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2024

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Identification Of Genes Associated With Zinc And Copper Concentrations In Walnut (Juglans Regia L.) By Gwas Analysis, Berfi̇n Nazlican Kaman, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş Dec 2024

Identification Of Genes Associated With Zinc And Copper Concentrations In Walnut (Juglans Regia L.) By Gwas Analysis, Berfi̇n Nazlican Kaman, Bülent Yağmur, Erdal Orman, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş

Turkish Journal of Botany

154 walnut genotypes from various geographic regions were analyzed in the study. Micronutrient concentrations of zinc (Zn) ranged from 1.61 to 8.98 mg/100 g, and the concentrations of copper (Cu) varied between 0.12 and 0.38 mg/100 g. 16,473 SNPs were generated using Diversity Array Technology (DArT) for genome-wide association (GWAS) studies. The Mixed Linear Model (MLM) utilizing the Q + K model revealed seven associated markers for the element Zn in 2021 and four in 2022. The MLM (Q + K) model indicated two associated markers for the element Cu in 2021 and three in 2022. The markers found in …

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Meaning As Process And Product: Hybridizing Metamodern Hylosemiotics With Postmodern And Contemporary American Poetry, Zeke Shomler Dec 2024

Meaning As Process And Product: Hybridizing Metamodern Hylosemiotics With Postmodern And Contemporary American Poetry, Zeke Shomler

English

This thesis expands on Jason Storm’s theory of metamodern hylosemiotics by addressing contemporary American poetic strategies and their relationship to modernism and postmodernism, especially through Cole Swenson and David St. John’s definition of the “American hybrid.” In modifying Storm’s theoretical system, I offer a hybridized semiotics that locates meaning both in the information or “content” inferred through the act of reading and the related processes of interacting with the text. Through readings of poetry by John Ashbery, Terrance Hayes, Clark Coolidge, and William Stafford, I show that hybridizing semiotics is not only necessary for the consistency and viability of metamodern …

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Cultivation Protocols For The Red Seaweeds, Devaleraea Mollis And Palmaria Hecatensis From Alaska, Muriel Dittrich Dec 2024

Cultivation Protocols For The Red Seaweeds, Devaleraea Mollis And Palmaria Hecatensis From Alaska, Muriel Dittrich

Marine Biology

Species diversification is crucial for the long-term viability, competitiveness, and sustainability of the seaweed farming industry in the United States. This study investigated the effects of temperature (4, 8 and 12 °C), photoperiod (8L:16D, 12L:12D and 16L:8D), and irradiance (20, 40, 100 ± 10 μmol photons m-2 s-1) on the specific growth rate (SGR) of Devaleraea mollis and Palmaria hecatensis from Alaska. Outputs were used to adjust indoor cultivation protocols for D. mollis and develop the first protocols for Palmaria hecatensis. This study also explored the use of two relatively low-cost commercial nutrient products (F/2 and Jack's Special 25-5-15) as …

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Spatial And Temporal Variability Of Carbohydrate Compositions In Cultivated Alaria Marginata, Nereocystis Luekteana, And Saccharina Latissima, Cameron Jardell Dec 2024

Spatial And Temporal Variability Of Carbohydrate Compositions In Cultivated Alaria Marginata, Nereocystis Luekteana, And Saccharina Latissima, Cameron Jardell

Marine Biology

Carbohydrates derived from Laminariales (kelp), including polysaccharides and sugar alcohols, present significant market opportunities for nascent mariculture industries. These carbohydrates can enhance crop biomass value through extractive processing, with applications in medicine, manufacturing, health supplements, and bio-plastics. The relative abundance and composition of carbohydrates in kelp can vary depending on species, life history, tissue type, season, and environmental conditions. In Alaska, mariculture of kelp focuses on three species: Alaria marginata, Nereocystis luetkeana, and Saccharina latissima. This study assessed the relative abundance of carbohydrates (glucan, mannitol, alginate, and fucoidan) in these species, as well as the sulfate content of fucoidan and …

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Exploring The Population Structure And Genetic Diversity In Apple Germplasm Using Ipbs-Retrotransposon Markers, Aigul Madenova, Angsagan Kuan, Amjad Ali, Muhammad Azhar Nadeem, Muhammad Tanveer Altaf, Balnur Kabylbekova, Dinara Kaldybaeva, Ti̇mur Turdi̇yev, Faheem Shahzad Baloch Dec 2024

Exploring The Population Structure And Genetic Diversity In Apple Germplasm Using Ipbs-Retrotransposon Markers, Aigul Madenova, Angsagan Kuan, Amjad Ali, Muhammad Azhar Nadeem, Muhammad Tanveer Altaf, Balnur Kabylbekova, Dinara Kaldybaeva, Ti̇mur Turdi̇yev, Faheem Shahzad Baloch

Turkish Journal of Botany

The apple (Malus domestica [Suckow] Borkh) is economically and culturally significant worldwide, thriving in temperate regions. This study examined genetic variations among 52 apple accessions from three research centers in Kazakhstan using the iPBS-retrotransposons marker system. Out of 35 screened markers, 12 highly polymorphic markers were selected for PCR amplification, resulting in 280 bands, 279 of which were polymorphic, yielding a 99.64% polymorphism rate. Genetic diversity indices showed substantial variation: effective number of alleles (ne=1.655), Shannon's information index (I=0.373), gene diversity (h=0.549), and an average genetic distance of 1.2. The analysis of molecular variance (AMOVA) indicated that 98.80% of the …

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Programs Agenda 12-17-24, Angela Brock Dec 2024

Programs Agenda 12-17-24, Angela Brock

Programs Committee (PC)

No abstract provided.

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Participatory Longitudinal Qualitative Interview Study To Understand Autistic Gynaecological And Obstetric Health: The Autism From Menstruation To Menopause Study Protocol, Amy Brown, Kathryn Williams, Aimee Grant, Gemma L. Williams, Harriet Axbey, Abigail Wilkins, Ellen Firth, Hazel Lim, Helen Cave, Christina Nicolaidis, Multiple Additional Authors Dec 2024

Participatory Longitudinal Qualitative Interview Study To Understand Autistic Gynaecological And Obstetric Health: The Autism From Menstruation To Menopause Study Protocol, Amy Brown, Kathryn Williams, Aimee Grant, Gemma L. Williams, Harriet Axbey, Abigail Wilkins, Ellen Firth, Hazel Lim, Helen Cave, Christina Nicolaidis, Multiple Additional Authors

School of Social Work Faculty Publications and Presentations

Autism is a lifelong minority neurotype present from birth. There is a dearth of credible evidence to suggest gender variation in Autism prevalence, despite historical under-diagnosis of women. Autistic people Assigned Female At Birth (AFAB) have worse physical and mental health compared with non-Autistic peers. To date, the reproductive health experiences of Autistic AFAB people have been under-investigated.Methods and analysis This study aims to co-develop a quality improvement intervention to improve the reproductive health of Autistic people. The study uses Community Partnered Participatory Research (an approach similar to Community-Based Participatory Research), largely through a Community Council that co-governs the study. …

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Maresin-Like 1 Ameliorates Neuropathology Of Alzheimer's Disease In Brains Of A Transgenic Mouse Model, Pallavi Shrivastava, Yan Lu, Shanchun Su, Yuichi Kobayashi, Yuhai Zhao, Nathan Lien, Abdul-Razak Masoud, Walter J. Lukiw, Song Hong Dec 2024

Maresin-Like 1 Ameliorates Neuropathology Of Alzheimer's Disease In Brains Of A Transgenic Mouse Model, Pallavi Shrivastava, Yan Lu, Shanchun Su, Yuichi Kobayashi, Yuhai Zhao, Nathan Lien, Abdul-Razak Masoud, Walter J. Lukiw, Song Hong

School of Medicine Faculty Publications

(1) Background: Impeded resolution of inflammation contributes substantially to the pathogenesis of Alzheimer's disease (AD); consequently, resolving inflammation is pivotal to the amelioration of AD pathology. This can potentially be achieved by the treatment with specialized pro-resolving lipid mediators (SPMs), which should resolve neuroinflammation in brains. (2) Methods: Here, we report the histological effects of long-term treatment with an SPM, maresin-like 1 (MarL1), on AD pathogenesis in a transgenic 5xFAD mouse model. (3) Results: MarL1 treatment reduced Aβ overload, curbed the loss of neurons in brains especially cholinergic neurons associated with cleaved-caspase-3-associated apoptotic degeneration, reduced microgliosis and the pro-inflammatory M1 …

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Selective Indel Marker Identification Across The Peanut (Arachis Hypogaea L.) Genome Using Ddradseq, Moin Qureshi, Bi̇rgül Guden, Hi̇lal Şule Tosun, Mojtaba Kordrostami, Sunil Shiwaji Gangurde, Bülent Uzun, Engi̇n Yol Dec 2024

Selective Indel Marker Identification Across The Peanut (Arachis Hypogaea L.) Genome Using Ddradseq, Moin Qureshi, Bi̇rgül Guden, Hi̇lal Şule Tosun, Mojtaba Kordrostami, Sunil Shiwaji Gangurde, Bülent Uzun, Engi̇n Yol

Turkish Journal of Botany

The advent of next-generation sequencing technologies, mainly double digest restriction site-associated DNA sequencing (ddRADSeq), has significantly advanced the development of molecular markers for crop genetics. This study used ddRADSeq to identify and develop insertion-deletion (InDel) markers in 25 peanut genotypes from diverse geographic regions. The bioinformatic analysis unveiled 62728 InDels across the peanut genome, predominantly between 1-5 bp, which constituted 96% of the total, while InDels of ≥ 6 bp accounted for 3.96%. We focused on 1013 InDels of at least 10 bp for further analysis, representing 1.61% of the total reads, with a distribution of 832 insertions and 181 …

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Co-Inhibition Of Tgli1 And Gp130 Using Fda-Approved Ketoconazole And Bazedoxifene Is Synergistic Against The Growth And Metastasis Of Her2-Enriched And Triple-Negative Breast Cancers, Sara Manore, Chuling Zhuang, Mariana K Najjar, Grace L Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo Dec 2024

Co-Inhibition Of Tgli1 And Gp130 Using Fda-Approved Ketoconazole And Bazedoxifene Is Synergistic Against The Growth And Metastasis Of Her2-Enriched And Triple-Negative Breast Cancers, Sara Manore, Chuling Zhuang, Mariana K Najjar, Grace L Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo

Faculty, Staff and Student Publications

Breast cancer stem cells (CSCs) are resistant to most cancer therapeutics and contribute to tumor recurrence and metastasis. Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and activator of transcription 3 (STAT3), have been reported to be frequently co-expressed in HER2-enriched breast cancer and triple-negative breast cancer (TNBC), undergo protein-protein interactions for gene regulation and activation, and functionally cooperate to promote breast CSCs. STAT3 can be activated by activated interleukin-6 receptor/glycoprotein-130 (IL-6R/GP130). Co-targeting of tGLI1 and IL-6R/GP130 has not been investigated in breast cancer or any tumor type. Here, we report that tGLI1 and …

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Phytoplankton As A Bioindicator For Evaluation Of The Irrigation Water Quality Near A Metal-Coating Factory, Mimatun Nasihah, Ardyati Ardyati, Dian Siswanto, Catur Retnaningdyah Dec 2024

Phytoplankton As A Bioindicator For Evaluation Of The Irrigation Water Quality Near A Metal-Coating Factory, Mimatun Nasihah, Ardyati Ardyati, Dian Siswanto, Catur Retnaningdyah

Makara Journal of Science

The irrigation water quality in Plosowahyu village, Lamongan District, Indonesia, has declined because of industrial waste disposal in irrigation canals. Specifically, waste from a metal-coating factory considerably threatens the aquatic ecosystem. To assess the impact, we evaluated water quality on the basis of phytoplankton diversity and various phys-icochemical parameters. We collected water and phytoplankton samples from four locations in Plosowahyu village: before the wastewater treatment plant (WWTP) outlet of the metal-coating factory, at this outlet, and from two sites in Wahyu River, with three repetitions at each site. The study measured several physicochemical parameters, including total dissolved solids (TDS), total …

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Unveiling Soil Microbial Communities And Resistomes In Northern Alaska National Wildlife Refuges, Bevyn Amber Cover Dec 2024

Unveiling Soil Microbial Communities And Resistomes In Northern Alaska National Wildlife Refuges, Bevyn Amber Cover

Biological Sciences

Microbial communities residing in pristine high-latitude soils play a critical role in ecosystem function, but also harbor potential threats such as acting as reservoirs of antimicrobial resistance (AMR) genes. Current knowledge about these microbial communities and the resistance genes they carry presents limits to the ability to predict how these ecosystems will respond to climate change. This knowledge gap is particularly concerning in light of the potential public health threat posed by antimicrobial resistance harbored within these communities as antibiotic-resistant human infections continue to increase. This study investigated the microbial communities and details the antimicrobial resistance gene reservoirs in previously …

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Effects Of Juvenile Mass On Reproduction And Calf Survival In A Low-Density Moose Population, Sara R. Henslee Dec 2024

Effects Of Juvenile Mass On Reproduction And Calf Survival In A Low-Density Moose Population, Sara R. Henslee

Biological Sciences

Moose (Alces alces) are a valuable big game species in Alaska and serve as a critical food source for residents. Near Nome, Alaska, the local moose population has remained at low densities for decades, and there is strong public interest in investigating the cause behind the population's failure to increase in abundance. Compared to other moose populations in Alaska, the population of moose near Nome does not appear to be nutritionally limited or close to carrying capacity. I sought to explore how juvenile mass, a widely used metric to assess moose nutritional status in Alaska, influences reproductive output and subsequent …

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Ucc Minutes 12-17-24, Angela Brock Dec 2024

Ucc Minutes 12-17-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

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How Do Anxiety, Stress, Impulsiveness, And Sleep Quality Affect Memory, Hodavia Tshiya Kaseya Dec 2024

How Do Anxiety, Stress, Impulsiveness, And Sleep Quality Affect Memory, Hodavia Tshiya Kaseya

Online Theses and Dissertations

Memory is a critical cognitive function that enables individuals to retain, recall, and apply knowledge across various contexts. Different memory systems, including working memory and long-term memory, collaborate to process and store information. Factors such as stress, sleep disturbances, anxiety, and impulsiveness can impact memory encoding and retrieval, especially in college students, whose academic success depends heavily on memory performance. This study examined the relationship between these everyday factors and memory performance by analyzing brain activity during memory encoding using Electroencephalography (EEG) and the Difference due to memory (DM) event-related potential (ERP) effect, to understand how stress, sleep, anxiety, and …

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Good For Her: Catharsis And Empowerment In Contemporary Literature, Jessica Lynn Vaught Dec 2024

Good For Her: Catharsis And Empowerment In Contemporary Literature, Jessica Lynn Vaught

Online Theses and Dissertations

A recent trend in readership within online discourse communities is the emergence of the genre called “Good for Her,” which contains themes of transgression beyond traditional expectations of socially acceptable feminine behavior by situating revenge arcs to celebrate actions that otherwise would have been perceived as reprehensible. The emergence and popularity of the genre in the post-2016 sociopolitical climate in the United States reflects the demand for marginalized communities to see versions of themselves represented in texts in which the protagonist avenges herself in the face of patriarchal oppression. The genre stems from canonical literary tropes also created in the …

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Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier Dec 2024

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …

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Touching Distant Time And Place: Place-Based Augmented Reality Storytelling, Misha Myers Dec 2024

Touching Distant Time And Place: Place-Based Augmented Reality Storytelling, Misha Myers

School of Art, Design and Architecture

Storying place through augmented reality technologies, such as software and applications which enhance and encourage interaction with physical environments with digital visual and audio elements and place digital objects in specific locations, offers multisensory tactile ways of inter-mediating relationships between self and changing environments. This chapter examines and compares how four site-specific, site-responsive and site-generic augmented reality storytelling works made for smartphones augment specific living environments through augmented spatiality, immersive audio, geo-located and interactive sound and/or visually augmented three-dimensional animations of digital entities and objects. This chapter considers how the application of specific augmented technologies in each of the works …

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The Imposition Of Power: Modernity And Nature In Hemingway And Mccarthy, Danielle Ball Dec 2024

The Imposition Of Power: Modernity And Nature In Hemingway And Mccarthy, Danielle Ball

Honors College Theses

This thesis focuses on the role of nature in opposition to modernity in Ernest Hemingway's “The Last Good Country” and “The End of Something” as well as Cormac McCarthy’s The Orchard Keeper. Each author places the forces of modernity, such as the logging industry or the introduction of the railroad, at odds with the untouched state of the natural world. Specifically, I emphasize the different portrayals of the natural world from each author. Hemingway’s nature is very closely tied to Romanticism, as nature is a spiritual and healing force for those who choose to commune with it. However, McCarthy portrays …

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The Activity And Origin Of The Chitinases In The Gut Of The Mediterranean House Gecko, Alec John Dec 2024

The Activity And Origin Of The Chitinases In The Gut Of The Mediterranean House Gecko, Alec John

Masters Theses (Archived)

Chitin is a major component of the exoskeleton of arthropods as well as the cell wall of fungi. This amino polysaccharide polymer provides structure and protection to these organisms and represents a significant barrier to digestion of arthropod prey and fighting fungal infections. Chitinases are enzymes that break down chitin. Smaller insectivores, based upon the higher surface-to-volume ratio of their even smaller prey, ingest a large amount of chitin per unit prey item. Therefore, they represent high-likelihood opportunities to bio prospect for novel chitinases that may be effective against pathogenic fungi. Fungal infections are notoriously difficult to treat, and they …

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Salmon, Stewardship, And Indigenous Livelihoods: Bridging Knowledge Systems And Reshaping Research Relationality In The Kuskokwim Region Of Southwestern Alaska, Janessa Esquible Dec 2024

Salmon, Stewardship, And Indigenous Livelihoods: Bridging Knowledge Systems And Reshaping Research Relationality In The Kuskokwim Region Of Southwestern Alaska, Janessa Esquible

Fisheries

This dissertation research is situated in southwestern Alaska, in the communities of Kongiganak, Quinhagak, Bethel, Aniak, and McGrath, spanning the Kuskokwim Bay and Kuskokwim River, and with Alaska Native Peoples (primarily Yup'ik and Athabascan fishing families) who have been salmon peoples and stewards of their ancestral homelands since time immemorial. This Indigenous-led project documented historical and current ways in which Yup'ik and Athabascan Peoples have served as salmon stewards, and the values and governance mechanisms pertaining to salmon stewardship. We utilized a participatory approach by involving Tribal governments, communities, and Indigenous local youth in all aspects of our research. We …

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Morphological And Molecular Identification Of Saurida Spp. (Teleostei: Synodontidae) From Saudi Arabia And Indonesia, Muhammad Browijoyo Santanumurti, Suciyono Suciyono, Mohamed Ahmed Abu El-Regal Dec 2024

Morphological And Molecular Identification Of Saurida Spp. (Teleostei: Synodontidae) From Saudi Arabia And Indonesia, Muhammad Browijoyo Santanumurti, Suciyono Suciyono, Mohamed Ahmed Abu El-Regal

Makara Journal of Science

Saurida is a unique fishery commodity because it is difficult to differentiate visually. They can be only effectively con-served once accurately identified. This study aimed to determine the morphology and molecular characteristics of Sau-rida spp. from Banyuwangi (Indonesia) and Jizan (Saudi Arabia). Meristic and morphometric analysis was performed for morphological identification, whereas COI gene analysis was performed for molecular identification. Morphological analysis was performed to identify Saurida in this study, such as S. tumbil (Jizan, Saudi Arabia) and S. micropectoralis (Banyuwangi, Indonesia). S. tumbil did not have dark brown spots on the lateral line and upper caudal fin, whereas S. …

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Activities Of Cellulolytic, Amylolytic, And Secondary Metabolites From Thermophilic Actinomycetes Collected From The Heated Soil Around Cisolok Geyser, Dhian Chitra Ayu Fitria Sari, Fitria Ningsih, Mazytha Kinanti Rachmania, Akira Yokota, Wellyzar Sjamsuridzal Dec 2024

Activities Of Cellulolytic, Amylolytic, And Secondary Metabolites From Thermophilic Actinomycetes Collected From The Heated Soil Around Cisolok Geyser, Dhian Chitra Ayu Fitria Sari, Fitria Ningsih, Mazytha Kinanti Rachmania, Akira Yokota, Wellyzar Sjamsuridzal

Makara Journal of Science

This study investigated the antimicrobial activity, cellulolytic, and amylolytic abilities of eight thermophilic Actinomy-cetes isolated from the heated soil around the Cisolok geyser, West Java, Indonesia. Cellulolytic and amylolytic abili-ties were screened for on media by adding 1% (w/v) soluble starch and carboxymethylcellulose (CMC), respectively. Antimicrobial activity was screened for using the agar-plug diffusion method by cultivating strains on various growth media. Growth at various temperatures showed that six strains could grow up to 50 °C. Seven out of eight strains showed amylolytic ability at 40 °C and 45 °C, and only four strains did so at 50 °C. Screening …

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Observations On The Biodegration By Solid State Fermentation Of The Giant Swamp Taro (Cyrtosperma Merkusii) Biomass By Two Endolichenic Fungi Isolates, Maria Helena, Helen Joan Lawalata, Dino Rahardiyan, Livana Dethris Rawung, Emma Mauren Moko Dec 2024

Observations On The Biodegration By Solid State Fermentation Of The Giant Swamp Taro (Cyrtosperma Merkusii) Biomass By Two Endolichenic Fungi Isolates, Maria Helena, Helen Joan Lawalata, Dino Rahardiyan, Livana Dethris Rawung, Emma Mauren Moko

Makara Journal of Science

Giant swamp taro (GST/Cyrtosperma merkusii), a local North Sulawesi coastal plant, is underutilized but has high po-tential for cultivation as a paludiculture plant on rewetted peatland restorations. GST has high starch content and is currently being explored for potential use. This study explored the potential of using the biomass pulp yielded as resi-dues of the starch extraction process. Endolichenic fungi (Trichoderma reesei and Aspergillus aculeatus) isolated from local lichens, were inoculated on the GST biomass in a solid state fermentation (SSF). Findings of this study indicate that both isolates were effective in degrading the lignocellulosic biomass of GST over an …

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Analysis Of Dense Metals Accumulation In Shikaripara Stone Mines, Gopinath Gorai, Nirajan Kumar Mandal Dec 2024

Analysis Of Dense Metals Accumulation In Shikaripara Stone Mines, Gopinath Gorai, Nirajan Kumar Mandal

Makara Journal of Science

This study aimed to measure the amount of dangerous substances in the cultivated area of the Shikaripara stone mines in Jharkhand, India, which are well known for their stone quarrying. Sixteen soil samples were collected at varying dis-tances from the Shikaripara stone mines in the Dumka District of Jharkhand. The metals found in these samples in-clude Pb, As, Zn, Mn, Cd, Cu, Fg, and Fe. The combined amount of the elements was calculated by inductively coupled plasma mass spectrometry. Enrichment factor, accumulation index, contamination factor, pollution load index (PLI), Nemerow index, and ecological risk index (RI) were employed to assess …

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Silent Stories: Exposing The Controversial Themes Behind Banned And Challenged Books, Catherine Chipongian Dec 2024

Silent Stories: Exposing The Controversial Themes Behind Banned And Challenged Books, Catherine Chipongian

Masters Theses (Archived)

This study, titled Silenced Stories: Exposing the Controversial Themes Behind Banned, and Challenged Books, captures the recurring themes of characteristics in books that have been banned or challenged in various contexts. The research dives deep into the cultural and socio-political aspects that target censorship; many of the challenged and banned texts include I Am Jazz, The Lorax, and The Name Jar. The study identifies the common themes that have been perceived as controversial or improper, such as LGBTQ Identities, Cultural Heritage, Stereotypes among children’s books, and Social Justice. These themes have been censorship targets and are examined due to their …

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Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia Dec 2024

Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia

Faculty, Staff and Students Publications

Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans—SPINT3, WFDC6, EPPIN, WFDC8, WFDC9, WFDC10A, WFDC11, WFDC10B, WFDC13, SPINT4, and WFDC3—and the 13 reproductive tract-specific orthologous genes in mice, form highly conserved syntenic gene clusters indicative of conserved, combined critical functions. Further, despite significant progress toward a nonhormonal male contraceptive targeting the protein encoded by one of these genes, epididymal peptidase inhibitor (EPPIN), and associations found between mutations in EPPIN and an increased risk of male infertility, neither EPPIN nor …

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Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni Dec 2024

Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni

Faculty, Staff and Students Publications

Therapeutic strategies targeting the DNA damage response, such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have revolutionized cancer treatment in tumors deficient in homologous recombination (HR). However, overcoming innate and acquired resistance to PARPi remains a significant challenge. Here, we employ a genome-wide CRISPR knockout screen and discover that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhances sensitivity to PARPi in HR-proficient ovarian cancer cells. We show that silencing or pharmacological inhibition of UBA1 sensitizes multiple cell lines and organoid models to PARPi. Mechanistic studies uncover that UBA1 inhibition not only impedes HR repair to sensitize cells to PARP inhibition …

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Organizational Leadership Strategies For Growing Membership In A Start-Up Online Business, Pascale Rheault Dec 2024

Organizational Leadership Strategies For Growing Membership In A Start-Up Online Business, Pascale Rheault

Walden Dissertations and Doctoral Studies

Leaders of small- and medium-sized enterprises (SMEs) play a critical role in driving the global economy; however, online start-ups often face high failure rates within their first year. Some start-up leaders fail to implement effective promotional strategies, hindering their ability to succeed in a competitive market. Grounded in the Baldrige performance excellence framework, the purpose of this qualitative single case study was to explore effective strategies business leaders use to grow membership in an online start-up business. The participants were two senior leaders in the Toronto region’s start-up sector. Data were collected using semistructured interviews as well as a review …

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Gene-Environment Interactions In Non-Alcoholic Fatty Liver Disease: Insights From Mexican American Populations, Eron G. Manusov, Vincent P. Diego, Marcio Almeida, Jacob Galan, Auwal A. Bala, Marco Arriaga, Natasha Garcia-Rodriguez, Renee Hernandez, Satish Kumar, John Blangero, Sarah Williams-Blangero Dec 2024

Gene-Environment Interactions In Non-Alcoholic Fatty Liver Disease: Insights From Mexican American Populations, Eron G. Manusov, Vincent P. Diego, Marcio Almeida, Jacob Galan, Auwal A. Bala, Marco Arriaga, Natasha Garcia-Rodriguez, Renee Hernandez, Satish Kumar, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Nonalcoholic Fatty Liver Disease (NAFLD) is a prevalent and complex condition influenced by both genetic and environmental factors. This chapter explores the genotype-by-environment interactions that contribute to the development and progression of NAFLD in the Mexican American population. Using advanced genetic epidemiology and bioinformatics approaches, we investigated how specific genetic variants interact with environmental factors such as depression, acculturation stress, and social determinants of health, to influence NAFLD risk and severity. Our findings reveal significant genotype-by-environment interactions for key NAFLD-related traits, including HbA1c, AST/ALT ratio, and steatosis-controlled attenuation parameter (CAP). We also discuss the application of cutting-edge proteomic and transcriptomic …

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