Digital Commons Network^™

Enrollment Of Females In Randomized Trials For Glucagon-Like Peptide 1 Receptor Agonists: A Systematic Review, Frederick Berro Rivera, Mc John Caro Ybañez, John Vincent Magalong, Mario Prado, Eloise Arias Aguirre, Ana Patricia Ting Cañares, Janos Marc Rubia, Allyn Ralph Hiyas, Polyn Luz S. Pine, Kyla Lara-Breitinger, Francisco Lopez-Jimenez, Martha Gulati

Ateneo School of Medicine and Public Health Publications

Background

Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.

Objectives

The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.

Methods

We reviewed eligible studies and extracted important variables. The proportion of females among the total participants was obtained per study. This was compared over time (year) of publication and over mean age of participants. This proportion was also compared between specific types of GLP-1RA received, diabetes status, indication of …

Kwon, H. (2024) Language Brokers: Children Of Immigrants Translating Inequality And Belonging For Their Families. Stanford University Press., Jeffrey Cabusao

History and Social Sciences Faculty Journal Articles

No abstract provided.

Interactional Ordering: Reconstructing Lon Fuller's Theory Of Private Law, Shyamkrishna Balganesh

Faculty Scholarship

While Lon Fuller is best remembered for his contributions to the fields of general jurisprudence and contract law, his work in each has long been seen as unrelated to the other. This Article shows that in a significantly underappreciated body of work, Fuller did connect the two and, in the process, developed the outlines of a robust theory of private law, best characterized as “interactional ordering.” Driven by Fuller’s efforts to develop a jurisprudence of form that was derived from conventionalism and natural law thinking, interactional ordering sees all normativity as originating in horizontal interactions between individuals in society, seeking …

Individual Dynamic Prediction For Cure And Survival Based On Longitudinal Biomarkers, Can Xie, Xuelin Huang, Ruosha Li, Alexander Tsodikov, Kapil Bhalla

Faculty, Staff and Student Publications

To optimize personalized treatment strategies and extend patients' survival times, it is critical to accurately predict patients' prognoses at all stages, from disease diagnosis to follow-up visits. The longitudinal biomarker measurements during visits are essential for this prediction purpose. Patients' ultimate concerns are cure and survival. However, in many situations, there is no clear biomarker indicator for cure. We propose a comprehensive joint model of longitudinal and survival data and a landmark cure model, incorporating proportions of potentially cured patients. The survival distributions in the joint and landmark models are specified through flexible hazard functions with the proportional hazards as …

Efficacy And Feasibility Of Intradialytic Plantar Electrical Stimulation In Patients With Diabetes: A Randomized Double-Blind Controlled Trial, Myeounggon Lee, Abdullah Hamad, Mehrnaz Azarian, Jaewon Beom, Abderrahman Ouattas, Mohammad Dehghan Rouzi, Naima Rodriguez, Nhi Quach, Rania Ibrahim, Mincy Mathew, Talal Talal, Fadwa Al-Ali, Bijan Najafi

Center on Aging Staff Publications

Objective: This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis sessions, aiming to improve mobility in patients with diabetes by providing a connection between E-Stim and enhanced mobility with minimal patient effort required.

Research design and methods: Participants aged ≥18 years with diabetes undergoing hemodialysis and able to walk at least 10 m with or without aid were recruited and divided into an intervention group receiving 1-h intradialytic E-Stim three times a week and a control group using an identical nonfunctional device for 12 weeks. Gait, physical activity, patient-reported …

Spine Mobilization Vs Manipulation: Effects On Neck Pain, Alfredo Loreto

Loma Linda University Electronic Theses, Dissertations & Projects

Several studies have found an association between cervical spinal mobilization (CSMob) and cervical spinal manipulation (CSM) on pain perception, disability, and satisfaction. However, choosing the proper technique continues to be a challenge for many practitioners. The purpose of this study was to clarify the discrepant evidence regarding the efficacy of a CSMob versus a CSM intervention as compared to a control group – hands-off, and patient education (PE) in isolation. 36 subjects with acute and non-specific mechanical neck pain were randomly assigned to one of 3 groups (CSMob, CSM, or control). Outcome measures using the Neck Disability Index (NDI), Numeric …

Microplastic Degradation Compared Among Dated Salton Sea Strandlines, Maria Alejandra Roman Medrano

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis investigates the environmental degradation of plastic materials, with a focus on polyethylene terephthalate (PET), through a multi-phase study conducted at the Salton Sea, a closed-basin lake in a semi-arid region of California. The research addresses three core objectives: (1) developing a microplastic (MP) extraction method tailored for clay-rich sediments, (2) characterizing surface degradation of various plastic types, including PET, BoPET, HDPE, LDPE, and EPS, using advanced microscopy and spectroscopy, and (3) examining the long-term weathering of PET through samples collected from dated lake strandlines.

The extraction protocol successfully isolates MPs without oxidation, using ZnCl₂ and extended soaking to …

Contesting And Controlling Abortion In China’S Courts, Molly Bodurtha, Benjamin L. Liebman, Li Chenquian, Xiaohan Wu

Faculty Scholarship

The decision of the United States Supreme Court in Dobbs v. Jackson Women’s Health Organization has brought renewed global attention to how legal systems protect and restrict women’s reproductive autonomy. Central themes have included how the rollback of reproductive rights in the United States coincides with the judiciary’s embrace of a broader “jurisprudence of masculinity” and the relationship between abortion restrictions and authoritarianism, as multiple countries have enacted restrictive measures while undergoing democratic backsliding.

Yet, the scholarly conversation on abortion, democracy, and how courts reflect and entrench gender disparities entirely omits China — the largest authoritarian state and a country …

“The Wonderful Improvement”: Landscape And Morals In Jane Austen’S Mansfield Park, Montanah Middleton

Honors Theses

This thesis examines how Jane Austen uses depictions of landscapes and estates in her novel Mansfield Park to explore questions of morality, comment on society, and explore humanity's relationship with the natural world. While previous scholarship has analyzed Austen's symbolic use of places like Sotherton and Mansfield Park itself, this study provides a more comprehensive investigation by closely reading the descriptions and judgments passed on two other estates featured in the novel not analyzed by the scholarship explored. Developing a nuanced definition of "landscape,” the analysis is grounded in Austen's verbal depictions that imbue the physical settings with moral significance. …

A Rose By Any Other Name: Impressionism As Definition And Aesthetic In The Music Of Claude Debussy, Erin Smith

Honors Theses

The premiere of Parisian composer Claude Debussy’s Prélude à l’après-midi d’un faune created a link between his music and the artistic Impressionism movement, which began in 1874 as a rejection of Realism. Musical Impressionism, initially an ill-fitting title, would gradually shift to encompass the compositional techniques of Debussy, and would also inspire new musical styles as a rejection of musical Impressionism. This project compares the defining features of Impressionism across artistic mediums, analyzes Debussy's music in relation to Impressionist painting, and examines his resistance to the label within a broader dialogue on evoking sensation through abstract forms. In doing so, …

A Linguistic Analysis Of The Language Surrounding Witchcraft In France From The 16th To 20th Centuries, Kaleigh Landers

Honors Theses

While the history of witchcraft in France is a subject that has received significant scholarly attention, little research has been conducted on the linguistic implications of the language used in regard to the subject. This study attempts to analyze the texts written about witchcraft between the 16^th and 20^th centuries in order to draw conclusions as to how language and culture affect each other. The aim of this study was to conduct a discourse analysis of these texts to identify cultural connotations, language trends, and insights regarding how the French language has evolved to communicate complex, dividing concepts …

Law And Equity On Appeal, Aaron-Andrew P. Bruhl

Faculty Publications

Most lawyers know that the Federal Rules of Civil Procedure merged the divergent trial procedures of the common law and of equity, but fewer are familiar with the development of federal appellate procedure. Here too there is a story of the merger of two distinct systems. At common law, a reviewing court examined the record for errors of law after the final trial judgment. In the equity tradition, an appeal was a rehearing of the law and the facts that aimed at achieving justice and did not need to await a final judgment. Unlike the story of federal trial procedure, …

Redressing Judicial Misbehavior: An Integrated Approach To Judicial Immunity, Nancy Amoury Combs

Faculty Publications

Immunities generate intense public interest and controversy. Whether it is the sweeping presidential immunity that former President Trump has claimed or the qualified immunity that rogue police invoke to evade financial responsibility for their brutality, immunities stand as a highly contested aspect of the American legal system. Judicial immunity incites similar controversy. American judges possess absolute immunity from civil suits for their judicial acts, so victims are barred from seeking civil compensation, even against judges who engage in purposeful or malicious misconduct from the bench. For decades scholars have sought to curtail absolute judicial immunity, but they have overlooked a …

External Validation Of The Epic Sepsis Predictive Model In 2 County Emergency Departments, Daniel G Ostermayer, Benjamin Braunheim, Amit M Mehta, Jeremy Ward, Sara Andrabi, Anwar Mohammad Sirajuddin

Faculty, Staff and Student Publications

Objective: To describe the diagnostic characteristics of the proprietary Epic sepsis predictive model best practice advisory (BPA) alert for physicians in the emergency department (ED).

Materials and methods: The Epic Sepsis Predictive Model v1.0 (ESPMv1), a proprietary algorithm, is intended to improve provider alerting of patients with a likelihood of developing sepsis. This retrospective cohort study conducted at 2 county EDs from January 1, 2023 to December 31, 2023 evaluated the predictive characteristics of the ESPMv1 for 145 885 encounters. Sepsis was defined according to the Sepsis-3 definition with the onset of sepsis defined as an increase in 2 points …

Implementing And Assessing Climate Change Education In A Pediatrics Residency Curriculum, Mark Mcshane, Shelley Kumar, Linessa Zuniga

Center for Medical Ethics and Health Policy Staff Publications

Background For physicians to effectively combat the growing health crisis that is climate change, they should begin learning during medical training about its health implications. However, there is little data on residents' knowledge of the climate crisis, and even less data regarding the effectiveness and acceptability of climate change education in graduate medical training programs. Objective To incorporate a new educational session on the health implications of climate change into a residency curriculum and evaluate the acceptability of the session and its effects on residents' knowledge, attitudes, and perceptions of the topic.

Methods In July 2021, a 90-minute, interactive, small-group …

Incorporating An Analytical Approach To Ethical Reasoning Into An Ethics Case Conference For Residents, Holland Kaplan, Alyssa Kahl, Jonathan Lim

Center for Medical Ethics and Health Policy Staff Publications

Educating residents to apply ethical principles in clinical practice is critical in achieving standards in professionalism. We implemented biweekly ethics morning report case conferences incorporating a validated analytical tool in medical ethics, the Four-Box Method, from July 2022 to June 2023 in our internal medicine residency program. In 24 ethics morning reports, over 73% of participants reported that the intervention helped them achieve each of three learning objectives in ethics education. Ninety-two percent of cases addressed > 1 ethical issue. Our intervention may be easily integrated into the morning report conference structure as an educational tool in medical ethics across internal …

Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

Methods: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.

Results: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10-8). Subgroup-specific analyses identified a haplotype on chromosome 14 including PSEN1 associated with AD in Hispanics, further supported by aggregate testing of rare coding and non-coding variants in the region. Common variants in LINC00320 were observed associated with AD in Black individuals (p = 1.9 × 10-9). Finally, we observed rare non-coding variants in the promoter of TOMM40 distinct of APOE in pooled-population analyses (p = 7.2 × 10-8).

Discussion: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.

Highlights: We determine the association of genetic variants with Alzheimer's disease (AD) using …

Perceived Barriers And Facilitators Of Behavioral-Health Modality Change Adoption During The Covid-19 Pandemic: A Systematic Review, Nicholas Sims-Rhodes, Hannah E. Cornwell, Emily Barena, Vandy C. Dubre, Kimberly S. Elliott, Eman H. Nabulsi, Nelly Yuen, Sarah Sass, Anastasia Miller, Yordanos M. Tiruneh, Karan P. Singh

Presentations and Publications

Introduction: During the Coronavirus Disease 2019 pandemic, there was a surge in demand for mental health services worldwide, presenting challenges for healthcare institutions as they navigated changes in policy and safety regulations. In the United States, this resulted in many behavioral health modality changes to remain in compliance with the Center for Disease Control guidelines. A growing body of literature has documented these, yet few explored barriers and facilitators affecting the adoption of these modality delivery changes. The researchers conducted a systematic review using the PRISMA method, focusing on service delivery changes across healthcare systems in the United States from …

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Laundry Program Evaluation, Jacen Greene, Sandra Comstock, Marisa Zapata

Homelessness Research & Action Collaborative Publications and Presentations

Nearly 4,000 people were reported as experiencing unsheltered homelessness in Multnomah County in 2023 (Theriault, Roots & Okeke, 2023). Studies by the Homelessness Research and Action Collaborative (HRAC) at Portland State University and other researchers have identified an urgent need for free laundry services among people experiencing unsheltered homelessness in the Portland region. A lack of access to clean laundry is associated with negative impacts on mental and physical health, as well as environmental impacts from wet or dirty textiles that are discarded rather than being reused.

In an attempt to address these and other issues, the City of Portland …

Front Matter - Jaepl - Volume 29, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

Front Matter. List of Board of Directors and List of Editors.

Introduction: The Confusion Of In-Between, Wendy Ryden

The Journal of the Assembly for Expanded Perspectives on Learning

Introduction to Volume 29 of JAEPL. The Confusion of In-Between by JAEPL Editor, Wendy Ryden.

Remembering James Moffett: An Interview And Dialogue With Sondra Perl, Sheridan Blau, Sondra Perl

The Journal of the Assembly for Expanded Perspectives on Learning

Teachers reading these descriptions of Moffett’s teaching are likely to find in them models they too will be inspired to adapt for use in their own writing classrooms, wherever they teach.

Moffett's Corner Introduction, Stephen Lafer, Jonathan M. Marine

The Journal of the Assembly for Expanded Perspectives on Learning

In this special edition of Moffett’s Corner, Sheridan Blau, former Professor of Practice in the teaching of English at Teachers College, Columbia University interviews the noted composition theorist Sondra Perl in order to solicit her memories of the late James Moffett.

Scholarship As A Source Of Innovation/Inspiration, Curtis Porter

The Journal of the Assembly for Expanded Perspectives on Learning

Introduction to Book Reviews: Scholarship as a Source of Innovation/Inspiration

Creative Reading: Using Poetic Inquiry In Research And Teaching, Clancy Ratliff, Abdullah Al Musayeb, Barja Islam, Mithila Mumtaz, Rosol Otear, Simon Richard, Noah Smith, Nuzhat Tarannum, Allyssa Veney

The Journal of the Assembly for Expanded Perspectives on Learning

Creative Reading: Using Poetic Inquiry in Research and Teaching:

Essay and Poetry.

Strom, Kathryn J. And Adrian D. Martin. Becoming-Teacher: A Rhizomatic Look At First-Year Teaching. Sense Publishers, 2017, 138 Pages., Iwona Ionescu

The Journal of the Assembly for Expanded Perspectives on Learning

Becoming-Teacher: A Rhizomatic Look at First-Year Teaching - A Review

Adare-Tasiwoopa Ápi, Sierra And Nathan K. Silva. Gamification In Higher Education: A How-To Instructional Guide. Routledge, 2024, 252 Pages., Willa Swift Black

The Journal of the Assembly for Expanded Perspectives on Learning

Gamification in Higher Education: A How-to Instructional Guide - A Review

The Role Of Government Assistance, Housing, And Employment On Postpartum Maternal Health Across Income And Race: A Mixed Methods Study, Chelsea L. Kracht, Kelsey O. Goynes, Madison Dickey, Briasha Jones, Emerson Simeon, Jada Butler, Maryam Kebbe, Kaja Falkenhain, Emily W. Harville, Elizabeth F. Sutton, Leanne M. Redman

Clinical Research Faculty Publications

Background: Stressful large-scale events, such as the COVID-19 pandemic and natural disasters, impact birthing individuals’ postpartum experiences and their mental health. Resultant changes in government assistance, housing, and employment may further exacerbate these impacts, with differences experienced by varying income levels and races. This study aimed to examine maternal depression and anxiety in postpartum individuals by income and race during a stressful large-scale event, and the mediating role of government assistance, housing, and employment. Methods: An explanatory sequential mixed methods study was conducted (QUANT + QUAL). For aim 1 (quantitative), birthing individuals who delivered during peak pandemic (June 2020 - …

Precision Prognostics For Cardiovascular Disease In Type 2 Diabetes: A Systematic Review And Meta-Analysis, Abrar Ahmad, Lee Ling Lim, Mario Luca Morieri, Claudia Ha Ting Tam, Feifei Cheng, Tinashe Chikowore, Monika Dudenhöffer-Pfeifer, Hugo Fitipaldi, Chuiguo Huang, Sarah Kanbour, Sudipa Sarkar, Robert Wilhelm Koivula, Ayesha A. Motala, Sok Cin Tye, Gechang Yu, Yingchai Zhang, Michele Provenzano, Diana Sherifali, Russell J. De Souza, Russell J. De Souza, Deirdre Kay Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo

Clinical Research Faculty Publications

Background: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcomes were reported for 321 biomarker studies, 48 genetic marker studies, and 47 risk score/model studies. Results: Out of all evaluated biomarkers, only 13 showed improvement in prediction performance. Results of pooled meta-analyses, non-pooled analyses, and assessments of improvement in prediction performance and risk of …