Digital Commons Network^™

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Author Correction: Single-Cell And Spatial Proteo-Transcriptomic Profiling Reveals Immune Infiltration Heterogeneity Associated With Neuroendocrine Features In Small Cell Lung Cancer, Ying Jin, Yuefeng Wu, Alexandre Reuben, Liang Zhu, Carl M Gay, Qingzhe Wu, Xintong Zhou, Haomin Mo, Qi Zheng, Junyu Ren, Zhaoyuan Fang, Teng Peng, Nan Wang, Liang Ma, Lungevity Panshi Initiative Consortium, Yun Fan, Hai Song, Jianjun Zhang, Ming Chen

Faculty, Staff and Student Publications

No abstract provided.

The Gestalt Effect Of Memory Poetry: A Response To The Cognitive Seriousness Of Literature, John R. Hart

Electronic Theses and Dissertations Archive

This project challenges the Anti-Cognitivist position that literature may have plenty to say about the world within a text, yet literature cannot contribute to knowledge outside the text. Drawing on the work of Cognitivists and others, I argue that at least one subgenre of literature—memory poetry—can deepen, enrich, and broaden areas or understanding. Indeed, there are cases where understanding may be so lacking as to only allow for us recognize how much we do not know about an experience, such as the experience of a post-traumatic flashback, at a more visceral level than the DSM-V can achieve in a clinical …

Harnessing Extrinsic Dissipation To Enhance The Toughness Of Composites And Composite Joints: A State-Of-The-Art Review Of Recent Advances, Gilles Lubineau, Marco Alfano, Ran Tao, Ahmed Wagih, Arief Yudhanto, Xiaole Li, Khaled Almuhammadi, Mjed Hashem, Ping Hu, Hassan A. Mahmoud, Fatih Oz

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Interfaces play a critical role in modern structures, where integrating multiple materials and components is essential to achieve specific functions. Enhancing the mechanical performance of these interfaces, particularly their resistance to delamination, is essential to enable extremely lightweight designs and improve energy efficiency. Improving toughness (or increasing energy dissipation during delamination) has traditionally involved modifying materials to navigate the well-known strength-toughness trade-off. However, a more effective strategy involves promoting non-local or extrinsic energy dissipation. This approach encompasses complex degradation phenomena that extend beyond the crack tip, such as long-range bridging, crack fragmentation, and ligament formation. This work explores this innovative …

Cmsi Translations #11: Mid-Life Overhaul And Upgrade Of The Type 052c Guided Missile Destroyer, Ju Lang

CMSI Translations

The construction of the Type 052C guided missile destroyer took a long time, and it was experimental in the sense of "taking small steps for rapid progress" (xiao bu kuai pao). In fact, it was also the engineering prototype of the standard fleet destroyer Type 052D. The first and second Type 052C ships were launched in April and October 2003, respectively. They were the most advanced guided missile destroyers of the PLAN at that time, but the subsequent four ships of the same type were launched in October 2010, July 2011, and January and July 2012, respectively.

Introduction 16(6) 2024: Special Issue: Emerging Scholar Research Summaries, Rosalind Latiner Raby

Journal of Comparative & International Higher Education

No abstract provided.

The Influences Of External And Sideways Factors On The Introduction Of English As A Medium Of Instruction Programs In East Asian Countries, Sainbayar Gundsambuu

Journal of Comparative & International Higher Education

No abstract provided.

Critically Examining The Mobilities Of A Critical Thinking Curriculum In Transnational Higher Education: A Case Study In West Africa, Coomerene Muilerman-Rodrigo

Journal of Comparative & International Higher Education

No abstract provided.

Cytoplasmic And Mitochondrial Calcium Influences Retinal Ganglion Cell Survival To Axon Injury, Sean Mccracken

Arts & Sciences Graduate Student Theses and Dissertations

Retinal Ganglion Cell (RGC) death is the final outcome in optic neuropathies like glaucoma and traumatic optic nerve injury, which represent the leading cause of irreversible blindness worldwide. There are currently no treatments for these diseases targeting RGCs directly, and mechanisms underlying RGC death are unclear. Calcium ion (Ca2+) dysregulation occurs in almost all neurodegenerative conditions, including glaucoma, which has been studied in rodents using a robust injury model of traumatic axon injury, optic nerve crush (ONC). However, the impact of homeostatic Ca2+ regulation in RGCs response to glaucoma or ONC is unknown. Furthermore, while some mechanisms that regulate Ca2+ …

Mechanism Of Impaired Cd8+ T Cell Activation During Ross River Virus Infection, Christopher Bullock

Arts & Sciences Graduate Student Theses and Dissertations

Ross River virus (RRV) is a mosquito transmitted virus endemic to Australia that infects humans and causes acute symptoms of rash, fever, myalgia, and fatigue. Although systemic viral infection subsides within a few weeks, joint pain lingers in many patients for months. Active viral replication is not readily detected in this chronic phase, although persistent viral RNA has been found in the synovial fluid of patients. This can be studied in mice, which can be productively infected with RRV when inoculated in the foot. Like in humans, in the chronic phase of disease, viral RNA is still present in the …

Promoting The Use Of Suicide Prevention Mobile Applications Among Clinicians To Reduce Suicide & Suicidal Behaviors In Adults Aged 18-45, Papetua Jepkoech Kimutai

Doctoral Dissertations and Projects

Suicide among adults aged 18-45 has increased significantly and has become a challenge to public health worldwide. The purpose of this scholarly project was to promote the use of suicide prevention mobile applications by clinicians to reduce suicide and suicidal behaviors among adults (18-45 years old). Safety Plan suicide prevention mobile app was used in addition to the standard method of preventing suicide. A quasi-experimental design was conducted to promote a suicide prevention mobile app in clinical practice. The clinician participants included three family nurse practitioners (FNPs) and five psychiatric mental health nurse practitioners (PMHNPs)The data were collected using pre …

Parents' Perceptions On The Impact Of Recreation On Emotion Regulation In At-Risk Youth, Latasha Harvey

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to examine the thoughts, attitudes, experiences, and beliefs of parents of at-risk youth participating in inner-city neighborhood programs regarding the use of fitness, sports, and cultural arts in recreation to attain emotion regulation. The self-determination theory, developed by Ryan and Deci (2017), guided this study. The theory is based on the principle that individuals possess the ability to think logically, manage their emotions, and judge optimistically. The central research question for this case was How do parents view involvement in recreation for at-risk youth as it pertains to emotional development? The study design …

A Review Of Education Policies And Their Impact On Gang Participation For Youth, Sarah Sanders

Doctoral Dissertations and Projects

Youth have suffered from gang violence in schools and neighborhoods at different rates per the Concentric Zone Model and the Strain theory. Gang violence is a concern for Little Rock, Arkansas. This study will follow the Concentric Zone Model and the Strain theory for data collection and evaluate the extent of gang violence linked to education in response to Zero-Tolerance policies for the Little Rock School District (LRSD) and Pulaski County Special School District (PCSSD), showing a holistic explanation of crime. This study will review secondary data from LRSD, PCSSD, and local law enforcement agencies to cross-reference reports of concerns …

Biblically-Based Songs: Agents Of Healing For Women Overcoming Rejection, Michal Rivera

Doctoral Dissertations and Projects

The purpose of this study is to examine how biblically-based songs can serve as aids to women who have overcome or are overcoming rejection. The research employs a hermeneutic phenomenological approach, in which interviews, in vivo coding, reflection, interpretation, and biblical analysis explore how biblically-based songs provide or have provided aid to Christian Hispanic Women. Interviews question women about their experiences and how they cope with rejection, the importance of the Word of God, and biblically-based songs, capturing the history and healing process and transformation of the participants. Worship leaders and worship ministries will be educated, exhorted, and challenged in …

The Soil Test: Facilitating Increased Receptivity To Spiritual Formation In A Large Church Through Education, Motivation, And Resources, Rosemary Moore

Doctoral Dissertations and Projects

Decades of recent research and writing about spiritual formation and discipleship assume that there will be growth in spiritual maturity if churches have more models and biblical information. However, the literature addresses the wrong problem; it presupposes that the church is ready for spiritual formation. In their efforts to facilitate it, those trying to help the church are like the farmer who sows seed onto unprepared soil. Good seeds, such as discipleship groups, are sown into the soil of the church without paying attention to whether the soil can produce a harvest. The project posited that five conditions should be …

Parental Phubbing And Adolescent Social Anxiety, Julie Ann Bowman

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to explore how parents experience social anxiety in their children, of ages six to fourteen, in the presence of parental phubbing. The modified version of Moustakas’ modified version of Stevick-Colaizzi-Keen’s analysis method was used to gather and analyze data. Participant requirements included being at least 21 years of age, having a child between the ages of 6-14, own a cell phone with texting and internet capabilities, and speak English fluently. Fifteen participants were used, however, data saturation was found by the ninth participant. This study explored two research questions: How do parents …

The Power And Purpose Of Intercessory Prayer: Equipping And Educating The Leaders Of Divine Providence Ministries Through An Intercessory Prayer Course, Tammanica S. Muse

Doctoral Dissertations and Projects

Intercessory prayer is a selfless act where believers pray to God on behalf of others, asking for His intervention. This type of prayer is a vital part of Christian life rooted in the example of Jesus, who intercedes between God and humanity. Jesus models the role of intercessor, reconciling mankind to God through His sacrifice. Believers are called to follow this example and pray for others regularly. This DMin research project examines the issue of leaders lacking a comprehensive understanding of prayer's purpose, power, and connection to intimacy with God. It also investigates why some leaders abandon prayer when faced …

Hormone Therapy Among Women Within A Clinical Setting: Health Literacy And Teach Back Method To Increase Understanding Of Potential Benefits And Risks Of Treatment, Mariah L. Petersen

Doctoral Dissertations and Projects

The purpose of this project was to examine hormonal therapy among women between the ages of 40 and 55 within a clinical setting. This project assessed women’s understanding of hormonal therapy for various treatments as well as the risks. The intervention utilized the teach-back method. The project also included the 10 essential elements the provider needs to be competent in the teach-back method. A pre- and post-test were given to patients to measure improvement of knowledge and understanding. The goal is to improve patients’ understanding of these treatments and to help them ask questions if they do not fully understand …

United In Purpose: Establishing Community Partnerships Amongst District-Level Music Education Programs And After-School Music Organizations In Delaware, Malcolm S. Richardson

Doctoral Dissertations and Projects

Despite the benefits of Music Education Programs in Delaware, there was a critical need to build community partnerships to enrich the music learning experience for all participants. This research explored implementing change by connecting with community leaders and organizations. It gathered perspectives from music educators, students and their parents, school administrators, community organization leaders, and after-school program directors. A qualitative, programmatic evaluative approach was applied to examine the impact of these community partnerships between district-level music programs in Delaware. The study addressed the purpose and framework of alliances, the need for establishing and maintaining them, and potential barriers to sustainable …

Title I Music Programs In Tennessee: Administrative Decisions In Allocated Funding, Aisha R. Allen

Doctoral Dissertations and Projects

The study of this project overviews a qualitative research study on the lack of funding for music education programs through allocated funding for Title I schools. The research reflects the choices made by the administration in different Title I schools and how these funds are applied. Classroom resources needed to develop these music education classes include performance equipment, instruments, and more. The state of Tennessee allocates a certain amount of funding for every school. However, most of these funds are used for testing, leaving the remainder of the funds available for music programs. Because the administration controls the funds, music …

Understanding Perceptions Of Lived Transition Experiences Of Supplemental Instruction Leaders At A Historically Black University, Cecil Wayne Mayhall

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand perceptions of lived transition experiences for supplemental instruction (SI) leaders at a large public historically Black research university in the Southeastern United States. Using the transition theory of Schlossberg et al. as a theoretical framework, this study attempted to answer the central research question: How do supplemental instruction (SI) leaders at a large public historically black research university in the Southeastern United States perceive their lived transition experiences? Sub-questions attempted to address participants' perception of the situation, self, support, and strategies when moving in, through, and out of, the SI …

The Commonwealth Of Israel: Overcoming The Doctrinal Divide Of Dispensationalism And Covenantalism Through Understanding Pauline Theology, Luke Newton Schier

Doctoral Dissertations and Projects

Beginning in the early part of the twentieth century, a notable theological schism began to emerge within mainstream Christianity which continues to divide evangelicals in the twenty-first century. Accordingly, adherents from both sides have systemized their theologies and developed labels to define their positions. New labels continue to evolve and change as sub-groups emerge into the conversation. Typically, the labels of dispensationalism and covenantalism are employed to identify the differing views; although covenantalism is also referred to as Reformed theology, replacement theology, or supercessionism. More recently, other labels have emerged such as progressive dispensationalism and progressive covenantalism as theologians strive …

Implementation Strategies To Improve Medication Adherence In Adolescents (Aged 13 To 17 Years) With Antipsychotic Induced Weight Gain: Educational Toolkit For Clinicians, Joy Asike

Doctoral Dissertations and Projects

Nonadherence to medication leads to relapses of condition, frequent hospitalization and poor outcomes. Although antipsychotics are effective in the management of mental disorders and psychosis, the side effects, especially weight gain negatively influence medication compliance. Anti-psychotics related to weight gain is one of the most concerning treatment-emergent side leading to a great burden on patients, parents, and clinicians. Obesity and antipsychotic-related weight gain increase the risks to short- and long-term physical health problems such as metabolic syndrome, dyslipidemia, diabetes, hypertension. Evidence has shown that there is generally low guideline adherence regarding the monitoring of antipsychotics, especially in children and adolescents. …

Analyzing Errors Across Nonword Repetition Tasks For Clinical Utility Among Children Who Speak African American English, Tatum Carver-Dews

LSU Master's Theses

Purpose

Within the context of African American English (AAE), this study aimed to examine the clinical utility of three different types of NWR tasks to differentiate children with Developmental Language Disorder (DLD) from those who are typically developing (TD), by percentage of phonemes correct (PPC) and by type of error (e.g., consonants or vowels; omissions or substitutions). Additionally, this study allowed for examination of the relationship between the children’s NWR performance and their density of dialect-specific forms.

Methods

The data came from 50 kindergarteners (25 females, 25 males) who had participated in a multi-year study of childhood DLD within the …

Epilepsy Therapies Symposium | Do We Really "Outgrow" Seizures?, Adam Ostendorf, Genna J Waldman, Lara Jehi, Mohammed Ilyas, Dean Naritoku, Alica M Goldman

Faculty, Staff and Students Publications

Initiation and maintenance of antiseizure therapy can be relatively straightforward in most patients. Depending on epilepsy type, patients may be more or less likely to enter remission or a resolution of their epilepsy and the International League Against Epilepsy developed clinically guiding definitions in this regard. The mechanisms by which resolution or remission are achieved are poorly understood which complicates clinical decision making and risk estimate for future seizure relapse. The impetus for the maintenance of medical therapy in a seizure-free patient is also age-dependent. In children, one ought to consider the unknown effects of antiseizure medications on the developing …

Il-12 Encoding Ondv Synergizes With Car-T Cells In Orthotopic Models Of Non-Small Cell Lung Cancer, Amanda Rosewell Shaw, Daisuke Morita, Caroline E Porter, Eric Tu, Greyson W Biegert, Sonia Agrawal, Nicholas Durham, Malcolm K Brenner, Masataka Suzuki

Faculty, Staff and Students Publications

Systemic administration of oncolytic viruses (OVs) is a promising approach for targeting metastatic solid tumors, but their anti-tumor activity is limited by pre-existing neutralizing antibodies against common human viruses. Therefore, investigators have developed OVs derived from non-human host viruses. Successful implementation of this strategy requires that the viral vector selectively infects and replicates within human cancer cells. Newcastle disease virus (NDV) is an avian paramyxovirus that, as NDV-based OVs (oNDVs), has demonstrated safety and activity against multiple human tumors in clinical trials. Their use as a single agent, however, is insufficient to cure tumors. Similarly, chimeric antigen receptor-modified T cells …

Quinoline-Based Compounds Can Inhibit Diverse Enzymes That Act On Dna, Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K Jain, Xing Zhang, Robert M Blumenthal, Taiping Chen, Yang Gao, Sergio Valente, Antonello Mai, Xiaodong Cheng

Faculty, Staff and Students Publications

DNA methylation, as exemplified by cytosine-C5 methylation in mammals and adenine-N6 methylation in bacteria, is a key epigenetic process. Developing non-nucleoside inhibitors to cause DNA hypomethylation is crucial for treating various conditions without the toxicities associated with existing cytidine-based hypomethylating agents. This study characterized fifteen quinoline-based analogs, particularly compounds with additions like a methylamine (9) or methylpiperazine (11), which demonstrate similar low micromolar inhibitory potency against human DNMT1 and Clostridioides difficile CamA. These compounds (9 and 11) intercalate into CamA-bound DNA via the minor groove, causing a conformational shift that moves the catalytic domain away from the DNA. This study …

Platelets On Fire During Chemotherapy, K Vinod Vijayan

Faculty, Staff and Students Publications

No abstract provided.

Age-Related Tfeb Downregulation In Proximal Tubules Causes Systemic Metabolic Disorders And Occasional Apolipoprotein A4-Related Amyloidosis, Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Hideaki Kawai, Isao Matsui, Tadashi Yamamuro, Ryuya Edahiro, Seiji Takashima, Akira Takasawa, Yukinori Okada, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

Duncan NRI Faculty and Staff Publications

With the aging of society, the incidence of chronic kidney disease (CKD), a common cause of death, has been increasing. Transcription factor EB (TFEB), the master transcriptional regulator of the autophagy/lysosomal pathway, is regarded as a promising candidate for preventing various age-related diseases. However, whether TFEB in the proximal tubules plays a significant role in elderly patients with CKD remains unknown. First, we found that nuclear TFEB localization in proximal tubular epithelial cells (PTECs) declined with age in both mice and humans. Next, we generated PTEC-specific Tfeb-deficient mice and bred them for up to 24 months. We found that TFEB …

Health Equity Innovation In Precision Medicine: Data Stewardship And Agency To Expand Representation In Clinicogenomics, Patrick J Silva, Vasiliki Rahimzadeh, Reid Powell, Junaid Husain, Scott Grossman, Adam Hansen, Jennifer Hinkel, Rafael Rosengarten, Marcia G Ory, Kenneth S Ramos

Center for Medical Ethics and Health Policy Staff Publications

Most forms of clinical research examine a very minute cross section of the patient journey. Much of the knowledge and evidence base driving current genomic medicine practice entails blind spots arising from underrepresentation and lack of research participation in clinicogenomic databases. The flaws are perpetuated in AI models and clinical practice guidelines that reflect the lack of diversity in data being used. Participation in clinical research and biobanks is impeded in many populations due to a variety of factors that include knowledge, trust, healthcare access, administrative barriers, and technology gaps. A recent symposium brought industry, clinical, and research participants in …