Digital Commons Network^™

Cultivation Protocols For The Red Seaweeds, Devaleraea Mollis And Palmaria Hecatensis From Alaska, Muriel Dittrich

Marine Biology

Species diversification is crucial for the long-term viability, competitiveness, and sustainability of the seaweed farming industry in the United States. This study investigated the effects of temperature (4, 8 and 12 °C), photoperiod (8L:16D, 12L:12D and 16L:8D), and irradiance (20, 40, 100 ± 10 μmol photons m-2 s-1) on the specific growth rate (SGR) of Devaleraea mollis and Palmaria hecatensis from Alaska. Outputs were used to adjust indoor cultivation protocols for D. mollis and develop the first protocols for Palmaria hecatensis. This study also explored the use of two relatively low-cost commercial nutrient products (F/2 and Jack's Special 25-5-15) as …

Spatial And Temporal Variability Of Carbohydrate Compositions In Cultivated Alaria Marginata, Nereocystis Luekteana, And Saccharina Latissima, Cameron Jardell

Marine Biology

Carbohydrates derived from Laminariales (kelp), including polysaccharides and sugar alcohols, present significant market opportunities for nascent mariculture industries. These carbohydrates can enhance crop biomass value through extractive processing, with applications in medicine, manufacturing, health supplements, and bio-plastics. The relative abundance and composition of carbohydrates in kelp can vary depending on species, life history, tissue type, season, and environmental conditions. In Alaska, mariculture of kelp focuses on three species: Alaria marginata, Nereocystis luetkeana, and Saccharina latissima. This study assessed the relative abundance of carbohydrates (glucan, mannitol, alginate, and fucoidan) in these species, as well as the sulfate content of fucoidan and …

Berkeley Pit Geochemical And Limnological Evaluation Pre-Design Investigation (Pdi) Work Plan, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Exploring The Population Structure And Genetic Diversity In Apple Germplasm Using Ipbs-Retrotransposon Markers, Aigul Madenova, Angsagan Kuan, Amjad Ali, Muhammad Azhar Nadeem, Muhammad Tanveer Altaf, Balnur Kabylbekova, Dinara Kaldybaeva, Ti̇mur Turdi̇yev, Faheem Shahzad Baloch

Turkish Journal of Botany

The apple (Malus domestica [Suckow] Borkh) is economically and culturally significant worldwide, thriving in temperate regions. This study examined genetic variations among 52 apple accessions from three research centers in Kazakhstan using the iPBS-retrotransposons marker system. Out of 35 screened markers, 12 highly polymorphic markers were selected for PCR amplification, resulting in 280 bands, 279 of which were polymorphic, yielding a 99.64% polymorphism rate. Genetic diversity indices showed substantial variation: effective number of alleles (ne=1.655), Shannon's information index (I=0.373), gene diversity (h=0.549), and an average genetic distance of 1.2. The analysis of molecular variance (AMOVA) indicated that 98.80% of the …

Programs Agenda 12-17-24, Angela Brock

Programs Committee (PC)

No abstract provided.

Icc Agenda 12-17-24, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Access Matters, Eric F. Spina

President's Blog: From the Heart

Imagine being the first in the history of your family to go to college. It can be daunting to thinkabout navigating the complex journey to and through college, let alone believing it’sfinancially feasible, particularly if you’re from a low-income family.

Seasonal Pollen Increases Traffic Fatalities In The United States, Monica Deza

Population Health Research Brief Series

Traffic fatalities are the among the leading causes of death in the United States. Motor vehicle crash death rates have declined overall in the U.S. in recent decades, but there is substantial variation in rates across the country. Due to climate change, exposure to pollen has increased in various parts of the U.S. The antihistamine response triggered by pollen can result in poor physical and cognitive symptoms, thus impacting an individual’s ability to drive and increasing the risk of motor vehicle fatalities. This brief summarizes findings from a study that used data from the National Allergy Bureau (NAB) Pollen and …

Mental Health Care Disparities Among Us Pregnant Individuals In 2020–2021: A Cross-Sectional Study, Julisa Tindall, Monique J. Brown Ph.D., Mph, Peiyin Hung

Faculty Publications

Purpose

To examine maternal characteristics associated with perceived unmet mental health needs and mental health care settings, focusing on residential rurality and race/ethnicity.

Methods

This cross-sectional study analyzed self-reported unmet mental health needs and mental health care settings among 1097 pregnant respondents in the 2020–2021 National Survey on Drug Use and Health, incorporating the complex sampling weights for national representativeness.

Findings

Non-Hispanic Black pregnant individuals and those living in nonmetro rural areas reported lower odds of unmet mental health needs compared to those in large metro areas and non-Hispanic White individuals. Pregnant individuals in nonmetro rural areas and non-Hispanic other …

Factors Influencing The Oral Health Behaviours Of Autistic Children And Young People: A Qualitative Study, Jo Erwin, Sarah Neill, Tara Vassallo, Isaac Vassallo, Rob Witton, Martha Paisi

Peninsula Dental School

Background: Poor oral health (OH) in childhood can cause pain, affect quality of life and significantly impact adult OH. Autistic children and young people (CYP) experience inequalities in OH and are at higher risk of cavities and gum disease than neurotypical CYP. Objective: To provide evidence and insights into the factors affecting the OH behaviours of ACYP from the perspective of ACYP, their parents/carers and Dental Health Professionals (DHPs). Method: Semi-structured online or face-to-face interviews were conducted with CYP, parents/carers and DHPs in Southwest England. Results: Nineteen ACYP (aged 5–18 years old), 20 parents/carers and 16 DHPs were interviewed. The …

Examining State Statutory Selection Methods, Term Limits, And Required Qualifications For Appellate Judges As A Model For Reform, Angelo Brown, Wesley Mccann, Ruibin Lu, Brenda I. Rowe, Craig Hemmens

Journal of Criminal Justice and Law

Several reform proposals have been pushed forward for the federal judiciary- namely the United States Supreme Court- in recent years, including term limits, changes in judicial selection, and qualification criteria. Such changes could ostensibly apply to all federal appellate judges as well. The purpose of this study is to determine if states can provide a roadmap for Supreme Court reform discussions. This study utilizes a state-level legal content analysis of all statutes pertaining to judicial selection and qualification criteria for appellate-level judges. Specifically, selection mechanisms, age limits, term limits, and qualifications for selection are examined. Whether state statutory schemes can …

An Exploratory Study Of Academic Self-Efficacy In High School Education Completion Among A Group Of Former Juvenile Offenders, Deneil D. Christian, Joshua L. Adams

Journal of Criminal Justice and Law

A primary goal of the United States (U.S.) juvenile criminal justice system is to foster an environment where a juvenile offender can complete a high school education or equivalent. Extant literature has explored persistence in obtaining a high school credential. However, little is known about the role of self-efficacy in such attainment, and research is further scant that involves the geographic region of Pennsylvania, U.S. This study aimed to explore how former juvenile offenders perceived their academic self-efficacy while pursuing their education in a juvenile correctional facility in Pennsylvania. This study was guided by the following research question: How do …

Emergency Vehicle Dispatching Model Considering Demand Urgency And Delivery Fairness, Long Kejun, Liu Jia, Gao Zhibo, Chen Suqian, Zhang Zhonggen

Journal of China & Foreign Highway

In emergency vehicle dispatching after unexpected events，it is crucial to prioritize critical nodes with high demand urgency while minimizing excessive delivery delays at other nodes to prevent secondary impacts.On this basis，this study developed an emergency vehicle dispatching model that considered demand urgency and delivery delay fairness.Firstly，the entropy weight-TOPSIS method was used to calculate the demand urgency for each node，and a delivery delay balance index was introduced to minimize disparities in delivery delays between nodes.Secondly，a multi-objective optimization model was established with total delivery time，overall cost，and delivery delay balance as objectives，while considering constraints such as inventory levels at distribution centers and route …

Corporate Social Responsibility Strategies For Retaining Skilled Talent To Enhance Competitive Advantage, Linwood Corneilus Cottner Jr.

Walden Dissertations and Doctoral Studies

Aviation business leaders often lack effective corporate social responsibility (CSR) strategies to retain highly skilled employees, a crucial factor in gaining a competitive advantage. To maintain this advantage, aviation leaders must consistently recognize employee retention as a critical challenge and a key element in sustaining long-term success. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative multiple-case study was to explore the corporate social responsibility strategies aviation business leaders use to retain highly skilled employees to enhance their competitive advantage. The participants were three aviation business leaders from the Midwest United States who successfully implemented corporate social responsibility strategies …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Clover (Clostridium Difficile Vaccine Efficacy Trial) Study: A Phase 3, Randomized Trial Investigating The Efficacy And Safety Of A Detoxified Toxin A/B Vaccine In Adults 50 Years And Older At Increased Risk Of Clostridioides Difficile Infection, Curtis J Donskey, Erik R Dubberke, Et Al.

2020-Current year OA Pubs

BACKGROUND: Clostridioides difficile infection (CDI) causes substantial mortality and healthcare burden. We assessed the detoxified toxin-A/B PF-06425090 vaccine for primary CDI prevention.

METHODS: This phase 3 observer-blinded study randomized (1:1) ≥50-year-olds at increased CDI risk (N = 17 535) to receive 3 PF-06425090 or placebo doses (0, 1, and 6 months). Primary end points were first CDI episode (≥3 unformed stools within 24 hours; central laboratory-confirmed toxin A/B positive) ≥14 days post-dose 3 (PD3; first primary) and post-dose 2 (PD2; second primary). CDI duration, need for CDI-related medical attention (secondary end points), and antibiotic use (post hoc analysis) PD3 were …

Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia

Faculty, Staff and Students Publications

Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans—SPINT3, WFDC6, EPPIN, WFDC8, WFDC9, WFDC10A, WFDC11, WFDC10B, WFDC13, SPINT4, and WFDC3—and the 13 reproductive tract-specific orthologous genes in mice, form highly conserved syntenic gene clusters indicative of conserved, combined critical functions. Further, despite significant progress toward a nonhormonal male contraceptive targeting the protein encoded by one of these genes, epididymal peptidase inhibitor (EPPIN), and associations found between mutations in EPPIN and an increased risk of male infertility, neither EPPIN nor …

Improving Clinical Information Extraction From Electronic Health Records: Leveraging Large Language Models And Evaluating Their Outputs, Kriti Bhattarai

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate extraction of clinical entities and phenotypes from unstructured electronic health record (EHR) text is crucial for various clinical research tasks, including cohort identification, tracking temporal patterns in disease progression and deciding treatment course. However, this task remains challenging due to the complexity and ambiguity of medical language. This dissertation explores the application of advanced generative pre-trained transformer (GPT) models, such as GPT-4, GPT-3.5-turbo, Llama-3.1, Llama-3 and Flan-T5, for clinical entity and phenotype extraction from EHRs. Building upon these findings, this dissertation also investigates a hybrid approach where integration of external knowledge sources, such as Unified Medical Language System (UMLS) …

The Pace Of Biological Aging Partially Explains The Relationship Between Socioeconomic Status And Chronic Low Back Pain Outcomes, Edwin N Aroke, Jai Ganesh Nagidi, Vinodh Srinivasasainagendra, Tammie L Quinn, Fiona B A T Agbor, Kiari R Kinnie, Hemant K Tiwari, Burel R Goodin

2020-Current year OA Pubs

INTRODUCTION: Having a lower socioeconomic status (SES) is a predictor of age-related chronic conditions, including chronic low back pain (cLBP). We aimed to examine whether the pace of biological aging mediates the relationship between SES and cLBP outcomes - pain intensity, pain interference, and physical performance.

METHODS: We used the Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE) software to determine the pace of biological aging in adults ages 18 to 85 years with no cLBP (n = 74), low-impact pain (n = 56), and high-impact pain (n = 77).

RESULTS: The mean chronological age of the participants was …

The C-Terminal Activating Domain Promotes Pannexin 1 Channel Opening, Erik Henze, Jacqueline J Ehrlich, Janice L Robertson, Eric Gelsleichter, Toshimitsu Kawate

2020-Current year OA Pubs

Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore. However, this simple pore-plugging mechanism alone cannot account for the observation that a Panx1 construct ending before the caspase cleavage site remains closed. Here, we show that a helical region located immediately before the caspase cleavage site, referred to as the "C-terminal activating domain (CAD)", plays a pivotal role in facilitating Panx1 activation. Electrophysiology and mutagenesis studies uncovered that two conserved …

Participatory Longitudinal Qualitative Interview Study To Understand Autistic Gynaecological And Obstetric Health: The Autism From Menstruation To Menopause Study Protocol, Amy Brown, Kathryn Williams, Aimee Grant, Gemma L. Williams, Harriet Axbey, Abigail Wilkins, Ellen Firth, Hazel Lim, Helen Cave, Christina Nicolaidis, Multiple Additional Authors

School of Social Work Faculty Publications and Presentations

Autism is a lifelong minority neurotype present from birth. There is a dearth of credible evidence to suggest gender variation in Autism prevalence, despite historical under-diagnosis of women. Autistic people Assigned Female At Birth (AFAB) have worse physical and mental health compared with non-Autistic peers. To date, the reproductive health experiences of Autistic AFAB people have been under-investigated.Methods and analysis This study aims to co-develop a quality improvement intervention to improve the reproductive health of Autistic people. The study uses Community Partnered Participatory Research (an approach similar to Community-Based Participatory Research), largely through a Community Council that co-governs the study. …

Multimodal Assessment Battery And Heart Rate Variability Enhance Clinical Utility Of Buffalo Concussion Treadmill Test, Daniel Miner, Michael Shiraishi, Pamela Gibbons, Rahul Soangra, Brent Harper

Physical Therapy Faculty Articles and Research

Context: The Buffalo Concussion Treadmill Test (BCTT) for exercise intolerance following concussion may highlight underlying autonomic dysfunction. Autonomic function at rest and with exertion may be predictive of neurocognitive performance for individuals with sports-related concussion. The purpose of this study is to explore the feasibility and utility of combining multimodal assessments with heart rate variability (HRV) measures during the BCTT for individuals with a remote history of concussion. Design: Prospective cohort study design, pretest/posttest. Methods: Participants included 5 males and 5 females (N = 10, age: 25.2 [3.3] y old, height: 173.2 [11.2] cm, mass: 73.4 [13.7] …

Guidelines For Returning To Dance Following Concussion: Adaptations From Sport Concussion Literature, Sheyi Ojofeitimi, Lauren Mcintyre, Elizabeth Barchi, Sarah S. Rae, Brittney Winnitoy, Jeffrey A. Russell

Department of Family & Community Medicine Faculty Papers

Sport concussion receives substantial attention as a public health concern. Conversely, performing artists, including dancers, sustain concussions, but these aesthetic athletes do not receive the same level of consideration nor care for this injury as that offered to traditional athletes. The concussion literature pertaining to dance is sparse, and, to our knowledge, no recommendations exist for the crucial aspect of care related to returning to dance following a concussion. The purpose of this article is to assimilate the current knowledge about post-concussion return to activity management in sport—the closest analog of the physical demands required in dance—as a means to …

Staff Education To Improve Depression Management Using Mindfulness Meditation Intervention, Ndubuisi Chimezie Obioha

Walden Dissertations and Doctoral Studies

Executive Summary: Staff Education Project Staff Education to Improve Depression Management Using Mindfulness Meditation Intervention by Ndubuisi Obioha MSN, Walden University, 2021 BSN, Grand Canyon University, 2017 Executive Summary Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University November 2024 Summary The problem of poor depression management guided this quality improvement staff educational project due to treatment nonadherence issues. The providers at the project site had minimal knowledge of self-help interventions that can be used to assist individuals with depression who often face treatment barriers. Failing to address the problem could result …

Strategies Business Owners Use To Comply With Federal State And Local Taxes, Olohigbe O. Abaya

Walden Dissertations and Doctoral Studies

Tax regulations are constantly changing, increasing complexity for business owners to meet federal, state, and local obligations. Non-compliance can lead to severe consequences, including fines, legal action, and damage to a company’s reputation. Grounded in the planned behavior theory, the purpose of this qualitative pragmatic inquiry was to identify and explore practical steps small business owners take to comply with federal, state, and local tax requirements. Participants were seven business leaders in the United States. Data were collected through semistructured interviews, as well as a review of public websites and documents. Through thematic analysis, three themes were identified: professional assistance, …

Attachment-Based Intervention For Inattention, Hyperactivity, And Impulsivity: Does Relationship Matter?, Stephanie M. Ess

Walden Dissertations and Doctoral Studies

While the prevailing notion attributes attention deficit hyperactivity disorder (ADHD) largely to a genetic response, there is increasing evidence of its multifactorial nature, involving both genetic and environmental factors, including the parent–child attachment relationship. Given the limitations of pharmacological and behavioral treatment methods, this study addressed the critical need for alternative ADHD interventions. The purpose of this study was to examine the differences in inattention, hyperactivity, and impulsivity among toddlers approximately 48 months old in an attachment-based intervention group (n = 63), a control intervention group (n = 58), and a low-risk group not requiring intervention (n = 52). Grounded …

Corporate Social Responsibility Strategies For Retaining Skilled Talent To Enhance Competitive Advantage, Linwood Corneilus Cottner Jr.

Walden Dissertations and Doctoral Studies

Aviation business leaders often lack effective corporate social responsibility (CSR) strategies to retain highly skilled employees, a crucial factor in gaining a competitive advantage. To maintain this advantage, aviation leaders must consistently recognize employee retention as a critical challenge and a key element in sustaining long-term success. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative multiple-case study was to explore the corporate social responsibility strategies aviation business leaders use to retain highly skilled employees to enhance their competitive advantage. The participants were three aviation business leaders from the Midwest United States who successfully implemented corporate social responsibility strategies …

Staff Education Project Strategies For Reducing No-Shows, Ekop Graham

Walden Dissertations and Doctoral Studies

The staff education project addressed a gap in managing patient no-shows at a psychiatric clinic, where approximately 25% of scheduled appointments were missed. This issue severely impacted patient care continuity, delayed necessary treatments, and increased healthcare costs. The clinic’s practices of using reminder calls and emails had been insufficient in reducing no-shows. A literature review highlighted several effective interventions in imprvoing patient adherence and reducing missed appointments, such as facilitated appointment scheduling, personalized communication, and patient-centered strategies. The project aimed to enhance the nursing staff’s knowledge in addressing patient no-shows by educating them on causes, including logistical barriers and psychological …

Decoding Ras Mutations In Thyroid Cancer: A Meta-Analysis Unveils Specific Links To Distant Metastasis And Increased Mortality, Isabel Riccio, Alexandra Laforteza, Madeleine B. Landau, Mohammad H. Hussein, Joshua Linhuber, Jonathan Staav, Peter P. Issa, Eman A. Toraih, Emad Kandil

School of Medicine Faculty Publications

Background/objectives: RAS mutations are common in thyroid cancer, but their impact on clinical outcomes remains controversial. This study aimed to evaluate the prevalence of RAS mutations in thyroid cancer and their association with various clinical and pathological features. Methods: We conducted a systematic review and meta-analysis of studies reporting on RAS mutations in thyroid cancer. Both one-arm and pairwise meta-analyses were performed to compare outcomes between RAS-mutated (RAS+) and wild-type (RAS-) thyroid cancers. Results: Our analysis included 2552 thyroid cancer patients from 17 studies. The overall prevalence of RAS mutations was 35.4 % (95 % CI: 22.7 %–50.7 %). NRAS …

Maresin-Like 1 Ameliorates Neuropathology Of Alzheimer's Disease In Brains Of A Transgenic Mouse Model, Pallavi Shrivastava, Yan Lu, Shanchun Su, Yuichi Kobayashi, Yuhai Zhao, Nathan Lien, Abdul-Razak Masoud, Walter J. Lukiw, Song Hong

School of Medicine Faculty Publications

(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer's disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology. This can potentially be achieved by the treatment with specialized pro-resolving lipid mediators (SPMs), which should resolve neuroinflammation in brains. (2) Methods: Here, we report the histological effects of long-term treatment with an SPM, maresin-like 1 (MarL1), on AD pathogenesis in a transgenic 5xFAD mouse model. (3) Results: MarL1 treatment reduced Aβ overload, curbed the loss of neurons in brains especially cholinergic neurons associated with cleaved-caspase-3-associated apoptotic degeneration, reduced microgliosis and the pro-inflammatory M1 …