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2024

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Articles 1681 - 1709 of 1709

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Restoration Is Repairing Relationships: Bridging Indigenous And Western Sciences To Assess The Socio-Ecological Restoration Of Wild Rice (Zizania Palustris) On Keweenaw Bay Indian Community Homelands, Cassandra M. Reed-Vandam Jan 2024

Restoration Is Repairing Relationships: Bridging Indigenous And Western Sciences To Assess The Socio-Ecological Restoration Of Wild Rice (Zizania Palustris) On Keweenaw Bay Indian Community Homelands, Cassandra M. Reed-Vandam

Dissertations, Master's Theses and Master's Reports

Manoomin (wild rice, Zizania palustris) is an ecologically and culturally significant plant relative for the Keweenaw Bay Indian Community (KBIC). Historically, manoomin was present across much of the Great Lakes, however, their presence has declined since the early 1900s and, by 1990, virtually disappeared within KBIC homelands. Employing ethnography, surveys, focus groups, and conversations with Ojibwa knowledge holders, this research defined successful manoomin restoration for KBIC and developed socio-ecological attributes and indicators to assess restoration presented in the Medicine Wheel Framework for Manoomin Restoration. Surface water, sediment, and pore water samples at six different manoomin sites were analyzed to …


Hydrologic Pathways Of A Northern Hardwood Catchment In The Great Lakes Basin Using End Member Mixing Analysis, Cory C. Burkwald Jan 2024

Hydrologic Pathways Of A Northern Hardwood Catchment In The Great Lakes Basin Using End Member Mixing Analysis, Cory C. Burkwald

Dissertations, Master's Theses and Master's Reports

This study investigated the seasonality of hydrologic pathways, the role of wetlands in streamflow generation, and how hydrologic pathways affect the export of nutrients by streamflow in the Sturgeon River using endmember mixing analysis. The results indicated that streamflow consists of three main components: shallow subsurface water from wetland soils, shallow groundwater, and surface runoff from precipitation. Snowmelt plays a dominating role in regulating stream water chemistry (~80% volume at peak) during the snowmelt season and likely also after that. Wetland soils store snowmelt, together with rainwater though the fraction is unknown, and then gradually release through summer in the …


Sediment Carbon Storage In Subtidal Beds Of The Invasive Seagrass Halophila Stipulacea Along An Extreme Water Depth Gradient, St. Thomas, U.S. Virgin Islands, Demian A. Willette, Kelsey M. Vaughn, Allie Durdall, Marilyn Brandt, Sophia Costa, Kristin Wilson Grimes Jan 2024

Sediment Carbon Storage In Subtidal Beds Of The Invasive Seagrass Halophila Stipulacea Along An Extreme Water Depth Gradient, St. Thomas, U.S. Virgin Islands, Demian A. Willette, Kelsey M. Vaughn, Allie Durdall, Marilyn Brandt, Sophia Costa, Kristin Wilson Grimes

Biology Faculty Works

Blue carbon ecosystems such as mangroves, salt marshes, and seagrass beds are found globally and are fundamental to fisheries production, storm surge protection, and carbon sequestration. The contribution of seagrass ecosystems to global carbon stocks is still not well understood, including in the United States Virgin Islands (USVI). No study has been published to-date assessing the sediment carbon density (SCD) in seagrass beds in the USVI. This study focused on the carbon storage ability of the invasive species, Halophila stipulacea, which is compact in size compared to common native seagrasses and has spread rapidly to become a dominant seagrass in …


Geographies Of Storage, Sayd Randle Jan 2024

Geographies Of Storage, Sayd Randle

Research Collection College of Integrative Studies

Resource storage has long played a key role in the production of socio-ecological arrangements and economic relations. Even so, storage as a concept has remained somewhat marginal within geographical scholarship, often obscured by an analytical focus on the dynamics of movement. Reviewing recent works from geography, science and technology studies, and anthropology that center sites and practices of storage, this essay elaborates the diverse ways in which storage arrangements mediate resource circulation and the production of space. This literature demonstrates that thinking systematically with storage can illuminate a range of novel temporal, material, and value entanglements in-the-making, pointing to potentially …


Developing Resources To Foster Farmed Animal Agency In Sanctuary Education, Emily Tronetti Jan 2024

Developing Resources To Foster Farmed Animal Agency In Sanctuary Education, Emily Tronetti

Antioch University Dissertations & Theses

Farmed animal sanctuaries provide lifelong care to formerly farmed animals. Many strive to educate their community about farmed animals and promote more compassionate lifestyles, such as veganism. Important to this is cultivating empathy and concern for the well-being of individual farmed animals. Essential to well-being is agency, which is the capacity of a living being to engage with their environments and to make choices for themselves. Farmed animals outside of sanctuaries have had their agency systematically suppressed and denied. Sanctuary educators can bring awareness to this and inspire alternative, agency-centered relationships with not only farmed animals but all living beings. …


Univariate Extreme Value Analysis Of Quantitative Investment Management, George Agbenyega Zumanu Jan 2024

Univariate Extreme Value Analysis Of Quantitative Investment Management, George Agbenyega Zumanu

Graduate Research Theses & Dissertations

The evolution of product development within the variable annuity (VA) business have sparked interest in quantitative investment management, particularly as most VA issuers have integrated volatility-controlled funds into their annuity portfolios. Despite the existence of empirical research on statistical analysis of extreme values in conventional investments, there has been a notable gap in research focus towards risk modeling in volatility-controlled funds.

This study contributes by analyzing and modeling the extreme values of investments in volatility-controlled funds, comparing them to conventional equity funds. The financial returns of S&P Dow Jones Indices (SPDJI) indices - SPXTR, risk control SPXT18UT, and managed risk …


Three Essays On Externalities Of Energy And Agricultural Production, Taiwo Foluso Akinyemi Jan 2024

Three Essays On Externalities Of Energy And Agricultural Production, Taiwo Foluso Akinyemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays exploring the externalities that arise from energy production and development in a developing country, Nigeria, and agricultural production in a developed nation, the United States (US). The research examines the benefits of energy development in terms of its impact on local wealth and the associated costs, including the health effects on communities living near energy production sites. Additionally, the dissertation analyzes the opportunity costs of policies aimed at preventing the relocation of nutrients, particularly nitrogen fertilizers, within the agricultural sector and their impact on the producer and consumer surplus.

The first essay examines the …


Exploring The Connection: Field Ecology Research And Student Wellbeing, Elizabeth Small Jan 2024

Exploring The Connection: Field Ecology Research And Student Wellbeing, Elizabeth Small

Graduate Research Theses & Dissertations

Field work is essential in ecological research, offering the opportunity to gather firsthand data, observe natural processes, and deepen our understanding of ecosystems. In my study on small mammal trophic niche dynamics, I investigate how small mammals—critical players in grassland food webs—adapt their diets in response to environmental disturbances. By examining the drivers of variation in trophic niche among three common small mammal species, I aim to uncover how these animals coexist despite similar dietary requirements. Understanding these dynamics is critical for informing global conservation efforts, especially as we work to reverse the biodiversity crisis and restore damaged ecosystems.However, the …


Beyond Fear: Inspiring Students To Appreciate Sharks And Understand Their Role In The Ocean, Carolina A. Souza, Janelle Seefelt, Jordyn Delikat, Brianna Rendon Jan 2024

Beyond Fear: Inspiring Students To Appreciate Sharks And Understand Their Role In The Ocean, Carolina A. Souza, Janelle Seefelt, Jordyn Delikat, Brianna Rendon

High Impact Practices Student Showcase Fall 2024

Our team visited a fourth-grade classroom of 26 students at Geneva Elementary School to speak on sharks. We highlighted the ecological significance of sharks, cultural respect for them in Polynesian and Hawaiian cultures, threats facing shark populations, and different ways students could help protect them. Our goal was to address negative stigma surrounding sharks. The students participated in a take-home project where they decorated their own paper bag shark puppet and wrote what they loved about sharks on the back. They also made shark tooth necklaces. Lastly, each student picked a marine organism, decorated it, and glued it onto a …


Impact Of Forest Plantations On Energy Poverty: An Assessment Of Reforestation Efforts In Uganda, Matilda Kabutey-Ongor Jan 2024

Impact Of Forest Plantations On Energy Poverty: An Assessment Of Reforestation Efforts In Uganda, Matilda Kabutey-Ongor

Graduate Student Theses, Dissertations, & Professional Papers

This study investigates the socio-economic impacts of reforestation initiatives on energy poverty in three Ugandan districts—Hoima, Dokolo, and Nakasongola. Implemented by the Ugandan National Forest Authority, these efforts aim to mitigate the adverse effects of deforestation, exacerbated by a growing population and increased demand for forest products. We hypothesize that through sustainable afforestation, access to biomass and other renewable energy sources can be improved, thereby alleviating energy poverty. The study establishes a causal relationship between reforestation and reductions in energy poverty and general poverty using advanced econometric methods, such as Ordinary Least Squares regression, Weighting, and matching techniques including Propensity …


Reinstatement Of The Poly Canyon Caretaker Program Through The Development Of A Tiny Home Community, Leily Martin Jan 2024

Reinstatement Of The Poly Canyon Caretaker Program Through The Development Of A Tiny Home Community, Leily Martin

Construction Management

The Poly Canyon Experimental Structures Laboratory, through its Design/Build program, is unique in the educational opportunity it provides Cal Poly College of Architecture and Environmental Design (CAED) students. However, since the conclusion of the Caretaker Program in 2011, the facility’s structures have deteriorated due to vandalism, purposeful destruction, and weathering. This study examines the perspectives of CAED students, the interim CAED Dean, Kevin Dong, and Cal Poly Risk Manager, Mike Morgan, on the effectiveness in reinstating the Caretaker Program through the development of a tiny home community. Results indicated educational value in this facility, so addressing these issues must occur …


Western Pacific K-12 Educators’ Adoption Of Digital Game-Based Learning, Lorraine Raqueño Catienza Jan 2024

Western Pacific K-12 Educators’ Adoption Of Digital Game-Based Learning, Lorraine Raqueño Catienza

Theses and Dissertations

Western Pacific educational institutions are investing heavily in technology in classrooms to meet the needs of K-12 students. Measuring the effective use of digital technologies in the learning environment has become a routine part of monitoring and evaluating classroom instruction. One area of technology integration that has seen tremendous growth is digital game-based learning (DGBL). The researcher is interested in examining K-12 western Pacific teachers’ willingness to adopt DGBL through a modified Technology Acceptance Model. This study aims to examine the extent to which teachers’ perceived usefulness, perceived ease of use, and technology self-efficacy effects attitude toward adopting DGBL methods. …


Assessment Of Potential Impacts Of Climate Change On Hydrology And Water Resource Availability In The Passaic River Basin, New Jersey, Felix Oteng Mensah Jan 2024

Assessment Of Potential Impacts Of Climate Change On Hydrology And Water Resource Availability In The Passaic River Basin, New Jersey, Felix Oteng Mensah

Theses, Dissertations and Culminating Projects

Streamflow dynamics in a basin is known to be a major driver of available water resources. In the context of climate change, it is expected that global warming will accelerate the global hydrologic cycle, which will drive more intense floods and droughts leading to changes in streamflow and water resource availability. Most researchers agree that the amount and intensity of precipitation have a direct impact on runoff. Yet, there is no consensus as to how warming can affect streamflow. Evapotranspiration (ET) plays a crucial role here. However, there is a shortage of real-world observations on it. And yet, ET is …


Fostering Entry Level Practitioner Knowledge, Confidence, And Competence In Trauma-Informed Care Application, Mollie Keyser, Mary A. Barnes Jan 2024

Fostering Entry Level Practitioner Knowledge, Confidence, And Competence In Trauma-Informed Care Application, Mollie Keyser, Mary A. Barnes

Journal of Occupational Therapy Education

Trauma is pervasive worldwide and is associated with poor health outcomes if left unaddressed, however, a gap in practice continues to exist in the implementation of trauma-informed care (TIC). Occupational therapy practitioners will encounter individuals, communities, and populations influenced by trauma, which warrants the need for TIC to improve overall service delivery across the lifespan. However, TIC is currently not systematically integrated into any Accreditation Council for Occupational Therapy Education (ACOTE) occupational therapy educational standards. The purpose of this study was to design, implement, and evaluate a TIC application-based workshop for a sample of entry-level occupational therapy doctorate (OTD) students. …


Atmospheric Deposition Of Microplastics In Shiraz, Iran, Sajjad Abbasi, Farnaz Ahmadi, Nafiseh Khodabakhshloo, Haniye Pourmahmood, Atefeh Esfandiari, Zeinab Mokhtarzadeh, Shaqayeq Rahnama, Reza Dehbandi, Arya Vazirzadeh, Andrew Turner Jan 2024

Atmospheric Deposition Of Microplastics In Shiraz, Iran, Sajjad Abbasi, Farnaz Ahmadi, Nafiseh Khodabakhshloo, Haniye Pourmahmood, Atefeh Esfandiari, Zeinab Mokhtarzadeh, Shaqayeq Rahnama, Reza Dehbandi, Arya Vazirzadeh, Andrew Turner

School of Geography, Earth and Environmental Sciences

The atmosphere plays a critical role in the regional and global transportation and redistribution of microplastics (MPs). However, the significance of rainfall and its means of scavenging MPs are not well understood. In this study, MP deposition was determined during successive dry and rainy events over eight consecutive days in the Shiraz region of Iran. Flux magnitudes and temporal distributions at six sites within and outside the city (including a remote, non-urbanised location) were similar and revealed a progressive increase in MP abundance and deposition during dry periods (up to about 50 MP m−2 h−1) and subsequent relatively rapid wet …


Insights From Early Career Researcher Representatives At The Sustainability Research & Innovation Congress 2022 Asia Spotlight Event, Cho Kwong Charlie Lam Jan 2024

Insights From Early Career Researcher Representatives At The Sustainability Research & Innovation Congress 2022 Asia Spotlight Event, Cho Kwong Charlie Lam

School of Geography, Earth and Environmental Sciences

The Sustainability Research & Innovation Congress 2022 Asia Spotlight Event (SRI-ASE 2022) was held virtually from June 21-24, 2022 and co-organized by Future Earth Global Secretariat Hubs in Asia based in Japan, Taipei, China, and South Asia, during the main sessions of the SRI 2022. SRI-ASE 2022 included over 70 speakers and more than 300 participants from within and outside the Asia region. The aim of the event was to provide space to reflect on inspiring research and discussions related to the themes: New Horizons, Different Ways of Knowing, Nexus Issues, and Cross-cutting Science and Innovation in Asia. This report …


The Impact Of Artificial Beach Lighting And Beach Renourishment On Loggerhead (Caretta Caretta) And Green Turtle (Chelonia Mydas) Nesting Success, Amanda M. Casaburi Jan 2024

The Impact Of Artificial Beach Lighting And Beach Renourishment On Loggerhead (Caretta Caretta) And Green Turtle (Chelonia Mydas) Nesting Success, Amanda M. Casaburi

Honors Undergraduate Theses

Sea turtles face numerous threats on their nesting beaches, including habitat degradation, artificial lighting, and human interventions like beach nourishment projects. These factors can disrupt nesting behavior and reduce overall reproductive success. This study examined the impact of anthropogenic disturbances, specifically artificial lighting and beach nourishment projects, on the nesting success (quantified as portion of adult female emergences resulting in a nest) of loggerhead (Caretta caretta) and green turtles (Chelonia mydas) in southern Brevard County, Florida. Utilizing a long-term dataset (1989-2023) from the UCF Marine Turtle Research Group, the research focused on the Archie Carr National Wildlife Refuge (ACNWR), a …


Phytochemistry Of Isolated Essential Oils From Cautleya Spicata (Sm.) Baker For Their Pesticidal Evaluation And In-Silico Approaches To Reveal The Mode Of Nematicidal Action, Sonu Kumar Mahawer, Manar Fawzi Bani Mfarrej, Ravendra Kumar, Himani Karakoti, Om Prakash, Satya Kumar, Dharmendra Singh Rawat, Aditi Kundu, Pieter Malan, Faheem Ahmad Jan 2024

Phytochemistry Of Isolated Essential Oils From Cautleya Spicata (Sm.) Baker For Their Pesticidal Evaluation And In-Silico Approaches To Reveal The Mode Of Nematicidal Action, Sonu Kumar Mahawer, Manar Fawzi Bani Mfarrej, Ravendra Kumar, Himani Karakoti, Om Prakash, Satya Kumar, Dharmendra Singh Rawat, Aditi Kundu, Pieter Malan, Faheem Ahmad

All Works

This study aimed to assess the chemical composition and pesticidal activities of essential oils (EOs) from Cautleya spicata rhizomes and aerial parts. The EOs were assessed against root-knot nematodes (Meloidogyne incognita) by mortality and hatchability bioassays and the phytotoxicity of the EOs was determined against Raphanus raphanistrum subspp. Sativus (radish) and Cichorium intybus (chicory) seeds. In-silico screening of the primary constituents of EOs and five chosen target proteins of the nematode was conducted to predict the expected mechanism of action of these oils. p-Cymene and β-pinene were the key compounds in the EOs from the rhizomes and aerial parts. The …


Loot Boxes May Exploit Gamers, But Their Sale Does Not Constitute Unlawful Gambling, John J. Chung Jan 2024

Loot Boxes May Exploit Gamers, But Their Sale Does Not Constitute Unlawful Gambling, John J. Chung

Law Faculty Scholarship

No abstract provided.


2023 Utah Farmers Market Data, Chandler Rosenberg, Steven Price, Roslynn Mccann Jan 2024

2023 Utah Farmers Market Data, Chandler Rosenberg, Steven Price, Roslynn Mccann

Environment and Society Faculty Publications

In 2023, the Utah Farmers Market Network collected customer, vendor, and manager data from three Utah markets. This data is shared for public use in an infographic style for ease of interpretation.


Utah Farmers Market Manager Handbook, Gwen Crist Jan 2024

Utah Farmers Market Manager Handbook, Gwen Crist

Environment and Society Faculty Publications

Welcome to the Utah Farmers Market Manager Handbook, designed by the Utah Farmers Market Network for market managers like you! We’re thrilled to support you in your job as a market manager by providing this Handbook of information and tools you’ll need to start a market from scratch or to grow your market, along with helpful links and resources, tips, and best practices for running a successful market.


Brown Thrasher (Toxostoma Rufum) Habitat Preferences In Pine Barrens, Shrublands, And Agricultural Areas In New England, Alec Woolf Jan 2024

Brown Thrasher (Toxostoma Rufum) Habitat Preferences In Pine Barrens, Shrublands, And Agricultural Areas In New England, Alec Woolf

Antioch University Dissertations & Theses

Early successional habitat and related species are in decline in the Northeastern United States. One species of shrubland bird that is declining in the northeast is the Brown Thrasher, considered a species of conservation concern in several states such as New Hampshire, Rhode Island, Connecticut, New York, Vermont, and New Jersey. However, few studies have focused on examining Brown Thrasher habitat preferences. The purpose of this study was to evaluate Brown Thrasher associations with early successional habitat adjacent to farmland, within deciduous forests, and within pine barrens. I conducted systematic point count surveys with playback to assess thrasher occupancy and …


"The Mission Of The Church In The Post-War Perspective Of Ukraine": International Theological Conference 2024, Vladyslav Fulmes Jan 2024

"The Mission Of The Church In The Post-War Perspective Of Ukraine": International Theological Conference 2024, Vladyslav Fulmes

Occasional Papers on Religion in Eastern Europe

On June 06, 2024 Volyn Orthodox Theological Academy (Lutsk, Ukraine) held an international theological conference “The Mission of the Church in the Post-war Perspective of Ukraine”. Brief information about this international scientific conference is given.


How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck Jan 2024

How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck

Undergraduate Research Posters

El-Niño Southern Oscillation (ENSO) causes regional changes in climate and has been found to have varying effects on the survival, fecundity, and recruitment of migratory songbirds. This study seeks to better understand the effect of ENSO on the fecundity of Virginia-breeding Prothonotary warbler (Protonotaria citrea; PROW), a neotropical migratory songbird. PROW breed in the Eastern United States and spend the non-breeding season primarily in Panama and Colombia. Ongoing research in Virginia has found a positive relationship between spring precipitation and predicted number of PROW fledgelings during La Niña, but the opposite during El Niño. To better understand this relationship, we …


Lycosidae Abundance And Diversity Across Lawn And Leaf Litter Substrate, Sage O. Lockett, Dan Albrecht-Mallinger Jan 2024

Lycosidae Abundance And Diversity Across Lawn And Leaf Litter Substrate, Sage O. Lockett, Dan Albrecht-Mallinger

Undergraduate Research Posters

Significant knowledge gaps exist in how land-cover impacts ground-hunting spider populations. To fill these gaps, this study investigates a common family of ground-hunting spiders, Lycosidae, to determine differences in their abundance and diversity in deciduous leaf litter and managed turfgrass (lawn). The study was conducted within a forested ecosystem at Virginia Commonwealth University's Rice Rivers Center in Charles City County, Virginia. I placed 10 belt transects (1m x 20m) on lawn substrate and 10 identical transects in deciduous forest leaf litter substrate. I performed repeated visual census via eyeshine and manual capture of up to three individuals per transect …


Identifying And Promoting Qualitative Methods For Impact Assessment, Heidi Walker, Jenny Pope, Angus Morrison-Saunders, Alan Bond, Alan P. Diduck, A. John Sinclair, Brendan Middel, Francois Retief Jan 2024

Identifying And Promoting Qualitative Methods For Impact Assessment, Heidi Walker, Jenny Pope, Angus Morrison-Saunders, Alan Bond, Alan P. Diduck, A. John Sinclair, Brendan Middel, Francois Retief

Research outputs 2022 to 2026

Qualitative methods for impact assessment (IA) represent a broad spectrum of approaches that are important for realising effective IA practice. The purpose of this paper is to identify and promote qualitative methods that are available for use in contemporary and future (next-generation) IA processes. From an extensive literature review, an international survey (145 responses), expert interviews (48 interviewees), and a workshop attended by 27 IA practitioners, 17 qualitative method categories were identified. These were further subdivided into three classes: conventional qualitative methods, highly participatory methods, and mixed methods. Each method is described, and an indication given of how each can …


Effective Land Use Classification Through Hybrid Transformer Using Remote Sensing Imagery, Muhammad Zia Ur Rehman, Syed Mohammed Shamsul Islam, Anwaar Ulhaq, David Blake, Naeem Janjua Jan 2024

Effective Land Use Classification Through Hybrid Transformer Using Remote Sensing Imagery, Muhammad Zia Ur Rehman, Syed Mohammed Shamsul Islam, Anwaar Ulhaq, David Blake, Naeem Janjua

Research outputs 2022 to 2026

Recent advances in deep learning for hyperspectral image (HSI) classification have shown exceptional performance in resource management and environmental planning through land use classification. Despite these successes, challenges continue to persist in land use classification due to the complex topology of natural and man-made structures. The uneven distribution of land cover introduces spectral-spatial variability, causing inter- and intra-class similarity. To address this issue, this study adopts a hybrid approach that combines convolutional neural networks (CNNs) and a transformer model. The technique comprises three key components: a spectral-spatial convolutional module (SSCM), a spatial attention module (SAM), and a transformer module. Each …


Trace And Rare Earth Elements Analysis Of Oligocene And Miocene Diamictites In The Cape Roberts Project, Ross Sea, Antarctica, Celina Flores Garza Jan 2024

Trace And Rare Earth Elements Analysis Of Oligocene And Miocene Diamictites In The Cape Roberts Project, Ross Sea, Antarctica, Celina Flores Garza

Theses, Dissertations and Culminating Projects

The West Antarctic Ice Sheet is a major contributor to global sea level rise, yet its origin and dynamics are poorly known. The geochemistry of 35 diamictite samples from the CRP-1 and CPR-2A cores recovered by the Cape Roberts Drilling Project in the Ross Sea, Antarctica is evaluated to understand glacial sedimentation and flow paths during the Oligocene and Miocene, a period of warmer than present climate in the past. The major hypothesis to be tested is if the early Miocene ice sheet advance was the first major West Antarctic ice advance in the Ross Sea. The provenance of older …


Predicting Radiation-Induced Immune Suppression In Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy, Jonathan Colen, Cam Nguyen, Seth W. Liyanage, Eric Aliotta, Joe Chen, Clayton Alonso, Kara Romano, Sean Peach, Timothy Showalter, Paul Read, James Larner, Krishni Wijesooriya Jan 2024

Predicting Radiation-Induced Immune Suppression In Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy, Jonathan Colen, Cam Nguyen, Seth W. Liyanage, Eric Aliotta, Joe Chen, Clayton Alonso, Kara Romano, Sean Peach, Timothy Showalter, Paul Read, James Larner, Krishni Wijesooriya

Data Science Faculty Publications

BACKGROUND: Stereotactic body radiation therapy (SBRT) is known to modulate the immune system and contribute to the generation of anti-tumor T cells and stimulate T cell infiltration into tumors. Radiation-induced immune suppression (RIIS) is a side effect of radiation therapy that can decrease immunological function by killing naive T cells as well as SBRT-induced newly created effector T cells, suppressing the immune response to tumors and increasing susceptibility to infections.

PURPOSE: RIIS varies substantially among patients and it is currently unclear what drives this variability. Models that can accurately predict RIIS in near real time based on treatment plan characteristics …