Digital Commons Network^™

Striking A Balance: Market Shock & Responses In Automotive Components Manufacturing, Emma Lane Mcgahey

All Theses

This thesis examines the effects of extreme market shocks on supply chain dynamics within the automotive industry. Through an analysis of demand data from an automotive manufacturer to its component suppliers (January 2018 to May 2024), the study investigates the relationship between market shocks and supply chain responses, providing insights into how auto components inventory management handles downstream responses to market shocks. With supporting public data—from FRED, BLS, and the U.S. Census Bureau resources—we explore two primary relationships: the impact of market shocks on the Average Standard Deviation of Demand (SDO) and the effect of demand variability on expedited pricing …

Lateral Dispersal Of Adult Trichoptera: Flight Distance And Traveling Pattern, Peilin Tan

All Theses

Trichoptera species (caddisfly) are usually used as bio-indictors for surface water quality due to their sensitivity to environmental changes, and if assessing water quality with light-trapped adults, knowing their travelling patterns will improve the accuracy of such assessments. To investigate how far a caddisfly will migrate from their emerging stream, three streams in South Carolina with different widths (Wildcat Creek 1.2 m, Brasstown Creek 11.2 m and Chattooga River 26.95 m) were selected for this study with light traps placed at three distances (0 m, 50 m, 100 m) from the streams. How long and when? Both species richness and …

Microbial-Chemical Degradation Of Styrene In Co-Mingled Plumes With Ethylbenzene, Benzene, And Carbon Tetrachloride, Marcela C. Flórez-García

All Theses

Industrial sites contaminated with a complex matrix of chemicals represent a problem for the ecosystem and a high risk for the health of all individuals. That is why remediation strategies are needed to mitigate this environmental impact. The latex zone, located at the Corteva industrial site in San Lorenzo, Argentina, is the subject of this research. The environmental impacts in this area are a consequence of petrochemical operations carried out for many years.

Monoaromatic hydrocarbons such as styrene, ethylbenzene, and benzene, and chlorinated methanes like carbon tetrachloride, chloroform, dichloromethane, and chloromethane are among the contaminants identified at the site that …

Avian Temporal Trends And Habitat Relations Within The South Atlantic Coastal Zone, Jordan Mccall

All Theses

Despite the significance of the Hobcaw Barony in a region historically known as a waterfowl hunting paradise, the long history of the Belle W. Baruch Institute of Coastal Ecology and Forest Science on Hobcaw Barony and the establishment of the James C. Kennedy Waterfowl and Wetlands Conservation Center at the Baruch Institute in 2014, no comprehensive study of waterbirds has occurred on site. Thus, basic information, such as the number of species present, relative abundance, migration chronology, and habitat use and selection, is lacking. This research aims to form a baseline of waterbird and wetland data on the Hobcaw Barony …

Inflammation, Physical Activity, And Disease-Free Survival In Stage Iii Colon Cancer: Cancer And Leukemia Group B-Southwest Oncology Group 80702 (Alliance), Justin C Brown, Chao Ma, Qian Shi, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Victor Chang, Richard M Goldberg, Eileen M O'Reilly, Anthony F Shields, Jeffrey A Meyerhardt

2020-Current year OA Pubs

BACKGROUND: Inflammation and insufficient physical inactivity contribute to individual-level risk of disease recurrence and death in stage III colon cancer. The extent to which increased inflammatory risk can be offset by sufficient physical activity remains unknown.

METHODS: This cohort study was nested within the Cancer and Leukemia Group B (now part of the Alliance for Clinical Trials in Oncology) and Southwest Oncology Group randomized trial. Inflammatory burden was quantified by high-sensitivity C-reactive protein, interleukin-6, and soluble tumor necrosis factor-α receptor 2 after recovery from tumor resection. Physical activity was measured during and after postoperative chemotherapy. The primary endpoint was disease-free …

Cxcr3-Cxcl11 Signaling Restricts Angiogenesis And Promotes Pericyte Recruitment, Jihui Lee, Megan E. Goeckel, Allison Levitas, Sarah Colijn, Jimann Shin, Anna Hindes, Geonyoung Mun, Zarek Burton, Bharadwaj Chintalapati, Ying Yin, Javier Abello, Lilianna Solnica-Krezel, Amber N. Stratman

2020-Current year OA Pubs

BACKGROUND: Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces; yet there is a lack of mechanistic understanding of the signaling pathways that underlie these events. Here, we have identified a novel signaling network regulated by blood flow in ECs-the chemokine receptor CXCR3 (CXC motif chemokine receptor 3) and one of its ligands, CXCL11 (CXC motif chemokine ligand 11)-that delimits EC angiogenic potential and promotes pericyte recruitment to ECs during development.

METHODS: We investigated the role of CXCR3 on vascular development using both 2- and 3-dimensional in vitro assays, to study EC-pericyte interactions and EC behavioral …

Correlating Clinical Course With Baseline Subcortical Shape In Provisional Tic Disorder, Tiffanie Che, Soyoung Kim, Deanna J Greene, Ashley Heywood, Jimin Ding, Tamara Hershey, Bradley L Schlaggar, Kevin J Black, Lei Wang

2020-Current year OA Pubs

OBJECTIVE: This study examined children at the onset of tic disorder (tics for less than 9 months: NT group), a population on which little research exists. Here, we investigate relationships between the baseline shape and volume of subcortical nuclei, diagnosis, and tic symptom outcomes.

METHODS: 187 children were assessed at baseline and a 12-month follow-up: 88 with NT, 60 tic-free healthy controls (HC), and 39 with chronic tic disorder/Tourette syndrome (TS), using T1-weighted MRI and total tic scores (TTS) from the Yale Global Tic Severity Scale to evaluate symptom change. Subcortical surface maps were generated using FreeSurfer-initialized large deformation diffeomorphic …

Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba

2020-Current year OA Pubs

Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describes healthcare disparities in the changing landscape of non-small cell lung cancer (NSCLC) in the United States, focusing on racial, ethnic, sex-based, and socioeconomic trends. Furthermore, strategies to address disparities, overcome challenges, and improve patient outcomes are proposed. Barriers exist across lung cancer screening, diagnosis, and treatment regimens, varying by sex, age, race and ethnicity, geography, and socioeconomic status. Incidence and mortality rates of lung cancer are higher among Black men than White men, and incidences in young women are substantially greater than …

Kras Mutations In Endometrial Cancers: Possible Prognostic And Treatment Implications, Karolina A Kilowski, Martin F Dietrich, Joanne Xiu, Yasmine Baca, Andrew Hinton, Sarfraz Ahmad, Thomas J Herzog, Premal Thaker, Robert W Holloway

2020-Current year OA Pubs

BACKGROUND/OBJECTIVES: Patients with recurrent or metastatic endometrial cancer (EC) have poor prognoses with limited therapeutic options following immunotherapy or immunochemotherapy treatments. Inhibitors of KRAS mutations (KRAS-mut) have shown efficacy in early solid tumor studies, but data in EC are lacking. This study describes the frequency of KRAS-mut relative to other oncogenic alterations in EC to identify genomic characteristics of KRAS-mut tumors that could lead to novel therapeutic options.

METHODS: A molecular database of 7870 ECs was queried for presence of oncogenic mutations and immunotherapy biomarkers. Comparisons were performed using Fisher-Exact/ChiSquare (p-values) and adjusted for multiple tests by Benjamini-Hochberg (q) and …

Acral Fibrochondromyxoid Tumor: A Clinicopathologic And Molecular Genetic Study Of 37 Cases, Carina A Dehner, Jonathan C Baker, John S A Chrisinger, Et Al.

2020-Current year OA Pubs

Acral fibrochondromyxoid tumor (AFCMT) is a recently described likely benign mesenchymal neoplasm arising in the distal extremities with distinctive histologic features and a recurrent THBS1::ADGRF5 fusion. We studied an additional 37 cases of AFCMT and expanded on the so-far reported clinicopathologic and molecular findings. Tumors occurred in 21 females and 16 males, ranging in age from 17 to 78 years (median age: 47), and solely involved the hands (24/37, 65%) or feet (13/37, 35%). Histologic examination revealed well-delineated uni- or multinodular tumors with prominent vasculature-rich septa and bland, chondrocyte-like tumor cells set within abundant chondromyxoid stroma. Immunohistochemical studies showed that …

Incident Cardiovascular Disease Risk Among Older Asian, Native Hawaiian And Pacific Islander Liver Cancer Survivors, Jing Wang, Yancen Pan, Chun-Pin Esther Chang, Anees Daud, Randa Tao, Mia Hashibe

2020-Current year OA Pubs

BACKGROUND: Cardiovascular disease (CVD) is a significant global health concern, particularly among Asian, Native Hawaiian, and Pacific Islander (ANHPI) communities that face unique health challenges. Liver cancer disproportionately affects ANHPI populations and has intricate associations with CVD risks due to shared pathophysiological mechanisms and metabolic disturbances. However, the specific CVD risk profile of ANHPI liver cancer patients remains poorly understood.

METHODS: Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified and matched 1150 ANHPI and 2070 Non-Hispanic White (NHW) liver cancer patients diagnosed between 2000 and 2017. We used the Fine-Gray sub-distribution hazard model to estimate hazard ratios (HRs) …

Research Priorities For Children With Hypoxic-Ischemic Encephalopathy Or Myelomeningocele: A Survey Of Parents, Renée A Shellhaas, Betsy Pilon, Judy Thibadeau, Stephanie M D Rau, John D E Barks, Ronald D Chervin

2020-Current year OA Pubs

No abstract provided.

Pathogenicity And Virulence Of Human Respiratory Syncytial Virus: Multifunctional Nonstructural Proteins Ns1 And Ns2, Trudy N Merritt, Jingjing Pei, Daisy W Leung

2020-Current year OA Pubs

Human respiratory syncytial virus (hRSV) is a major cause of lower respiratory tract infections in young children, the elderly, and immunocompromised. Despite its discovery over 60 years ago and the global impact on human health, limited effective prophylactic or therapeutic options have been available for hRSV infections. This has largely been attributed to the legacy of vaccine failure in the 1960s using a formalin-inactivated RSV , which led to enhancement of disease post exposure to hRSV infection and hampered subsequent development of vaccine candidates. Recent FDA approval of vaccines for older adults and pregnant individuals are major advancements but leaves …

The Brief Mind Wandering Three-Factor Scale (Bmw-3), Anna-Lena Schubert, Gidon T Frischkorn, Kathrin Sadus, Matthew S Welhaf, Michael J Kane, Jan Rummel

2020-Current year OA Pubs

In recent years, researchers from different fields have become increasingly interested in measuring individual differences in mind wandering as a psychological trait. Although there are several questionnaires that allow for an assessment of people's perceptions of their mind wandering experiences, they either define mind wandering in a very broad sense or do not sufficiently separate different aspects of mind wandering. Here, we introduce the Brief Mind Wandering Three-Factor Scale (BMW-3), a 12-item questionnaire available in German and English. The BMW-3 conceptualizes mind wandering as task-unrelated thought and measures three dimensions of mind wandering: unintentional mind wandering, intentional mind wandering, and …

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society Expert Consensus Statement On Catheter And Surgical Ablation Of Atrial Fibrillation, Stylianos Tzeis, Ralph J Damiano, Et Al.

2020-Current year OA Pubs

In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017. Seven years after the last consensus, an updated document was considered necessary to define a …

The Norwood With Blalock-Taussig-Thomas Shunt—Worth A Second Look?, Manasa Gadiraju, Dhaval Chauhan, Alexandra Schray, James O'Brien, Edo Bedzra

Manuscripts, Articles, Book Chapters and Other Papers

Background: Shunt repair for the Norwood procedure with either the right ventricle to pulmonary artery shunt (RVPAS) or the modified Blalock-Taussig-Thomas Shunt (BTTS) varies by institution and surgeon preference. Shunt choice has been informed by landmark trials including the Single Ventricle Reconstruction trial and modern outcomes data may engender future complementary studies. Methods: We conducted a retrospective analysis of all patients who underwent the Norwood procedure from 2014–2022 at a single center to compare outcomes by shunt type. The primary outcome measure was freedom from death or transplant. Secondary outcome measures included hospital length of stay, complications, and unplanned interventions. …

Real-Time Predictive Analytics For Healthcare Monitoring And Terrain Classification Using Data Streaming And Online Learning, Ayemon Baraka

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis develops a scalable, real-time predictive framework aimed at improving outcomes in healthcare monitoring and gait classification. Specifically, it addresses two primary applications: early detection of cardiovascular events, myocardial infarction (MI) and arrhythmia, through continuous analysis of ECG data streams; and adaptive terrain classification from gait data. Utilizing data streaming technologies such as Apache Kafka and Apache Spark, coupled with machine learning models, this framework enables near real-time and precise predictions from high-throughput, real-time data. Furthermore, the integration of online learning frameworks, including the River API and TensorFlow I/O, allows for continuous model adaptation, enhancing the system’s responsiveness and …

Analyzing Sars-Cov-2 Wastewater Surveillance Data For Public Health Impact In Southern Nevada, Casey A. Barber

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Early in the COVID-19 pandemic, researchers determined that levels of severe acute respiratory coronavirus 2 (SARS-CoV-2) genetic material in wastewater could provide information about COVID-19 occurrence in communities. Wastewater-based epidemiology (WBE) efforts have subsequently expanded throughout the U.S. and internationally; the U.S. Centers for Disease Control and Prevention (CDC) initiated its National Wastewater Surveillance System (NWSS) in September of 2020 and continues its SARS-CoV-2 wastewater monitoring efforts following the end of the federal COVID-19 public health emergency in May 2023. The field of WBE has reached a critical juncture in determining the future of how SARS-CoV-2 wastewater surveillance data …

Exploring The Interactive Effects Of Officer, Subject, And Encounter Factors On Police Use Of Force Outcomes, Jeremy David Barnum

UNLV Theses, Dissertations, Professional Papers, and Capstones

Police use of force incidents are highly complex events that can be characterized by factors pertaining to the officers, subjects, and immediate encounter. These factors and the dynamic interrelationships between them encompass the situational context of use of force and have been widely studied in the criminological literature (Bolger, 2015). However, extant research has almost exclusively focused on identifying the main effects of situational factors on use of force with little consideration of how effects may vary across specific situational contexts. This limits our understanding of police use of force and complicates efforts to develop policy or training that ensures …

Biological Reduction Of Mixed Oxyanions In Wastewater Brine, Katherine J. Earp

UNLV Theses, Dissertations, Professional Papers, and Capstones

Treatment of contaminated brine water is an area of active research spurred by the use of advanced treatment technologies, such as membrane separation, reverse osmosis, ion exchange, etc. for water reuse and recycling, which has become critical due to the impact of climate change on water resources throughout the globe. Biological reduction of harmful organic and inorganic pollutants in water has been demonstrated as an effective method for water and wastewater treatment and would be a potential technology for brine treatment. However, biodegradation of contaminants in high salinity waters is challenging because most microbial communities cannot survive brine environments. The …

Understanding Levels Of Perceived Racism And Discrimination When Utilizing Perinatal Care, Alexandria S. Evans

UNLV Theses, Dissertations, Professional Papers, and Capstones

Social and structural determinants of health, grounded in historical racism and discrimination, significantly influence maternal health outcomes. Because of this, communities of color experience a higher burden of maternal health disparities. In the last several decades, there has been an increased awareness of the need to integrate critical race theory into public health research to address maternal health disparities in the context of perinatal care delivery, policy, and funding decisions.

This three-manuscript dissertation utilized mixed methods to examine the ways in which systemic racism and discrimination are perceived and how it impacts the utilization of perinatal care services in historically …

Effect Of Epistemic Cognition And Self-Regulation On The Evaluation Of Online Information, Devin T. Foschi

UNLV Theses, Dissertations, Professional Papers, and Capstones

While research has shown that epistemic cognition plays an important role in self-regulation, the way in which it does so in online contexts needs further research. The objective of this dissertation was to examine the relationship between Internet-specific epistemic cognition and Internet-specific self-regulated learning, and to use a mixed-methods approach in order to expand upon the way learners undergo the evaluation of information in online spaces beyond the traditional method of only using self-report measures and other common quantitative techniques. Using an explanatory sequential mixed-methods design, Phase 1 (N = 117) used quantitative methods to first look at the relationship …

The Assignment Despite Objection Construct: Its Efficacy And Utility In Measuring Nurse-Perceived Unsafe Staffing Events And Associated Outcomes, Debra F. Fox

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: This three-manuscript approach provided a progressively built overview of Assignment Despite Objection as a construct used by nurses to document their perceptions of unsafe staffing events and as an unstudied concept in the staffing outcomes literature.

Background: All nurses have an ethical, legal, and professional responsibility to refuse or object to assignments they believe are unsafe for their well-being or their patient’s safety. Assignment Despite Objection being the only widely used construct nurses use to document these perceptual details. No studies have focused on Assignment Despite Objection as a construct or concept, leaving a complete gap in understanding its …

Social Network Analysis: How Social Media Groups Can Influence Policies Among Hispanic Families, Valeria Gurr

UNLV Theses, Dissertations, Professional Papers, and Capstones

The COVID-19 pandemic in March 2020 impacted the entire world in various ways. On March 15, 2020, education in Nevada was significantly impacted when the Governor announced the closure of public schools due to the pandemic. When the schools were closed, students were forced to stay home and receive their education through virtual instruction. This transition to distance education affected the Hispanic/Latino(a) communities in pronounced ways and highlighted issues such as limited access to the Internet, technology, lack of hardware devices, as well as language barriers and more. This study uses social networking analysis techniques to examine the nature of …

Uptake Of Contaminants Of Emerging Concerns (Cecs) By Plants Irrigated With Recycled Waters, Abid Hussain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing demand for water in arid and semi-arid regions necessitates the use of recycled water (RW) for irrigation. RW is a viable alternative to conventional irrigation water at most locations, but it can be a major route for contaminants of emerging concerns (CECs) to be taken up by the tissues of food crops, thereby leading to their subsequent entry into the food chain. CECs include pharmaceuticals, personal care products, and industrial chemicals that are generally present at low concentrations in environmental waters, hence their common designation as trace organic compounds (TOrCs), and CECs also include microbiological constituents such as …

Physiology And Genomics At The Bottom Of The World: Genome To Phenome, Amy Christine Klink

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mammals are exposed to a suite of physiological challenges based on the environment in which they inhabit. Animal individuals can overcome challenges associated with the dynamic nature of their habitat through variation in phenotypic traits. The plasticity of a phenotype relies on an individual’s genome and the transcription factors that act on regulatory elements. Species living in Antarctica display physiological specializations to withstand harsh conditions, such as severe cold temperatures, shifts in available ice habitat, and annual fluctuations in daylight. To explore the connections between an individual’s genome and its phenotype, we investigated two physiologies of the Antarctic Weddell seal …

Exploring Staff Nurses’ Perceptions Of Nursing Student Enculturation Within Clinical Teaching: A Focused Ethnography, Larizza Limjuco Woodruff

UNLV Theses, Dissertations, Professional Papers, and Capstones

The traditional clinical education model in nursing has utilized on-site learning experiences in clinical settings with patient encounters. With the growing complexity and demands of contemporary nursing care today, it is imperative to question the principal assumptions that guide the design and use of traditional clinical teaching experiences. Staff nurses working with nursing students can illuminate the impact of sociocultural workplace factors on clinical teaching and learning when preparing students for practice. Yet there is little known about staff nurses’ perspectives of nursing culture and how enculturation prepares nursing students for the profession. By understanding the perceptions of enculturation among …

Peer Led Learning Curriculum On Sexual Education, Hannah Harris

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sexual education is a necessary course that teaches students about health and safety. There have been many obstacles that educators have faced in implementing into schools. This has led to a statewide division in how the topic is taught. Because of this, gaps in students' knowledge can lead to harmful practices or actions. A comprehensive sex ed, or CSE, needs to be utilized across the United States as this curriculum focuses on empirically based evidence and facts. Having an unbiased curriculum will improve student’s knowledge and help prevent parent backlash. However, sex ed needs to embrace peer-led learning as many …

The Relationship Between Police Stress And Officer Misconduct, Leobardo Lopez-Cristobal

UNLV Theses, Dissertations, Professional Papers, and Capstones

Recent high-profile and controversial police-related incidents have sparked an intensified public discourse on police misconduct. This has resulted in increasing calls for greater accountability and transparency within U.S. police agencies. Much of the existing research on police misconduct centers around two competing explanations: the "bad apples" perspective, which attributes misconduct to individual officers, and the "bad barrels" perspective, which points to systemic or organizational factors (Rojek, Decker, & Wagner, 2015). However, one factor that has been underexplored in the literature is the role of police stress in influencing deviant police behavior. Previous studies suggest a potential link between police-related stress …

Using Neighborhood Information To Improve Fiber Direction Estimation From Neuroimaging Data, Anjan Mandal

UNLV Theses, Dissertations, Professional Papers, and Capstones

Accurately estimating neuronal fiber directions is crucial in neuroimaging analysis. The Ball-and-Stick Model (BSM), introduced by Behrens et al. (2003), and widely used in software tools like FSL, remains one of the most popular models for this purpose. BSM analyzes each voxel individually, based solely on its signal information.In this dissertation, we propose modifications to BSM, that incorporate signal information from neighboring voxels in the estimation process, potentially improving the accuracy of the estimates. Additionally, within the estimation process, we introduce two novel proposal distributions to enhance the efficiency of the Markov chain Monte Carlo sampling procedure on the simplex …