Digital Commons Network^™

A Service-Oriented Approach To Clinical Trial Recruitment For Dementia And Brain Health: Methods And Case Examples Of Myalliance For Brain Health, Eric D Vidoni, Emma Swinford, Kelli Barton, Jaime Perales-Puchalt, C Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger-Schmidt, Jill Peltzer, Joellen Wurth, Jannette Berkley-Patton, Ryan A Townley, W Todd Moore, Ashley R Shaw, Mickeal N Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M Burns

Faculty, Staff and Student Publications

Introduction: Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge. The primary goal of this manuscript is to provide an overview of an approach to diversifying research recruitment and to provide case examples of several methods for achieving greater diversity in clinical research enrollment.

Methods: The University of Kansas Alzheimer's Disease Research Center (KU ADRC) developed MyAlliance for Brain Health (MyAlliance), a service-oriented recruitment model. MyAlliance comprises a Primary Care Provider Network, a Patient and Family Network, and a Community Organization Network, each delivering tailored value to relevant parties while …

Employee Handbook, Saint Mary's College Of California

Employee & Staff Handbook

No abstract provided.

Causal Association Between Gut Microbiomes And Different Types Of Aneurysms: A Mendelian Randomization Study, Youjia Qiu, Yucheng Hou, Xingzhou Wei, Menghan Wang, Ziqian Yin, Minjia Xie, Aojie Duan, Chao Ma, Ke Si, Zhong Wang

Faculty, Staff and Student Publications

BACKGROUND: Previous studies suggests that gut microbiomes are associated with the formation and progression of aneurysms. However, the causal association between them remains unclear.

METHODS: A two-sample Mendelian randomization was conducted to investigate whether gut microbiomes have a causal effect on the risk of intracerebral aneurysm (IA), thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA), and aortic aneurysm (AA). Single nucleotide polymorphisms (SNPs) smaller than the locus-wide significance level (1 × 10

RESULTS: The phylum

CONCLUSION: Our MR analysis confirmed the causal association of specific gut microbiomes with AAA, and these microbiomes were considered as protective factors. Our result …

Generalized Conditional Feedback System With Model Uncertainty, Chengbo Dai, Zhiqiang Gao, Yangquan Chen, Donghai Li

Electrical and Computer Engineering Faculty Publications

Model uncertainty creates a largely open challenge for industrial process control, which causes a trade-off between robustness and performance optimality. In such a case, we propose a generalized conditional feedback (GCF) system to largely eliminate conflicts between robustness and performance optimality. This approach leverages a nominal model to design an optimal control in the virtual domain and defines an ancillary feedback controller to drive the physical process to track the trajectory of the virtual domain. The effectiveness of the proposed GCF scheme is demonstrated in a simulation for six typical industrial processes and three model-based control methods, and in a …

2023-2024 Louisiana Adult Justice, Institute For Public Health And Justice, Data Collecting And Reporting

Policy & Position Papers

No abstract provided.

2023-2024 Louisiana Juvenile Justice, Institute For Public Health And Justice, Data Collecting And Reporting

Policy & Position Papers

No abstract provided.

Social Determinants Of Health Predict Readmission Following Covid-19 Hospitalization: A Health Information Exchange-Based Retrospective Cohort Study, Micaela N Sandoval, Jennifer L Mikhail, Melyssa K Fink, Guillermo A Tortolero, Tru Cao, Ryan Ramphul, Junaid Husain, Eric Boerwinkle

Faculty, Staff and Student Publications

INTRODUCTION: Since February 2020, over 104 million people in the United States have been diagnosed with SARS-CoV-2 infection, or COVID-19, with over 8.5 million reported in the state of Texas. This study analyzed social determinants of health as predictors for readmission among COVID-19 patients in Southeast Texas, United States.

METHODS: A retrospective cohort study was conducted investigating demographic and clinical risk factors for 30, 60, and 90-day readmission outcomes among adult patients with a COVID-19-associated inpatient hospitalization encounter within a regional health information exchange between February 1, 2020, to December 1, 2022.

RESULTS AND DISCUSSION: In this cohort of 91,007 …

Lysophospholipids Are Associated With Outcomes In Hospitalized Patients With Mild Traumatic Brain Injury, Aaron M Gusdon, Jude Pj Savarraj, John B Redell, Atzhiry Paz, Sarah Hinds, Angela Burkett, Glenda Torres, Xuefang Ren, Neeraj Badjatia, Georgene W Hergenroeder, Anthony N Moore, H Alex Choi, Pramod K Dash

Faculty, Staff and Student Publications

Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and cell signaling. As TBI can compromise plasma membrane integrity and alter brain cell function, we sought to identify circulating phospholipid alterations after mTBI, and determine if these changes were associated with clinical outcomes. Patients with mTBI (Glasgow Coma Score [GCS] ≥13 and loss of consciousness <30 >min) were recruited. A total of 84 mTBI subjects were enrolled after admission to a level I trauma center, with the majority having evidence of traumatic intracranial hemorrhage on brain computed tomography …

Increased Resolvin E1 Production By Peripheral Blood Mononuclear Cells In Periodontitis Patients: Pilot Study, Lina J Suárez, Wilmer González-Duarte, Rodrigo Torrez-Velasco, Viviana Salinas, Nelly S Roa-Molina, Sindy M Muñoz, Luz-Stella Rodríguez, Roger M Arce, Jamil A Shibli, Adriana Rodríguez-Ciodaro

Faculty, Staff and Student Publications

This study quantified the production of the pro-resolving agent Resolvin E1 by peripheral blood mononuclear cells (PBMC) from 20 systemically healthy volunteers with and without periodontitis after stimulation with lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg). Ten periodontitis patients and 10 healthy volunteers (30-50 years old), matched by age and sex, were recruited. Peripheral blood mononuclear cells were isolated and stimulated in culture plates for 24 hours with Pg LPS. Resolvin E1 levels were measured in the supernatants by enzyme-linked immunosorbent assay. Significantly higher production of Resolvin E1 was observed in both groups when stimulated with LPS compared to baseline levels …

A Virtual Culinary Medicine Intervention For Ethnically Diverse Individuals With Type 2 Diabetes: Development Of The Nourishing The Community Through Culinary Medicine, Lorena Macias-Navarro, John Wesley Mcwhorter, Diana C Guevara, Sarah S Bentley, Shreela V Sharma, Jennifer H Torres, David Ai, Natalia I Heredia

Faculty, Staff and Student Publications

Virtual culinary medicine education interventions have the potential to improve dietary behaviors, nutrition knowledge, cooking skills, and health outcomes for ethnically diverse individuals with type 2 diabetes. The purpose of this study is to describe the adaptation of the Nourishing the Community through Culinary Medicine (NCCM) program for virtual delivery, and the protocol for pilot testing this intervention. The intervention includes five 90-min virtual NCCM sessions streamed live from a Teaching Kitchen. Feasibility outcomes are recruitment, retention, acceptability, and satisfaction. Short-term effectiveness outcomes are measured through self-administered questionnaires, including perceived health, average daily servings of fruits and vegetables, frequency of …

Circulating Sphingolipids In Relation To Cognitive Decline And Incident Dementia: The Cardiovascular Health Study, Kristine F Moseholm, Héléne T Cronjé, Manja Koch, Annette L Fitzpatrick, Oscar L Lopez, Marcia C De Oliveira Otto, W T Longstreth, Andrew N Hoofnagle, Kenneth J Mukamal, Rozenn N Lemaitre, Majken K Jensen

Faculty, Staff and Student Publications

INTRODUCTION: Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain.

METHODS: We measured 14 sphingolipid species in plasma samples from 4488 participants (mean age 76.2 years; 40% male; and 25% apolipoprotein E (

RESULTS: Higher plasma levels of sphingomyelin-d18:1/16:0 (SM-16) were associated with a faster cognitive decline measured with 3MSE, in contrast, higher levels of sphingomyelin-d18:1/22:0 (SM-22) were associated with slower decline in cognition measured with DSST. In Cox regression, higher levels of SM-16 (hazard ration [HR] = 1.24 [95% confidence interval [CI]: 1.08-1.44]) and ceramide-d18:1/16:0 (Cer-16) (HR = 1.26 [95% CI: 1.10-1.45]) …

Trio Rvemvs: A Bayesian Framework For Rare Variant Association Analysis With Expectation-Maximization Variable Selection Using Family Trio Data, Duo Yu, Matthew Koslovsky, Margaret C Steiner, Kusha Mohammadi, Chenguang Zhang, Michael D Swartz

Faculty, Staff and Student Publications

It is commonly reported that rare variants may be more functionally related to complex diseases than common variants. However, individual rare variant association tests remain challenging due to low minor allele frequency in the available samples. This paper proposes an expectation maximization variable selection (EMVS) method to simultaneously detect common and rare variants at the individual variant level using family trio data. TRIO_RVEMVS was assessed in both large (1500 families) and small (350 families) datasets based on simulation. The performance of TRIO_RVEMVS was compared with gene-level kernel and burden association tests that use pedigree data (PedGene) and rare-variant extensions of …

Variant Of The Lactase Lct Gene Explains Association Between Milk Intake And Incident Type 2 Diabetes, Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M Rebholz, Tao Wang, Carmen R Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D Burk, Robert C Kaplan, Qibin Qi

Faculty, Staff and Student Publications

Cow's milk is frequently included in the human diet, but the relationship between milk intake and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic Community Health Study/Study of Latinos, we show that in both sexes, higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactase LCT gene, single nucleotide polymorphism rs4988235 ) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal that among LNP individuals, higher milk intake is associated with alterations in gut microbiota (for …

The Relationship Of Neighborhood Disadvantage, Biological Aging, And Psychosocial Risk And Resilience Factors In Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis, Ganga S Bey, James R Pike, Anthony S Zannas, Qian Xiao, Bing Yu, Amil M Shah, Priya Palta

Faculty, Staff and Student Publications

Objectives: Deprived living environments contribute to greater heart failure (HF) risk among non-Hispanic Black persons, who disproportionately occupy disadvantaged neighborhoods. The mechanisms for these effects are not fully explicated, partially attributable to an insufficient understanding of the individual factors that contribute additional risk or resilience to the impact of neighborhood disadvantage on health. The objective of this study was, therefore, to clarify the complex pathways over which such exposures act to facilitate more targeted, effective interventions. Given the evidence for a mediating role of biological age and a moderating role of individual psychosocial characteristics in the neighborhood disadvantage-HF link, we …

Self-Perception Of Mental Health, Covid-19 And Associated Sociodemographic-Contextual Factors In Latin America, Pablo Roa, Guillermo Rosas, Gloria Isabel Niño-Cruz, Sergio Mauricio Moreno-López, Juliana Mejía-Grueso, Haney Aguirre-Loaiza, Javiera Alarcón-Aguilar, Rodrigo Reis, Adriano Akira Ferreira Hino, Fernando López, Deborah Salvo, Andrea Ramírez-Varela

Faculty, Staff and Student Publications

This study aimed to estimate the prevalence of alterations in self-perceived mental health during the COVID-19 pandemic and their associated factors in four Latin American countries. This is a cross-sectional study based on data collected from adults in 2021 through the Collaborative Response COVID-19 Survey by the MacDonnell Academy at Washington University in St. Louis (United States). The sample was composed of 8,125 individuals from Brazil, Colombia, Mexico, and Chile. A generalized linear model for a binary outcome variable with a logistic link and fixed country effects was used. There were 2,336 (28.75%) individuals who considered having suffered alterations in …

Prozone Masks Elevated Sars-Cov-2 Antibody Level Measurements, Micaela N Sandoval, Samuel P Mcclellan, Stephen J Pont, Jessica A Ross, Michael D Swartz, Mark A Silberman, Eric Boerwinkle

Faculty, Staff and Student Publications

We report a prozone effect in measurement of SARS-CoV-2 spike protein antibody levels from an antibody surveillance program. Briefly, the prozone effect occurs in immunoassays when excessively high antibody concentration disrupts the immune complex formation, resulting in a spuriously low reported result. Following participant inquiries, we observed anomalously low measurement of SARS-CoV-2 spike protein antibody levels using the Roche Elecsys® Anti-SARS-CoV-2 S immunoassay from participants in the Texas Coronavirus Antibody Research survey (Texas CARES), an ongoing prospective, longitudinal antibody surveillance program. In July, 2022, samples were collected from ten participants with anomalously low results for serial dilution studies, and a …

Functionalized Microfiltration Membranes For Aerosol Capture To Chloro-Organic Degradation, Rollie George Mills

Theses and Dissertations--Chemical and Materials Engineering

The environmental remediation of water and air sources is a challenging field, due to widespread contamination, pollutant variety, and efficiency of existing treatment options. Remediation of certain pollutants, such as per- and polyfluorinated chemicals (PFAS), polychlorinated biphenyls (PCBs), volatile organic compounds (VOCs), and viral aerosols, has shown promise via adsorptive, degradative, or filtration-based processes, each with their respective advantages and limitations. Membrane technology is one option that has exhibited considerable pollutant removal from environmental sources via reverse osmosis (RO) filtration, but is limited by low permeabilities and lack of pollutant detoxification. With the support of NIEHS and NSF, the functionalization …

Sustained Release Systems For Endometrial Cancer, Claire E. Rowlands

Theses and Dissertations--Chemical and Materials Engineering

Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is the most common cancer of female reproductive organs. From 2007-2016 there has been a global rise in incidence of EC of 1.3 %. Typically, EC is treated with surgery, but at later stages surgery is less effective requiring chemotherapy and/or radiation therapy. These treatment options are less effective than surgery and there are very few FDA approved chemotherapies for EC. The minuscule number of effective treatment options as well as an increase in incidence shows the need for creating improved treatments for EC. There has been …

Experimental Characterization And Quantification Of Deformation Behavior In A Porous Carbon Fiber Network, Robert N Quammen

Theses and Dissertations--Chemical and Materials Engineering

Due to their wide range of attractive functional properties (such as low thermal conductivity and low density) porous materials are utilized in a variety of applications. In order to characterize these properties and others, the intrinsically heterogeneous microstructures of these materials need to be taken into account. These microstructures result in interactions across multiple length scales spanning several orders of magnitude. This makes the creation of robust computational models and straight-forward predictions of mechanical properties difficult for porous materials. With this in mind, this dissertation aims to provide experimental mechanical and deformation information spanning the length scales of interest for …

The Effects Of The Video Modeling Product Gemiini© On Verbal Response Production Of Individuals With Autism Spectrum Disorder Who Are Nonspeaking Or Minimally Speaking, Miranda Ann Galvin

Dissertations and Theses

The current study evaluates the effectiveness of the commercial video modeling program GemIIni© (GemIIni© Educational Systems, 2012) in increasing expressive spoken language production in individuals who exhibit characteristics of autism spectrum disorder and are considered nonspeaking or minimally speaking. Based upon the principles of Applied Behavioral Analysis, video modeling has been identified as an evidence-based practice in teaching skills to students with disabilities. In this study, the criteria for using a single-case alternating treatment design embedded within an AB experimental design was implemented to evaluate the effect of the video modeling system on the number of responses produced.

Whiteness And Quaker Universalism In Britain, Mark D. Russ

Quaker Religious Thought

In this article I do not address Fox’s message or his cultural limitations. Rather, I turn this question back on to the Quaker universalist discourse itself. How is the theology of the Quaker Universalist Group shaped by the conditions of its time?

A Bayesian Analysis Of E-Cigarette Risk Perceptions In The United Kingdom, W. Kip Viscusi

Vanderbilt Law School Faculty Publications

Public Health England has communicated that e-cigarettes provide at least a 95% risk reduction compared to conventional cigarettes. This article's survey evidence indicates that adults in the United Kingdom believe that e-cigarettes are only 30%–40% safer overall and that they reduce lung cancer risks and total mortality risks by a similar percentage. A Bayesian analysis of risk beliefs finds that e-cigarette risk perceptions are anchored on prior cigarette risk beliefs. The public, especially smokers, underestimates the magnitude of the risk reduction being communicated by public health officials. Those who are aware of e-cigarette messages from Public Health England assess lower …

The Impact Of Banning Confidential Settlements On Discrimination Dispute Resolution, Joni Hersch, Blair D. Bullock

Vanderbilt Law School Faculty Publications

The #MeToo movement exposed how workplace harassment plagues employment in the United States. Several states responded by passing legislation aimed at curbing harassment and employment discrimination in the workplace. One of the most common legislative efforts was to ban confidentiality provisions in certain settlement agreements. These bans, in part, attempted to stop “secret settlements” by shining light on workplace discrimination and exposing serial harassers as a means to motivate firms to actively deter workplace discrimination.

But do bans on confidentiality agreements deter the bad act? For these laws to have a deterrent effect, claims must be revealed in a public …

Thoughts On Corporate Law And The Problem Of Human Capital, Margaret Blair

Vanderbilt Law School Faculty Publications

The theme of this Symposium takes me back more than thirty years to work I did on corporations and human capital at the Brookings Institution in the 1990s. Although I have been on the faculty of law schools since 2000, I am not a lawyer, and in fact, never went to law school. I did my Ph.D. in economics, and I wrote my dissertation on merger waves-in particular, I developed a macroeconomic theory to explain the wave of corporate mergers and takeo- vers that happened in the 1980s. The most prominent and popular idea about takeovers at the time was …

Corrigendum To “Green Synthesis And Characterization Of Senps Using Pediastrum Boryanum Extract And Evaluation Of Their Biological Activities”

Mansoura Veterinary Medical Journal

No Abstract

Molecular Detection Of Virulence Genes And Extended Spectrum Beta-Lactam Producing Enzymes Of Proteus Mirabilis Isolates From Fishes In Federal Capital Territory (Fct) Abuja, Nigeria, Victor Bitrus Shammah, Samuel Mailafia, James A. Ameh, Casmir Ifeanyichukwu Cejetan Ifeanyi Dr., Benshak John Audu, Hafsat Jagab, Job Gideon

Mansoura Veterinary Medical Journal

Objective: To study the molecular characterization of three virulence genes and phenotypic detection of extended spectrum beta-lactam-producing enzymes in Proteus mirabilis isolates from fish in the Federal Capital Territory (FCT).

Design: cross-sectional study.

Animal: A total of 400 fish were purchased from various markets and sites in the Federal Capital Territory. Thirteen (32.5%) P. mirabilis isolates were obtained. This study used amoxicillin with clavulanate and ceftazidime, a third-generation cephalosporin antibiotics, to treat all phenotypically typed isolates utilizing Extended Spectrum Beta-Lactam (ESBL). Polymerase Chain Reaction (PCR) was used for molecular characterization to identify the pathogenic genes of interest, including ure …

Students For Fair Admissions: Affirming Affirmative Action And Shapeshifting Towards Cognitive Diversity?, Steven A. Ramirez

Seattle University Law Review

The Roberts Court holds a well-earned reputation for overturning Supreme Court precedent regardless of the long-standing nature of the case. The Roberts Court knows how to overrule precedent. In Students for Fair Admissions v. Harvard (SFFA), the Court’s majority opinion never intimates that it overrules Grutter v. Bollinger, the Court’s leading opinion permitting race-based affirmative action in college admissions. Instead, the Roberts Court applied Grutter as authoritative to hold certain affirmative action programs entailing racial preferences violative of the Constitution. These programs did not provide an end point, nor did they require assessment, review, periodic expiration, or revision for greater …

The Quest For Funding Under The Dutch Wamca: Third Party Funding And The Viability Of A Procedural Fund, Xandra Kramer

Emory International Law Review

A new chapter started for collective actions with the 2020 Dutch Mass Damage Settlement in Collective Actions Act (WAMCA) and the E.U. Directive on representative actions for consumer cases. The expansion of the class action mechanism has not only raised procedural and practical questions but has also triggered debates on the funding of inherently expensive collective claims for damages. Absent appropriate public legal aid schemes, third-party litigation funding has been on the rise and commercial funding has become one of the most discussed and controversial topics in European civil justice. Developments in collective actions and funding have prompted the Dutch …

A Composite Cognitive Workload Evaluation Of The Hysteresis Effect, Jon Vogl

Dissertations and Theses

Advancements in technology have changed the dynamic of work as it is performed in safety-critical tasks. Today, many systems offer operators the option to ease the burden of complex tasks by offloading subtasks to automation technology. The goal of adaptive automation is to eliminate the need for operators to engage/disengage automation, and instead have automated control of subtasks adapt to the needs of the operator in real time. However, each change in automation also creates a task demand transition, which have been shown to elicit unexpected effects on cognitive workload metrics. Adaptive automation systems need to be ready to account …

Implementing A Stepped Care Model: A Case Study Of Two College Counseling Centers, Stephanie L Johnson-Kane

Dissertations and Theses

The demand for mental health counseling services has surged, but the capacity of college counseling centers to meet this demand has not kept pace. The effects of COVID-19 have exacerbated this already fragile system of care. College students are enrolling in college with increased levels of anxiety, depression, disordered eating, suicidal ideation, and substance use. College counseling center staff are facing burnout. The waitlist to receive mental health services is at critical capacity. This multi-site case study was designed to foster an understanding of two college counseling centers' implementation of the stepped care approach as a mental health service delivery …