Digital Commons Network^™

Assessing Minority Language In The South Sulawesi Province: Limola Language, Satwiko Budiono, Taufan Jaya

Paradigma: Jurnal Kajian Budaya

The Limola language is a minority language spoken in South Sulawesi Province. Based on the number of speakers, which ranges between 100 and 600, the Limola language is at risk. This situation underscores the urgent need for preservation efforts. One approach to preserving the language is by assessing its vitality. The assessment of the Limola language aims to evaluate its current status and identify factors contributing to its vitality. These findings will inform future language preservation strategies. The study employs a descriptive qualitative method, with data collection techniques including observation, interviews, and focus group discussions. Data analysis is based on …

Symbolic Cultural Value: Creativity And Counterproductivity In Citayam Fashion Week 2022 In Indonesia, Fuad Noorzeha, Agus Sutono, John Abraham Ziswan Suryosumunar

Paradigma: Jurnal Kajian Budaya

The phenomenon of Citayam Fashion Week has symbolically influenced the way lower-class youth dress in central Jakarta. What was once an urban area in Sudirman has transformed into a fashion arena after videos of young people sporting distinctive clothing styles went viral. More than just a social gathering, this occurrence has attracted significant attention on social media, showcasing unique fashion expressions. However, this spontaneous and instantaneous trend has sparked a wide range of responses, with opinions varying from viewing it as a creative expression to considering it counterproductive. This study employs Jean Baudrillard’s theory as its formal framework in qualitative …

A Vygotskian Perspective On Multicultural Education: A Social-Based Learning Process In The Minangkabau Community, West Sumatra, Indonesia, Isnarmi Moeis, Junaidi Indrawadi, Zaenuddin Hudi Prasojo, Fatmariza Fatmariza, Rika Febriani

Paradigma: Jurnal Kajian Budaya

Multicultural education and local wisdom function as crucial social assets in promoting unity within diverse societies. Indonesia, a country rich in ethnic diversity, possesses abundant local wisdom, particularly within the Minangkabau community of West Sumatra. This study examines the integration of Minangkabau local wisdom into the core elements of multicultural education, focusing on areas such as cultural awareness, sensitivity, cross-cultural communication, critical thinking, reflection, and cultural competence. Grounded in Vygotsky’s theory of learning as a process of social and cultural adaptation, this research adopts a qualitative methodology, utilizing in-depth interviews and focus group discussions for data collection. The analysis, carried …

The Semiotic Construction Of Meaning And Value: Canthik Kiai Rajamala As A Symbol In The Contemporary Social Perspectives, Rosa Bila Putri Dewi, Hutomo Putra, Rochtri Agung Bawono, I Nyoman Wardi

Paradigma: Jurnal Kajian Budaya

Canthik Kiai Rajamala is one of the heirlooms owned by the Keraton Kasunanan Surakarta. There are two Canthik Kiai Rajamala, each stored in the Keraton Surakarta Museum and the Radya Pustaka Museum. Surakarta is the only region traversed by the Bengawan Solo River that possesses a canthik, making it a distinctive and unique cultural heritage for the people of Surakarta. This research addresses the issue of how the meaning and value construction of Canthik Kiai Rajamala can be interpreted through Pierce's semiotic triangle theory. Additionally, this study examines how contemporary Surakarta society perceives the Canthik Kiai Rajamala. The objective …

The Impact Of Competition Law On The Digital Markets Act – On The Interrelationship Between Regulations And Future Prospects, Iga Małobęcka-Szwast

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Competition law, or rather the experience of its application in digital markets by the European Commission, national competition authorities (NCAs) and courts (in particular the Court of Justice of the European Union), has had a key influence on shaping the content of the Digital Markets Act (DMA). The article shows the complex relationship between competition law and the DMA, and discusses examples of decisions of the Commission and national competition authorities that have had an impact on the shaping of the catalogue of obligations imposed on gatekeepers under the DMA. The role of national competition authorities in ensuring the effectiveness …

European Soft Law Instruments For Sustainability Agreements – Presentation Of Procedural Issues, Critical Analysis And Recommendations For The President Of The Occp, Agata Zawłocka-Turno

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The article focuses on the procedural aspects of soft law tools employed by competition authorities in Europe, in order to help businesses advance sustainable development. In response to global challenges, such as the climate crisis, some authorities have introduced guidelines and informal guidance to enable companies to undertake pro-environmental collaboration, without breaching competition laws. Examples include guidelines from the European Commission, as well as those from the UK, Dutch, and French competition authorities. The article examines how effective these tools are, their impact on legal certainty for businesses, and explores how a similar approach could be implemented by the Polish …

Legal Professional Privilege In Proceedings Before The Polish Competition Authority Over The 20 Years Of Poland’S Membership In The Eu, Anna Gulińska, Paweł Fortuna

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The article presents how EU and Polish rules on the protection of the confidentiality of communications between a qualified lawyer and a client (legal professional privilege, LLP) have evolved over the 20 years of Poland’s membership in the European Union. In addition, the article attempts to critically assess current Polish legal provisions, as amended in 2023, particularly in light of EU case law. A generally positive assessment of introducing the self-standing rules on LPP into the Polish competition law system is supplemented by critical remarks aimed at developing an interpretation of these legal provisions, which fully takes into account EU …

The Impact Of The Judgment In Case C-211/22 Super Bock On The Assessment Of Vertical Pricing Agreements, Krzysztof Kanton

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The article discusses the impact of the judgment of the Court of Justice of the European Union (CJEU) in the Super Bock case (C-211/22) on the assessment of vertical pricing agreements under EU competition law. The judgment underscores the need to apply an economic approach when assessing whether an agreement, which provides for the setting of fixed or minimum resale prices, constitutes a restriction of competition ‘by object’. In this judgment, the CJEU rejects the previous formalistic approach – present in the practice of the EC and NCAs – which automatically qualified RPMs as anti-competitive, without analyzing its economic and …

Entire Issue Vol. 13 No. 4

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Vol 13(4)

Effective Revenue Growth Strategies For Nonprofit Organizations, Girum Assefa Gebretsadik

Walden Dissertations and Doctoral Studies

Nonprofit organizations serving under-resourced communities often face persistent challenges in securing sustainable revenue streams for fulfilling their mission and maintaining essential services, which can negatively impact vulnerable populations. Using the Baldrige excellence framework (BEF) as a conceptual lens, this qualitative single case study was conducted to explore effective revenue growth strategies to enhance financial stability, reduce financial uncertainty, strengthen resilience, and enhance community service delivery. Data collection included in-depth interviews with client leadership in the northeastern United States, an analysis of organizational documents, and financial data to support methodological triangulation. Thematic analysis using Yin’s 5-step process led to four core …

The 40th Annual Tei-Sjsu High Tech Tax Institute Conference On Nov 4-5, 2024: The Future Of The Corporate Tax Department, Cynthia Flores

The Contemporary Tax Journal

No abstract provided.

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH

Cross-Generational Perception Analysis Of The Role Of Sharia Economics In Reducing Social Inequality In Jakarta (Case Study Of Gen Z, Gen Y, Gen X, And Early Gen X), Kuncoro Hadi, Nuraini Nuraini

Journal Of Middle East and Islamic Studies

This study aims to analyze cross-generational perceptions of the role of Islamic economics in reducing social inequality in Jakarta. Using a quantitative approach, this study collected data from 994 respondents divided into four age groups (18-25 years, 26-35 years, 36-45 years, and 46-55 years). Data were analyzed using the Kruskal-Wallis test to evaluate differences in perceptions between age groups on the basic principles of Islamic economics, the fairness of the system, and the effectiveness of its implementation. The results showed significant differences in understanding and perception between age groups, with 26-35 years old having the highest level of understanding. The …

How Halal Certification And Islamic Ethics Tackle Greenwashing: New Solutions For A Sustainable Economy, Muhammad Afif Ryan Pratama

Journal Of Middle East and Islamic Studies

This research explores the role of halal certification and Islamic ethics in addressing greenwashing within the financial sector. Greenwashing, the practice of exaggerating environmental responsibility, undermines genuine sustainability efforts and trust among consumers and investors. Islamic finance, based on principles of transparency, social justice, and ethical business practices, provides a robust framework to counter such deceptive practices. The study proposes expanding halal certification to incorporate environmental standards, ensuring that companies demonstrate both ethical and sustainable practices. This integrated approach offers a unique solution to combat greenwashing and aligns with broader sustainability goals. By including sustainability in halal certification, the credibility …

Unravelling Dynamics And Connectedness: Distinguishing The Influence Of Sustainable Finance And Artificial Intelligence On Energy Sustainability In China, Chi Wei Su, Meng Qin

Bulletin of Monetary Economics and Banking

This article examines the significant roles of sustainable finance and Artificial Intelligence (AI) in advancing China’s energy sustainability by employing the TVP-VAR-SV model to track dynamic interactions among the Green Bond Index (GBI), New Economy Index (NEI), and Energy-related Uncertainty Index (EUI). Findings indicate that both GBI and NEI reduce EUI, with GBI exerting a stronger influence due to its direct link to sustainable finance, underscoring its role in mitigating energy market uncertainties. EUI, however, negatively affects GBI, revealing that high energy uncertainty may impede sustainable finance progress. Interestingly, EUI has a mixed effect on NEI, suggesting that energy uncertainties …

Quantitative Analysis Of Machine Learning Model Performance And The Need To Consider Explainability, Vishnu S. Pendyala

Open Educational Resources

This presentation, titled "Quantitative analysis of Machine Learning model performance and the need to consider explainability," delves into various metrics used for evaluating machine learning models. It thoroughly examines fundamental classification metrics like accuracy, precision, recall, and F-score, while also discussing more advanced measures such as the Kappa Statistic and Matthews Correlation Coefficient (MCC), particularly highlighting their relevance in scenarios with imbalanced datasets. The presentation underscores the importance of model accuracy in real-world applications and briefly introduces regression metrics like R-squared and F-statistic. Additionally, it addresses challenges related to data imbalance and fairness in ML models, stressing the critical need …

Assessing Nutrition Intake, Participation, And Education Retention: Among Middle School Participants Of A 12-Week Culinary Nutrition Program, Kathryn Antonopulos

Electronic Theses and Dissertations Archive

Abstract According to the World Health Organization, over 39 million children are categorized as obese.1 Several factors contribute to obesity: diet, lifestyle, environment, genetics, and socioeconomic factors.2 The most effective form of eradicating obesity is through preventative measures.2 Prevention through early exposure to nutrition education can build healthy habits and reduce the likelihood of obesity related comorbidities.3 This study’s aim was to determine if children who participate in a 12-week nutrition education program could sustain similar eating patterns, participation in meal preparation, and nutrition knowledge 6 months post program. Outcomes were assessed using quantitative and qualitative survey research. 13 participants …

The Uses Of The Border, Salvador G. Sarmiento

San Diego Law Review

It is a good and necessary time to discuss “American Law at the Border” to better understand and engage with the politics and laws ostensibly addressing U.S. borders. Let’s hope it is also an exercise in understanding the borders of U.S. law itself—the limits, the periphery, and the jagged edges. A discussion on American law at the border should make clear that what is considered at the margins—starting with migrant labor—is central to U.S. economic, legal, and political life.

The first section of this Article will discuss the political uses of the border, beginning with the most recent example of …

Volume 33, Number 3, Winter 2024/25, Office Of Communications, Illinois Wesleyan University

Illinois Wesleyan University Magazine, 2018-present

VOLUME 33 | NUMBER 3 | Winter 2024/25

ON OUR COVER:

Lauren Giannini '08 and Andrew Herrington-Gilmore '09 are the founders of the The Gilmore Family Foundation, which has raised more than half a million dollars to support research for rare diseases.

22 A Family for Care, For Lauren Giannini '08 and Andrew Herrington-Gilmore '09, receiving their children's diagnoses of rare and life threatening diseases became their life's greatest challenge and their new inspiration to help others.

Dlk-Dependent Axonal Mitochondrial Fission Drives Degeneration After Axotomy, Jorge Gómez-Deza, Matthew Nebiyou, Mor R Alkaslasi, Francisco M Nadal-Nicolás, Preethi Somasundaram, Anastasia L Slavutsky, Wei Li, Michael E Ward, Trent A Watkins, Claire E Le Pichon

Faculty, Staff and Students Publications

Currently there are no effective treatments for an array of neurodegenerative disorders to a large part because cell-based models fail to recapitulate disease. Here we develop a reproducible human iPSC-based model where laser axotomy causes retrograde axon degeneration leading to neuronal cell death. Time-lapse confocal imaging revealed that damage triggers an apoptotic wave of mitochondrial fission proceeding from the site of injury to the soma. We demonstrate that this apoptotic wave is locally initiated in the axon by dual leucine zipper kinase (DLK). We find that mitochondrial fission and resultant cell death are entirely dependent on phosphorylation of dynamin related …

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …

Age-Dependent Regulation Of Axoglial Interactions And Behavior By Oligodendrocyte Ankyring, Xiaoyun Ding, Yu Wu, Anna Vainshtein, Victoria Rodriguez, Emily Ricco, James T Okoh, Yanhong Liu, Daniel C Kraushaar, Elior Peles, Matthew N Rasband

Faculty, Staff and Students Publications

The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG (AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expressed at comparable levels in oligodendrocytes and facilitates the efficient assembly of paranodal junctions. However, the physiological roles of glial AnkG in the mature nervous system, and its contributions to BD-like phenotypes, remain unexplored. Here, we show that oligodendroglia-specific AnkG conditional knockout results in destabilization of axoglial interactions in aged but not young adult mice. In …

A Review Of Kristin M. Girten's Sensitive Witnesses: Feminist Materialism In The British Enlightenment, Peter West

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Sensitive Witnesses by Kristin M. Girten by Peter West.

“Strange And Unusual Things”: Teaching The Speculative Fiction Of Margaret Cavendish, E Mariah Spencer

ABO: Interactive Journal for Women in the Arts, 1640–1830

Margaret Cavendish, a prolific author and natural philosopher, defies categorization with her multifaceted contributions to literature and philosophy. While she is recognized for her groundbreaking work in various academic fields, her literature also resonates within the realms of science fiction, weird fiction, and speculative genres. This essay explores innovative approaches to teaching Cavendish's work, particularly within the realm of speculative literature, using an interdisciplinary lens. Drawing on perspectives including monster theory and the concept of the abject, students are prompted to critically engage with Cavendish's texts. By examining themes such as the monstrous, the supernatural, and the occult, students uncover …

Teaching Margaret Cavendish Through The Lens Of Scientific Anti-Realism, Kevin Lower

ABO: Interactive Journal for Women in the Arts, 1640–1830

Margaret Cavendish (1623-1673) only began receiving sustained attention by historians of philosophy in recent decades, but she is being rapidly integrated into the early modern philosophical canon. This essay explores one dimension of teaching Cavendish that presents difficulties for introductory philosophy students: her criticisms of experimental philosophy. Section one explains how I integrate Cavendish into the narrative of my course, identifying both historical and thematic strategies for including her in introductory philosophy courses. Section two describes methods for teaching Cavendish’s natural philosophy and identifies a pedagogical challenge to presenting her criticisms of experimental philosophy. In their first exposure to Cavendish, …

An Argumental Discourse Before All: An Approach To Teaching Cavendish, Jonathan L. Shaheen

ABO: Interactive Journal for Women in the Arts, 1640–1830

Cavendish directs readers of Observations upon Experimental Philosophy to begin engaging her work through "An Argumental Discourse." In this piece, I describe a way of thinking about the structure of that piece and how to understand two of its major moments in relationship to standardly taught material. The first moment is the dilemma about how inanimate matter is moved, with its response centered on treating a horse and its rider as a paradigm example of causation. The article shows how the argument involves Cavendish's conceptions of causation, minds, bodies, and mind-body interaction. The second moment has to do with the …

Photo-Feminists: The Inter-Textual Discussion Of Eighteenth-Century Periodical Frontispieces, Karenza Sutton-Bennett

ABO: Interactive Journal for Women in the Arts, 1640–1830

The visual afterlife of the two frontispieces from the first volume of Eliza Haywood’s periodical, The Female Spectator (1744-46) promotes the argument that middling women should be allowed to learn the same proto-disciplinary topics that men studied by representing how women could include both amusements and informal learning in between their duties as wives and mothers. The Female Spectator’s frontispiece, the emblem to Frances Brooke’s The Old Maid (1755-56), the frontispiece to Charlotte Lennox’s The Lady’s Museum (1760-61) and the 1789 frontispiece to The Lady’s Magazine (1770-1847) have the common element of the image of Minerva to visually continue the …

Playing Proverbs With Madame De Genlis, Rebecca Cypess

ABO: Interactive Journal for Women in the Arts, 1640–1830

The theatrical genre known as the proverbe dramatique, which flourished as a pastime of French high society during the late eighteenth century, has often been understood through the written exemplars left by the author and artist Louis Carrogis, known as Carmontelle. Yet Carmontelle’s literary contributions to the genre have obscured the vast range of activities known as jouer des proverbes (playing proverbs)—activities associated especially with women—which included conversational games, pantomime, poetry, dance, and music making. Attending to the many descriptions of jouer des proverbes left by Stéphanie Félicité Ducrest de Saint-Aubin, the Com­tesse de Genlis, reveals that the literary …

Simulating An Eighteenth-Century Enlightenment Salon: Embodied Experience And Scholarly Investigation, Jennifer M. Jones

ABO: Interactive Journal for Women in the Arts, 1640–1830

This paper reflects on my experience simulating an 18th-century French salon for an academic conference and in an undergraduate classroom. I argue that simulating a salon is heuristically as well as pedagogically useful and allows historians to test hypotheses about the nature of the salon and the role of the salonnière proposed by scholars such as Dena Goodman and Antoine Lilti. The essay also engages with some of the important insights gained from feminist and performance theory regarding historical reenactment. Thus I caution against naive attempts to reenact the past and instead suggest practices that foster open-ended conversations about the …

Toxic Varnishes: Perfumes, Stench, And Glow In Eighteenth-Century French Salons, Érika Wicky

ABO: Interactive Journal for Women in the Arts, 1640–1830

As several historians, including Alain Corbin, have noted, a new sensitivity to odors emerged in the 18^th century that increased people’s negative responses to strong smells and heightened the demand for fragrances that were not only pleasant but also light and subtle. Some scholars see this period as a true “olfactory revolution.” How was this expressed in the salon, perceived both as a luxurious space and a site of elite sociability? This focus on the smell of varnish aims to illustrate how the scent of materials intertwined with the pleasures of decorative arts, both in the entire space of …