Digital Commons Network^™

Case Report: Long-Term Follow-Up Of Patients Who Received A Fimch Vaccine For Prevention Of Recurrent Urinary Tract Infections Caused By Antibiotic Resistant Enterobacteriaceae: A Case Report Series, Elise Perer, Helen Stacey, Terri Eichorn, Heidi Hughey, Julie Lawrence, Eric Cunningham, Mark O'Neil Johnson, Kevin Bacon, Andrew Kau, Scott J Hultgren, Thomas M Hooton, Jennifer L Harris

2020-Current year OA Pubs

Urinary tract infections (UTI) caused by carbapenem-resistant Enterobacteriaceae (CRE) are considered one of the most urgent health threats to humans according to the Centers for Disease Control (CDC), and the World Health Organization (WHO). A FimCH Vaccine expanded access study is being conducted in patients with a history of antibiotic resistant UTIs who are considered to be at risk for development of CRE UTI. This case series describes the clinical, safety and immunogenicity findings for four participants who received a FimCH four-vaccine series. Participants were followed for 12 months after administration of the fourth vaccine for safety, general health status …

Interventions Connecting Young People Living In Africa To Healthcare; A Systematic Review Using The Re-Aim Framework, Titilola Abike Gbaja-Biamila, Chisom Obiezu-Umeh, Ucheoma Nwaozuru, David Oladele, Alexis Engelhart, Thembekile Shato, Stacey Mason, Victoria Carter, Juliet Iwelunmor-Ezepue

2020-Current year OA Pubs

INTRODUCTION: Africa's young people are among the least focused groups in healthcare linkage. The disproportionally high burden of youth-related health problems is a burden, especially in developing regions like Africa, which have a high population of young people. More information is needed about factors that impact linkages in healthcare and the sustainability of health interventions among young people in Africa.

METHODS: A systematic literature search was performed from October 2020 to May 2022 in PubMed, CINAHL, Scopus, Global Health, and the Web of Science. Studies included in the review were conducted among young people aged 10-24 living in Africa, written …

Modular Horizontal Network Within Mouse Primary Visual Cortex, Andreas Burkhalter, Weiqing Ji, Andrew M Meier, Rinaldo D D'Souza

2020-Current year OA Pubs

Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states. Layer 1 (L1) is an important part of the underlying network. This cell-sparse layer is a target of feedback and local inputs, and nexus for contacts onto apical dendrites of projection neurons in the layers below. Importantly, L1 is a site for coupling inputs from the outside world with internal information. To determine whether all of these circuit elements overlap in L1, we labeled the horizontal network within mouse V1 …

Recruiting A Prospective Community Cohort To Study Alzheimer's Disease And Structural And Social Determinants Of Health Among Adults Racialized As Black: The Arches Cohort, Alexis I B Walker, Jean-Francois Trani, Christian F Banks, Samantha A Murphy, Wenqing Zha, Monique M Williams, Gregory S Day, Yiqi Zhu, Beau M Ances, Carl V Hill, Darrell L Hudson, Ganesh M Babulal

2020-Current year OA Pubs

INTRODUCTION: This ongoing, prospective study examines the effectiveness of methods used to successfully recruit and retain 238 Black older adults in a longitudinal, observational Alzheimer's disease (AD) study.

METHODS: Recruitment strategies included traditional media, established research registries, speaking engagements, community events, and snowball sampling. Participants were asked to complete an annual office testing session, blood-based biomarker collection, optional one-time magnetic resonance imaging (MRI) scan, and community workshop.

RESULTS: Within the first 22 months of active recruitment, 629 individuals expressed interest in participating, and 238 enrolled in the ongoing study. Of the recruitment methods used, snowball sampling, community events, and speaking …

Cognitive And Functional Performance And Plasma Biomarkers Of Early Alzheimer's Disease In Down Syndrome, Emily K Schworer, Beau M Ances, Et Al.

2020-Current year OA Pubs

INTRODUCTION: People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of AD pathology are correlated with early cognitive and functional impairments in DS, and if these biomarkers could be used to track the early stages of AD in DS or to inform inclusion criteria for clinical AD treatment trials.

METHODS: This large cross-sectional cohort study investigated the associations between plasma biomarkers of amyloid beta (Aβ)42/40, total tau, and …

Impahct: A Randomized Phase 2b/3 Study Of Inhaled Imatinib For Pulmonary Arterial Hypertension, Hunter Gillies, Murali M Chakinala, Benjamin T Dake, Jeremy P Feldman, Marius M Hoeper, Marc Humbert, Zhi-Cheng Jing, Jonathan Langley, Vallerie V Mclaughlin, Ralph W Niven, Stephan Rosenkranz, Xiaosha Zhang, Nicholas S Hill

2020-Current year OA Pubs

AV-101 (imatinib) powder for inhalation, an investigational dry powder inhaled formulation of imatinib designed to target the underlying pathobiology of pulmonary arterial hypertension, was generally well tolerated in healthy adults in a phase 1 single and multiple ascending dose study.

Overall And Non- Lung Cancer Incidence And Mortality In The National Lung Screening Trial: Opportunities For Multi-Cancer Early Detection, Alpa V. Patel, Ellen T. Chang, Allan Hackshaw, Sam M. Janes, Diana S.M. Buist, Earl Hubbell, Christina A. Clarke, Graham A. Colditz

2020-Current year OA Pubs

No abstract provided.

Negligence In Biomedical Research: An Anti-Racist Approach For Substance Use Researchers, Jonathan Lehman, Danniella Balangoy, Angie P Mejia, Carlos Cardenas-Iniguez, Scott Marek, Anita C Randolph

2020-Current year OA Pubs

Racism is embedded in the fabric of society at structural, disciplinary, hegemonic, and interpersonal levels, working as a mechanism that drives health disparities. In particular, stigmatized views of substance use get entangled with racialization, serving as a tool to uphold oppressive systems. While national health institutions have made commitments to dismantle these systems in the United States, anti-racism has not been integrated into biomedical research practice. The ways in which substance use researchers use and interpret race data-without engaging in structural racism as a mechanism of health inequity-can only be described as inadequate. Drawing upon concepts from the Public Health …

Comparison Of Cerebrospinal Fluid, Plasma And Neuroimaging Biomarker Utility In Alzheimer's Disease, Karin L Meeker, Patrick H Luckett, Nicolas R Barthélemy, Diana A Hobbs, Charles Chen, James Bollinger, Vitaliy Ovod, Shaney Flores, Sarah Keefe, Rachel L Henson, Elizabeth M Herries, Eric Mcdade, Jason J Hassenstab, Chengjie Xiong, Carlos Cruchaga, Tammie L S Benzinger, David M Holtzman, Suzanne E Schindler, Randall J Bateman, John C Morris, Brian A Gordon, Beau M Ances

2020-Current year OA Pubs

Alzheimer's disease biomarkers are crucial to understanding disease pathophysiology, aiding accurate diagnosis and identifying target treatments. Although the number of biomarkers continues to grow, the relative utility and uniqueness of each is poorly understood as prior work has typically calculated serial pairwise relationships on only a handful of markers at a time. The present study assessed the cross-sectional relationships among 27 Alzheimer's disease biomarkers simultaneously and determined their ability to predict meaningful clinical outcomes using machine learning. Data were obtained from 527 community-dwelling volunteers enrolled in studies at the Charles F. and Joanne Knight Alzheimer Disease Research Center at Washington …

Factors Associated With Never Treatment And Acceptability Of Mass Drug Administration For The Elimination Of Lymphatic Filariasis In Guyana, 2021, Claudia Duguay, Reza A. Niles-Robin, Charles R. Thickstun, Horace Cox, Annastacia Sampson, Jean Seme-Fils Alexandre, Nathely Caleb-Mars, Charles W. Goss, Ana Morice, Ronaldo G. Carvalho Scholte, Alison Krentel

2020-Current year OA Pubs

Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination of LF requires repeated annual mass drug administration (MDA) with sufficient levels of coverage for success. This study assesses the acceptability and never treatment of LF MDA using data from a routine assessment survey in 2021. A subset of individuals, over 20 years of age (n = 2498), were selected to receive an expanded questionnaire to examine factors associated with acceptability and never treatment. Assessed factors include respondent demographics, knowledge, risk perceptions of LF, and opinions on the MDA programme. The majority (73%) of those …

Health System Barriers To Hypertension Care In Peru: Rapid Assessment To Inform Organizational-Level Change, Kendra N. Williams, Lindsay J. Underhill, Lisa De Las Fuentes, Elvin H. Geng, Victor G. Davila-Roman, Et Al.

2020-Current year OA Pubs

Traditional patient- and provider-level hypertension interventions have proven insufficient to halt hypertension as the leading cause of morbidity and mortality globally. Systems-level interventions are required to address factors challenging hypertension control across a social ecological framework, an under-studied topic particularly salient in low- and middle-income countries (LMICs) such as Peru. To inform such interventions, we sought to identify key health systems barriers to hypertension care in Puno, Peru. A participatory stakeholder workshop (October 2021) and 21 in-depth interviews (October 2021-March 2022) were conducted with 55 healthcare professionals (i.e., doctors, nurses, midwives, dentists, nutritionists), followed by a deductive qualitative analysis of …

A Global Scoping Review Of Adaptations In Nurturing Care Interventions During The Covid-19 Pandemic, Lidia Godoi, Simone Schenkman, Ana A Baumann, Aylene Bousquat, Gabriela Buccini

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, children faced a disproportionate burden of malnutrition and poor health outcomes. Nurturing care interventions (NCIs) including actions toward good health, adequate nutrition, responsive care, opportunities for early learning, and security and safety are critical for promoting equity. Due to the need for evidence-based responses and preparedness, we analyzed adaptations in NCIs' implementation strategies during COVID-19 according to the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS).

METHOD: We conducted a global scoping review including peer-reviewed and non-peer-reviewed literature. The databases searched were PubMed, Embase, Scopus, BVS, Scielo, and Web of Science. This …

Changing Hearts And Minds: Theorizing How, When, And Under What Conditions Three Social Influence Implementation Strategies Work, Bryan J Weiner, Rosemary D Meza, Predrag Klasnja, Rebecca Lengnick-Hall, Gretchen J Buchanan, Aaron R Lyon, Kayne D Mettert, Marcella H Boynton, Byron J Powell, Cara C Lewis

2020-Current year OA Pubs

BACKGROUND: Opinion leadership, educational outreach visiting, and innovation championing are commonly used strategies to address barriers to implementing innovations and evidence-based practices in healthcare settings. Despite voluminous research, ambiguities persist in how these strategies work and under what conditions they work well, work poorly, or work at all. The current paper develops middle-range theories to address this gap.

METHODS: Conceptual articles, systematic reviews, and empirical studies informed the development of causal pathway diagrams (CPDs). CPDs are visualization tools for depicting and theorizing about the causal process through which strategies operate, including the mechanisms they activate, the barriers they address, and …

Tourette Syndrome Research Highlights From 2023 [Version 2; Peer Review: 3 Approved], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Nanette Mol Debes, Simon Morand-Beaulieu, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.

Protocol For A Pilot Clinical Trial Of The Senolytic Drug Combination Dasatinib Plus Quercetin To Mitigate Age-Related Health And Cognitive Decline In Mental Disorders [Version 2; Peer Review: 1 Approved, 2 Approved With Reservations], Abigail Schweiger, Breno Diniz, Ginger Nicol, Julie Schweiger, Andes E Dasklakis-Perez, Eric J Lenze

2020-Current year OA Pubs

BACKGROUND: Major depressive disorder (MDD) and schizophrenia are linked to accelerated aging leading to reduced lifespan, health span and cognitive decline. Cellular senescence, in which cells lose proliferative capacity and develop a senescence-associated secretory phenotype (SASP), plays a role in this process. Emerging research suggests that the senolytic regimen of dasatinib+quercetin (D+Q) reduces senescent cells, potentially mitigating age-related health and cognitive decline. This pilot study aims to assess the feasibility and safety of D+Q in older adults with schizophrenia, schizoaffective disorder, and treatment-resistant depression (TRD).

METHODS: This single-center study will recruit 30 participants total aged 50 years or older with …

Shared Decision-Making During Virtual Care Regarding Rheumatologic And Chronic Conditions: Qualitative Study Of Benefits, Pitfalls, And Optimization, Lisa Zickuhr, Catherine Mccarthy, Emma Nolan-Thomas, Tiffany Westrich-Robertson, Elizabeth A Baker, Janice L Hanson

2020-Current year OA Pubs

OBJECTIVE: Virtual care (VC) is an accepted modality of care delivery, and shared decision-making (SDM) benefits patients with rheumatologic and chronic conditions (RCCs). Unfortunately, research suggests reduced quality of SDM during VC. This study explores the benefits and shortcomings of SDM regarding RCCs during VC with suggestions for optimally using VC during SDM.

METHODS: Following Stiggelbout's framework for SDM, we conducted focus groups of patients with RCCs and providers to understand their experiences with SDM during VC, probing for facilitating and challenging factors. We conducted content analysis of the transcripts, defining themes, and inductively reasoned to identify relationships among themes. …

Arid1a Loss Is Associated With Increased Nrf2 Signaling In Human Head And Neck Squamous Cell Carcinomas, Vinh Nguyen, Travis P. Schrank, Michael B. Major, Bernard E. Weissman

2020-Current year OA Pubs

Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two classes of mutations appeared to independently contribute to tumor development, recent reports have demonstrated a mechanistic link between these two regulatory mechanisms in specific cancer types and cell models. In this work, we expand upon these data by exploring the relationship between mutations in BAF and PBAF subunits of the SWI/SNF complex and activation of NRF2 signal transduction across many cancer types. ARID1A/B mutations were strongly associated with NRF2 transcriptional …

Exploring Teachers’ Perspectives On Integrating Gaming Into Agriculture Education Through Nasef Farmcraft, Carrie Settles Livers

Murray State Theses and Dissertations

With a growing population and a decrease in arable land, it is vital to prepare the next generation of agriculturalists. However, enrollment in agricultural education programs has been on the decline. Incorporating digital games into the classroom could serve to engage future students and encourage careers in agriculture. This study explored how Georgia agriculture teachers' technological and pedagogical knowledge influences their willingness to adopt digital games, specifically Georgia Farmcraft and Minecraft for Education, in their teaching. Additionally, it sought to identify demographic factors that might impact adoption and to determine effective professional development strategies to support teachers in using these …

University Student Worker Productivity: A Qualitative Analysis, Amanda S. Mansfield

Murray State Theses and Dissertations

Student worker productivity is an important aspect of higher education, since many functional units rely on student employees to operate. Student workers communicate with all stakeholders of universities, including incoming and current students and their families, alumni, faculty, staff, and community members. Universities facing issues related to budgeting, enrollment, retention, and employability of their graduates can combat those issues by strengthening the largest labor pool on campus, student workers. The study explored what it means to be a productive university student worker within the framework of Social Exchange Theory and Grounded Theory. The study sought to provide recommendations to universities …

Perceptions Of Available Funding Opportunities For West Tennessee’S Young And Beginning Row Crop Farmers, Logan Meeks

Murray State Theses and Dissertations

Research quickly identified many different avenues of funding available to new and beginning traditional row-crop farmers in Tennessee, but questions surrounding local farmers’ knowledge of these opportunities are in question. Many programs specific to the New and Beginning Farmer demographic boasted the potential benefits of using these programs as well as the good work these programs are accomplishing. The current increase in cost of traditional row-crop funding continues to drive the need for more funding resources with New and Beginning Farmers. Providing resources of where farmers can find the best available funds for their operation will expand the level of …

Early-Career Georgia Agriculture Teachers' Agricultural Mechanics Professional Development Needs, Christopher Crump

Murray State Theses and Dissertations

Agricultural mechanics is a prominent topic in Georgia Agricultural Education, as it is the agricultural subject matter area with the second-largest enrollment across all school systems in the state. However, with Georgia agricultural teacher preparation programs only requiring three credit hours in the subject matter area, questions arise as to whether Georgia agriculture teachers are properly prepared to teach this subject matter area, especially if those teachers did not complete a traditional teacher preparation program. This nonexperimental, quantitative study assessed early-career Georgia agriculture teachers’ professional developmental (PD) needs in agricultural mechanics. Qualtrics was utilized to collect responses to a research …

Relationship Analysis Of Storyline Curriculum Engagement And Academic Performance, Cassandra Shockley

Murray State Theses and Dissertations

Secondary educators are responsible for moving students from dependent learners to independent individuals who can solve problems and be productive members of society. Science education has changed since 2012 when the PISA and TIMSS results were analyzed and showed that American students perform significantly lower than other countries. In 2013, Kentucky adopted new science standards that replaced the extensive lists of facts to be memorized with a set of performance expectations. Students are now tested on their ability to apply content knowledge to solve a phenomenon. Seventh-grade science teachers in classrooms with wide ranges of academic readiness have resisted switching …

The Effect Of Asynchronous Pre-Service Training On Aac Strategy Use, Cheri Dodge Chin

Murray State Theses and Dissertations

This dissertation investigates the impact of a one-time online, asynchronous training program on graduate students' use of communication partner strategies for Augmentative and Alternative Communication (AAC) users. The study examines the training effect on the overall correct usage of naturalistic communication partner strategies, the implementation immediacy, the influence of feedback, and the training's benefits and drawbacks. Using an A-B single case research design with qualitative feedback, the study included pre-service university students studying speech pathology or education. Participants engaged in storybook reading activities with communication devices at a university clinic to establish baseline measures. Following this, they completed a one-hour …

The Effectiveness Of Aac Training For Nursing Students To Increase The Knowledge And Success For Communicating With Patients With Complex Communication Needs, Hanna Hill Webb

Murray State Theses and Dissertations

Effective communication is an essential practice for nurses and is fundamental for the care of patients. Nurses have significant difficulties communicating with patients with complex communication needs (CCN), which can lead to communication breakdowns and sentinel events. While AAC is a viable option for communicating with patients with CCN, nurses do not receive any training on how to effectively communicate or use AAC with patients with CCN. Nursing students are in the ideal position for learning how to use AAC and communicate with AAC, as they are in the process of learning and entering the field for medical placements. This …

Factors Influencing Engineering Student Persistence: A Two Institution Study, Stephen Drawbaugh

Murray State Theses and Dissertations

The purpose of this study was to investigate the persistence factors of undergraduate engineering students and compare those factors at an R2 research university and a regional university. The study further investigated if these factors are different based on gender and race/ethnicity. This study used quantitative methodology to determine the significance of the differences in universities, genders, and races/ethnicities. Tinto’s (1975, 1993) student departure theory, Bean’s (1988, 2001) student departure model, Astin’s student involvement and development theory, and a study by Marra et al. (2012) provided the theoretical framework for this study. Findings from the survey sample of 52 students …

Factors That Influence Males To Teach Agricultural Education, Ashley Thoron

Murray State Theses and Dissertations

The need for more males entering the teaching profession is linked to the idea of the gender gap in school with females outperforming males, and the need for young men to have strong role models. Therefore, the purpose of this study is to determine factors that influence males to teach agricultural education. This study utilized an adapted version of the Ag-Ed FIT Choice Instrument to collect data through a modified version of Dillman’s Tailored Design Method, with three contacts of a pre-notice letter, emailed instrument, and a thank you/reminder. The population consisted of male agricultural education students enrolled in teacher …

Changing Demographics In Career & Technical Student Organizations, Elizabeth Hunt Galloway

Murray State Theses and Dissertations

The state of Georgia’s demographics has consistently changed in the last twenty years. Since 2010, the population of Georgia has steadily increased by 1% (Georgia Population by Year, County, Race, & More, 2023). A mirror of the state population increases occurred in the school system with 1% growth each year between 2010 and 2022 (Georgia Population by Year, County, Race, & More, 2023). The demographics of the state of Georgia has changed along with the population with an increase in Hispanic and Black population while the White population has decreased (Hauer, n.d.). The need to increase membership in Career Technical …

A Statewide Examination Of Racial Equity, Culturally Responsive Teaching, And Career Technical Education Outcomes In Kentucky, Reginald L. Mcdaniel Jr.

Murray State Theses and Dissertations

This study examines the implementation of Racial Equity Policies (REP) and Culturally Responsive Teaching (CRT) practices in Career and Technical Education (CTE) across the Commonwealth of Kentucky's public school districts. This quantitative research incorporates perspectives from district leaders, educators, and administrators, exploring the interplay between racial equity policies and teaching practices. The study highlighted the influential role of district leaders in shaping positive perceptions and awareness of the tools available to support equity work. The study also revealed disparities among districts, with urban areas leading integration, while rural districts express confidence in their commitment to racial equity.

The study's practical …

Listen Up: Perceptions Of Audiobooks By Teachers, Librarians, And Parents, Megan Bright

Murray State Theses and Dissertations

Reading is a critical component of education. From learning to read, to eventually reading to learn, students and teachers rely upon texts to help make sense of the world around them. Methods and tools vary, but teachers, librarians, and parents can all agree that reading is a fundamental skill their students need. However, students are sometimes told to limit their use of audiobooks in favor of reading with their eyes. These limitations may prevent students from finding the books they love and also limit students’ opportunities to use books to learn about the world around them. This study sought to …

Examining Stigma In Rural Mental Health Care Settings: A Mixed Methods Approach, Lainie Krumenacker

Murray State Theses and Dissertations

More than half of Americans will be diagnosed with a mental illness in their lifetime (CDC, 2021), yet stigma towards mental health affects both patients and providers. Although programs exist to address stigma, improve cultural competency among providers, and educate families on the importance of support, facilities are often limited on programs they provide due to allocation of resources and funds. Without a shift in treatment and programing, stigma will continue to impact patient care and outcome.

This study explored stigma among mental health providers in rural communities, while exploring potential differences in treatment among patients due to race. Mental …