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September 12, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Autonomic Nervous System And Viscera-Related Responses To Manual Therapy: A Narrative Overview, Murdi Alanazi, Brian Degenhardt Do, Gwyn Kelley-Franklin, Eric Jacobson, Sandy Fritz, Norman Kettner, Vaclav Kremen, Laura Lipke, William Reed

Library Scholarship

Background: Manual therapy (MT) has long-held that it physiologically impacts autonomic nervous system (ANS)and viscera-related function. This narrative review is intended to serve as a consolidated interdisciplinary resource of original studies related to physiological effects of MT as it relates to the ANS for MT clinicians and researchers new to this MT-related topic.

Objective: This review seeks to identify ANS and viscera-related physiological responses to MT interventions using search terms commonly used by chiropractic, massage, osteopathic, physical therapy, and structural integration clinicians and to provide a quick reference resource of original MT-related studies investigating ANS effects.

Methods: For this interdisciplinary …

Impact Of Career And Technical Education (Cte) On Adolescent Literacy In The Mississippi Delta, Shawana Lee Powell

Student Theses and Dissertations

Many students lack the comprehension skills required to navigate high school and the world (Turner, 2019). This qualitative narrative analysis study examined how the background of Career and Technical Education (CTE) educators’ shaped their educational experiences when embedding literacy in the CTE curriculum. The researcher interviewed ten CTE teachers in two public schools in the Mississippi Delta to understand CTE teacher experiences with embedding literacy in Grades 9–12 CTE content area classrooms. CTE teacher experiences regarding integrating literacy into the CTE curriculum and degree of certification was explored using Bandura’s social cognitive theory as a theoretical lens for this research …

Media Framing Of Transportation, Agriculture, And Gasoline In The Russia-Ukraine War, Sk Farhan Rabbi

Student Theses and Dissertations

The war between Russia and Ukraine has the potential to exacerbate social and economic effects on a worldwide scale, impacting several industries including energy, transportation, and agriculture crisis. Due to their heavy reliance on imports of key foods, the Middle East and North Africa are the most susceptible countries. The COVID-19 epidemic increased worldwide demand, and bad harvests all occurred at the same time as the conflict, further pressuring the food supply, transportation, and gasoline costs. Previous studies identified three categories: countries with diminishing fuel security, those making little advancements, and Latvia, which has undertaken noteworthy initiatives. Sanctions against Russia …

Oncostatin M Receptor-Dependent Signaling Assessed By Rna Sequencing In Mouse Hematopoietic Stem Cells., Logan S Schwartz, Ruth L. Saxl, Timothy M Stearns, Maria Telpoukhovskaia, Jennifer J. Trowbridge

Faculty Research 2024

Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and has been found to have anti-inflammatory and pro-inflammatory properties in various cellular and disease contexts. OSM signals through two receptor complexes, one of which includes OSMRβ. Here, we investigated OSM-OSMRβ signaling in adult mouse hematopoietic stem cells (HSCs) using the conditional Osmrfl/fl mouse model B6;129-Osmrtm1.1Nat/J. We crossed Osmrfl/fl mice to interferon-inducible Mx1-Cre, which is robustly induced in adult HSCs. From these mice, we isolated HSCs by flow cytometry, stimulated with recombinant OSM or vehicle for 1 hour, and assessed gene expression changes in control versus Osmr …

Evaluating The Texas Risk Assessment System (Tras) Predictors Of Revocation And Early Release In Adult Felony Probation, Sarah A. El Sayed, Carley R. Shelton, Michael F. Teneyck

Open Initiatives Grant Funded Publications-Archive

Although much is known about recidivism risk, less is known about factors predicting early release. The current study analyses a sample of 2,070 adult felony probation clients to see if offense characteristics, domains from the Texas Risk Assessment System (TRAS), and demographic variables impact both revocation and successful early release. Results revealed that predictors of early release mirrored those of revocation with one exception—race. Specifically, Black clients were 27% less likely to be granted early release. The findings highlight the TRAS is an effective tool to help mitigate bias for revocation of probation but not for granting early release.

Full Issue, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

Perhaps, Agnes Otieno

Stimulus: A Medical Humanities Journal

No abstract provided.

Creator Biographies, The Stimulus Team

Stimulus: A Medical Humanities Journal

No abstract provided.

Efficacy Of Thoracic Endovascular Aortic Repair Versus Medical Therapy For Treatment Of Type B Aortic Dissection, Karam Motawea, Samah Rouzan, Rowan Elhalag, Abdelrhaman Abdelwahab, Hussam Al Hennawi, Salem Elshenawy, Mai Saad Mohamed, Pensée Chébl, Mohamed Salem Madian, Mostafa Elsayed Elsayed Hewalla, Sarya Swed, Wael Hafez, Bisher Sawaf, Samer Kaspo, Naim Battikh, Mohammed Najdat Seijari, Amr Farwati, Amine Rakab

Abington Jefferson Health Papers

BACKGROUND: Techniques in endovascular therapy have evolved to offer a promising alternative to medical therapy alone for Type B aortic dissections (TBADs).

AIM: The aim of this meta-analysis was to compare mortality and overall complications between thoracic endovascular aortic repair (TEVAR) and best medical therapy (BMT) in patients with TBADs.

METHODS: We included randomized control trials and prospective or retrospective cohort studies that compared TEVAR and BMT for the treatment of type B aortic dissection. Multiple electronic databases were searched.

RESULTS: Thirty-two cohort studies including 150,836 patients were included. TEVAR was associated with a significantly lower 30-day mortality rate than …

The Current - Volume 35 Issue 2, Nova Southeastern University

Student Newspapers

No abstract provided.

Mouse Monocytes Express Cd127 By Immune Cells, Not Lps, Reza Yazdani, Mozhde Askari, Amir Moghadam-Ahmadi, Gholamreza Azizi, Bogoljub Ciric, Alexandra Boehm, Guang-Xian Zhang, Mohamad Rostami

Department of Neurology Faculty Papers

The essential role of interleukin 7 (IL-7) signaling via its receptor (IL-7Rα; CD127) in T cell development and function has been well documented. However, CD127 expression and function in myeloid cells, including monocytes, are less clear, especially in mice. In the present study we report an inducible CD127 expression in mouse monocytes/macrophages. This induction is dependent on the presence of other immune cells, highlighting that regulation of CD127 expression on monocytes differs in mice and humans. We demonstrate that CD127 is functional, as IL-7 downregulated its expression. We also saw decreased CD127 expression during inflammation in vivo. Overall, upregulation …

On Explaining Why The (Human) World Is Rich, Bart J. Wilson

ESI Working Papers

The wealth of the modern world is a natural historical marvel. Explaining it has traditionally been the purview of economic historians, as exemplified by the recent book How the World Became Rich by Mark Koyama and Jared Rubin. Economic historians, though, tend to only ask process-oriented “how” questions and “by what means” questions of the Great Enrichment. The eight co-authors of Explaining Technology, who are not economic historians, engage the debate asking a different question. Their goal is to explain the exponential shape of our enrichment with a model of the combinatorial evolution of technology. With an eye toward how …

September 12, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Expanding The Crispr Base Editing Toolbox In Drosophila Melanogaster, Michael Clark, Christina Nguyen, Hung Nguyen, Aidan Tay, Samuel J Beach, Maciej Maselko, Víctor López Del Amo

Faculty, Staff and Student Publications

CRISPR base editors can introduce point mutations into DNA precisely, and cytosine base editors (CBEs) catalyze C to T transitions. While CBEs have been thoroughly explored in cell culture and organisms such as mice, little is known about DNA base editing in insects. In this study, we evaluated germline editing rates of three different CBEs expressed under actin (ubiquitous) or nanos (germline) promoters utilizing Drosophila melanogaster. The original Rattus norvegicus-derived cytosine deaminase APOBEC1 (rAPO-1) displayed high base editing rates (~99%) with undetectable indel formation. Additionally, we show that base editors can be used for generating male sterility and female lethality. …

Barriers And Opportunities In Pancreatic Cancer Immunotherapy, Yixin Ju, Dongzhi Xu, Miao-Miao Liao, Yutong Sun, Wen-Dai Bao, Fan Yao, Li Ma

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) presents a fatal clinical challenge characterized by a dismal 5-year overall survival rate, primarily due to the lack of early diagnosis and limited therapeutic efficacy. Immunotherapy, a proven success in multiple cancers, has yet to demonstrate significant benefits in PDAC. Recent studies have revealed the immunosuppressive characteristics of the PDAC tumor microenvironment (TME), including immune cells with suppressive properties, desmoplastic stroma, microbiome influences, and PDAC-specific signaling pathways. In this article, we review recent advances in understanding the immunosuppressive TME of PDAC, TME differences among various mouse models of pancreatic cancer, and the mechanisms underlying resistance to …

Characterization Of Dna Damage Repair Pathway Utilization In High-Grade Serous Ovarian Cancers Yields Rational Therapeutic Approaches, Erika Nakatsuka, Lijun Tan, Brianna Cunneen, Caroline Foster, Yu Leo Lei, Karen Mclean

Faculty, Staff and Student Publications

While poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have improved the prognosis of ovarian high-grade serous carcinoma (HGSC) tumors that are homologous recombination (HR) deficient (HRD), new therapeutic strategies are needed for tumors that are HR proficient (HRP) because they demonstrate greater resistance to current treatments and thus have poorer clinical outcomes. Additionally, clinical precautionary statements regarding potential risks associated with PARPi, such as myelodysplastic syndrome, highlight the need for combinatorial approaches that can lessen the dose and duration of PARPi treatment to reduce toxicities. Here, we evaluated DNA double-strand damage repair pathways in HRD and HRP ovarian cancer cell lines …

Evaluation Of The Garmin Vivofit 4 For Assessing Sleep In Youth Experiencing Sleep Disturbances., Paul R. Hibbing, Madison Pilla, Lauryn Birmingham, Aniya Byrd, Tumusifu Ndagijimana, Sara Sadeghi, Nedra Seigfreid, Danielle Farr, Baha Al-Shawwa Md, David G. Ingram Md, Jordan A. Carlson

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Wearable monitors are increasingly used to assess sleep. However, validity is unknown for certain monitors and populations. We tested the Garmin Vivofit 4 in a pediatric clinical sample.

METHODS: Participants (n = 25) wore the monitor on their nondominant wrist during an overnight polysomnogram. Garmin and polysomnography were compared using 95% equivalence testing, mean absolute error, and Bland-Altman analysis.

RESULTS: On average (mean ± SD), the Garmin predicted later sleep onset (by 0.84 ± 1.60 hours) and earlier sleep offset (by 0.34 ± 0.70 hours) than polysomnography. The resulting difference for total sleep time was -0.55 ± 1.21 hours. …

Context-Aware Single-Cell Multiomics Approach Identifies Cell-Type-Specific Lung Cancer Susceptibility Genes, Erping Long, Jinhu Yin, Ju Hye Shin, Yuyan Li, Bolun Li, Alexander Kane, Harsh Patel, Xinti Sun, Cong Wang, Thong Luong, Jun Xia, Younghun Han, Jinyoung Byun, Tongwu Zhang, Wei Zhao, Maria Teresa Landi, Nathaniel Rothman, Qing Lan, Yoon Soo Chang, Fulong Yu, Christopher I Amos, Jianxin Shi, Jin Gu Lee, Eun Young Kim, Jiyeon Choi

Faculty, Staff and Students Publications

Genome-wide association studies (GWAS) identified over fifty loci associated with lung cancer risk. However, underlying mechanisms and target genes are largely unknown, as most risk-associated variants might regulate gene expression in a context-specific manner. Here, we generate a barcode-shared transcriptome and chromatin accessibility map of 117,911 human lung cells from age/sex-matched ever- and never-smokers to profile context-specific gene regulation. Identified candidate cis-regulatory elements (cCREs) are largely cell type-specific, with 37% detected in one cell type. Colocalization of lung cancer candidate causal variants (CCVs) with these cCREs combined with transcription factor footprinting prioritize the variants for 68% of the GWAS loci. …

Volume 53-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 53-2 Complete Issue

Geographical Variation In The Photosynthesis Characteristics Of Sugar Maple (Acer Saccharum) Lab- And Field-Grown Seedlings, David Goldblum, Christa Kennett, Alicia Lisowski

The Geographical Bulletin

A number of recent studies suggest that in light of anthropogenic climate change, sugar maple (Acer saccharum) may not be adapted to persist over much of its current range. We consider variation in the species’ photosynthetic properties across its range. Seeds from Tennessee, Illinois, and Michigan were grown under laboratory conditions and in two experimental plots in Illinois and Michigan forests. In the Michigan forest, seedlings derived from Michigan seeds had significantly higher rates of carbon assimilation than those from Illinois. In the Illinois forest, seedlings from Tennessee had significantly greater carbon assimilation rates and light saturation points than seedlings …

Weather Influences On Raptor Migration Along The Kittatinny Ridge, Pennsylvania, Tara E. Gettig, Timothy W. Hawkins

The Geographical Bulletin

This paper analyzes the relationship between weather patterns and bird migration to determine the feasibility of a site-specific migration forecast. Autumn migration data from Hawk Mountain Sanctuary, Pennsylvania for ten species were correlated with individual weather variables. Stepwise multiple linear regressions revealed a positive relationship with raptor migration to northwesterly winds and wind speed and an inverse relationship to sea level pressure. Composite maps were created using data from days with the greatest migration counts for each species and categorized by synoptic situations. A relationship between bird migration and cold-front passage was revealed, with five of the species having their …

A Breadth Review Of Digital Landscape And Related Foundational Theories, Jie Gao Fowler, Amy Watson

Atlantic Marketing Journal

The dominating information technology of the present time is digital media. Platforms, like Facebook, Instagram, and TikTok encourage new types of connection, influencing friendships, family and peer groups, and business relationships while reshaping public involvement and discourse through influencers, memes, and viral media. However, algorithms dictate how social media is consumed, as well as the influence these platforms can have on individuals and society. As a result, the primary goal of this study is to investigate the impact of social media/artificial intelligence on society. This study examines the digital media ecosystem and its interaction with today's customers in depth. Furthermore, …

Oh My God, Cape Cod, Hana Huebler

PoemMemoirStory (literary magazine)

pp. 90-99

Guernica, Morgan Finn

PoemMemoirStory (literary magazine)

pp. 23-28

Pms 16 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

An Advanced Way To Ensure Data Quality Of Retrieval Augmented Generation (Rag) Pipelines, Kautuk Pandey

Defensive Publications Series

The present disclosure provides a method of an automated way to calculate and evaluate quality factor of metadata provided to Retrieval Augmented Generation (RAG) pipelines for ensuring data quality of RAG pipelines used in LLM apps for Generative Artificial Intelligence (AI) application. The method includes capturing metadata of vectors/ embeddings while receiving vectors/ embeddings, applying Anomaly Detection models to generate threshold for expected metadata, applying quality score based filtering based on metadata on the Approximate Nearest Neighbour (ANN) search while generating output response in response to user query, providing output response based on the filtered vectors

Counseling In Virtual Spaces And Into The Metaverse: A Framework For Reflection, Conversation, And Future Scholarship, Staci Hayes, Yahyahan Aras, Kathy Caputo, James Hoag, Lindsay Ibos, Sania Khan, Kelly Smith

Journal of Technology in Counselor Education and Supervision

Given the success of Virtual Reality (VR) in the gaming community and strides in mental health, both VR and the Metaverse provide limitless opportunities and possibilities in the field of counseling. This article aims to provide important definitions, an overview of the use of VR in clinical counseling, clinical supervision, counselor education and its potential emergence into the Metaverse. Implications are presented in hopes of prompting conversation on how we may accept technological and cultural shifts and remain true to our counseling roots. Specifically, how to maximize the potential benefits with counseling specific rationale and address the limitations and potential …

Spartan Daily, September 11, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 163, Issue 8

Brain-Wide Projections Of Mouse Dopaminergic Zona Incerta Neurons, Bono, Kenichiro Negishi, Yasmina Dumiaty, Monica Ponce, Titilayo Akinbode, Kayla Baker, C. Duncan Spencer, Elizabeth Mejia, Marina Guirguis, Alex Herbert, Arshad Khan, Melissa Chee

Departmental Papers (Biology)

No abstract provided.