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Articles 781 - 810 of 60031
Full-Text Articles in Entire DC Network
Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar
Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar
McKelvey School of Engineering Graduate Student Theses & Dissertations
Alzheimer’s Disease (AD) is the leading cause of dementia, characterised by cognitive and functional impairments that disrupt daily activities. Different clinical modalities such as neuroimaging biomarkers, cognitive assessments, fluid biomarkers and genetic data provide unique and complementary information, contributing to a more comprehensive understanding of disease progression and heterogeneity in disease characteristics. With recent advancements in computational capabilities, particularly in deep learning, multimodal representation learning frameworks aim to integrate diverse clinical modalities into a cohesive framework, capturing the most significant patterns within each modality. Existing data-driven multimodal representation learning frameworks in AD research have two major limitations. First, AD progresses …
Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang
Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang
McKelvey School of Engineering Graduate Student Theses & Dissertations
Cancer is a complex disease driven by genetic mutations, epigenetic modifications, and alterations in the tumor microenvironment. Understanding these intricate molecular mechanisms is crucial for advancing cancer diagnosis, prognosis, and treatment. RNA sequencing (RNA-seq) has emerged as a powerful tool to study cancer by providing comprehensive insights into gene expression, alternative splicing, and mutations at the transcriptome level. This dissertation leverages RNA-seq data to explore different dimensions of cancer biology through multi-omics integration and computational approaches. The research is divided into three main projects. First, I developed OncoDB, an interactive database to analyze gene expression, methylation patterns, and viral interactions …
Terpene Bioproduction From Non-Model Yeast: Omics Analysis And Metabolic Modeling For Guiding Scaleup Optimization, Alyssa Worland
Terpene Bioproduction From Non-Model Yeast: Omics Analysis And Metabolic Modeling For Guiding Scaleup Optimization, Alyssa Worland
McKelvey School of Engineering Graduate Student Theses & Dissertations
Sustainability efforts have driven significant advancements in synthetic biology, particularly through the development of microbial cell factories designed for waste reduction and resource conservation. This dissertation seeks to characterize a microbial biorefinery platform for the biosynthesis of terpene compounds from yeast, with an emphasis on the industrial bioconversion of waste lipids. Terpene compounds play crucial roles in various industrial applications; however, traditional methods of terpene production have sustainability and productivity challenges that could be overcome by using microbial biosynthesis. The yeast Yarrowia lipolytica is a microbial host well suited for converting waste oils into value-added terpenes due to its native …
Quantitative Approaches To Dissect Bivalent Antibody Binding And Detect Viruses From Aerosolized Samples, Ananya Benegal
Quantitative Approaches To Dissect Bivalent Antibody Binding And Detect Viruses From Aerosolized Samples, Ananya Benegal
McKelvey School of Engineering Graduate Student Theses & Dissertations
Influenza A virus (IAV) poses substantial epidemiological burdens around the world, with an estimated annual global mortality rate in the hundreds of thousands. Its rapid rate of mutation gives it a propensity for causing seasonal epidemics and occasional pandemics. As an airborne virus, IAV is most commonly transmitted through droplets and aerosols. Antibodies play a crucial role in the immune defense against IAV infection. By understanding the mechanisms of antibody-mediated defense and the transmission dynamics of IAV, we can better inform strategies for prevention, vaccination, and treatment, ultimately mitigating its impact on public health. The work encompassed in this dissertation …
Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta
Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta
McKelvey School of Engineering Graduate Student Theses & Dissertations
Deep learning driven computational methods have profoundly impacted medical imaging by advancing feature extraction, and by establishing a critical foundation for downstream image analysis and interpretation. Co-clinical trials are an emerging area of investigation in which a clinical trial is coupled with a corresponding preclinical study to inform the corresponding clinical trial to enhance translational accuracy and therapeutic development. Within this framework, quantitative imaging and pathology plays a fundamental role in both clinical and preclinical arms of co-clinical trials. Quantitative imaging enables enabling identification and validation of imaging biomarkers which are leveraged to predict therapeutic response, characterize disease phenotypes, and …
Developing Naturalistic Precision Functional Mapping For High-Density Diffuse Optical Tomography, Aahana Bajracharya
Developing Naturalistic Precision Functional Mapping For High-Density Diffuse Optical Tomography, Aahana Bajracharya
McKelvey School of Engineering Graduate Student Theses & Dissertations
Advancements in non-invasive imaging have enabled extensive research into higher-order cognitive functions of the brain. Functional Magnetic Resonance Imaging (fMRI) has provided valuable insights into brain networks underlying various cognitive processes. However, limitations such as confined environments and scanner noise pose challenges for fMRI to be broadly applicable across all demographics and experimental conditions, especially in speech and language studies. Because of this, there is a need for complementary techniques that can help understand the brain as it functions during everyday scenarios. High Density Diffuse Optical Tomography (HD-DOT) is an emerging functional near-infrared spectroscopy-based technique with comparative advantages over fMRI, …
Reimagining The Machine Vision Pipeline In Cyber Physical Systems For Trustworthiness And Efficiency, Adith Boloor
Reimagining The Machine Vision Pipeline In Cyber Physical Systems For Trustworthiness And Efficiency, Adith Boloor
McKelvey School of Engineering Graduate Student Theses & Dissertations
Cyber-physical systems (CPS), including autonomous vehicles, drones, and mobile robots, rely on intricate sensors, actuators, and machine learning algorithms to perceive the physical world and execute actions within their surroundings. In the context of vision-driven CPS, achieving this demands processing a substantial volume of visual data captured by on-board cameras. The data is subsequently channeled through digital processors and harnessed by deep neural networks for tasks such as image classification, object detection, and depth perception. This data-centric, machine-vision-infused CPS fosters intelligent decision-making, thereby enhancing overall system performance. Trustworthiness, encompassing the robustness of the entire machine-vision pipeline, and system-level efficiency are …
Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar
Multimodal Representation Learning Frameworks For Modeling Progression And Heterogeneity In Alzheimer’S Disease, Sayantan Kumar
McKelvey School of Engineering Graduate Student Theses & Dissertations
Alzheimer’s Disease (AD) is the leading cause of dementia, characterised by cognitive and functional impairments that disrupt daily activities. Different clinical modalities such as neuroimaging biomarkers, cognitive assessments, fluid biomarkers and genetic data provide unique and complementary information, contributing to a more comprehensive understanding of disease progression and heterogeneity in disease characteristics. With recent advancements in computational capabilities, particularly in deep learning, multimodal representation learning frameworks aim to integrate diverse clinical modalities into a cohesive framework, capturing the most significant patterns within each modality. Existing data-driven multimodal representation learning frameworks in AD research have two major limitations. First, AD progresses …
Terpene Bioproduction From Non-Model Yeast: Omics Analysis And Metabolic Modeling For Guiding Scaleup Optimization, Alyssa Worland
Terpene Bioproduction From Non-Model Yeast: Omics Analysis And Metabolic Modeling For Guiding Scaleup Optimization, Alyssa Worland
McKelvey School of Engineering Graduate Student Theses & Dissertations
Sustainability efforts have driven significant advancements in synthetic biology, particularly through the development of microbial cell factories designed for waste reduction and resource conservation. This dissertation seeks to characterize a microbial biorefinery platform for the biosynthesis of terpene compounds from yeast, with an emphasis on the industrial bioconversion of waste lipids. Terpene compounds play crucial roles in various industrial applications; however, traditional methods of terpene production have sustainability and productivity challenges that could be overcome by using microbial biosynthesis. The yeast Yarrowia lipolytica is a microbial host well suited for converting waste oils into value-added terpenes due to its native …
Reimagining The Machine Vision Pipeline In Cyber Physical Systems For Trustworthiness And Efficiency, Adith Boloor
Reimagining The Machine Vision Pipeline In Cyber Physical Systems For Trustworthiness And Efficiency, Adith Boloor
McKelvey School of Engineering Graduate Student Theses & Dissertations
Cyber-physical systems (CPS), including autonomous vehicles, drones, and mobile robots, rely on intricate sensors, actuators, and machine learning algorithms to perceive the physical world and execute actions within their surroundings. In the context of vision-driven CPS, achieving this demands processing a substantial volume of visual data captured by on-board cameras. The data is subsequently channeled through digital processors and harnessed by deep neural networks for tasks such as image classification, object detection, and depth perception. This data-centric, machine-vision-infused CPS fosters intelligent decision-making, thereby enhancing overall system performance. Trustworthiness, encompassing the robustness of the entire machine-vision pipeline, and system-level efficiency are …
Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta
Development Of Computational Imaging Pipelines To Advance Quantitative Co-Clinical Imaging And Pathology, Kaushik Dutta
McKelvey School of Engineering Graduate Student Theses & Dissertations
Deep learning driven computational methods have profoundly impacted medical imaging by advancing feature extraction, and by establishing a critical foundation for downstream image analysis and interpretation. Co-clinical trials are an emerging area of investigation in which a clinical trial is coupled with a corresponding preclinical study to inform the corresponding clinical trial to enhance translational accuracy and therapeutic development. Within this framework, quantitative imaging and pathology plays a fundamental role in both clinical and preclinical arms of co-clinical trials. Quantitative imaging enables enabling identification and validation of imaging biomarkers which are leveraged to predict therapeutic response, characterize disease phenotypes, and …
Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang
Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang
McKelvey School of Engineering Graduate Student Theses & Dissertations
Cancer is a complex disease driven by genetic mutations, epigenetic modifications, and alterations in the tumor microenvironment. Understanding these intricate molecular mechanisms is crucial for advancing cancer diagnosis, prognosis, and treatment. RNA sequencing (RNA-seq) has emerged as a powerful tool to study cancer by providing comprehensive insights into gene expression, alternative splicing, and mutations at the transcriptome level. This dissertation leverages RNA-seq data to explore different dimensions of cancer biology through multi-omics integration and computational approaches. The research is divided into three main projects. First, I developed OncoDB, an interactive database to analyze gene expression, methylation patterns, and viral interactions …
Womb, Gravity, And Space: Shifting Towards The Cerebellum-Basal Ganglia Paradigm In Dystonia, Diego Iacono
Womb, Gravity, And Space: Shifting Towards The Cerebellum-Basal Ganglia Paradigm In Dystonia, Diego Iacono
Department of Neurology Faculty Papers
No abstract provided.
I Hear A New World, Katie Christ
I Hear A New World, Katie Christ
Theses
“I Hear a New World” is a documentary short film that reflects on the relevance and persistence of nostalgia and tradition during a time of rapid technological advancement and societal change. The film highlights the memories and musings of 8 college students, who were all Class of 2020 high school seniors and whose senior traditions were inevitably brought entirely online due to the Covid-19 global pandemic to varied degrees of success. In rambling, thoughtful delivery, the Gen Z interviewees provide insight into their pre-pandemic internet obsession that led to their teenage reclusivity and how this perspective changed greatly following the …
Body Study, Annaliese "Ace" Taylor
Body Study, Annaliese "Ace" Taylor
Theses
A paper chronicling the creation of my graduate thesis film, Body Study.
From Sampling To Simulating: Single-Cell Multiomics In Systems Pathophysiological Modeling, Alexandra Manchel, Michelle M. Gee, Rajanikanth Vadigepalli
From Sampling To Simulating: Single-Cell Multiomics In Systems Pathophysiological Modeling, Alexandra Manchel, Michelle M. Gee, Rajanikanth Vadigepalli
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
As single-cell omics data sampling and acquisition methods have accumulated at an unprecedented rate, various data analysis pipelines have been developed for the inference of cell types, cell states and their distribution, state transitions, state trajectories, and state interactions. This presents a new opportunity in which single-cell omics data can be utilized to generate high-resolution, high-fidelity computational models. In this review, we discuss how single-cell omics data can be used to build computational models to simulate biological systems at various scales. We propose that single-cell data can be integrated with physiological information to generate organ-specific models, which can then be …
…And So It Ends In A Tie, Crystal Hou
…And So It Ends In A Tie, Crystal Hou
Theses
…and so it ends in a tie is a 2D frame-by-frame animated short film produced during the course of my 3rd year as a Master of Fine Arts student in the School of Film & Animation at Rochester Institute of Technology. The film explores themes of homosexuality, female sexuality, and the history of Japanese rope bondage through the fictionalized story of a fateful encounter between a rope-wielding martial artist and a mysterious woman who captures her attention. This paper serves as a documentation of the filmmaking process, a discussion of the ideologies and goals behind its creation, and a retrospective …
Fort Hays State University Tiger Weekly, December 20, 2024, University Relations
Fort Hays State University Tiger Weekly, December 20, 2024, University Relations
Tiger Weekly Newsletters
No abstract provided.
Re-Indigenizing And Collaboratively Tending Urban Greenspaces, Divinity Nnenne Adewale
Re-Indigenizing And Collaboratively Tending Urban Greenspaces, Divinity Nnenne Adewale
University Honors Theses
This work details the active process of land tending with the intention of re-Indigenization in the Pacific Northwest at several Portland sites; The Native American Student Community Center, PSU Oak Savanna, and the Ridgefield National Wildlife Refuge. Land tending is an intuitive process, one rooted in love and respect for life of all forms as well as becoming the perpetual student; land tending is not a skill to be mastered, only practiced. Unlike environmental management, tending cannot be done separate from the earth, in a classroom or otherwise. Connections are what tending is built on top of: the foundation; effort …
Benefits Marketplace, Ana Luisa Wu, Jenny Ramirez, Jose Ricardo Tafur Jr, Ricardo Collada, Maikel Zuniga, Manuel Ferreiro Caballero, Salvador Ricardo, Liset Iturriaga Chavez, Francisco Alberdi, Alexander Dale, Orlando Quesada, Ernesto Garcia Vazquez, Daniel Astudillo, Laura Figueroa, Sebastian Hernandez, Cristina Villarroel, Yuset Rosello Moya, Rachel Quijano Vizoso
Benefits Marketplace, Ana Luisa Wu, Jenny Ramirez, Jose Ricardo Tafur Jr, Ricardo Collada, Maikel Zuniga, Manuel Ferreiro Caballero, Salvador Ricardo, Liset Iturriaga Chavez, Francisco Alberdi, Alexander Dale, Orlando Quesada, Ernesto Garcia Vazquez, Daniel Astudillo, Laura Figueroa, Sebastian Hernandez, Cristina Villarroel, Yuset Rosello Moya, Rachel Quijano Vizoso
Defensive Publications Series
A method of provisioning a benefits marketplace platform is disclosed. According to the method, a payment network server computer presents payment network benefits to a consumer and receives feedback from the consumer based on the payment network benefits presented to the consumer. A profiling module profiles the payment network benefits based on the feedback received from the consumer and provides a benefits profile to the payment network server computer. The payment network server provides a recommendation of benefits to the consumer based on the benefits profile. A benefits module receives benefits selected by the consumer from a checkout function, applies …
Technology And Language Learning: Exposure To Tv And Radio News And Speaking Proficiency, Taher Bahrani, Tam Shu Sim
Technology And Language Learning: Exposure To Tv And Radio News And Speaking Proficiency, Taher Bahrani, Tam Shu Sim
Kritika Kultura
Technology has dominated the world by extensive improvements in audio/visual mass media such as TV and radio. TV and radio are not just entertainment tools anymore, but can be used as pedagogically valuable technology that can provide authentic language input for language learning. This study examines the effect of exposure to TV and radio news on improving EFL learners’ speaking proficiency. To achieve this purpose, a speaking proficiency test is administered to 200 language learners, with 60 intermediate language learners selected and randomly divided into Groups 1 and 2. During the experiment, Group 1 participants are exposed to TV and …
Writing Philippine History Of Ideas And Fernando Amorsolo's Modern Art, Jovino G. Miroy
Writing Philippine History Of Ideas And Fernando Amorsolo's Modern Art, Jovino G. Miroy
Kritika Kultura
Writing Philippine history of ideas requires that we problematize the discipline of intellectual history itself. Rethinking of itself vis-a-vis cultural and social history, Philippine history of ideas would no longer rehearse the development of philosophy in the Philippines, but also of art, religion, etc. The paper discusses how Amorsolo may be considered a modern painter. Amorsolo’s art eludes comprehension because his notion of subjectivity as well as intersubjectivity transgresses the Cartesian break between subject and object. As a modern painter, he positioned himself as an individualist, but was still able to communicate to his culture.
Primates In Paradise: Critical Possibilities Of The Milieu Movie, Joel David
Primates In Paradise: Critical Possibilities Of The Milieu Movie, Joel David
Kritika Kultura
The use of multiple lead characters in cinema is a fairly recent development, although the strategy (and its resultant variety of structures) had been present for some time in theater and literature. The typical Classical Hollywood action-driven narrative operated most efficiently through a singular hero, allowing the audience to undergo the film experience via the process of singular identification. With the breakdown in identificatory requisites popularized by various New Wave and Third Cinema movements, and the consequent assimilation of this trend starting with the New American Cinema, mainstream Hollywood was ready to embark upon a series of multi-character movies, with …
Sisa's Vengeance: Rizal And The Mother Of All Insurgencies, E. San Juan Jr.
Sisa's Vengeance: Rizal And The Mother Of All Insurgencies, E. San Juan Jr.
Kritika Kultura
A new appraisal of Rizal is needed today in the light of 9/11, the collapse of finance capital, state terrorism, and neoliberal decadence and barbarism. Rizal’s revolutionary critique can be discovered by shifting the center of inquiry to the Dapitan years and after, the Liga’s resonance, and the Sisa-Maria Clara-Salome nexus. By exposing the limits of Simoun’s romantic idealism, Padre Florentino’s eschatological impulse, and the carnivalesque colonial world bereft of god/nomos, Rizal anticipates the post-capitalist predicament. Women’s vengeance against patriarchal nihilism lies submerged in Rizal’s communicative action to the Malolos collective, mobilizing emergent and residual historical forces in a dialectical …
Confession As A Narrative Mode In Gay Indie Films, Gary D. Devilles
Confession As A Narrative Mode In Gay Indie Films, Gary D. Devilles
Kritika Kultura
This paper is interested in confession as a narrative mode of media, specifically gay independent films, and the specific codes and mechanisms inherent in a confession that enable one to generate pity over the viewing public. I would discuss four gay indie films, Ang Lalaki sa Parola, Daybreak, Sagwan, and Selda, and look specifically at how these films use confession in their narration, as a cinematic style to develop their characters, and ultimately as a form of politics of viewing by which gay films in general become a sort of “public confession” constituting their viewers as their preferred “confessors.” Such …
The New Challenge Of The Mother Tongues: The Future Of Philippine Postcolonial Language Politics, T. Ruanni F. Tupas
The New Challenge Of The Mother Tongues: The Future Of Philippine Postcolonial Language Politics, T. Ruanni F. Tupas
Kritika Kultura
For much of postcolonial language politics around the world, the fight has largely been between a foreign (read: colonial) language and (a) dominant local language(s). This is true in the Philippines where the debates have focused on English and Filipino, the Tagalog-based national language. In recent years, however, the mother tongues have posed a challenge to the ideological structure of the debates. Although local languages have long been acknowledged as positively contributing to the enhancement of learning in school, they have been co-opted mostly as a nationalist argument against English, American (neo)colonialism and imperialist globalization. The current initiatives to establish …
Philippine Studies And The End Of The American Century, Cynthia Tolentino
Philippine Studies And The End Of The American Century, Cynthia Tolentino
Kritika Kultura
The current struggles over US military bases and territorial sovereignty in the Pacific, wars in Iraq and Afghanistan, and the phenomenon of globalization, alongside what is being called the “end of the American Century,” have pushed interdisciplinary scholars to develop new frameworks for engaging US Empire. The paper attempts to draw out the various figurations of “Philippine Studies” and “US empire” in the papers, which may include analyses of comparative colonialisms, class and participation in social justice movements, as well as the intersections between globalization and imperial conquest. By considering the papers’ insights on disciplinary formation and knowledge practices, the …
Clinical Applications Of Phenomenology: Analysis Of Lived Experience Of Eye Disease, Kimberly Tucker
Clinical Applications Of Phenomenology: Analysis Of Lived Experience Of Eye Disease, Kimberly Tucker
Graduate Student Research Symposium
This paper presents a phenomenological study that explores the embodied experience of vision loss within the context of eye disease, while also providing a detailed discussion of the methodological approaches utilized in the research. Phenomenology is integrated to address clinical epistemic concerns, particularly the limitations of conventional vision tests in fully capturing perception and the lived experiences of vision loss. This interdisciplinary approach builds on the clinical understanding of eye disease by incorporating the broader dimensions of the lifeworld that intersect with visual impairment in degenerative eye diseases. While standard clinical approaches focus primarily on measurable aspects of visual function, …
The Effort To Promote Lichens For Human Consumption In Nineteenth-Century Europe, Michael E. Mitchell
The Effort To Promote Lichens For Human Consumption In Nineteenth-Century Europe, Michael E. Mitchell
European Journal of Food Drink and Society
In 1683 a lichen long relied in Iceland as a grain substitute was detected in Sweden, where chemical analysis revealed an appreciable nutritive content. Use of the lichen as food in Lapland was reported in the following century, but its composition was not again studied until the Spanish famine of 1805/6. The results of that investigation amply demonstrated the species’ potential as an emergency food, which led to lichens being recommended for domestic use and commercial bread production during successive European famines. Amateur attempts in France and Germany to distil alcohol from lichens proved uneconomic, a problem temporarily solved when …
Works By Trent Carruth, Trent Carruth
Works By Trent Carruth, Trent Carruth
Ought: The Journal of Autistic Culture
No abstract provided.