Digital Commons Network^™

Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the Supplementary information section in the online version of the article. Citations to Supplementary Data 3 in the article remain unchanged.

Early Life Energy Balance: The Development Of Infant Energy Expenditure And Intake In The Context Of Obesity, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: This review aims to provide a summary of the current knowledge on measurement tools and most recent evidence for prenatal and postnatal modulators of energy balance in young infants. Recent Findings: The prevention of pediatric obesity depends upon curating the perfect imbalance of energy intake to energy expenditure, taking into consideration the energy needs for healthy growth. We summarize the recent evidence for the programming of fetal and infant metabolism influenced by maternal preconception health, prenatal metabolic milieu, and physical activity behaviors. In the early postnatal environment, caregiver feeding behaviors shape the extent of energy imbalance through …

Precision Treatment Of Beta-Cell Monogenic Diabetes: A Systematic Review, Rochelle N. Naylor, Kashyap A. Patel, Jarno L.T. Kettunen, Jonna M.E. Männistö, Julie Støy, Julie Støy, Jacques Beltrand, Michel Polak, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Beta-cell monogenic forms of diabetes have strong support for precision medicine. We systematically analyzed evidence for precision treatments for GCK-related hyperglycemia, HNF1A-, HNF4A- and HNF1B-diabetes, and mitochondrial diabetes (MD) due to m.3243 A > G variant, 6q24-transient neonatal diabetes mellitus (TND) and SLC19A2-diabetes. Methods: The search of PubMed, MEDLINE, and Embase for individual and group level data for glycemic outcomes using inclusion (English, original articles written after 1992) and exclusion (VUS, multiple diabetes types, absent/aggregated treatment effect measures) criteria. The risk of bias was assessed using NHLBI study-quality assessment tools. Data extracted from Covidence were summarized and presented as descriptive …

Effective Interventions In Preventing Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, Wubet Worku Takele, Kimberly K. Vesco, Jami Josefson, Leanne M. Redman, Wesley Hannah, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J. Fawcett, Andrea J. Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K.W. Leung, Kai Liu, Eskedar G. Mekonnen, Eskedar G. Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Gebresilasea G. Ukke, Shao J. Zhou, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds

Clinical Research Faculty Publications

Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR) framework was used to examine intervention characteristics (who, what, when, where, and how). Subgroup analysis was performed by intervention characteristics. Results: 116 studies involving 40,940 participants are included. Group-based physical activity interventions (RR 0.66; 95% CI 0.46, 0.95) reduce the incidence of GDM compared with individual or mixed (individual and group) …

Islet Autoantibodies As Precision Diagnostic Tools To Characterize Heterogeneity In Type 1 Diabetes: A Systematic Review, Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Kurt J. Griffin, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr

Clinical Research Faculty Publications

Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Results: …

Precision Stratification Of Prognostic Risk Factors Associated With Outcomes In Gestational Diabetes Mellitus: A Systematic Review, Zhila Semnani-Azad, Romy Gaillard, Alice E. Hughes, Kristen E. Boyle, Kristen E. Boyle, Deirdre K. Tobias, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu

Clinical Research Faculty Publications

Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through September 30th, 2021, that focused on the above outcomes of interest with respect to sociodemographic factors, lifestyle and behavioral characteristics, traditional clinical traits, and ‘omics biomarkers in the mothers and offspring during the perinatal/postpartum periods and across the lifecourse. Studies that did not report …

The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter

Clinical Research Faculty Publications

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease …

Impact Of Amyloid And Cardiometabolic Risk Factors On Prognostic Capacity Of Plasma Neurofilament Light Chain For Neurodegeneration, Keun You Kim, Eosu Kim, Jun Young Lee, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing, Norman Relkin, Karen Elizabeth Smith, Hyungsub Shim, Laura L.Boles Ponto, Susan K. Schultz, Antero Sarrael, Raymundo Hernando, Nunzio Pomara, Dick Drost, Andrew Kertesz, John Rogers, Irina Rachinsky, Stephen Pasternak, Elizabether Finger, David Bachman, Kenneth Spicer, Jacobo Mintzer, Bruce L. Miller, Howard J. Rosen, Stephen Correia, Paul Malloy, Stephen Salloway, Geoffrey Tremont, Henry Querfurth, Brian R. Ott, Franklin Watkins

Clinical Research Faculty Publications

Background: Plasma neurofilament light chain (NfL) is a blood biomarker of neurodegeneration, including Alzheimer’s disease. However, its usefulness may be influenced by common conditions in older adults, including amyloid-β (Aβ) deposition and cardiometabolic risk factors like hypertension, diabetes mellitus (DM), impaired kidney function, and obesity. This longitudinal observational study using the Alzheimer’s Disease Neuroimaging Initiative cohort investigated how these conditions influence the prognostic capacity of plasma NfL. Methods: Non-demented participants (cognitively unimpaired or mild cognitive impairment) underwent repeated assessments including the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) scores, hippocampal volumes, and white matter hyperintensity (WMH) volumes at 6- or 12-month …

Sex Differences In Interacting Genetic And Functional Connectivity Biomarkers In Alzheimer’S Disease, Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing, Norman Relkin, Karen Elizabeth Smith, Hyungsub Shim, Laura L.Boles Ponto, Susan K. Schultz, Antero Sarrael, Raymundo Hernando, Nunzio Pomara, Dick Drost, Andrew Kertesz, John Rogers, Irina Rachinsky, Stephen Pasternak, Elizabether Finger, David Bachman, Kenneth Spicer, Jacobo Mintzer, Bruce L. Miller, Howard J. Rosen, Stephen Correia, Paul Malloy

Clinical Research Faculty Publications

As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer’s disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex and may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity. The purpose of this study was to determine if the ApoE genotype plays a role in the observed sex differences in …

Many-Body Enhancement Of High-Harmonic Generation In Monolayer Mos2, Victor Chang Lee, Lun Yue, Mette B. Gaarde, Yang Hao Chan, Diana Y. Qiu

Faculty Publications

Many-body effects play an important role in enhancing and modifying optical absorption and other excited-state properties of solids in the perturbative regime, but their role in high harmonic generation (HHG) and other nonlinear response beyond the perturbative regime is not well-understood. We develop here an ab initio many-body method to study nonperturbative HHG based on the real-time propagation of the non-equilibrium Green’s function with the GW self energy. We calculate the HHG of monolayer MoS2 and obtain good agreement with experiment, including the reproduction of characteristic patterns of monotonic and nonmonotonic harmonic yield in the parallel and perpendicular responses, respectively. …

Metabarcoding The Arctic Ocean Helps Reveal Its Hidden Microbial Community Composition, Rafet Çağrı Öztürk, Yahya Terzi, Sheila Rodríguez-Machado, Ersan Başar, Ali Muzaffer Feyzioğlu, Dilek Ustaoğlu, Ertuğrul Ağırbaş, Prosanta Chakrabarty

Faculty Publications

The Arctic Ocean supports a unique and dynamic microbial community, yet its composition, structure, and response to environmental shifts remain incompletely understood. In this study, 16S rRNA gene metabarcoding (targeting the V3-V4 and V4-V5 hypervariable regions) was used to assess surface water microbial diversity across 20 stations in the Barents Sea, focusing on latitudinal variations within two contrasting current systems: the West Spitsbergen Current (WSC) and the East Spitsbergen Current (ESC). Our results showed that the microbial community is dominated by three primary families—Pseudoalteromonadaceae, Moraxellaceae, and Flavobacteriaceae (14.20%). Comparative analysis of the V3-V4 and V4-V5 regions reveals that each region …

Global Well-Posedness For Supercritical Sqg With Perturbations Of Radially Symmetric Data, Aynur Bulut, Hongjie Dong

Faculty Publications

We study the global well-posedness of the supercritical dissipative surface quasi-geostrophic (SQG) equation, a key model in geophysical fluid dynamics. While local well-posedness is known, achieving global well-posedness for large initial data remains open. Motivated by enhanced decay in radial solutions, we aim to establish global well-posedness for small perturbations of potentially large radial data. Our main result shows that for small perturbations of radial data, the SQG equation admits a unique global solution.

Creating A Bio-Based Circular Economy From Louisiana Sugarcane Byproducts, G. Aita, D. Bhatnagar, G. O. Bruni, M. Deliberto, G. Eggleston, A. Finger, K. Gravois, M. Isied, W. Judice, K. T. Klasson, I. M. Lima, J. L. Purswell, M. Souliman, E. Terrell, B. S. Tubaña, H. L. Waguespack, J. J. Wang, P. M. White

Faculty Publications

Abstract: Sugarcane (Saccharum officinarum) is Louisiana's number one row crop. Growing and processing sugarcane produces significant amounts of byproducts, including bagasse, crop residue, molasses, filter-press mud, and boiler fly ash. These products represent an important opportunity to generate value-added and specialty products and enhance sugarcane's sustainability by facilitating a circular economy, where agricultural by-products are reused instead of disposing them (linear economy), in order to reduce resource use and energy demand. Examples of value-added products range from biochar, construction materials, animal feed, biofuels, nanoparticles, and fertilizer. Paramount to the success of the bio-based circular economy is creating useful products that …

Rotaxanes With A Photoresponsive Macrocycle Modulate The Lipid Bilayers Of Large And Giant Unilamellar Vesicles, Udyogi N.K. Conthagamage, Rajitha Rajeshwar T, Stijn Van Der Ham, Nasim Akhtar, Macallister L. Davis, Senuri G. Jayawardana, Lilia Lopez, Hanumantha Rao Vutukuri, Jeremy C. Smith, Micholas Dean Smith, Víctor García-López

Faculty Publications

Rotaxanes equipped with actuators hold great potential for developing highly functional molecular machines. Such systems could significantly enhance our ability to study and manipulate biological and artificial membranes. Here, we introduce a rotaxane with a ring featuring two azobenzene photoswitches, which retain their photoreversibility and can be stochastically shuttled along the axle in solution. Studies in model bilayers, supported by molecular dynamics simulations, show how azobenzene photoswitching alters the interaction of rotaxanes with surrounding lipids, leading to changes in lipid packing. Such changes in the lipid bilayer were leveraged to induce the light-triggered release of sulforhodamine B from large unilamellar …

Labrad : Vol 49, Issue 2 - December 2024, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• EDITORIAL
• ARTICLES
• Anti-Glomerular Basement Membrane (GBM) Disease: Pathogenesis, Presentation, and Diagnostic Insights
• Advanced Total Laboratory Automation (TLA) Workflow: A Comprehensive Approach towards High-Throughput Analyzers in Clinical Chemistry
• Precision Under Pressure: Challenges in Therapeutic Drug Monitoring for Immunosuppressants
• Frozen Section: Diagnostic Accuracy, Pitfalls and Use of Digital Pathology
• Working Environment Perspective of a Learner
• AI Training: A Must-Have Skill for Tomorrow’s Radiologists
• Challenges in Blood Supply: Importance of Voluntary Donations
• Leadership Skills and Emotional Intelligence For Professional Capacity Building in Histopathology – A Broad Perspective
• Factor VIII and XI Deficiency; A Finding That Could Have Been Missed-A Case Report
• Accelerated Phase …

Predicting Agricultural Sciences Students’ Media Literacy In A Post-Truth Era, Abigail Durheim, Kasey Harmon, Taylor Ruth, Cara Lawson

Journal of Human Sciences and Extension

As more individuals turn to various forms of online media to seek information, misinformation and skepticism are on the rise when considering news media. Media literacy, or how individuals evaluate information they see in the news media, is critical to addressing this growing problem. This study aimed to explore the predictors of agricultural sciences students’ perceived news media literacy to gather preliminary data around this topic. Through an online survey, students enrolled in an agricultural communication class at the University of Nebraska-Lincoln completed a literacy reflection assignment. Students were asked to answer questions about their news media use, perceived media …

Personal Protective Equipment For Minoritized U.S. Agricultural Farmworkers: Community-Based Efforts During The Pandemic & Implications For Extension, Helen Trejo

Journal of Human Sciences and Extension

There are an estimated 2 million farmworkers who are essential to the food system in the United States; however, they are exposed to hazardous environmental conditions with limited access and/or use of Personal Protective Equipment (PPE). The primary purpose of this research is to evaluate community-based organizational efforts to provide farmworkers with apparel-textile basic needs, such as face masks. A primary goal is to address the research gap regarding common environmental factors that impact farmworkers, including pesticides and the pandemic, their use of available PPE, and community-based efforts to improve access to face masks as basic PPE. We consider the …

Extension Partnerships For Innovative Programming: A Community-Based Training On Artificial Intelligence For Workforce Development, Paul A. Hill, Lendel K. Narine, Jordan L. Rushton, Clint J. Reid

Journal of Human Sciences and Extension

The AI Training Series was Washington County, Utah’s first community education offering on the topic of generative AI (GenAI). The training provided community members with an overview of the capabilities and advantages of GenAI and assisted them in making informed technology adoption decisions. Utah State University Extension partnered with Dixie Technical College and Zonos, a software company, to evaluate the effectiveness of the learning experience based on anticipated outcomes. Results showed the training was effective for disseminating information and advancing knowledge on the topic of GenAI. However, students’ intentions to adopt AI were lower than expected due to perceived barriers …

Using The Perspectives Of Kentucky Family And Consumer Sciences Extension Agents To Develop A Sustainable Eating Curriculum, Lindley Barker, Heather Norman-Burgdolf, Annie Koempel, Katie Pickford, Tammy Stephenson, Dawn Brewer

Journal of Human Sciences and Extension

Sustainable eating may benefit both the environment and human health. Currently, no Extension programs addressing healthy and sustainable eating are available that target adults in communities. Since sustainable eating is a sensitive topic, this project engaged Family and Consumer Sciences (FCS) Extension agents in Kentucky, to garner their community expertise and perspectives on sustainable eating to help develop an appropriate Extension curriculum. By following the Curriculum Development Process for Cooperative Extension Programming model, we involved FCS agents in developing and reviewing a sustainable eating curriculum. The proposed curriculum included content that reflected sustainable eating principles of reducing overconsumption of foods, …

Exploring The Role Of Mass Media In Enhancing Farmer-To-Farmer Extension Activities In Bosomtwe District, Ghana, Anthony Kwame Appiah, Enoch Kwame Tham-Agyekum, Fred Nimoh, John-Eudes Andivi Bakang, Fred Ankuyi

Journal of Human Sciences and Extension

Farmer-to-farmer extension has always existed among farmers. It helps to strengthen information flow, reduce extension costs, and empower farmers playing a crucial role in enhancing their livelihoods. Currently, scanty information exists on the role of mass media in enhancing farmer-farmer extension activities. It is against this background that this study was carried out. Descriptive and inferential statistics were used to analyze data from 400 farmers who were selected using the multi-stage sampling technique. The results show that, compared to newspapers, books, TV, radio, computers, and social media, the mobile phone is the most accessible and most used mass media tool …

What’S The Beef? Current Trends Of The Florida Beef Cattle Industry As Perceived By Florida Beef Cattle Industry Leaders, Micah Gallagher, Matt Benge, Lauri Baker

Journal of Human Sciences and Extension

Agriculture plays a vital role in Florida’s economy, as it is the second largest industry behind tourism. Additionally, Florida is a leading cow-calf production state in the United States which is impacted by numerous factors internal and external to the industry itself. The Theory of Reasoned Action was used to explore current trends of the Florida beef cattle industry as perceived by Florida cattle industry leaders. Thirteen themes emerged from the data, such as environmental protection and alternative proteins. Florida ranchers need support from government entities to continue participation in conservation, education, and improvement of the cattle industry in Florida. …

The First World War Letters Of H.J.C. Peirs: A Case Study Of The Creation And Growth Of A Collaborative, Pedagogy-Driven Digital History Project, Amy E. Lucadamo, R.C. Miessler, Ian A. Isherwood

All Musselman Library Staff Works

This chapter concerns the development of a First World War Digital Humanities project at a small US liberal arts college. The project, based on a manuscript collection of documents, photographs, artefacts, and nearly 300 letters (primarily written between 1915 and 1919), was designed from the beginning to be truly collaborative, featuring the creative and scholarly work of undergraduate students, a faculty member, a librarian, and an archivist to tell a unique story from the Western Front. What initially began as a project to digitally preserve and promote primary source materials for a wider audience adapted and changed over the course …

Wings & Horns: Visualizing The Drought In Lakes, Wetlands, And Bogs, Somayeh Faal

Graduate Theses in Studio Art

No abstract provided.

Unboxing The Balikbayan: Filipino Third Culture Kids' Sense Of Identity And Belonging Upon Repatriation, Zayda De Guzman

Undergraduate Honors Theses

Third Culture Kids (TCKs), or children who grow up in a country different from their parent’s home country, have a unique identity formation is attributed to their mobile upbringing, and is described as “rootless” due to their sense of identity and belonging going past a geographical place. Due to their upbringing, TCKs often struggle with repatriation distress, finding it difficult to maintain a sense of belonging upon returning to their passport country. While TCKs have garnered significant attention from scholars, most of that has been directed towards TCKs from Western countries, such as the United States. This thesis explores how …

Sustainability Spotlight, Hanley Sustainability Institute

Hanley Sustainability Institute Newsletter

No abstract provided.

Dynamics Of The Blood Plasma Proteome During Hyperacute Hiv-1 Infection, Jamirah Nazziwa, Eva Freyhult, Mun-Gwan Hong, Emil Johansson, Filip Årman, Jonathan Hare, Kamini Gounder, Melinda Rezeli, Tirthankar Mohanty, Amin Hassan

Institute for Human Development, East Africa

The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased …

Comparing Conventional And Modified Cage Wheel Performance In Lowland Conditions, Rosalinda Abad, Michael Duldulao, Arthur Fajardo

The Philippine Agricultural Scientist

In agricultural production, significant cost consumption from tillage due to high energy input and low work performance may be reduced by improving the design of hand tractor components, specifically tractive devices. This study aimed to compare the field performance of conventional and modified cage wheels for hand tractors in terms of field efficiency (FE), wheel slip, and fuel consumption (FC). Using the Philippine standard methods of testing for walking-type tractors and a two-tailed t-test to analyze the data, results showed that the modified cage wheel had an FE of 90.09%, wheel slip of 7.78%, FC of 0.22 L/h, and FC …

Production Objectives And Trait Preferences Of Smallholder Farmers In The Philippines: Implications For Designing Breeding Schemes Utilizing Indigenous Swine Genetics, Joy Banayo, Kathlyn Louise Manese, Kaito Furusho, Madeline Kingan, Justine Ayomen, Marcelino Saliw-An, Karina Marie Nicolas, Kayvin Joel Petipit, Dorothy Pagbilao, Vea Roven Arellano, Rene Santiago, Flomella Caguicla, Arnolfo Monleon, Giselle Perlas, Giselle Perlas, Rea Palma Ortego, Sharon Singzon, Agapita Salces, Takahiro Yamagata

The Philippine Agricultural Scientist

Profit maximization is not the only production objective in farming. For smallholder farms worldwide, family sustenance often takes priority, with production being viewed more as savings-oriented than market-oriented. Furthermore, market pressures can lead to the mismanagement of indigenous livestock resources, increasing their risk of genetic erosion. To ensure the long-term conservation of the Philippine native pig, this study aimed to determine the various types of native pig farmers and define the intervention strategies for each type. A total of 432 native pig farmers representing seven provinces in the Philippines (Benguet, Kalinga, Isabela, Nueva Vizcaya, Quezon, Marinduque, and Eastern Samar; n …

Monitoring Nekton Response To Salt Marsh Restoration In The Great Marsh Estuary, Ma, Alexandria E. Sangermano

Master's Theses and Capstones

Salt marshes are intertidal, vegetated habitats that develop in protected, low energy areas within temperate estuaries. Notably, the North American coast comprises approximately 40% of the world's salt marshes which are valued for their numerous ecosystem services including coastal protection, carbon sequestration, and outdoor recreation. Additionally, salt marshes are vital habitats for estuarine nekton (fish and crustaceans), which rely on creeks, channels, the vegetated marsh, and isolated pools within the marsh surface for reproduction, foraging, and refuge from predators. In New England, the historic practice of salt marsh ditching for agricultural development and mosquito management has resulted in significant changes …

Restoration Of The Cantilever Deck Structure, Calvin P. Vigeant, Roger G. Biddle, Calvin S. Morgan

Architectural Engineering

The Restoration of the Cantilever Deck Structure is an inter-disciplinary project seeking to provide public safety, the continuity of a historic structure, and contribute to the life of the Poly Canyon Experimental Structures Laboratory. This project brought together architectural engineering students Roger Biddle and Calvin Vigeant and construction management student Calvin Morgan for a year long journey of Learn by Doing. The structure is visually stunning and gives the impression of a ship cresting a wave, featuring two prominent steel masts and large tapered wood beams. The deck is perched on a steep hillside site over a seasonal creek that …