Digital Commons Network^™

Pmp2+ Scs Maintain The Survival And Functioning Of Large-Caliber Motor Axons, Mikolaj Kozlowski

Arts & Sciences Graduate Student Theses and Dissertations

Neurodegenerative diseases are characterized by selective neuronal vulnerability, a phenomenon in which a specific pathology induces the death of a particular subpopulation of neurons. For example, selective neuronal vulnerability in the peripheral nervous system results in sensory, motor, or mixed peripheral neuropathies. While the intrinsic differences between neuronal subtypes cannot fully explain the basis of selective neuronal vulnerability, it is plausible that it partially stems from neuron extrinsic mechanisms such as the malfunction of distinct Schwann cell (SC) subtypes. Recently, we identified an exciting subpopulation of myelinating SCs characterized by the expression of Adamtsl1, Cldn14, and Pmp2 (hereafter referred to …

Next-Generation Compositional And Chronological Sample Analysis Of Lunar Low-Ti Basalts And Volcanic Glasses, Christopher Yen

Arts & Sciences Graduate Student Theses and Dissertations

The Moon, our celestial satellite, has been a source of awe and inspiration persistent through the course of humankind’s existence. Scientific exploration of the Moon began with terrestrial observations, and since the dawning of the space age has accelerated alongside technological advancements. Analysis of lunar samples has marked the remarkable advancement of our knowledge of not just our Moon, but also the formation and evolution of Earth and planetary bodies. Beginning with the Apollo program, human exploration has returned samples from the Moon that allow sophisticated laboratory studies that led to the development of major theories in the field of …

Participatory Longitudinal Qualitative Interview Study To Understand Autistic Gynaecological And Obstetric Health: The Autism From Menstruation To Menopause Study Protocol, Amy Brown, Kathryn Williams, Aimee Grant, Gemma L. Williams, Harriet Axbey, Abigail Wilkins, Ellen Firth, Hazel Lim, Helen Cave, Christina Nicolaidis, Multiple Additional Authors

School of Social Work Faculty Publications and Presentations

Autism is a lifelong minority neurotype present from birth. There is a dearth of credible evidence to suggest gender variation in Autism prevalence, despite historical under-diagnosis of women. Autistic people Assigned Female At Birth (AFAB) have worse physical and mental health compared with non-Autistic peers. To date, the reproductive health experiences of Autistic AFAB people have been under-investigated.Methods and analysis This study aims to co-develop a quality improvement intervention to improve the reproductive health of Autistic people. The study uses Community Partnered Participatory Research (an approach similar to Community-Based Participatory Research), largely through a Community Council that co-governs the study. …

Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni

Faculty, Staff and Students Publications

Therapeutic strategies targeting the DNA damage response, such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have revolutionized cancer treatment in tumors deficient in homologous recombination (HR). However, overcoming innate and acquired resistance to PARPi remains a significant challenge. Here, we employ a genome-wide CRISPR knockout screen and discover that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhances sensitivity to PARPi in HR-proficient ovarian cancer cells. We show that silencing or pharmacological inhibition of UBA1 sensitizes multiple cell lines and organoid models to PARPi. Mechanistic studies uncover that UBA1 inhibition not only impedes HR repair to sensitize cells to PARP inhibition …

Evaluation Of An Artificial Intelligence-Based Intraocular Lens Calculator: Ai-Based Iol-Optimized Formula, Li Wang, Hendrik Burwinkel, Nicolas Bensaid, Douglas D Koch

Faculty, Staff and Students Publications

Purpose: To evaluate the ZEISS AI IOL Calculator (ZEISS AI) and compare its accuracy in refractive prediction to the Barrett Universal II (BUII) and Kane formulas.

Setting: Cullen Eye Institute, Baylor College of Medicine, Houston, TX.

Design: Retrospective case series.

Methods: The ZEISS AI IOL Calculator (ZEISS AI) is an artificial intelligence (AI) based IOL-optimized formula. The refractive prediction errors (PEs) were calculated in the entire dataset and subgroups of short eyes (axial length (AL) ≤ 22.5 mm) and long eyes (AL ≥ 25.0 mm). The standard deviation (SD), root-mean-square absolute error (RMSAE), mean absolute error (MAE), median absolute error …

The Teacher Mental Health Crisis: A Mixed Methods Examination Of The Factors Contributing To Teacher Burnout, Minerva Carrasco

Masters Theses (Archived)

For decades, teachers' mental health and burnout have been an issue nationwide (Sewell, 1971). This has been an even larger struggle in the education field in recent years because turnover is high, the COVID-19 pandemic, and districts are struggling to find ways to retain teachers to stay in their profession. There are things that administrators and teachers can do to guide districts to ensure that teachers are comfortable in their classrooms and their school campus. There are coping strategies that teachers can do to prevent teacher mental health and burnout and there are ways that administrators can support their teachers …

“It’S Not Just Finding Them A Job”, (Re) Imagining Meaningful Employment And Economic Inclusion Among Forced Migrants: Narratives From Service Providers, Hanna Haran, Yesenia Alvarez Padilla, Jaclyn Kirsch, Arati Maleku

Online Journal for Workforce Education and Development

Refugees and other forced migrants encounter numerous obstacles in securing employment that match their skills and qualifications. Building upon existing migration literature that explores integration into the United States labor market, this study investigates economic inclusion and the challenges and opportunities newcomers face in obtaining meaningful employment and utilizing their past education and work experience. We collected data through one-on-one interviews with service providers and community leaders (N = 11) engaged in refugee and forced migrant employment support, with over half (54.4%) identifying as migrants themselves. Data was analyzed using grounded theory techniques. The analysis yielded five overarching themes: (1) …

Comprehensive Guide For Cte Teachers: Implementing Functional Behavioral Assessments And Individualized Behavior Support Plans For Students With Intellectual And Developmental Disabilities, Hannah Martinez-Davenport, Debra Heban, Dawn Sandt

Online Journal for Workforce Education and Development

The training and requirements for initial licensure of Career and Technical Education (CTE) teachers exhibit considerable variation across states, potentially resulting in a limited familiarity with high-impact special education practices among CTE educators. Two critical practices within this domain are the conduct of Functional Behavior Assessments (FBAs) and the design of Individualized Behavior Support Plans (IBSPs). The FBA process entails a thorough, team-based approach to data collection and analysis aimed at identifying the underlying causes of behaviors that impede a student with a disability from achieving academic, social, emotional, and vocational objectives. Based on the insights derived from the FBA, …

Book Review: Decentering Whiteness In Libraries: A Framework For Inclusive Collection Management, Andrea Jamison, Shala K. Howell

School of Information Student Research Journal

No abstract provided.

Provocative And Problematic: The Complicated Legacy Of Chain-Gang All-Stars, Shweta Sinha

Journal of Critical Race and Ethnic Studies

No abstract provided.

Book Review: The Sociology Of Cardi B: A Trap Feminist Approach, Dominique Dillard

Journal of Critical Race and Ethnic Studies

No abstract provided.

Creating Spaces To Shift The Power Dynamics: Counter-Storytelling Through The Voices Of Empowerment Conference, Jordan González, Yolanda Sealey-Ruiz, Lonice Eversley, Aliya Holmes, Natalie Byfield

Journal of Critical Race and Ethnic Studies

This qualitative study explores the transformative potential of counterstory as a method for promoting educational equity through the lens of racial literacy and the "Archeology of Self" framework. Rooted in critical race theory, counterstory enables marginalized voices to challenge and reshape dominant narratives within educational research and practice (Delgado & Stefancic, 1996; Delgado, Stefancic, & Harris, 2012; Ladson-Billings, 2013; Ladson-Billings, 2021; Martinez, 2020). The community-based study using a counter-storytelling approach draws on data from a focus group held during the 2024 Voices of Empowerment Conference, part of the Institute for Critical Race and Ethnic Studies (CRES) at St. John's University. …

Should We Clear The Cobwebs In Our Minds Or Dismantle Racial Structures? Reflections On The Lack Of Critical Thinking Of Higher Education Staff In The Uk, Chrissie Da Costa

Journal of Critical Race and Ethnic Studies

Higher education in the UK constantly emphasises  critical thinking for students. However, analysis of comments made about *Black students and staff indicate that some academic staff fail to critically analyse their thoughts, words, and deeds. This paper sets out to analyse these utterances of HE staff and to investigate whether they actively reproduce and are intended to reproduce racist practices in HE, which could affect the experience, performance, and confidence of some of these students and staff who identify as Black and Global Majorities.  Applying critical race theory and socio-ideological analysis of language (Bakhtin 1981 and Voloshinov 1973) to analyse …

Closing The Literacy Gap: Correlation Of Chronic Illnesses On Reading Fluency, Nicolette Falvo

Education Theses

The purpose of this study is to investigate the impact of chronic physical health issues on literacy fluency among students spanning Pre-Kindergarten through eighth grade. Chronic illnesses, such as asthma, diabetes, and sickle cell disease, can significantly hinder academic performance, particularly in literacy. This research seeks to explore how specific literacy interventions can improve reading fluency for students managing health-related challenges. Utilizing a single-subject design, the study will examine individual cases to determine the effectiveness of tailored literacy strategies. The methodology includes both a baseline assessment phase and an intervention phase. Baseline assessments revealed that students with chronic health conditions …

Mathematical Modelling Of Disease Outbreak, Favour Christian, Matthew Molloy

SURE Journal: Science Undergraduate Research Experience Journal

Establishing a model framework for more research necessitates a thorough understanding of the causes, distribution, prevalence, and evolution of infectious illnesses. The main mathematical concept used in this modelling simulation is ordinary differential equations (ODEs). The purpose of this study was to investigate the significance of the many criteria linked to a zombie virus spread. The zombie framework provides an accessible and relatively simple representation of the nature of infectious disease spread, allowing for tractable assumptions and the development of more complex situations.

The models are designed around a zombie outbreak in which the zombie virus is spread through a …

Total Organic Carbon Analysis Of Residual Contaminants In Bioreactor Equipment: A Cleaning Verification Study Using Surface Swabbing, Ciara E. Fitzpatrick, James J. Roche

SURE Journal: Science Undergraduate Research Experience Journal

Contamination is a major issue in the biopharmaceutical industry. Bioreactors must be meticulously cleaned to remove residual impurities and avoid cross-contamination. Cleaning validation is necessary to ensure residual contaminants are reduced to the lowest acceptable limits. Bacterial cells represent the paramount challenge in manufacturing equipment cleaning because they are composed of insoluble organic contaminants. Total organic carbon (TOC) analysis is a fast, highly sensitive, and inexpensive analytical technique commonly used to evaluate the approximate level of organic contamination.

A study was conducted to assess the effectiveness of cleaning procedures in the removal of contaminants from bioreactor equipment by measuring the …

Career And Advising Services Integration., Leezel F. Ramos, Josh C. Oakland

MAGIS: Student Development Journal

Career services exist on college campuses to provide support and guidance for students in their career formation and development. This paper proposes a career services model that integrates academic advising, continuing professional development, and collaboration. Framing site visits and interviews with student affairs practitioners focused on collaboration and student learning, this paper brings together four examples of emerging practices in career services as a way to increase student success and retention. A literature review was also conducted to understand best practices across the fields of career and academic advising and how advisers are supported as professionals in the field of …

Words Matter: The Art Of Language In Advising., Nadeje Alexandre, Sue Ann Bube

MAGIS: Student Development Journal

Academic advising is an important factor in student development. This article discusses how to assist students in having positive academic experiences through the use of language by applying the principals of developmental academic advising. A specific advising experience is explored to demonstrate how effective communication can have a positive influence on a student’s college experience. Specifically, the application of active listening, framing, and emotional intelligence will be used within the developmental advising model.

2024 Program, Georgia Southern University

Georgia Association for Positive Behavior Support Conference

No abstract provided.

The Enduring Enigma Of Tom Bombadil: From Riddlic Styling To Metaphorical Encounter, Derek Simon

Journal of Tolkien Research

Conversationalists and critics alike continue to take delight in Tom Bombadil, yet remain perplexed by his enduring enigma. Interpretive positioning appears to be determined by the semantics of the term enigma deployed and how it intersects with any of the several textual standpoints adopted. The primary contention of this article is that the enigma is intentionally both a riddle (noun) and a riddling (verb). Reading the enigma through literary features of the Old English riddle-song can yield an alternate interpretation of Tom Bombadil that has received scant attention in critical commentary. In support of this contention, I propose to read …

Analysis Of The Longitudinal Effect Of Home Advantage In The Brazilian Football Championship – Série A, Werlayne Leite, Marcelo C. Zanetti

Baltic Journal of Health and Physical Activity

Athletes and teams typically obtain an advantage when competing at home, a phenomenon known as home advantage (HA). This study investigates the longitudinal effect of HA in the Brazilian Football Championship (Série A) over 21 seasons, analyzing 8,405 matches from 2003 to 2023. The results showed that the average HA was 35.1 ± 7.7%, while the competitive balance (CB) was 0.838 ± 0.145. A negative, non-significant correlation (r = -0.321, p = 0.157) was found between HA and CB, with CB explaining 10.3% of HA variation in the Brazilian league. HA de-creased over time, likely due to improved logistics, …

Empathetic Moments: A Student Affairs Reflection, Emily B. Kolby

MAGIS: Student Development Journal

This reflection piece represents the culmination of my quarter-long exploration of the concept of empathy as it relates to my work within student affairs. Empathy is examined through the lens of my experiences as a college student and as an academic advisor at Bellevue College. The definition of empathy and its challenges and implications for use within academic advising are briefly discussed. This piece was adapted from a workshop that I presented at a department retreat in December 2014.

So You Want To Work With Students, Jeremy Stringer

MAGIS: Student Development Journal

Honoring Jeremy Stringer: Reflections on Caring

Magis Volume 9 Entire Volume, Editors Of Magis

MAGIS: Student Development Journal

No abstract provided.

Back Matter

The Journal of Purdue Undergraduate Research

No abstract provided.

Origins Of Art: Demystifying The Scheuring Icon Collection, Mikayla Klemp

The Journal of Purdue Undergraduate Research

No abstract provided.

Implication Of Generative Ai On Education And Research, Riddhi Gupta

The Journal of Purdue Undergraduate Research

No abstract provided.

A Meteorological Investigation Of A Tornado- Producing, “Hybrid” Supercell-Multicell Storm Near Delphi, Indiana, On May 8, 2023, Evelyn Rose K. Girardi

The Journal of Purdue Undergraduate Research

No abstract provided.

Predictive Maintenance Analysis Of Turbofan Engine Sensor Data, Stanley A. Melkumian

The Journal of Purdue Undergraduate Research

Predictive maintenance in aviation and aerospace applications is among the most explored problems in machine learning (ML) and artificial intelligence (AI), and datasets such as NASA’s C-MAPPS turbofan engine degradation simulation data have proven invaluable, helping researchers explore numerous questions on engine performance, maintenance, and failure. The purpose of this study was to extend the current research on predicting the remaining useful life (RUL) of engines and their risk classification. Starting with simple yet under-investigated nonlinear survival and random forest models, the analysis implemented eXtreme Gradient Boosting (XGBoost) and long short-term memory (LSTM) from TensorFlow’s Keras library. For both regression …

The Influence Of Soil Properties And Land Management On Soil Porewater Chemistry, Bethany Kettleborough

The Journal of Purdue Undergraduate Research

Soil water dynamics influence vegetation health, soil geochemical reactions, and stream chemistry. Water dynamics can be controlled by soil type and land management. It is important to understand water movement due to its influence on soil weathering, microbial activity, and nutrient transport. Water movement can be investigated using water stable isotope variability as a tracer. The purpose of this ongoing study was to analyze stable isotopes and dissolved ions in prairie and agricultural land management sites in Nebraska and Illinois. Prairies typically contain deep-rooted grasses, while agricultural lands contain shallow-rooted row crops. Root depth is considered a major control on …