ulezko Antonova, Richard P Rood, Anas Gremida, Chien-Huan Chen, Alexandra Gutierrez, Deborah C Rubin, Martin H Gregory, Mate Gergely, Guadalupe Oliva Escudero, Katherine Huang, Natalia Jaeger, Marina Cella, Rodney D Newberry, Nicholas O Davidson, Matthew A Ciorba, Parakkal Deepak, Marco Colonna

2020-Current year OA Pubs

BACKGROUND & AIMS: The pathophysiology of Crohn's-like disease of the pouch (CDP) in patients with a history of ulcerative colitis (UC) is unknown. We examined mucosal cells from patients with and without CDP using single-cell analyses.

METHODS: Endoscopic samples were collected from pouch body and prepouch ileum (pouch/ileum) of 50 patients with an ileal pouch-anal anastomosis. Single-cell RNA sequencing was performed on pouch/ileal tissues of patients with normal pouch/ileum and CDP. Mass cytometry was performed on mucosal immune cells from patients with UC with normal pouch/ileum, CDP, pouchitis, and those with familial adenomatous polyposis after pouch formation. Findings were independently …

Pet Clinical Study Of Novel Antipsychotic Lb-102 Demonstrates Unexpectedly Prolonged Dopamine Receptor Target Engagement, Dean F Wong, Ganesh B Chand, Nicole Caito, Anna Eramo, Vincent T Grattan, Mark S Hixon, Ginger Nicol, Erin Lessie, Zachary Prensky, Hiroto Kuwabara, Lucy Tian, Ines Valenta, Thomas H Schindler, Gerhard Gründer, Andrew R Vaino

2020-Current year OA Pubs

Regulation of dopamine activity has important clinical consequences, most notably in schizophrenia. LB-102, N-methyl amisulpride, is a novel dopamine D