Digital Commons Network^™

Trust And Reliability Of Information Sources On Facebook For Presidential Candidates: A Study Of Voter Perceptions, Kristina Harrison, Shawn Thelen, Boonghee Yoo

Journal of Applied Marketing Theory

This exploratory research, utilizing both open-ended and likert-type questions, identifies who voters trust on Facebook for information about Presidential candidates as well as the benefits of using Facebook for obtaining this information. In line with Social Identity Theory, results indicate that some sources, especially those that are respected/intimate are far more trusted than others, e.g., local media, national media, and celebrities. Findings indicate that voters, drawn from a national online sample, enjoy the social aspects of connecting with like-minded individuals, use it to source information about candidates, find the platform convenient, but express some concerns over the reliability of information …

Epinephrine Versus Dopamine In Children, What Is The Current Evidence And What Do We Need? A Systematic Review And Meta-Analysis, Rohit S Loomba, Riddhi D Patel, Enrique G Villarreal, Juan S Farias, Saul Flores

Faculty, Staff and Students Publications

Introduction: Pediatric patients often receive vasoactive agents following cardiothoracic surgery or when in shock. The use of vasoactive agents varies between different settings and has largely changed because of anecdotal observations or small observational studies. Although vasoactive agents are frequently used, there are limited studies in pediatric populations comparing them to one another. The purpose of this systematic review is to quantify the comparative effects of epinephrine and dopamine while identifying gaps in knowledge.

Methods: A systematic review of published manuscripts was completed to identify full-text manuscripts in English using PubMed, Embase, and Cochrane databases. Studies were included if they …

General Sport Skills Performance Following The Combined Use Of Accentuated Eccentric Loading And Cluster Sets During A Strength-Endurance Training Phase, David Nelson

Electronic Theses and Dissertations

The purpose of this study aimed to evaluate the efficacy of resistance training with accentuated eccentric loading (AEL) and cluster sets (CS) versus traditional resistance training (TRAD) on general sports skills and power performance in recreationally trained individuals. Seventeen subjects (11 males, 6 females; mean age 23.2 ± 4.1 years; body mass 81.3 ± 22.2 kg; height 172.1 ± 10.0 cm; relative 1 RM back squat 1.5 ± 0.3) were randomly assigned to AEL (n = 9) or TRAD (n = 8) groups. After an initial familiarization and baseline testing, both groups underwent a four-week strength-endurance training regimen. The AEL …

Graduation Rates Of Students With Disabilities At A Participating Southern University, Kelly Mitchell

Electronic Theses and Dissertations

The purpose of this non-experimental, correlational quantitative study was to compare the graduation rates of first-time, full-time students with disabilities to those of first-time, full-time students in the general population at the participating university. The sample used for analysis was full-time, first-time students entering between 2015 and 2020. Using archival data from the Disability Services database and the University's Banner system, four- and six-year graduation rates were compared. The original data set consisted of 22,070 students in the starting focus cohorts. After removing entering transfer students and students who enrolled in less than 15 credits for their entering semester, 8,337 …

Self-Rated Interprofessionalism Between Allied Health Professionals, Courtney Andrews

Electronic Theses and Dissertations

Preventable deaths due to medical errors are a significant cause of death in the United States. Decreased communication and collaboration has been cited as a potential reason for these preventable medical errors. Interprofessional practice (IPP) is a service delivery method where medical professionals from different disciplines intentionally work together in order to provide collaborated and collective care for patients. Interprofessional education (IPE) training programs are becoming more common in healthcare education, and have been cited as one way to improve IPP among healthcare providers. However, gaps exist in the literature regarding how to best structure and implement these programs so …

Community College Student Success During Covid-19 Pandemic Based On Class Modality, Rebecca Aslinger

Electronic Theses and Dissertations

The purpose of this non-experimental, quantitative, comparative study was to determine whether there were significant differences in Introduction to Education grades as measured by GPA among community college students between 2018-23 with the change of class modality due to the Covid-19 pandemic.

This study examined differences in Introduction to Education grades as measured by GPA at three community colleges from 2018-23. Archival data were used for this study. The population for this study consisted of all students enrolled in the Introduction to Education course at three institutions. Both in-person and online classes were examined during the time before, during, and …

Fournier's Gangrene Severity Index And Charlson Comorbidity Index Predict Mortality, Intensive Care Unit Admission, And Length Of Hospital Stay In Patients With Fournier's Gangrene: An Analysis Of 264 Consecutive Patients, Nicholas Hauser, Chenlin Huang, Girija Vaidya, Timothy Chrusciel, Krithika Narayana Kumarasan, John Culhane, Sameer Siddiqui

Faculty, Staff and Students Publications

Introduction: Fournier’s gangrene (FG) is a rapidly progressing necrotizing fasciitis. The Fournier's Gangrene Severity Index (FGSI), in conjunction with the Charlson Comorbidity Index (CCI), has been used as a mortality predictor during hospitalization. Patients with diabetes have also been shown to be at an increased risk for the development of FG. This study explores the potential of using FGSI, CCI, and patient diabetes status in predicting more extensive patient outcomes, including intensive care unit (ICU) admission and length of hospital stay.

Methods: From 2013 to 2023, inpatient admissions with the diagnosis of FG were selected from the EPIC Clarity database …

Implementation Of Delirium Screening In The Emergency Department: A Qualitative Study With Early Adopters, Anita N Chary, Annika R Bhananker, Elise Brickhouse, Beatrice Torres, Ilianna Santangelo, Kyler M Godwin, Aanand D Naik, Christopher R Carpenter, Shan W Liu, Maura Kennedy

Faculty, Staff and Students Publications

Introduction: Delirium affects 15% of older adults presenting to emergency departments (EDs) but is detected in only one-third of cases. Evidence-based guidelines for ED delirium screening exist, but are underutilized. Frontline staff perceptions about delirium and time and resource constraints are known barriers to ED delirium screening uptake. Early adopters of ED delirium screening can offer valuable lessons about successful implementation.

Methods: We conducted semi-structured interviews with clinician-administrators leading ED delirium screening initiatives from 20 EDs in the United States and Canada. Interviews focused on experiences of planning and implementing ED delirium screening. Interviews lasted 15 to 50 minutes and …

Randomized, Observer-Blind, Controlled Phase 1 Study Of The Safety And Immunogenicity Of The Na-Gst-1/Alhydrogel Hookworm Vaccine With Or Without A Cpg Odn Adjuvant In Hookworm-Naïve Adults, David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

Faculty, Staff and Students Publications

BACKGROUND: Recombinant Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) formulated on Alhydrogel (Na-GST-1/Alhydrogel) is being developed to prevent anemia and other complications of N. americanus infection. Antibodies induced by vaccination with recombinant Na-GST-1 are hypothesized to interfere with the blood digestion pathway of adult hookworms in the host. Phase 1 trials have demonstrated the safety of Na-GST-1 formulated on Alhydrogel, but further optimization of the vaccine adjuvant formulation may improve humoral immune responses, thereby increasing the likelihood of vaccine efficacy.

METHODS: A randomized, observer-blind, dose escalation Phase 1 trial was conducted in 24 healthy, hookworm-naïve adults. In each cohort of 12 participants, 4 …

Fournier's Gangrene Severity Index And Charlson Comorbidity Index Predict Mortality, Intensive Care Unit Admission, And Length Of Hospital Stay In Patients With Fournier's Gangrene: An Analysis Of 264 Consecutive Patients, Nicholas Hauser, Chenlin Huang, Girija Vaidya, Timothy Chrusciel, Krithika Narayana Kumarasan, John Culhane, Sameer Siddiqui

Faculty, Staff and Students Publications

Introduction

Fournier’s gangrene (FG) is a rapidly progressing necrotizing fasciitis. The Fournier's Gangrene Severity Index (FGSI), in conjunction with the Charlson Comorbidity Index (CCI), has been used as a mortality predictor during hospitalization. Patients with diabetes have also been shown to be at an increased risk for the development of FG. This study explores the potential of using FGSI, CCI, and patient diabetes status in predicting more extensive patient outcomes, including intensive care unit (ICU) admission and length of hospital stay.

Methods

From 2013 to 2023, inpatient admissions with the diagnosis of FG were selected from the EPIC Clarity database …

Lenvatinib Plus Ifosfamide And Etoposide In Children And Young Adults With Relapsed Osteosarcoma: A Phase 2 Randomized Clinical Trial, Nathalie Gaspar, Giun-Yi Hung, Sandra J Strauss, Quentin Campbell-Hewson, Filemon S Dela Cruz, Julia L Glade Bender, Kyung-Nam Koh, Sarah B Whittle, Godfrey Chi-Fung Chan, Nicolas U Gerber, Sauli Palmu, Daniel A Morgenstern, Alessandra Longhi, Fredrik Baecklund, Jun Ah Lee, Franco Locatelli, Catalina Márquez Vega, Katherine A Janeway, Geoffrey Mccowage, Martin G Mccabe, Behzad Bidadi, Jie Huang, Jodi Mckenzie, Chinyere E Okpara, Francisco Bautista, Olie Study Investigators

Faculty, Staff and Students Publications

IMPORTANCE: The combination of ifosfamide and etoposide (IE) is commonly used to treat relapsed or refractory osteosarcoma; however, second-line treatment recommendations vary across guidelines.

OBJECTIVE: To evaluate whether the addition of lenvatinib to IE (LEN-IE) improves outcomes in children and young adults with relapsed or refractory osteosarcoma.

DESIGN, SETTING, AND PARTICIPANTS: The OLIE phase II, open-label, randomized clinical trial was conducted globally across Europe, Asia and the Pacific, and North America. From March 22, 2020, through November 11, 2021, the trial enrolled patients aged 2 to 25 years with high-grade osteosarcoma, measurable or evaluable disease per Response Evaluation Criteria in …

The Bacterial Cell Wall Components Lipopolysaccharide And Peptidoglycan Initiate Divergent Local Tissue And Systemic Inflammatory Response Profiles In The Chicken Model, Kristen A. Byrne, Gisela F. Erf

Poultry Science Faculty Publications and Presentations

The innate immune system plays an important role in the early defense against pathogens. To better understand the chicken’s innate inflammatory responses, we concurrently examined the cellular responses at the injection site and in the blood following intradermal (i.d.) injections of lipopolysaccharide (LPS) or peptidoglycan (PGN) into the pulp of growing feathers (GFs). Both LPS from Gram-negative bacteria and PGN from Gram-positive bacteria are potent stimulators of innate inflammatory responses. The time-course study conducted revealed similarly elevated levels of heterophils and macrophages in injected GF-pulps during the first 24 h for both LPS and PGN. However, PGN also stimulated rapid …

Impact Of Pegylated Liposomes On Cytotoxicity Of Tamoxifen And Piperine On Mcf-7 Human Breast Carcinoma Cells, Klaudi K. Vaiphei, A Prabakaran, Singh Snigdha, Satyajit Laxman Murkute, Purusottam Mohapatra, Rakesh Kumar Sahoo, Sanya Batheja, Umesh Gupta, Anu Puri, Upal Roy

Health & Biomedical Sciences Faculty Publications

Tamoxifen (TMF) is an anticancer agent used for managing estrogen receptor-positive breast cancer. It has limited therapeutic efficacy against breast cancer, which could be enhanced by the coadministration of herbal drugs like piperine (PIP). However, the hydrophobic nature of TMF and PIP restricts their therapeutic application. Therefore, the present study focuses on the impact of the anticancer activity of TMF in combination with PIP and after entrapping them into liposomes (TMF-PIP-LPs and TMF-PIP-PEG-LPs). The liposomes were prepared using the thin film hydration method. In addition, the morphology of the prepared liposomes was found spherical after SEM and TEM analyses. Further, …

Pediatric High Blood Pressure Recognition Associated With Electronic Decision Support: A Cohort Analysis, Justin P Zachariah, Tavleen Singh, Shannon Collinson, Justin Rahman, Alisa A Acosta, Jessica F Campbell, Mary Hoang, Katharine E Sigler, Elizabeth A Onugha, Shweta S Shah, S Kristen Sexson-Tejtel, Mark Farrior, Scott Watson

Faculty, Staff and Students Publications

Background: Pediatric high blood pressure (BP) predicts future cardiovascular disease events. High BP is improperly measured, underrecognized, and undermanaged especially in disadvantaged populations. In a large, diverse, academic pediatric practice, we detail the associations of a comprehensive initiative with high BP provider recognition.

Methods: A comprehensive BP initiative was promulgated including (1) retraining providers and staff on BP management; (2) deploying equipment at 55+ sites; and (3) electronic decision support tool alerting staff and clinicians and suggesting management. During the 14-month preintervention and 14-month postintervention periods, data on BP and patient characteristics were collected. The outcome was incident BP recognition …

Machine Learning-Based Prediction Model For Icu Mortality After Continuous Renal Replacement Therapy Initiation In Children, Sameer Thadani, Tzu-Chun Wu, Danny T Y Wu, Aadil Kakajiwala, Danielle E Soranno, Gerard Cortina, Rachana Srivastava, Katja M Gist, Shina Menon, Worldwide Exploration Of Renal Replacement Outcomes Collaborative In Kidney Diseases (We-Rock) Collaborators

Faculty, Staff and Students Publications

BACKGROUND: Continuous renal replacement therapy (CRRT) is the favored renal replacement therapy in critically ill patients. Predicting clinical outcomes for CRRT patients is difficult due to population heterogeneity, varying clinical practices, and limited sample sizes.

OBJECTIVE: We aimed to predict survival to ICUs and hospital discharge in children and young adults receiving CRRT using machine learning (ML) techniques.

DERIVATION COHORT: Patients less than 25 years of age receiving CRRT for acute kidney injury and/or volume overload from 2015 to 2021 (80%).

VALIDATION COHORT: Internal validation occurred in a testing group of patients from the dataset (20%).

PREDICTION MODEL: Retrospective international …

“Standing” In The Way Of Equality: Acheson Hotels, Llc, V. Laufer, Hayley R. Mullen

University of Dayton Law Review

No abstract provided.

Investigating The Effect Of Active Living Wall On Indoor Air Quality And Energy Consumption: Case Study In Uaeu Closed Offices, Atina Mohsen Ghunaim

Theses

Extreme hot climates can significantly affect Indoor Air Quality (IAQ) and ventilation, resulting in higher energy demands. Numerous studies have demonstrated that outdoor greening, such as trees and landscaped areas, can reduce a building’s energy consumption. However, less research has been conducted on the impact of indoor vegetation on energy use and air quality. Indoor vegetation decreases Carbon Dioxide (CO₂) concentration by absorbing CO₂ and releasing oxygen (O₂), while the evapotranspiration process further enhances (IAQ) and reduces energy expenditure. The United Arab Emirates has dry arid climate and summers with high humidity levels, causing individuals to stay longer indoors, which …

Passing The Whiteness Threshold: The Lived Experiences Of Uk-Based Turkish Academics, Tugay Durak Tugay Durak

Journal of Comparative & International Higher Education

No abstract provided.

Insights From Glocal Educators: Unveiling The Transformative Journeys Of Educational Developers, A Eltayb, J Valcke

Journal of Comparative & International Higher Education

No abstract provided.

Academic Voices: Continuing Professional Development For Teaching In Internationalized Classrooms, Lucie Weissova, Jeanine Gregersen-Hermans, Darko Pantelic

Journal of Comparative & International Higher Education

No abstract provided.

Troubling Paradise: Exploring The Experiences Of National Student Exchange Participants To The University Of HawaiʻI At Mānoa, Allison Yap

Journal of Comparative & International Higher Education

No abstract provided.

The Policy And Practice Of Internationalization In The Global-South: African International Students’ Experiences In South Africa During Covid-19, Patience Mukwambo, Faith Mkwananzi, Winter Seshoka

Journal of Comparative & International Higher Education

No abstract provided.

Practice Unveils Weaknesses: Analysing The Implementation Of Regulations On Seafarers’ Work/Rest Hours, Bikram S. Bhatia

World Maritime University Ph.D. Dissertations

Seafarers’ fatigue risk management is rooted in regulations on manning and work/rest hours. These regulations establish a minimum fatigue management standard achieved through work/rest hours compliance. Seafarers must maintain daily records of their work/rest hours and report any non-compliance to their company. However, adjustments to these records have been reported in the literature. Such malpractice obscures instances of non- compliance and hinders the feedback necessary for resolving these issues, including flag State review and amendments to minimum safe manning documents. It compromises the integrity of fatigue risk management and underscores the need for further research.

This study examined the implementation …

Synergistic Anticancer Effect Of Pistacia Lentiscus Essential Oils And 5-Fluorouracil Co-Loaded Onto Biodegradable Nanofibers Against Melanoma And Breast Cancer, Obaydah Abd Alkader Alabrahim, Hassan Mohamed El Said Azzazy

Faculty Journal Articles

Chemoresistance and severe toxicities represent major drawbacks of chemotherapy. Natural extracts, including the essential oils of Pistacia lentiscus (PLEO), exhibit substantial anticancer and anti-inflammatory activities where different cancers are reported to dramatically recess following targeting with PLEO. PLEO has promising antimicrobial, anticancer, and anti-inflammatory properties. However, the therapeutic properties of PLEO are restricted by limited stability, bioavailability, and targeting ability. PLEO nanoformulation can maximize their physicochemical and therapeutic properties, overcoming their shortcomings. Hence, PLEO was extracted and its chemical composition was determined by GC–MS. PLEO and 5-Fluorouracil (5FU) were electrospun into poly-ε-caprolactone nanofibers (PCL-NFs), of 290.71 nm to 680.95 nm …

Derivation Of A Novel Antimicrobial Peptide From The Red Sea Brine Pools Modified To Enhance Its Anticancer Activity Against U2os Cells, Mona Elradi, Ahmed I. Ahmed, Ahmed M. Saleh, Khaled M.A. Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Faculty Journal Articles

Cancer associated drug resistance is a major cause for cancer aggravation, particularly as conventional therapies have presented limited efficiency, low specificity, resulting in long term deleterious side effects. Peptide based drugs have emerged as potential alternative cancer treatment tools due to their selectivity, ease of design and synthesis, safety profile, and low cost of manufacturing. In this study, we utilized the Red Sea metagenomics database, generated during AUC/KAUST Red Sea microbiome project, to derive a viable anticancer peptide (ACP). We generated a set of peptide hits from our library that shared similar composition to ACPs. A peptide with a homeodomain …

Improving Communication Between Providers And Patients During Pediatric Cancer Care, Yuritza Arciga

Capstone Projects and Master's Theses

The Listen First Survivorship project explores the communication barriers faced by young adults and their families during cancer treatment. The project focuses on identifying communication gaps and developing strategies to better support Jacob’s Heart's young adult cancer survivors. This project was implemented by Jacob’s Heart Children’s Cancer Support Services and Dr. Stephanie Smith of the Pediatric Oncology department at Stanford Children’s Hospital. The participants described feeling overwhelmed with too much information and not enough answers to their questions during their appointments. Through qualitative interviews and focus groups, key findings revealed that young adults experienced significant gaps in knowledge due to …

Active Transportation Term Guide, Kalonni Steib

Capstone Projects and Master's Theses

The Monterey County Health Department, through its Planning, Evaluation, and Policy (PEP) Department, is dedicated to promoting health equity by implementing strategic plans, aligning performance standards with national accreditation, and addressing social and environmental policies. Serving underserved and unincorporated communities, PEP focuses on overcoming language barriers in Monterey County, which has a significant Hispanic and Latino population. This project aimed to develop a bilingual glossary of active transportation terms to enhance communication between the community and government agencies. Implemented over three to six months, the glossary was piloted for feedback and updates. The project successfully identified key transportation terms and …

Communicating Development For Adults With Developmental Disabilities, Ruby Mandujano

Capstone Projects and Master's Theses

Adults with intellectual and developmental disabilities (IDDs) often face significant communication barriers that hinder their ability to express needs, access essential services, and engage fully in social, vocational, and healthcare settings. This paper explores how American Sign Language (ASL) can effectively reduce these communication barriers and promote self-advocacy among adults with developmental disabilities. The Gateway Center of Monterey County, an agency serving adults with intellectual and developmental disabilities aged 18 and over, provides a model of communication support by incorporating ASL into its programs. Although Gateway serves only a tiny percentage of the larger population of adults with intellectual and …

Comprehensive Community Medicine, Alexander Walther

Capstone Projects and Master's Theses

Comprehensive Community Medicine (CCM) is a theoretical framework designed to address the complex needs of individuals with dual diagnoses of mental illness and substance use disorders (SUDs). Dual diagnosis is highly prevalent, particularly among populations experiencing homelessness, and is associated with poorer health outcomes and increased healthcare service utilization. Structural inequities, including a fractured healthcare system, exacerbate the challenges faced by this vulnerable group. Research indicates that effective care for dually diagnosed individuals requires a layered approach addressing clinical, systemic, legal, and housing barriers.

The development of CCM has been informed by interviews with local stakeholders, including County EMS board …

Identifying Gaps: Mixtec Parents’ Experiences Within The Salinas Union High School District, Daniela Maldonado Prudencio

Capstone Projects and Master's Theses

The Salinas Union High School District has identified low academic performance among Mixtec-speaking students as a significant issue. Since these students are learning English and Spanish simultaneously, they often face language barriers that affect their academic progress. The school system lacks culturally relevant systems and practices to support their unique needs. This gap also leads to limited parental engagement, as Mixtec-speaking parents struggle to navigate the school system further impacting student’s success. Low graduation rates, limited access to higher education, and limited career opportunities are some of the outcomes. In response, Salinas Union High School Pupil and Personnel Services worked …