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Microplastic Degradation Compared Among Dated Salton Sea Strandlines, Maria Alejandra Roman Medrano

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis investigates the environmental degradation of plastic materials, with a focus on polyethylene terephthalate (PET), through a multi-phase study conducted at the Salton Sea, a closed-basin lake in a semi-arid region of California. The research addresses three core objectives: (1) developing a microplastic (MP) extraction method tailored for clay-rich sediments, (2) characterizing surface degradation of various plastic types, including PET, BoPET, HDPE, LDPE, and EPS, using advanced microscopy and spectroscopy, and (3) examining the long-term weathering of PET through samples collected from dated lake strandlines.

The extraction protocol successfully isolates MPs without oxidation, using ZnCl₂ and extended soaking to …

Characterizing Tropical Forest Structure Using Semivariance And Crown Delineation, Brittani Joy Evon Chapman

Master's Theses and Capstones

The study of terrestrial carbon stocks is essential to understand global carbon cycles and the magnitude of anthropogenic carbon emissions. Forests are significant terrestrial carbon stores, with the above ground biomass of the Brazilian rainforest alone conservatively estimated to contain ten percent of the terrestrial carbon stock (Asner et al., 2001; Drake et al., 2002; Keller et al., 2004; Lloyd et al., 2007; Truehaft et al., 2014; Cushman et al., 2021). The Amazon Basin primarily consists of closed-canopy tropical forest, covering 5.8 x 106 km2 interspersed with substantial portions of cerrado surrounding the Amazon River and its tributaries in the …

Synthesis And Testing Of Peptide Iron Probes In Cell Studies, Fran Gomez

Master's Theses and Capstones

The study of iron within cells has advanced significantly since the Fenton reaction was proposed as a mechanism for ferroptosis. Various chemical probes have been developed for examining iron and reactive oxygen species (ROS), both of which are involved in the Fenton reaction. Iron, the most abundant transition metal in the human body, primarily exists as Fe(II) and Fe(III) in the cellular environment. The labile iron pool (LIP) is suspected to predominantly exist as Fe(II) due to endogenous reductants. Under ferroptotic conditions, Fe(III) produced in the Fenton reaction can be reduced back to Fe(II), even when chelated, re-inducing hydroxyl radical …

Identification Of Lncrnas Involved In The Host Response To Venezuelan Equine Encephalitis Virus Infection, Mahgol Behnia

Biomedical Sciences ETDs

Venezuelan equine encephalitis virus (VEEV) is an enveloped positive-sense RNA virus in the alphavirus genus of the Togaviridea family, that causes encephalitis in humans and equids. Currently no FDA-approved vaccine or treatment is available for human use, emphasizing the importance of studying host-VEEV interaction. lncRNAs are regulatory RNAs involved in modulation of antiviral pathways during viral infections. Here we report differential lncRNAs expression in primary mouse astrocytes and neurons during non-pathogenic (TC-83) but not pathogenic (TrD) VEEV infection. We further demonstrated that suppression of four lncRNAs increased TC-83 replication, with lncRNA small nucleolar RNA host gene 15 (Snhg15) increasing TC-83 …

Timigp: A Computational Framework To Determine The Tumor Immune Microenvironment Associated With Prognosis And Immunotherapy Response, Chenyang Li

Dissertations and Theses (Open Access)

Accumulating evidence has suggested that the tumor immune microenvironment (TIME) drastically impacts cancer patients’ clinical outcomes, including prognosis and immunotherapy response. However, understanding TIME remains challenging due to its complexity and heterogeneity. In this dissertation, we introduce TimiGP (Tumor Immune Microenvironment Illustration based on Gene Pairs), a computational framework designed to address this challenge. Leveraging single-cell RNA-seq (scRNA-seq) and bulk gene expression data alongside clinical information, TimiGP constructs a cell-cell interaction network that elucidates the relationship between immune cell function and relevant clinical outcomes, such as prognosis and treatment response. With immunological insights, these cell-cell interactions also facilitate the development …

The Role Of Wt1 In Müllerian Duct Development, Jace Aloway

Dissertations and Theses (Open Access)

WT1 is a zinc finger transcription factor widely expressed in the urogenital system. Human mutations of WT1 lead to pediatric nephroblastoma as well as frequent differences of sex development (DSDs). Previous studies have suggested that WT1 acts as an activator for Amhr2, a necessary component of typical male differentiation. We used the mouse as a model to investigate the role of WT1 in sex development, where we deleted Wt1 in the Müllerian duct (MD) mesenchyme using a novel conditional null reporter allele, Wt1 flox-RFP. This allele utilizes the Cre-lox system to delete exons 8 and 9 of Wt1 …

Pharmacological Inhibition Of Lsd1/Kdm1a In Diffuse Midline Glioma Models And Impact On Kinase Signaling, Faith Angelina Hernandez, Faith Angelina Hernandez

Dissertations and Theses (Open Access)

Diffuse Midline Gliomas (DMG) occur in the midline structures of the brain such as the brainstem. DMG, a subset of pediatric high-grade gliomas (pHGGs), confers poor prognosis in children with survival rates below two years post-diagnosis. This is heavily due to limited treatment options as radiation and chemotherapy are only temporarily effective and surgery pose high risks. DMG are characterized by histone mutations typically occurring in histone 3.1 and 3.3 alleles, with about more than 80% of patients containing the H3K27 mutation. Recent publications, highlight epigenetic modulators as promising cancer-specific targets emphasizing their potential as a novel therapeutic strategy. Epigenetic …

Characterizing And Targeting The Genomic Consequences Of Atrx Deficiency In Glioma, Sharvari Dharmaiah

Dissertations and Theses (Open Access)

Mutational inactivation of histone chaperone ATRX (a-thalassaemia/mental retardation X-linked) represents a defining molecular feature in several cancers, including malignant glioma. As standard of care only leads to transient responses and poor outcomes, there is an unmet clinical need for developing new therapies that target ATRX-deficient glioma. Loss of ATRX gives rise to abnormal G-quadruplex DNA secondary structures at GC-rich sites of the genome, such as telomeric and pericentromeric regions, enhancing replication stress and genomic instability. These mutations are mutually exclusive with TERT promoter mutations, promoting the alternative lengthening of telomeres (ALT) pathway as a telomere maintenance mechanism in ATRX-deficient glioma. …

When Is It Convenient For Indigenous Women To Influence State Policies?, Alaide Vences Estudillo, Norma Don Juan Pérez, Patricia Torres Sandoval, Fabiola Del Jurado Mendoza

Peace and Conflict Studies

This paper examines the difficulties that a network of Indigenous women in Mexico deal with when they seek peace for their people under a hybrid political structure. This paper discusses some distinctive aspects of the politics that these women engage in, how they conceive their political ideas, and how they use these ideas to structurally transform the colonial relationship that the liberal state maintains toward their people. They devise various strategies to influence state policies and to withstand the discrimination they face whenever they participate in democratic affairs.

Mothering, Leadership, And Career: A Narrative Analysis, Joanne Susan Roehm

Dissertations

In March 2020, much of the world was “sent home” from work and periods of lockdown began. In West Michigan, Friday, March 13 was the day that most workplaces closed their doors and employees began working from home for what was assumed to be a period of weeks. In the spring of 2020 between March and April, some million mothers living with school-age children left active work—either shifting into paid or unpaid leave, losing their job, or exiting the labor market all together.

The stories of mothers who experienced the “balancing act” of mothering and working at home during the …

Volume 108, Number 2 (2024)

Judicature

No abstract provided.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

Examination Of Urban Spatial Structure After Covid Based On Hedonic Price Model, Shaoting Wen

Honors Theses

The traditional monocentric and polycentric city model assumes that people commute to the urban centers/subcenters (UCS) for work and, thus the houses close to the centers have convenience premium in commuting cost which drives up their prices. However, with more and more people switching to hybrid /remote working, average commute cost decreases, leading to the location of UCS and commute time influence less on housing price. This paper revisited the hedonic price model under the polycentric city context with the introduction of kernel density estimation (KDE). By choosing three of the top ten high-remote potentials and three of the top …

The Bridge Newsletter Winter 2024, Missouri University Of Science And Technology

The Bridge Newsletter

• TED x Missouri S&T: Unveiling Resilience
• ElGawady named interim chair
• Ma named inaugural Kummer Impact Professor
• Sensor patent granted
• Burken awarded ASCE President’s Medal

Editorial Board

Nursing & Health Sciences Research Journal

No abstract provided.

Pregnancy Outcomes After Covid-19 Infection, Angela M. Blanco Guertin, Arvinder Singh, Arianna Tapia, Emily Dickinson

Nursing & Health Sciences Research Journal

Background: Since the onset of the Coronavirus 19 (COVID-19) pandemic in 2020, the medical community has raced to keep up with the continued healthcare sequelae of the virus. During this time, pregnant women and newborns have been of particular concern. A higher incidence of pregnancy-related complications was seen among women during the pandemic. This study aimed to assess the relationship between COVID-19 and pregnancy complications among women. Methods: This retrospective study analyzed records of pregnant women with active COVID-19 or a history of COVID-19 during pregnancy, admitted to a South Florida hospital between March 2020 and December 2021. Patients’ charts …

Field Assessment Of Fertilization, Nursery, And Crop Management Practices Among Tomato (Solanum Lycopersicum L.) Growers In The Ilocos Provinces, Philippines, Annalissa Aquino, Sancho Bon, Angelica Guanlao, Ann Mylalulex Magnaye, Filomena Sta Cruz, Pompe C. Sta. Cruz

The Philippine Agricultural Scientist

Growth and yield of many economically important vegetables like tomatoes are heavily influenced by crop management practices, particularly fertilizer application, irrigation scheme, and pest management. To attain maximum tomato yields and increase farmers’ profits, these crop production components must be optimized in local farm levels. Before optimization measures can be conducted, baseline information on prevailing practices needs to be evaluated. To assess the nutrient management and other crop production practices of tomato farmers in the Ilocos provinces, Philippines, on-farm surveys were conducted in 16 and 18 barangays planting fresh-type and processing-type tomatoes, respectively. The study involved a total of 88 …

Hildegard Of Bingen’S Embryology: Enabling Women’S Reproductive Power Without Seed, Minji Lee

Department of Religion Faculty Scholarship and Creative Works

This paper examines Hildegard of Bingen’s embryological theory within the intricate landscape of medieval medicine and religion. It situates Hildegard’s understanding of conception within ongoing historical debates surrounding the roles of male and female reproductive substances, particularly the concept of seed or semen. By analyzing her conceptual framework against prevailing classical and medieval reproductive theories, the research illuminates Hildegard’s distinctive contribution to understanding conception as a holistic bodily process. Classical embryological discourse predominantly oscillated between Aristotle’s one-seed theory—which positioned men as sole generative agents—and Galen’s two-seed theory, which marginally acknowledged female reproductive participation. While technically aligning with Aristotelian principles by …

Systematic Review And Meta-Analysis Of Physical Activity Interventions To Increase Elementary Children’S Motor Competence: A Comprehensive School Physical Activity Program Perspective, Jongho Moon, Collin A. Webster, David F. Stodden, Ali Brian, Kelly Lynn Mulvey

Department of Kinesiology Scholarship and Creative Works

Background: Regular participation in physical activity (PA) benefits children’s health and well-being and protects against the development of unhealthy body weight. A key factor in children’s PA participation is their motor competence (MC). The comprehensive school physical activity program (CSPAP) framework offers a way to classify existing PA interventions that have included children’s MC development and understand the potential avenues for supporting children’s MC. However, there have been no systematic reviews or meta-analyses of PA interventions and their effects on the MC of elementary school children (aged 5–12 years) from a CSPAP perspective. Methods: This study was conducted in accordance …

Impact Of Human Immunoglobulin Genetic Variants On The Expressed Antibody Repertoire., Eric Engelbrecht

Electronic Theses and Dissertations

B cells produce immunoglobulins (IGs; antibodies), which are critical protein components of the immune system. Human IGs are composed of two pairs of identical ‘heavy’ chains and ‘light’ kappa or lambda chains, encoded by genes located at three loci in the genome: the IG heavy chain locus (IGH, chromosome 14), and the IG lambda (IGL, chromosome 22) and kappa (IGK, chromosome 2) loci. Each locus spans ~920-100 kilobase pairs (Kbp) of DNA and harbors families of gene segments that are somatically rearranged during B cell development. The IG loci collectively harbor >180 functional genes, many of which are part of …

Toward An Urban Food Commons: Participatory Action Research On Food Apartheid And Community-Based Agrifood System Governance In Louisville, Ky., Mary Abigail Rudolph

Electronic Theses and Dissertations

This dissertation investigates the structural inequities fueling food apartheid in Louisville, Kentucky’s agrifood system and explores community-based governance as a path toward food justice. Through a participatory action research (PAR) framework, this study combines participatory geographic information systems (PGIS), focus groups, and autoethnography to engage directly with affected community members and collaborate with the Food in Neighborhoods (FIN) coalition. By prioritizing the voices of those most impacted by food insecurity, this research offers contributions to the fields of food justice, participatory governance, and urban food commons. The study situates Louisville’s food access issues within the broader neoliberal global agrifood system, …

Examining Anxiety And Coping Strategies With Persons With Parkinson's Disease (Pwpd) Who Routinely Exercise, Ashlynn Milburn, Angela Labrie Blackwell, Karen Aranha, Maggie Abbott

Fall 2024 OTD Capstone Symposium

Forty to 50% of the PwPD are reported to experience anxiety (Kwok et al., 2019). Anxiety is psychological distress characterized by excessive worry, and apprehension about future events (Khatri et al., 2020). Psychological distress with this population is secondary to care dependency, poor work and social function, increased physical and cognitive decline, increased dementia risk, and high mortality rate (Kwok et al., 2019).Exercise and meditation have been found to be useful coping strategies to manage one’s physical condition as well as psychosocial factors such as anxiety, with PD (Mantri et al., 2021).Although these coping strategies have the potential to reduce …

Benefits Of Occupational Therapy In Concussion Treatment For Professional Athletes, Alexandria Brown, Zeida Gutierrez Ph.D., Mhs, Otr/L, James Wersal Otd, Msot, Otr/L, Cbis, Drs, Dcs

Fall 2024 OTD Capstone Symposium

Concussions are a significant concern in sports, with an estimated 1.6 to 3.8 million cases in the U.S. annually, many of which go unreported. These traumatic brain injuries result from various impacts, causing symptoms like headaches, dizziness, and memory loss, which can disrupt an athlete's daily life. Recovery typically follows a staged protocol, with professional organizations implementing concussion management guidelines. Despite these measures, athletes often hesitate to report symptoms due to concerns about playing time or team expectations. There is a gap in treatment for concussions as activities of daily living and occupations are not addressed. Occupational therapy can help …

Preventing Depression In Grandparents Raising Grandchildren: An Educational Video Series, Sabrina Casares, Steven Gerardi, Meghan Skidmore

Fall 2024 OTD Capstone Symposium

Grandparent caregivers often face increased risk for depression, yet access to mental health resources—particularly self-help approaches—is limited. Texas Grandparents Raising Grandchildren (TXGRG), a non-profit organization supporting grandparent caregivers, lacked a specific mental health resource to address this need. This capstone project developed and implemented a self-help, occupation-based educational video series to provide practical strategies for preventing and managing depression. Designed for accessibility and ease of use, the video series offers tools grounded in daily occupations to promote mental well-being. This project fills a critical gap by equipping TXGRG and its caregivers with a proactive, occupation-focused mental health resource to support …

Life Review And Reminiscence In Occupational Therapy Practice: An Educational Video Series, Andrea Garza, Steven M. Gerardi Phd, Otd, Mss, Otr

Fall 2024 OTD Capstone Symposium

Dementia is a progressive neurological disorder that impacts millions of people, leading to cognitive decline and functional impairment. Life review therapy and reminiscence therapy are effective treatment approaches that have been used with people with dementia to stimulate cognitive processes and provide emotional support by reflecting on past experiences. Although therapeutic occupations based on reminiscence and life review have been used in occupational therapy (OT) practice, there is limited literature on the topic to guide clinical practice. Problem: There is a lack of guidance on the integration of occupation-based life review and reminiscence into OT practice for people with dementia. …

Cuisine As A Compass: Exploring The Therapeutic Benefits Of Community, Cooking, And More Within The Lgbtqia+ Population, Sera Shevchenko, Karen Park Otd, Otr/L, Bcp, Susan Macdermott Otd, Otr/L

Fall 2024 OTD Capstone Symposium

Background: The LGBTQIA+ population experiences unique barriers to occupation and well being. Anti-LGBTQ legislation encroaches on inclusive and affirming care affecting occupational access. Limited occupational participation and additional exhaustive adaptive strategies to engage in occupations safely have an emotional cost. This research study explores how food or mealtime occupations such as cooking, eating, and hosting can support LGBTQIA+ well-being. This research was made possible by LGBTQIA+ participants that are experts of their lived experience.

Methods: This mixed methods research used both qualitative and quantitative methods to gather data on the significance of food-based occupations, culture, mental health, and identity in …

Increasing Teacher-Ot Collaboration In A School-Based Setting, Shayla Ransome, L. Brook Sawyer, Angela Labrie Blackwell

Fall 2024 OTD Capstone Symposium

Pre-service PreK-4 teachers receive little to no education about SBOT practice, which hinders not only collaboration opportunities but also potentially impacts student performance and participation outcomes negatively. This capstone seeks to develop an interprofessional educational unit to increase collaboration between pre-service PreK-4 teachers and pre-OT practitioners, which will promote positive student performance and participation outcomes.

Neurodivergent Adults: Cultivating Intimate Partner Relationships Through Diverse Dating Platforms To Improve Well-Being And Life Satisfaction, Victoria R. Wolf, Mary Jan Greer

Fall 2024 OTD Capstone Symposium

This capstone project focuses on program development to increase the social participation of neurodivergent adults in establishing intimate partner relationships (AOTA, 2020). Creating an opportunity for neurodivergent individuals to meet each other with the intent of forming intimate partner relationships can increase their social participation and overall life satisfaction (Mitran, 2022). According to AOTA (2020), intimate partner relationships are essential to many individuals' lives. Altering the modern-day approach and building online and in-person platforms that support the individuality of the neurodivergent population will enable them to form connections without prejudice or judgment (Mitran, 2022).

Adapting Classroom Activities To Increase Social Engagement, Ivie Hacker, Mary Jan Greer Ph.D., Otr

Fall 2024 OTD Capstone Symposium

This capstone program focuses on enhancing the development of children with disabilities through adaptive play strategies. It aims to create a supportive, engaging environment that accommodates the unique needs of children on the autism spectrum. By incorporating individualized play techniques, the program promotes social, emotional, and cognitive skills, fostering greater communication, creativity, and physical coordination. The project explores the role of adaptive play in improving social interactions, reducing sensory sensitivities, and building self-confidence, ultimately contributing to the overall well-being and development of children with autism.

Sex Education Program For Individuals With Disabilities, Kalynne Coates, Keisa Boykin

Fall 2024 OTD Capstone Symposium

The purpose of this project is to develop and implement a program to discuss the ADL of sex education with individuals with intellectual and developmental disabilities (IDD).