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Articles 811 - 840 of 1255
Full-Text Articles in Entire DC Network
Occupational Therapy's Role In Preventing Geriatric Learned Dependency Through Caregiver Training, Anna Dediemar
Occupational Therapy's Role In Preventing Geriatric Learned Dependency Through Caregiver Training, Anna Dediemar
MOT Student Capstones
Occupational therapy (OT) plays an important role in the training of geriatric caregivers to reduce learned dependency and caregiver burden, which can ultimately reduce hospital readmissions. Studies have highlighted the importance of caregiver education and training in promoting independence among geriatric patients, but OT's role in this area has yet to be explored. Caregivers play a crucial role in the geriatric patient's functional progress at home, so it is essential to educate and train them thoroughly to prevent dependency which may lead to negative patient outcomes, longer recovery times, increased risk of injury or complications, and higher readmission rates. The …
Exploratory Multiple Regression Analysis Of Predictive Factors On Pediatric Concussion Recovery, Jaimeen Shah
Exploratory Multiple Regression Analysis Of Predictive Factors On Pediatric Concussion Recovery, Jaimeen Shah
Senior Theses
This study ultimately aimed to find how different extra-clinical factors correlate with different aspects of concussion recovery. This study evaluated 8 different independent variables and their correlation to 4 different dependent variables (that are composed of 11 sub-dependent variables). It was hypothesized that these predictive variables will have a statistically significant impact on somatic, psychological, and cognitive outcomes. Additionally, it was hypothesized that the majority of these predictive factors will have the largest statistically significant impact on cognitive outcomes and that time to biological sex, age, prior concussion history, and household income (in that respective order) would have the strongest …
Csbs Kudos, Spring & Summer 2024, University Of Northern Iowa. College Of Social And Behavioral Sciences.
Csbs Kudos, Spring & Summer 2024, University Of Northern Iowa. College Of Social And Behavioral Sciences.
CSBS Kudos
Contents:
--- Faculty Accolades
--- Retirements: Pita Agbese; Cindy Juby
--- In Memoriam: David Whitsett; Christopher R. Edginton
--- A Hub for Civic Education
--- Normalizing Death, One Café Conversation at at Time
--- UNI to House Papers of Senator Chuck Grassley, Offer Endowed Professorship
--- UNI Forms 3+1 Family Services Program with University in Kosovo
--- UNI Professor’s Selfless Act of Organ Donation Saves a Life
--- As a Nurse, She Saved His Life. Now at UNI, They’re Co-workers.
--- Donors Launch Scholarship Initiative for UNI Nursing Students
--- Giving Back to Caregivers
--- Student Highlights
--- Students and …
Taps-Top Active Pre-Screening And Education: A Pre-Kidney Transplant Quality Improvement Initiative, Stacie Myers Bsn, Rn
Taps-Top Active Pre-Screening And Education: A Pre-Kidney Transplant Quality Improvement Initiative, Stacie Myers Bsn, Rn
Doctor of Nursing Practice Projects
Background: Due to the large number of patients waiting for a kidney transplant and the prolonged wait times, once a kidney becomes available some patients may not be medically ready. For this reason, some patients may miss out on a kidney transplant.
Objective: To assess the effects and outcomes of a one-to-one touch point interview and education seminar for pre-kidney transplant patients who are currently waitlisted for a kidney transplant.
Method: This quality improvement project evaluated the effectiveness of one-to-one interviews and an education seminar with a nurse navigator for approximately 60 adult pre-kidney transplant patients on …
Reducing 30-Day Hospital Readmission Rates By Addressing Social Determinants Of Health In The Home Health Care Setting, Kelly-Ann Federle Reilly
Reducing 30-Day Hospital Readmission Rates By Addressing Social Determinants Of Health In The Home Health Care Setting, Kelly-Ann Federle Reilly
Doctor of Nursing Practice Projects
Background: In 2013, Medicare penalties for high hospital readmission rates spurred initiatives to reduce these figures. Despite efforts, 25% of elderly patients are readmitted within 30 days post-discharge, often due to unaddressed Social Determinants of Health (SDoH) like food, housing, and medication access.
Objectives: The project aimed to assess the effectiveness of interventions targeting SDoH for patients over 65 receiving home care services. It specifically sought to evaluate the impact of these interventions on 30-day readmission rates, focusing on addressing food, housing, and medication insecurities.
Methods: This project evaluated interventions targeting SDoH in-home care among patients over 65 to reduce …
Characterizing The First 6-Year Hospital Data For Sarcopenia Using Its First International Classification Of Diseases (Icd-10-Cm) Diagnosis Code, Laura F. Goodfield, Amy Tsurumi
Characterizing The First 6-Year Hospital Data For Sarcopenia Using Its First International Classification Of Diseases (Icd-10-Cm) Diagnosis Code, Laura F. Goodfield, Amy Tsurumi
GW Research Showcase 2021-2026
No abstract provided.
Did You Do Your Admission Ortho's?, Haven Snyder Bsn, Rn, Karla Perallon Bsn, Rn, Fatimah Alsalman Bsn, Rn, Johanny Martinez Bsn, Rn
Did You Do Your Admission Ortho's?, Haven Snyder Bsn, Rn, Karla Perallon Bsn, Rn, Fatimah Alsalman Bsn, Rn, Johanny Martinez Bsn, Rn
Vizient/ AACN Nurse Residency Program™ EBP Projects
No abstract provided.
Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba
Kajian Literatur Distribusi Kompensasi Dampak Tempat Pengelolahan Sampah Terpadu (Tpst) Bantargebang: Analisis Keadilan Distributif Dan Keadilan Sosial, Wahyu Pratama Tamba
Jurnal Ilmu Kesejahteraan Sosial
The waste problem in Jakarta is a complex issue related to the large volume of waste, dependence on Bantargebang TPST, and the various environmental impacts caused. Waste from Jakarta brought to Bantargebang TPST reaches 6,500-7,000 tons daily. This TPST hurts the environment and the health of the surrounding community, as well as the risk of ARI, air pollution, groundwater pollution, and environmental aesthetics. As compensation for these negative impacts, the DKI Jakarta Provincial Government allocates compensation funds for affected communities. This is regulated in Article 10 letter (e) of DKI Jakarta Regional Regulation number 4 of 2019 which states that …
Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis
Telaah Konsep Asset Bassed Comunity Development Bagi Pembangunan Pariwisata Berbasis Masyarakat, Silva Amanda, Rudi Saprudin Darwis
Jurnal Ilmu Kesejahteraan Sosial
The tourism sector is one of the sectors that contributes the largest foreign exchange in Indonesia. To develop this, the Ministry of Tourism and Creative Economy continues to encourage the community-based tourism industry, with one of them developing a tourist village program. One way to realize the tourist village program in Indonesia is to use the Asset Based Community Development approach by emphasizing the use of potential assets owned by an area. The purpose of this research is to identify the potential or assets that exist in a village/region that can be developed into a tourist village by emphasizing community …
Service Learning In The Secondary Classroom, Kristine Putz
Service Learning In The Secondary Classroom, Kristine Putz
School of Education and Leadership Student Capstone Projects
This capstone project is entitled “Service Learning in the Secondary Classroom” and explores the question: How can service learning be integrated into high school units to strengthen the connection between the classroom and the community and to make instruction more relevant? This question is answered through the creation of a six to seven week length unit that integrates service learning into a research and writing unit within an upper-level writing course. Specifically, this project is intended for students taking a concurrent enrollment course at their high school through a local community college partnership. Key influences in the creation of this …
The Older Adults; Oral Health Crisis: An Exploration Into Barriers, Intervention, And Development, Sydney Wojcieszak
The Older Adults; Oral Health Crisis: An Exploration Into Barriers, Intervention, And Development, Sydney Wojcieszak
USF St. Petersburg campus Honors Program Theses (Undergraduate)
This thesis examines the growing oral health crisis among older adults in the United States by exploring the barriers that prevent access to dental care and evaluating potential strategies for improvement. Through an interdisciplinary review of literature spanning dentistry, public health, gerontology, and healthcare policy, the study highlights the significant relationship between oral health and overall well-being, demonstrating how conditions such as dental caries, periodontal disease, tooth loss, and reduced salivary flow can contribute to systemic illnesses, diminished quality of life, and increased healthcare costs. The research identifies key barriers faced by older adults, including limited mobility, transportation challenges, cognitive …
A Comparative Study Of A Non-Small Cell Lung Cancer Associated Egfr Missense Variant Of Uncertain Significance, Vanessa Mejia
A Comparative Study Of A Non-Small Cell Lung Cancer Associated Egfr Missense Variant Of Uncertain Significance, Vanessa Mejia
Theses
Non-small cell lung cancer (NSCLC) is a form of lung cancer that can be driven by heightened activity of epidermal growth factor receptor encoded by the EGFR gene. Genetic variants in EGFR have been identified that lead to abnormal cell growth and tumorigenesis. The objectives of this study was to 1) determine if an EGFR variant of uncertain significance (VUS) associated with NSCLC is potentially damaging based on evaluation of the ortholog let-23 in the model organism, C. elegans, and 2) identify conserved missense VUS loci associated with NSCLC. Through ClinVar, the EGFR VUS c.845G>C(p.Gly282Ala) was identified in …
Fedfsa: Hybrid And Federated Framework For Functional Status Ascertainment Across Institutions, Sunyang Fu, Heling Jia, Maria Vassilaki, Vipina K Keloth, Yifang Dang, Yujia Zhou, Muskan Garg, Ronald C Petersen, Jennifer St Sauver, Sungrim Moon, Liwei Wang, Andrew Wen, Fang Li, Hua Xu, Cui Tao, Jungwei Fan, Hongfang Liu, Sunghwan Sohn
Fedfsa: Hybrid And Federated Framework For Functional Status Ascertainment Across Institutions, Sunyang Fu, Heling Jia, Maria Vassilaki, Vipina K Keloth, Yifang Dang, Yujia Zhou, Muskan Garg, Ronald C Petersen, Jennifer St Sauver, Sungrim Moon, Liwei Wang, Andrew Wen, Fang Li, Hua Xu, Cui Tao, Jungwei Fan, Hongfang Liu, Sunghwan Sohn
Faculty, Staff and Student Publications
Introduction: Patients' functional status assesses their independence in performing activities of daily living, including basic ADLs (bADL), and more complex instrumental activities (iADL). Existing studies have discovered that patients' functional status is a strong predictor of health outcomes, particularly in older adults. Depite their usefulness, much of the functional status information is stored in electronic health records (EHRs) in either semi-structured or free text formats. This indicates the pressing need to leverage computational approaches such as natural language processing (NLP) to accelerate the curation of functional status information. In this study, we introduced FedFSA, a hybrid and federated NLP framework …
Navigating Financial Landscapes: A Brief Introduction Of Financial Planning Needs And Professional Guidance For The Korean American Community, Wookjae Heo
KAUPA Letters
This paper addresses the need for financial planning and literacy among Korean Americans, who are often reluctant to seek professional financial help. Highlighting the complexity of modern financial systems and the financial challenges faced by Korean Americans, the paper underscores the importance of enhancing financial literacy to navigate these complexities effectively. It explores the barriers to accessing financial professionals, rooted in cultural and environmental factors, and discusses the diverse roles and ethical codes of financial planning professionals such as Certified Financial Planners and Accredited Financial Counselors. By understanding the fiduciary duties and ethical considerations within the financial planning profession, the …
Social Participation Program For Older Adults With Dementia Residing In Long Term Care Facilities, Keri Mcclelland
Social Participation Program For Older Adults With Dementia Residing In Long Term Care Facilities, Keri Mcclelland
Student Capstone Papers
Social participation is characterized by activities that involve social interaction with others and supports social interdependence; individuals engage in this occupation through a variety of contexts including with their community, family, friends, and peers (American Occupational Therapy Association, 2020). Social participation has been discovered to influence general health and well-being, cognitive health, risk of dementia, and stress (Sommerlad et al., 2023). Dementia is a prevalent disease affecting approximately 50 million individuals worldwide (Sommerlad et al., 2023) causing increased dependence and disability among the older adult population and is shown to be growing as the aging population increases in number (Wang …
Reducing Hemoglobin A1c Using Diabetes Self-Management Education And Support (Dsmes) For Hispanic Adults In A Primary Care Setting, Gita Gyawali Sedai
Reducing Hemoglobin A1c Using Diabetes Self-Management Education And Support (Dsmes) For Hispanic Adults In A Primary Care Setting, Gita Gyawali Sedai
Doctor of Nursing Practice Final Project Abstract
Background: Members of the Hispanic population have a 50% or higher chance of developing diabetes and often do so at a younger age than other adults in the United States (CDC, 2022a). Diabetes complications also impact the Hispanic population harder, with higher rates of kidney failure caused by diabetes, along with diabetes-related vision loss and blindness (CDC, 2022a). DSMES programs have shown significant improvements in A1C and blood sugar control in different settings (Powers et al., 2020). However, it has not been implemented in many primary care settings.
Purpose: The purpose of this project was to implement and evaluate …
Does A Reduction In Receiving Assistance With Daily Activities Among Older Adults In Mexico Indicate An Increase In Unmet Needs Or A Decrease In Needs For Care?, Brian Downer, Rafael Samper-Ternent, Philip Cantu, Matthew Miller, Rebeca Wong
Does A Reduction In Receiving Assistance With Daily Activities Among Older Adults In Mexico Indicate An Increase In Unmet Needs Or A Decrease In Needs For Care?, Brian Downer, Rafael Samper-Ternent, Philip Cantu, Matthew Miller, Rebeca Wong
Faculty, Staff and Student Publications
OBJECTIVES: The percentage of older adults in Mexico with difficulty completing activities of daily living (ADL) who receive assistance from family appears to be decreasing. We compared 2 birth cohorts of older adults in Mexico to investigate whether this trend reflects an increase in unmet caregiving needs or a decrease in the need for care.
METHODS: We selected Mexican Health and Aging Study participants aged 60-76 in 2001 (n = 4,805) and 2018 (n = 6,494). ADL tasks were dressing, walking, bathing, getting in and out of bed, and toileting. Participants who reported difficulty with an ADL were asked if …
The Dementia Care Study (D-Care): Recruitment Strategies And Demographic Characteristics Of Participants In A Pragmatic Randomized Trial Of Dementia Care, Mia Yang, Rafael Samper-Ternent, Elena Volpi, Aval-Na'ree Green, Maya Lichtenstein, Katy Araujo, Pamela Borek, Peter Charpentier, James Dziura, Thomas M Gill, Rebecca Galloway, Erich J Greene, Kristin Lenoir, Peter Peduzzi, Can Meng, Jordan Reese, Amy Shelton, Eleni A Skokos, Jenny Summapund, Erin Unger, David B Reuben, Jeff D Williamson, Alan B Stevens
The Dementia Care Study (D-Care): Recruitment Strategies And Demographic Characteristics Of Participants In A Pragmatic Randomized Trial Of Dementia Care, Mia Yang, Rafael Samper-Ternent, Elena Volpi, Aval-Na'ree Green, Maya Lichtenstein, Katy Araujo, Pamela Borek, Peter Charpentier, James Dziura, Thomas M Gill, Rebecca Galloway, Erich J Greene, Kristin Lenoir, Peter Peduzzi, Can Meng, Jordan Reese, Amy Shelton, Eleni A Skokos, Jenny Summapund, Erin Unger, David B Reuben, Jeff D Williamson, Alan B Stevens
Faculty, Staff and Student Publications
INTRODUCTION: Pragmatic research studies that include diverse dyads of persons living with dementia (PLWD) and their family caregivers are rare.
METHODS: Community-dwelling dyads were recruited for a pragmatic clinical trial evaluating three approaches to dementia care. Four clinical trial sites used shared and site-specific recruitment strategies to enroll health system patients.
RESULTS: Electronic health record (EHR) queries of patients with a diagnosis of dementia and engagement of their clinicians were the main recruitment strategies. A total of 2176 dyads were enrolled, with 80% recruited after the onset of the pandemic. PLWD had a mean age of 80.6 years (SD 8.5), …
Obesity: The Effects On Health And Healthcare, Nadia Abdulbaki
Obesity: The Effects On Health And Healthcare, Nadia Abdulbaki
Posters - 2024
▪ In 2022, 1 in 8 people in the world were living with obesity.
▪ 2.8 million people die each year due to being overweight and obese.
▪ Obesity is a medical disease that raises the likelihood of developing various conditions and diseases that increase the chances of mortality for affected individuals.
▪ Obesity can be caused by several influences, whether behavioral, socioeconomic, environmental, hormonal, or genetic; however, the primary cause of obesity is mostly attributed to lifestyle. Specifically, it is the consumption of a high amount of calories in conjunction with a low amount of calories expended. This is …
Big Data Searches And The Future Of Criminal Procedure, Mary Fan
Big Data Searches And The Future Of Criminal Procedure, Mary Fan
Articles
This Article proceeds in three parts. Part I illuminates the nostalgic Luddism that influences Fourth Amendment jurisprudence and the challenges posed by evolving technologies to this dominant lens. This Part explains the operation of geofence and keyword warrants and how their power to crack cold cases by unidentified perpetrators both tempt and terrify. The confusion in the courts over the constitutionality of geofence and keyword warrants is emblematic of the larger challenges of the Romantic Luddism in Fourth Amendment originalism that has grown in influence over the decades.
Part II frames and theorizes the concepts of collateral impact and collateral …
Program Development For Group Interventions Targeting Loneliness In Older Adults, Antoinette Cave
Program Development For Group Interventions Targeting Loneliness In Older Adults, Antoinette Cave
Capstone Projects
The topic of loneliness is complex and subjective in nature, and treatment of the condition requires the client-centered approach that occupational therapy encompasses within its scope of practice. Using an occupation-based, mental health approach to develop the program, weekly focus groups were created based on participant-preferred activities to decrease loneliness among older adults at PACE InnovAge’s outpatient and assisted living locations in Thornton, Colorado. Education was provided to participants and staff throughout the 14-week experience. Further training and sustainability efforts were created and distributed among participants and staff at the end of the experience through an occupation-based handout with external …
Recollection-Based Occupational Therapy: An Activities Program For Catholic Dominican Sisters With Dementia, Alyssa J. Visockis
Recollection-Based Occupational Therapy: An Activities Program For Catholic Dominican Sisters With Dementia, Alyssa J. Visockis
Capstone Projects
Recollection-based occupational therapy is a nonpharmacological approach to dementia, involving five categories of activities: horticultural, physical, art, musical, and instrumental activities of daily living (IADLs). The purpose of this approach is to incorporate memories of a person’s childhood, adulthood, and older adulthood before dementia in activities. Furthermore, the Grand Rapids Catholic Dominican sisters at Aquinata Hall needed a method to gather psychosocial history on their residents as well as new activity programming on the dementia- care unit that had meaningful purpose. Therefore, during this capstone experience, a psychosocial history assessment was created and conducted with the sisters. Using the results …
Implementing The Positive Approach To Care® Methods As An Effective Training Curriculum For Staff At An Adult Day Center, Delaney Acri
Implementing The Positive Approach To Care® Methods As An Effective Training Curriculum For Staff At An Adult Day Center, Delaney Acri
Capstone Projects
Dementia, a neurodegenerative disorder affecting multiple brain regions, significantly disrupts daily life (Feurich, 2023). Occupational therapists, guided by the Occupational Therapy and Performance Framework (OTPF-4), address cognitive and functional challenges in individuals with dementia (American Occupational Therapy Association, 2020). Therapists employ compensatory strategies to enhance quality of life of people with dementia, as well as their family caregivers. Adult day centers serve as valuable resources for family caregivers, offering respite care during working hours. Despite regulations in most states, Michigan lacks specific dementia training laws in some healthcare settings (Burke & Orlowski, 2015). As a result, many facilities that serve …
Implementation Of An Occupation-Focused Education Program For Community-Dwelling Older Adults, Riley Janssen
Implementation Of An Occupation-Focused Education Program For Community-Dwelling Older Adults, Riley Janssen
Capstone Projects
A Doctoral Capstone Experience (DCE) and project was completed at the conclusion of Western Michigan University’s Occupational Therapy program with the goal of implementing an occupation-focused educational program dedicated toward topics relevant for community-dwelling older adults. The capstone project took place at the Clinton Township Senior Adult Life Center (CTSC) under the mentorship of Ericka Tringali, CPRP. The Accreditation Council for Occupational Therapy Education (ACOTE) focus area of this project was program development. The program consisted of three educational classes focusing on topics including Basic Activities of Daily Living (BADLs), creating healthy habits and routines, and fall prevention and energy …
Tavr In Older Adults, Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger, Michael W Rich, Dae Hyun Kim, Roberta Y Wang, Daniel E Forman, Ashok Krishnaswami
Tavr In Older Adults, Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger, Michael W Rich, Dae Hyun Kim, Roberta Y Wang, Daniel E Forman, Ashok Krishnaswami
Faculty, Staff and Student Publications
Calcific aortic stenosis can be considered a model for geriatric cardiovascular conditions due to a confluence of factors. The remarkable technological development of transcatheter aortic valve replacement was studied initially on older adult populations with prohibitive or high-risk for surgical valve replacement. Through these trials, the cardiovascular community has recognized that stratification of these chronologically older adults can be improved incrementally by invoking the concept of frailty and other geriatric risks. Given the complexity of the aging process, stratification by chronological age should only be the initial step but is no longer sufficient to optimally quantify cardiovascular and noncardiovascular risk. …
Combating Social Isolation Among Older Adults Through Intergenerational Relationships With Children; Facilitating Meaningful Connection During Intergenerational Interactions By Improving Sensory Environment And Increasing Engagement During Group Activities, Lillian John
Capstone Projects
The following capstone project focused on the enhancement of meaningful engagement among all participants of an intergenerational care center. The interventions implemented within the intergenerational program were put in place to facilitate communication, improve behavioral regulation, modify sensory environment, create the just right challenge for group activities, and increase independence to promote meaningful engagement and social connection. The implementation of the interventions was completed through on-site education to the employees, the creation of various educational binders to support the participants individually, and adjustments to the environment and group activities. This capstones projects’ primary goal was to improve the efficacy of …
Occupational Therapy Newsletter, Spring 2024, Occupational Therapy Department
Occupational Therapy Newsletter, Spring 2024, Occupational Therapy Department
News, Magazines and Reports
Highlights: Dr. Mary-Ellen Johnson Retires, Busher and Weinstein Awards 2023, ConnOTA Fall SIS Conference, Capstone Presentations, Department News: Dr. Stefanie Seanor, Professor Morgan Villano, Professor Nicole Peloso Smith, Newly Elected Officials for SOTA and COTAD
Considerations For Walking Adaptive Devices Used By The Older Adult Population For Functional Mobility, Amanda Beth Firoved
Considerations For Walking Adaptive Devices Used By The Older Adult Population For Functional Mobility, Amanda Beth Firoved
Rehabilitation Sciences Theses & Dissertations
Statement of the problem: Walking adaptive devices (ADs) are commonly used by older adults to increase stability and prevent falls, yet the effectiveness and safety of these devices remain uncertain. This dissertation study investigates the impact of ADs on older adult falls through evidence-based practice concepts of best research evidence, patient values and circumstances, and clinician expertise. Methods: Three distinct studies were conducted, each addressing an essential aspect of EBP. The first study, representing the best research evidence, explored the effect of AD on gait spatiotemporal parameters and motions at the center of mass of twenty-five healthy participants. The second …
Cyclophilin A Supports Translation Of Intrinsically Disordered Proteins And Affects Haematopoietic Stem Cell Ageing, Laure Maneix, Polina Iakova, Charles G Lee, Shannon E Moree, Xuan Lu, Gandhar K Datar, Cedric T Hill, Eric Spooner, Jordon C K King, David B Sykes, Borja Saez, Bruno Di Stefano, Xi Chen, Daniela S Krause, Ergun Sahin, Francis T F Tsai, Margaret A Goodell, Bradford C Berk, David T Scadden, André Catic
Cyclophilin A Supports Translation Of Intrinsically Disordered Proteins And Affects Haematopoietic Stem Cell Ageing, Laure Maneix, Polina Iakova, Charles G Lee, Shannon E Moree, Xuan Lu, Gandhar K Datar, Cedric T Hill, Eric Spooner, Jordon C K King, David B Sykes, Borja Saez, Bruno Di Stefano, Xi Chen, Daniela S Krause, Ergun Sahin, Francis T F Tsai, Margaret A Goodell, Bradford C Berk, David T Scadden, André Catic
Faculty, Staff and Students Publications
Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl isomerase A (PPIA or cyclophilin A) as a dominant chaperone in haematopoietic stem and progenitor cells. Depletion of PPIA accelerates stem cell ageing. We found that proteins with intrinsically disordered regions (IDRs) are frequent PPIA substrates. IDRs facilitate interactions with other proteins or nucleic acids and can trigger liquid-liquid phase separation. Over 20% of PPIA substrates are involved in the formation of supramolecular membrane-less organelles. PPIA affects regulators of stress granules (PABPC1), P-bodies (DDX6) and nucleoli (NPM1) to promote phase separation and increase cellular stress resistance. …
Shaping The Future Of Vascular Care: The Evolution Of Advanced Practice Providers (Apps)., Alexandra Moran Baird, Katherine Hays, Danielle Vlazny
Shaping The Future Of Vascular Care: The Evolution Of Advanced Practice Providers (Apps)., Alexandra Moran Baird, Katherine Hays, Danielle Vlazny
Medical Education Articles
No abstract provided.