Digital Commons Network^™

The Effectiveness Of The Gnana Laryngeal Mask Airway Ii (Gla-Ii) With Novel Suction Tubing In Gastrointestinal (Gi) Cases, Shahab Ahmadzadeh, Landyn D. Johnson, William T. Barham, James Ilochi, Matthew Fredericks, Giustino Varrassi, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

INTRODUCTION: The Gnana laryngeal mask airway II (GLA-II) is a supraglottic airway device similar to the classic laryngeal mask airway, except it has an additional suction port. This suction port allows for the removal of secretions and saliva. A previous version of the Gnana laryngeal airway 4 was made of silicone, while this newer version is made of polyvinyl chloride (PVC), which is more affordable. This study aimed to demonstrate the effectiveness and tolerability of this PVC-designed GLA-II and evaluate its ability to suction secretions. METHODS: The prospective cohort study included 100 gastrointestinal (GI) cases to determine the effectiveness and …

Long-Term Dementia Risk In Parkinson Disease, Julia Gallagher, Caroline Gochanour, Chelsea Caspell-Garcia, Roseanne D Dobkin, Dag Aarsland, Roy N Alcalay, Matthew J Barrett, Lana Chahine, Alice S Chen-Plotkin, Christopher S Coffey, Nabila Dahodwala, Jamie L Eberling, Alberto J Espay, James B Leverenz, Irene Litvan, Eugenia Mamikonyan, James Morley, Irene H Richard, Liana Rosenthal, Andrew D Siderowf, Tatyana Simuni, Michele K York, Allison W Willis, Sharon X Xie, Daniel Weintraub, Parkinson's Progression Markers Initiative

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and had other limitations. We aimed to determine long-term dementia risk in PD using data from two large, ongoing, prospective, observational studies.

METHODS: Participants from the Parkinson's Progression Markers Initiative (PPMI), a multisite international study, and a long-standing PD research cohort at the University of Pennsylvania (Penn), a single site study at a tertiary movement disorders center, were recruited. PPMI enrolled de novo, untreated …

Knocking Out Amr Project Review, Lovleen Tina Joshi, Catrin E. Moore

Peninsula Dental School

No abstract provided.

Big Geospatiotemporal Data Approaches To Monitoring And Mitigating Environmental Impacts In Agriculture, Olatunde D. Akanbi, Vibha S. Mandayam, Erika I. Barcelos, Arafath Nihar, Yinghui Wu, Jeffrey Yarus, Roger H. French

Student Scholarship

This research explores the application of geospatial techniques for global agricultural monitoring, integrating satellite imagery and soil data to assess crop health and soil conditions. Our approach provides actionable insights to improve agricultural productivity and sustainability, addressing food security challenges through advanced machine learning models.

The Neurogenic Effects Of Pasak Bumi (Eurycoma Longifolia Jack) And Seluang Fish (Rasbora Spp.) In Malnutrition-Induced Rat, Didik Dwi Sanyoto, Triawanti, Meitria Syahadatina Noor, Dimas Ikhsan Airlangga

Folia Medica Indonesiana

Highlights:
1. This study analyzed the effects of using locally sourced pasak bumi extract and seluang fish on the parameters of neurogenesis in malnourished rat models.
2. It promotes further exploration into modified treatments for malnutrition, emphasizing nutritional strategies that harness locally available natural resources.


Abstract
Early developmental malnutrition exerts adverse effects on the structural, neurochemical, and neurophysiological maturation of cerebral cells by disrupting the process of neurogenesis. Pasak bumi (Eurycoma longifolia Jack) and seluang fish (Rasbora spp.), two indigenous natural resources of South Kalimantan, Indonesia, are believed to harbor nutritional components capable of mitigating these deleterious effects. We aimed …

Neuroinflammation And Brain Health Risks In Veterans Exposed To Burn Pit Toxins, Athena Brooks, Brian Sandri, Joshua Nixon, Timothy Nurkiewicz, Paul Barach, Janeen Trembley, Tammy Butterick

College of Population Health Faculty Papers

Military burn pits, used for waste disposal in combat zones, involve the open-air burning of waste materials, including plastics, metals, chemicals, and medical waste. The pits release a complex mixture of occupational toxic substances, including particulate matter (PM), volatile organic compounds (VOCs), heavy metals, dioxins, and polycyclic aromatic hydrocarbons (PAHs). Air pollution significantly impacts brain health through mechanisms involving neuroinflammation. Pollutants penetrate the respiratory system, enter the bloodstream, and cross the blood-brain barrier (BBB), triggering inflammatory responses in the central nervous system (CNS). Chronic environmental exposures result in sustained inflammation, oxidative stress, and neuronal damage, contributing to neurodegenerative diseases and …

Variants In Lrrc7 Lead To Intellectual Disability, Autism, Aggression And Abnormal Eating Behaviors., Jana Willim, Daniel Woike, Daniel Greene, Sarada Das, Kevin Pfeifer, Weimin Yuan, Anika Lindsey, Omar Itani, Amber L. Böhme, Debora Tibbe, Hans-Hinrich Hönck, Fatemeh Hassani Nia, Undiagnosed Diseases Network, Michael Zech, Theresa Brunet, Laurence Faivre, Arthur Sorlin, Antonio Vitobello, Thomas Smol, Cindy Colson, Kristin Baranano, Krista Schatz, Allan Bayat, Kelly Schoch, Rebecca Spillmann, Erica E. Davis, Erin Conboy, Francesco Vetrini, Konrad Platzer, Sonja Neuser, Janina Gburek-Augustat, Alexandra Noel Grace, Bailey Mitchell, Alexander Stegmann, Margje Sinnema, Naomi Meeks, Carol Saunders, Maxime Cadieux-Dion, Juliane Hoyer, Julien Van-Gils, Jean-Madeleine De Sainte-Agathe, Michelle L. Thompson, E Martina Bebin, Monika Weisz-Hubshman, Anne-Claude Tabet, Alain Verloes, Jonathan Levy, Xenia Latypova, Sönke Harder, Gary A. Silverman, Stephen C. Pak, Tim Schedl, Kathleen Freson, Andrew Mumford, Ernest Turro, Christian Schlein, Vandana Shashi, Hans-Jürgen Kreienkamp

Manuscripts, Articles, Book Chapters and Other Papers

Members of the leucine rich repeat (LRR) and PDZ domain (LAP) protein family are essential for animal development and histogenesis. Densin-180, encoded by LRRC7, is the only LAP protein selectively expressed in neurons. Densin-180 is a postsynaptic scaffold at glutamatergic synapses, linking cytoskeletal elements with signalling proteins such as the α-subunit of Ca²⁺/calmodulin-dependent protein kinase II. We have previously observed an association between high impact variants in LRRC7 and Intellectual Disability; also three individual cases with variants in LRRC7 had been described. We identify here 33 individuals (one of them previously described) with a dominant neurodevelopmental disorder due …

Targeting Prmt3 Impairs Methylation And Oligomerization Of Hsp60 To Boost Anti-Tumor Immunity By Activating Cgas/Sting Signaling, Yunxing Shi, Zongfeng Wu, Shaoru Liu, Dinglan Zuo, Yi Niu, Yuxiong Qiu, Liang Qiao, Wei He, Jiliang Qiu, Yunfei Yuan, Guocan Wang, Binkui Li

Faculty, Staff and Student Publications

Immune checkpoint blockade (ICB) has emerged as a promising therapeutic option for hepatocellular carcinoma (HCC), but resistance to ICB occurs and patient responses vary. Here, we uncover protein arginine methyltransferase 3 (PRMT3) as a driver for immunotherapy resistance in HCC. We show that PRMT3 expression is induced by ICB-activated T cells via an interferon-gamma (IFNγ)-STAT1 signaling pathway, and higher PRMT3 expression levels correlate with reduced numbers of tumor-infiltrating CD8+ T cells and poorer response to ICB. Genetic depletion or pharmacological inhibition of PRMT3 elicits an influx of T cells into tumors and reduces tumor size in HCC mouse models. Mechanistically, …

Study Of The Immunoserological Patterns Of Respiratory Infections In Children Under 15 Years Of Age In The Riobamba Region Based On Refined Neutrosophic Statistics, Lizbeth Geovanna Silva Guayasamín, Christian Andrés Silva Sarabia, Lisbeth Josefina Reales Chacón, Isaac Germán Pérez Vargas, Natalia Eliana Cáceres Cadena, Cesar Lenin Pilamunga Lema, Carlos Antonio Escobar Suárez, María José Terán Bejarano

Neutrosophic Sets and Systems

Acute respiratory infection (ARI) is an important cause of consultation in the emergency room and depending on the general condition of the person; it can become complicated and lifethreatening. The general objective of this study is to identify the immunoserology of acute respiratory infections in children under 15 years of age in the city of Riobamba, Ecuador in 2023; it consists of a statistical study in 85 children and adolescents. This research made it possible to identify the presence or absence of acute respiratory infections. The infections found are provoked by viruses, atypical bacteria, or a combination of both pathogens. …

Sensory Dysfunction, Microbial Infections, And Host Responses In Alzheimer's Disease, Praveen Bathini, Emanuele Brai, Brian J Balin, Lynn Bimler, David B Corry, Davangere P Devanand, Richard L Doty, Garth D Ehrlich, William A Eimer, Tamas Fulop, David L Hahn, Christine J Hammond, Joseph Infanti, Ruth Itzhaki, Richard Lathe, Christopher Scott Little, Rima Mcleod, Shima T Moein, Amy R Nelson, George Perry, Or A Shemesh, Rudolph E Tanzi, Wilmore C Webley, Nikki M Schultek, Lavinia Alberi Auber

Faculty, Staff and Students Publications

Sensory functions of organs of the head and neck allow humans to interact with the environment and establish social bonds. With aging, smell, taste, vision, and hearing decline. Evidence suggests that accelerated impairment in sensory abilities can reflect a shift from healthy to pathological aging, including the development of Alzheimer's disease (AD) and other neurological disorders. While the drivers of early sensory alteration in AD are not elucidated, insults such as trauma and infections can affect sensory function. Herein, we review the involvement of the major head and neck sensory systems in AD, with emphasis on microbes exploiting sensory pathways …

Addressing Dispersion In Mis-Measured Multivariate Binomial Outcomes: A Novel Statistical Approach For Detecting Differentially Methylated Regions In Bisulfite Sequencing Data., Kaiqiong Zhao, Karim Oualkacha, Yixiao Zeng, Cathy Shen, Kathleen Klein, Lajmi Lakhal-Chaieb, Aurélie Labbe, Tomi Pastinen, Marie Hudson, Inés Colmegna, Sasha Bernatsky, Celia M T Greenwood

Manuscripts, Articles, Book Chapters and Other Papers

Motivated by a DNA methylation application, this article addresses the problem of fitting and inferring a multivariate binomial regression model for outcomes that are contaminated by errors and exhibit extra-parametric variations, also known as dispersion. While dispersion in univariate binomial regression has been extensively studied, addressing dispersion in the context of multivariate outcomes remains a complex and relatively unexplored task. The complexity arises from a noteworthy data characteristic observed in our motivating dataset: non-constant yet correlated dispersion across outcomes. To address this challenge and account for possible measurement error, we propose a novel hierarchical quasi-binomial varying coefficient mixed model, which …

Mitochondrial Reprogramming By Activating Oxphos Via Glutamine Metabolism In African American Patients With Bladder Cancer, Karthik Reddy Kami Reddy, Danthasinghe Waduge Badrajee Piyarathna, Jun Hyoung Park, Vasanta Putluri, Chandra Sekhar Amara, Abu Hena Mostafa Kamal, Jun Xu, Daniel Kraushaar, Shixia Huang, Sung Yun Jung, Livia S Eberlin, Jabril R Johnson, Rick A Kittles, Leomar Y Ballester, Krishna Parsawar, M Minhaj Siddiqui, Jianjun Gao, Adriana Langer Gramer, Roni J Bollag, Martha K Terris, Yair Lotan, Chad J Creighton, Seth P Lerner, Arun Sreekumar, Benny Abraham Kaipparettu, Nagireddy Putluri

Faculty, Staff and Students Publications

Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared with European American (EA) patients, but the molecular mechanism underlying race-specific differences are unknown. To address this gap, we conducted comprehensive RNA-Seq, proteomics, and metabolomics analysis of BLCA tumors from AA and EA. Our findings reveal a distinct metabolic phenotype in AA BLCA characterized by elevated mitochondrial oxidative phosphorylation (OXPHOS), particularly through the activation of complex I. The results provide insight into the complex I activation-driven higher OXPHOS activity resulting in glutamine-mediated metabolic rewiring and increased disease progression, which was also confirmed by [U]13C-glutamine tracing. Mechanistic studies further …

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Presynchronization In Sheep Ensures Synchronization Of Next Estrus And Improves Fertility, Bülent Bülbül, Mehmet Köse, Mesut Kırbaş, Kenan Çoyan, Mehmet B. Ataman, Emine A. Bekçi, Seyit Ümütlü, Uğur Demirci, Bumin E. Teke

The Thai Journal of Veterinary Medicine

In this study, fertility was evaluated either in the first hormonally synchronized or in the subsequent natural estrus among 202 sheep during the breeding season. Intramuscular (im) PGF2α was administered 11 days apart in both the PG (n=50) and Pre-PG (n=50) groups, while im PGF2α was given at the removal of an intravaginal progesterone sponge (after 11 days) in the Sponge (n=51) and Pre-Sponge (n=51) groups. Estrus was monitored following the last hormonal application (day 0) in all groups and starting from day 16 in the Pre-PG and Pre-Sponge groups for 5 days. Ewes were mated during the first hormonally …

Development Of A Silicone-Based Goat Uterine Model For Artificial Insemination Training, Sakdichod Kimsakulvech

The Thai Journal of Veterinary Medicine

A goat uterine model for artificial insemination (AI) training has not been created previously. The eight goat uteri were collected from the slaughterhouse and measured to serve as a prototype size for the model. A goat uterine model was developed based on silicone material. This study compared the suitability of silicone between 20,000 and 30,000 centipoise viscosity and the cervical opening between the circular and linear types for this model. These were made up of four models with alternating differences between viscosity and cervical openings. Twenty AI officers evaluated the satisfaction score of the internal and external appearance of the …

Exploring Breed-Related Patterns And Diagnostic Factors In Canine Hypothyroidism: Unveiling Novel Paradigms, Narinthip Buckland, Chalermpol Lekcharoensuk, Monchanok Vijarnsorn, Smith Pongcharoenwanit, Natpreeya Premjaroen, Thanachote Tangporntawee, Narudee Kashemsant

The Thai Journal of Veterinary Medicine

Canine primary hypothyroidism is one of the most common endocrinopathy diseases in dogs affecting various body systems. In veterinary practice, the measurement of total thyroxine together with canine thyroid-stimulating hormone (TSH) was suggested to have high accuracy for diagnosing this disease. However, the changes in these recommended diagnostic parameters can be distinguished only in a hypothyroid dog with progressive deterioration or later in the disease. This study investigated the relevant predicting factors of canine primary hypothyroidism from animal characteristics and blood chemistry. Among the 672 dogs that met the inclusion criteria, 77 dogs had hypothyroidism and 179 had non-hypothyroidism. Age …

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Pms 3 (End Matter), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

p. 118-123

Ruth's Tooth, Jacqueline Rasnic

PoemMemoirStory (literary magazine)

pp. 92-103