Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2024

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 511 - 540 of 79511

Full-Text Articles in Entire DC Network

A Review Of Managing Catastrophes In Robotic-Assisted Thoracic Surgery, Shamele Battan-Wraith, Kevin Wang, Ahmed Elkamel, Kameron Durante, Hope Conrad, Kayla Iannarelli, Olugbenga Okusanya, Praveen Sridhar, Stephanie G. Worrell Dec 2024

A Review Of Managing Catastrophes In Robotic-Assisted Thoracic Surgery, Shamele Battan-Wraith, Kevin Wang, Ahmed Elkamel, Kameron Durante, Hope Conrad, Kayla Iannarelli, Olugbenga Okusanya, Praveen Sridhar, Stephanie G. Worrell

Department of Surgery Faculty Papers

Lung cancer is the most commonly diagnosed cancer worldwide in 2022, with over 2.5 million new cases, or 1 in 8 of all cancers diagnosed worldwide. Lung cancer is the leading cause of cancer related mortality in the United States, with non-small cell lung cancer (NSCLC) being the most prevalent type. For early-stage NSCLC, lung resection with anatomic lobectomy remains the standard of care. Robot-assisted lobectomy is gaining popularity over video-assisted thoracoscopic surgery (VATS) and open thoracotomy due to improved visualization, ergonomics, and instrumentation. Despite these advancements, intraoperative complications and a steep learning curve present significant barriers to the widespread …


Self-Compassion And Peer Social Support: Do They Influence Self-Efficacy In Career Decision Making Of Generation Z Students?, Wildan Madani, Helli Ihsan, Farhan Zakariyya Dec 2024

Self-Compassion And Peer Social Support: Do They Influence Self-Efficacy In Career Decision Making Of Generation Z Students?, Wildan Madani, Helli Ihsan, Farhan Zakariyya

Jurnal Kajian Bimbingan dan Konseling

This study aims to determine the effect of self-compassion and peer social support on career decision-making self-efficacy (CDMSE) among Generation Z college students in Indonesia. This study uses quantitative methods with a regression analysis approach. Sampling was conducted using non-probability sampling techniques with an accidental sampling approach. This study involved 367 active college students from Generation Z, aged 18-24, residing or studying in the metropolitan area of Greater Bandung. Greater Bandung was chosen as the research location because it represents the characteristics of Generation Z in Indonesia. The city is a center of education and culture with diverse higher education …


Exploring The Impact Of Self-Control, Motivation, And Resilience On Students' Self-Compassion, Diani Akmalia Apsari, Adi Atmoko, Ika Andrini Farida, Nur Eva, Augusto Da Costa, Aidah Fuadiyah Dec 2024

Exploring The Impact Of Self-Control, Motivation, And Resilience On Students' Self-Compassion, Diani Akmalia Apsari, Adi Atmoko, Ika Andrini Farida, Nur Eva, Augusto Da Costa, Aidah Fuadiyah

Jurnal Kajian Bimbingan dan Konseling

The core purpose of Pendidikan Profesi Guru Prajabatan (PPG) is to educate prospective teachers to become professional teachers. To achieve this goal, students requires psychological abilities when facing challenges such as dense and demanding tasks based on the curriculum that must be completed in 2 semesters. This study aims to (1) test the theoretical model of regression of self-compassion, and (2) determine the contribution of self-control, motivation, and resilience to self-compassion in PPG students. This study used a causal relationship design. Data were collected with (1) Brief Self Control Scale, (2) The Academic Motivation Scale, (3) The Connor-Davidson Resilience Scale, …


The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning Dec 2024

The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning

Faculty, Staff and Student Publications

To assess the preliminary therapeutic impact of a novel treatment, futility monitoring is commonly employed in Phase II clinical trials to facilitate informed decisions regarding the early termination of trials. Given the rapid evolution in cancer treatment development, particularly with new agents like immunotherapeutic agents, the focus has often shifted from objective response to time-to-event endpoints. In trials involving multiple time-to-event endpoints, existing monitoring designs typically select one as the primary endpoint or employ a composite endpoint as the time to the first occurrence of any event. However, relying on a single efficacy endpoint may not adequately evaluate an experimental …


Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien Dec 2024

Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien

Faculty, Staff and Student Publications

Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days. The low-saline solutions contained 2.13 g of salt dissolved in eight ounces of warm water, while the high-saline solution contained six grams of …


Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang Dec 2024

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH


Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao Dec 2024

Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao

Faculty, Staff and Student Publications

One goal of precision medicine is to develop effective treatments for patients by tailoring to their individual demographic, clinical, and/or genetic characteristics. To achieve this goal, statistical models must be developed that can identify and evaluate potentially heterogeneous treatment effects in a robust manner. The oft-cited existing methods for assessing treatment effect heterogeneity are based upon parametric models with interactions or conditioning on covariate values, the performance of which is sensitive to the omission of important covariates and/or the choice of their values. We propose a new Bayesian nonparametric (BNP) method for estimating heterogeneous causal effects in studies with zero-inflated …


Cross-Generational Perception Analysis Of The Role Of Sharia Economics In Reducing Social Inequality In Jakarta (Case Study Of Gen Z, Gen Y, Gen X, And Early Gen X), Kuncoro Hadi, Nuraini Nuraini Dec 2024

Cross-Generational Perception Analysis Of The Role Of Sharia Economics In Reducing Social Inequality In Jakarta (Case Study Of Gen Z, Gen Y, Gen X, And Early Gen X), Kuncoro Hadi, Nuraini Nuraini

Journal Of Middle East and Islamic Studies

This study aims to analyze cross-generational perceptions of the role of Islamic economics in reducing social inequality in Jakarta. Using a quantitative approach, this study collected data from 994 respondents divided into four age groups (18-25 years, 26-35 years, 36-45 years, and 46-55 years). Data were analyzed using the Kruskal-Wallis test to evaluate differences in perceptions between age groups on the basic principles of Islamic economics, the fairness of the system, and the effectiveness of its implementation. The results showed significant differences in understanding and perception between age groups, with 26-35 years old having the highest level of understanding. The …


From Hell To Heaven: How Climate Risks Hurt The Poor And Climate Finance Heals Them, Dr. Kangyin Dong, Congyu Zhao, Xiucheng Dong Dec 2024

From Hell To Heaven: How Climate Risks Hurt The Poor And Climate Finance Heals Them, Dr. Kangyin Dong, Congyu Zhao, Xiucheng Dong

Bulletin of Monetary Economics and Banking

This study explores the global impact of climate finance on wealth and income inequality, utilizing the IV-GMM model to capture nuanced relationships. Key findings indicate that climate finance effectively reduces both forms of inequality, benefiting low-income populations and suggesting it as a viable tool for inequality reduction. Notably, the impact of climate finance is asymmetric: countries with lower initial inequality levels experience more pronounced benefits, while the effect lessens as inequality increases. Additionally, climate risks—represented by natural disasters— worsen inequality, underscoring climate finance’s dual role in directly reducing inequality and indirectly mitigating disaster impacts. These insights offer valuable policy implications, …


Impact Of Covid-19 On International Trade, Paresh Kumar Narayan, Chun Ping Chang, Xin-Xin Zhao Dec 2024

Impact Of Covid-19 On International Trade, Paresh Kumar Narayan, Chun Ping Chang, Xin-Xin Zhao

Bulletin of Monetary Economics and Banking

Using a global monthly unbalanced panel dataset of 70 countries from January 2020 to May 2023, we first examine the impact of COVID-19 on global trade. The empirical results show a detrimental impact of COVID-19 on countries’ foreign trade, which persists over six months. We evaluate the robustness of our findings by employing an alternative dependent variable and different estimators. Our main findings hold and two features of our results standout: first, that COVID-19 hurt international trade more for non-Asian countries; and second, that sectoral sensitivity to COVID-19 was heterogenous. These results have important policy implications.


Urgensi Ppl Ppg Prajabatan Terhadap Peningkatan Profsionalisme Calon Guru Bimbingan Dan Konseling Di Era Society 5.0, Ayu Puspita Sari, Adi Atmoko Dec 2024

Urgensi Ppl Ppg Prajabatan Terhadap Peningkatan Profsionalisme Calon Guru Bimbingan Dan Konseling Di Era Society 5.0, Ayu Puspita Sari, Adi Atmoko

Journal of Innovation and Teacher Professionalism

In the era of society 5.0, the rapid development of science and technology demands Guidance and Counseling (BK) teachers to continuously improve their professionalism. One of the government's efforts is through the Pre-Service Teacher Professional Education (PPG) program, which requires prospective teachers to undertake Field Experience Practice (PPL). This qualitative research with a descriptive approach aims to examine the urgency of PPL PPG Pre-Service in enhancing the professionalism of prospective BK teachers in the era of society 5.0. The results show that PPL PPG Pre-Service has a strategic role in honing the four core competencies of counselors, namely pedagogical, personal, …


Metakaolin-Based Geopolymer Concrete; Synthesis, Development And Characterization, Heba Fouad Dec 2024

Metakaolin-Based Geopolymer Concrete; Synthesis, Development And Characterization, Heba Fouad

Theses and Dissertations

Geopolymers are rendered as an essential sustainable replacement to the widely used Ordinary Portland Cement (OPC) which causes immense carbon dioxide emissions, hence a detrimental impact on society’s health and the environment. Geopolymers are three-dimensional networks of polymerized tetrahedral silicate and aluminate in the form of Q4(4Al), Q4(3Al) and Q4(2Al) which act as the principal binding phase in concrete. Past research has reported the synthesis of geopolymers from different aluminosilicates precursors, their characterization, and their wide range properties. However, previous studies still have not properly investigated effective range of synthesis ratios for a particular source material, optimum curing regimes, short- …


State Of Utah, Plaintiff And Appellee V. Jessica Buck, Defendant And Appellant : Reply Brief, Utah Court Of Appeals Dec 2024

State Of Utah, Plaintiff And Appellee V. Jessica Buck, Defendant And Appellant : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

ON DIRECT APPEAL FROM A SENTENCE JUDGMENT COMMITMENT ENTERED BY THE HONORABLE JUDGE JEREMIAH HUMES OF THE SEVENTH JUDICIAL DISTRICT COURT IN AND FOR CARBON COUNTY, STATE OF UTAH

K. ANDREW FITZGERALD, Attorney for Appellant


Transition To Enteral Triazole Antifungal Therapy For Pediatric Invasive Candidiasis: Secondary Analysis Of A Multicenter Cohort Study Conducted By The Pediatric Fungal Network, Robert F T Bucayu, Craig L K Boge, Inci Yildirim, Martha Avilés-Robles, Surabhi B Vora, David M Berman, Tanvi S Sharma, Lillian Sung, Elio Castagnola, Debra L Palazzi, Lara Danziger-Isakov, Dwight E Yin, Emmanuel Roilides, Gabriela Maron, Alison C Tribble, Pere Soler-Palacin, Eduardo López-Medina, José Romero, Kiran Belani, Antonio C Arrieta, Fabianne Carlesse, Dawn Nolt, Natasha Halasa, Daniel Dulek, Sujatha Rajan, William J Muller, Monica I Ardura, Alice Pong, Blanca E Gonzalez, Christine M Salvatore, Anna R Huppler, Catherine Aftandilian, Mark J Abzug, Arunaloke Chakrabarti, Michael Green, Irja Lutsar, Elizabeth D Knackstedt, Sarah K Johnson, William J Steinbach, Brian T Fisher, Rachel L Wattier Dec 2024

Transition To Enteral Triazole Antifungal Therapy For Pediatric Invasive Candidiasis: Secondary Analysis Of A Multicenter Cohort Study Conducted By The Pediatric Fungal Network, Robert F T Bucayu, Craig L K Boge, Inci Yildirim, Martha Avilés-Robles, Surabhi B Vora, David M Berman, Tanvi S Sharma, Lillian Sung, Elio Castagnola, Debra L Palazzi, Lara Danziger-Isakov, Dwight E Yin, Emmanuel Roilides, Gabriela Maron, Alison C Tribble, Pere Soler-Palacin, Eduardo López-Medina, José Romero, Kiran Belani, Antonio C Arrieta, Fabianne Carlesse, Dawn Nolt, Natasha Halasa, Daniel Dulek, Sujatha Rajan, William J Muller, Monica I Ardura, Alice Pong, Blanca E Gonzalez, Christine M Salvatore, Anna R Huppler, Catherine Aftandilian, Mark J Abzug, Arunaloke Chakrabarti, Michael Green, Irja Lutsar, Elizabeth D Knackstedt, Sarah K Johnson, William J Steinbach, Brian T Fisher, Rachel L Wattier

Faculty, Staff and Students Publications

Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was successful in 66 participants who transitioned to enteral therapy.


Dlk-Dependent Axonal Mitochondrial Fission Drives Degeneration After Axotomy, Jorge Gómez-Deza, Matthew Nebiyou, Mor R Alkaslasi, Francisco M Nadal-Nicolás, Preethi Somasundaram, Anastasia L Slavutsky, Wei Li, Michael E Ward, Trent A Watkins, Claire E Le Pichon Dec 2024

Dlk-Dependent Axonal Mitochondrial Fission Drives Degeneration After Axotomy, Jorge Gómez-Deza, Matthew Nebiyou, Mor R Alkaslasi, Francisco M Nadal-Nicolás, Preethi Somasundaram, Anastasia L Slavutsky, Wei Li, Michael E Ward, Trent A Watkins, Claire E Le Pichon

Faculty, Staff and Students Publications

Currently there are no effective treatments for an array of neurodegenerative disorders to a large part because cell-based models fail to recapitulate disease. Here we develop a reproducible human iPSC-based model where laser axotomy causes retrograde axon degeneration leading to neuronal cell death. Time-lapse confocal imaging revealed that damage triggers an apoptotic wave of mitochondrial fission proceeding from the site of injury to the soma. We demonstrate that this apoptotic wave is locally initiated in the axon by dual leucine zipper kinase (DLK). We find that mitochondrial fission and resultant cell death are entirely dependent on phosphorylation of dynamin related …


Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao Dec 2024

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …


Age-Dependent Regulation Of Axoglial Interactions And Behavior By Oligodendrocyte Ankyring, Xiaoyun Ding, Yu Wu, Anna Vainshtein, Victoria Rodriguez, Emily Ricco, James T Okoh, Yanhong Liu, Daniel C Kraushaar, Elior Peles, Matthew N Rasband Dec 2024

Age-Dependent Regulation Of Axoglial Interactions And Behavior By Oligodendrocyte Ankyring, Xiaoyun Ding, Yu Wu, Anna Vainshtein, Victoria Rodriguez, Emily Ricco, James T Okoh, Yanhong Liu, Daniel C Kraushaar, Elior Peles, Matthew N Rasband

Faculty, Staff and Students Publications

The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG (AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expressed at comparable levels in oligodendrocytes and facilitates the efficient assembly of paranodal junctions. However, the physiological roles of glial AnkG in the mature nervous system, and its contributions to BD-like phenotypes, remain unexplored. Here, we show that oligodendroglia-specific AnkG conditional knockout results in destabilization of axoglial interactions in aged but not young adult mice. In …


Fentanyl, Narco-Terrorism, And National Security Politics, J. Richard Broughton Dec 2024

Fentanyl, Narco-Terrorism, And National Security Politics, J. Richard Broughton

San Diego Law Review

This Article examines the use of a counterterrorism model to attack the fentanyl crisis. Rather than advocate for or against such a model, this Article envisions what employing a counterterrorism model against international drug traffickers would look like. Noting the dimensions of national security politics that intersect with counter-fentanyl policy, this Article will evaluate three distinct counterterrorism approaches: (1) using criminal counterterrorism statutes in federal indictments and prosecutions; (2) designating drug trafficking organizations as Foreign Terrorist Organizations (FTOs); and (3) authorizing the use of military force against Mexican cartels. While the current state of bellicose national security politics can inform …


Afghan Allies In Limbo: Discrimination In The U.S. Immigration Response, Lindsay M. Harris, Yalda Royan Dec 2024

Afghan Allies In Limbo: Discrimination In The U.S. Immigration Response, Lindsay M. Harris, Yalda Royan

San Diego Law Review

After the fall of Kabul in August 2021, the U.S. government airlifted an estimated 120,000 people to safety from Afghanistan. An airlift of this scale was unprecedented, but also woefully inadequate as a solution to the Afghan humanitarian crisis. This Article, a contribution to participatory law scholarship, is written by a U.S. law professor and immigration expert and an Afghan woman evacuated from Afghanistan in 2021 and analyzes the United States’s immigration response to the Afghan humanitarian crisis following the Taliban takeover. While the United States granted humanitarian parole for two years to approximately 76,000 individuals, permitting them to enter …


Operational Solutions To Everyday Problems From Border Advocates At Jewish Family Service Of San Diego, Kate Clark, Reilly Frye Dec 2024

Operational Solutions To Everyday Problems From Border Advocates At Jewish Family Service Of San Diego, Kate Clark, Reilly Frye

San Diego Law Review

Day in and day out, across administrations at all levels of government, a cadre of impassioned change agents, including advocates, service providers, community stakeholders, and grassroots organizations, are called to action to fight. Through exhaustion and fatigue, this group unequivocally continues to center humanity and uplift sustainable solutions.

As a “border attorney,” I have been proximate to this work and space for more than fourteen years, the entirety of which has been at Jewish Family Service of San Diego (JFS), a refugee resettlement organization, pro bono legal service provider, and operator of the San Diego Rapid Response Network Migrant Shelter …


The Uses Of The Border, Salvador G. Sarmiento Dec 2024

The Uses Of The Border, Salvador G. Sarmiento

San Diego Law Review

It is a good and necessary time to discuss “American Law at the Border” to better understand and engage with the politics and laws ostensibly addressing U.S. borders. Let’s hope it is also an exercise in understanding the borders of U.S. law itself—the limits, the periphery, and the jagged edges. A discussion on American law at the border should make clear that what is considered at the margins—starting with migrant labor—is central to U.S. economic, legal, and political life.

The first section of this Article will discuss the political uses of the border, beginning with the most recent example of …


Evaluasi Ekonomi Total Hip Arthroplasty Protokol Enhance Recovery After Surgery Dibandingkan Konvensional Di Rsup Fatmawati Jakarta, Hanna Elisabet Lumbangaol, Mardiati Nadjib Dec 2024

Evaluasi Ekonomi Total Hip Arthroplasty Protokol Enhance Recovery After Surgery Dibandingkan Konvensional Di Rsup Fatmawati Jakarta, Hanna Elisabet Lumbangaol, Mardiati Nadjib

Jurnal Ekonomi Kesehatan Indonesia

Total hip arthroplasty (THA) is a common orthopedic procedure performed to replace damaged hip joints with prostheses. The demand for this procedure is expected to rise in the future. Enhanced Recovery After Surgery (ERAS) has been introduced as an evidence-based, multidisciplinary approach aimed at optimizing postoperative recovery and reducing hospital length of stay. This study aims to evaluate the costs and effectiveness, including hospital stay duration and surgical success rates, of THA using the ERAS protocol compared to conventional approaches. This cross-sectional study involved data collection from healthcare providers between January 2020 and May 2023. The analysis showed that both …


Quantitative Analysis Of Machine Learning Model Performance And The Need To Consider Explainability, Vishnu S. Pendyala Dec 2024

Quantitative Analysis Of Machine Learning Model Performance And The Need To Consider Explainability, Vishnu S. Pendyala

Open Educational Resources

This presentation, titled "Quantitative analysis of Machine Learning model performance and the need to consider explainability," delves into various metrics used for evaluating machine learning models. It thoroughly examines fundamental classification metrics like accuracy, precision, recall, and F-score, while also discussing more advanced measures such as the Kappa Statistic and Matthews Correlation Coefficient (MCC), particularly highlighting their relevance in scenarios with imbalanced datasets. The presentation underscores the importance of model accuracy in real-world applications and briefly introduces regression metrics like R-squared and F-statistic. Additionally, it addresses challenges related to data imbalance and fairness in ML models, stressing the critical need …


Alcohol-Induced Gut Microbial Reorganization And Associated Overproduction Of Phenylacetylglutamine Promotes Cardiovascular Disease, Zhen Li, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S. Li, Zhihong Yang, Jing Ma, Themis Thoudam, Kristina Chandler, Maggie Hesler, Laura Heathers, Kiersten Gorse, Thanh Trung Van, David Wong, Aaron M. Gibson, Zeneng Wang, Christopher M. Taylor, Pearl Quijada, Catherine A. Makarewich, Stanley L. Hazen, Suthat Liangpunsakul, J Mark Brown, David J. Lefer, David A. Welsh, Thomas E. Sharp Dec 2024

Alcohol-Induced Gut Microbial Reorganization And Associated Overproduction Of Phenylacetylglutamine Promotes Cardiovascular Disease, Zhen Li, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, Marko Mrdjen, Xinmin S. Li, Zhihong Yang, Jing Ma, Themis Thoudam, Kristina Chandler, Maggie Hesler, Laura Heathers, Kiersten Gorse, Thanh Trung Van, David Wong, Aaron M. Gibson, Zeneng Wang, Christopher M. Taylor, Pearl Quijada, Catherine A. Makarewich, Stanley L. Hazen, Suthat Liangpunsakul, J Mark Brown, David J. Lefer, David A. Welsh, Thomas E. Sharp

School of Medicine Faculty Publications

The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology. Fecal microbiota transplantation from pair-/alcohol-fed mice into naïve male mice demonstrates the transmissibility of PAGln production and the CVD phenotype. Independent of alcohol exposure, pharmacological-mediated increases in PAGln elicits direct cardiac and vascular dysfunction. PAGln induced hypercontractility and altered calcium cycling in isolated cardiomyocytes …


Patient And Parent Knowledge, Understanding, And Concerns After A New Diagnosis Of Ehlers Danlos Syndrome., Jordan T. Jones, Lora L. Black, William R. Black Dec 2024

Patient And Parent Knowledge, Understanding, And Concerns After A New Diagnosis Of Ehlers Danlos Syndrome., Jordan T. Jones, Lora L. Black, William R. Black

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: After diagnosis of Ehlers Danlos Syndrome (EDS), it is unclear what information patients and parents need and understand about EDS. The objective of this study is to characterize patient and parent knowledge and concerns about EDS after a diagnosis of EDS is made to determine patient and parent concerns and identify barriers that cause discomfort with the diagnosis.6 METHODS: A convenience sample of patient and parent dyads were recruited after new diagnosis of EDS. Patients and parents completed questionnaires that assessed knowledge, comfort, and barriers of EDS before and after diagnosis, EDS education materials accessed, and additional clinical needs …


Dampak Faktor Ekonomi Dan Non Ekonomi Terhadap Jumlah Anak Di Indonesia: Analisis Data Demographic Health Survey 2017, Maysarah Qonita Munthe, Nasywa Nayifa Salsabila, Achmad Kautsar Dec 2024

Dampak Faktor Ekonomi Dan Non Ekonomi Terhadap Jumlah Anak Di Indonesia: Analisis Data Demographic Health Survey 2017, Maysarah Qonita Munthe, Nasywa Nayifa Salsabila, Achmad Kautsar

Jurnal Ekonomi Kesehatan Indonesia

Indonesia has a large population, with a declining annual growth trend. Economic and non-economic factors contribute to the desired number of children. This study uses the latest data from the 2017 Demographic and Health Survey (DHS) to analyze the relationship between these factors and the desired number of children. A logit model is employed to evaluate the probability of having more than two children.The findings indicate that higher economic status is associated with a lower likelihood of having more than two children. Women in the middle economic group are 7.1% less likely to have more than two children compared to …


Faktor Yang Memengaruhi Kinerja Verifikasi Dokter Verifikator Internal Medis Dalam Proses Klaim Pasien Jaminan Kesehatan Nasional Di Rumah Sakit Cipto Mangunkusumo, Immanuel Natanael Tarigan, Puput Oktamianti, Ede Surya Darmawan Dec 2024

Faktor Yang Memengaruhi Kinerja Verifikasi Dokter Verifikator Internal Medis Dalam Proses Klaim Pasien Jaminan Kesehatan Nasional Di Rumah Sakit Cipto Mangunkusumo, Immanuel Natanael Tarigan, Puput Oktamianti, Ede Surya Darmawan

Jurnal Ekonomi Kesehatan Indonesia

Since the implementation of the National Health Insurance, hospitals must be able to manage JKN claims properly. One way to properly manage the situation is by employing a medical internal verification doctor. This study aims to determine the factors that influence the performance of medical internal verification doctor based on the percentage of claim eligibility that has been verified. The research was conducted using a case study method with a qualitative and quantitative approach. The study was conducted on 16 medical internal verification doctors using questionnaires and in-depth interviews. The results of the study found that the performance of medical …


Analisis Klaim Pending, Verifikasi Dan Audit Pascaklaim Jaminan Kesehatan Nasional, Anugrah Aulia Ulil Amri, Atik Nurwahyuni Dec 2024

Analisis Klaim Pending, Verifikasi Dan Audit Pascaklaim Jaminan Kesehatan Nasional, Anugrah Aulia Ulil Amri, Atik Nurwahyuni

Jurnal Ekonomi Kesehatan Indonesia

The implementation of Indonesia’s National Health Insurance (JKN) poses new challenges for hospitals as service providers. Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan, the program’s administrator, now routinely conducts post-claim verifications and audits after claims have been paid. This often results in claim adjustments or even full reversals of previously reimbursed amounts. This case study examines JKN claim management at a Type D General Hospital in 2022, focusing on pending claims, verification, and post-claim audits, using a systems theory framework. Key issues in pending claims include incomplete medical records (29%), insufficient supporting documents (24%), and coding errors (21%). Post-claim problems primarily …


Faktor Pemicu Dan Penghambat Fraud Dalam Program Jaminan Kesehatan Nasional Dan Strategi Pencegahannya: Sebuah Scoping Review, Julius Sam Tito, Kemal Nazaruddin Siregar Dec 2024

Faktor Pemicu Dan Penghambat Fraud Dalam Program Jaminan Kesehatan Nasional Dan Strategi Pencegahannya: Sebuah Scoping Review, Julius Sam Tito, Kemal Nazaruddin Siregar

Jurnal Ekonomi Kesehatan Indonesia

Fraud in the National Health Insurance program (JKN) has become one of the challenges faced by the government because it can harm the state finances and negatively impact the decline in the quality of health services. This research aims to identify triggering factors, inhibiting factors, and also strategies in preventing fraud in the JKN program. The study was conducted using the scoping review method according to the Arksey & O'Malley guidelines by searching 5 electronic databases and finding 2,622 articles. The literature search results were performed according to PRISMA-Scr, and 20 articles were analyzed in this study. The study results …


Efisiensi Biaya Dalam Perawatan Stroke Non-Hemoragik: Studi Kasus Di Rumah Sakit Islam Sunan Kudus, Chusnul Mubarok, Chriswardani Suryawati, Puji Harto Dec 2024

Efisiensi Biaya Dalam Perawatan Stroke Non-Hemoragik: Studi Kasus Di Rumah Sakit Islam Sunan Kudus, Chusnul Mubarok, Chriswardani Suryawati, Puji Harto

Jurnal Ekonomi Kesehatan Indonesia

Stroke is one of the leading causes of morbidity and mortality globally, with over 12 million new cases each year. In Indonesia, the prevalence of stroke increased from 8.3% in 2007 to 12.1% in 2013, with the age group of 55-64 years recording the highest prevalence. This study aims to analyse the actual costs of non-hemorrhagic stroke care for patients under the National Health Insurance (JKN) at the Islamic Hospital of Sunan Kudus using the Activity-Based Costing (ABC) method. A descriptive quantitative method was applied, collecting data from hospitalised non-hemorrhagic stroke patients during 2023. The results showed a discrepancy between …