Digital Commons Network^™

Moths To A Flame: The Light And Dark Of Reading Accidents In North American Mountaineering, Leath Tonino

Appalachia

A climber finds two issues of the American Alpine Club’s annual accidents reports from 2013 and 2014 and ruminates on his obsessions.

More Than Meets The Eye: Step By Step, Exploring Connecticut's Great Mountain Forest, David K. Leff

Appalachia

The 6,300-acre Great Mountain Forest in northwestern Connecticut, once an industrial landscape of charcoal making for iron ore smelting, today is one of the most wild and remote tracts in southern New England.

Why The World Needs The Night: A Visit To The Appalachian Mountain Club's International Dark Sky Park, Laura Poppick

Appalachia

A visit to Second Annual See the Dark Festival at the Appalachian Mountain Club’s International Dark Sky Park in the North Maine Woods.

The Long Way Home: A New Take On Wilderness: Hermits, Bears, And Opportunism, Christine Woodside

Appalachia

Christopher Knight, a notorious hermit, burglarized cottages and a camp in Maine for 27 years. Comparison of stealth camping to behavior of wild animals.

Appalachia Summer/Fall 2024: Complete Issue

Appalachia

Summer/Fall 2024 - Volume LXXV, Number 2 - Issue #258. Dark Places: Exploring pitch black skies, a forest, and a storm.

Human Capital At Home: Evidence From A Randomized Evaluation In The Philippines, Noam Angrist, Sarah Kabay, Dean S. Karlan, Lincoln Lau, Kevin M. Wong

Education Division Scholarship

Children spend most of their time at home in their early years, yet efforts to promote human capital at home in many low- and middle-income settings remain limited. We conduct a randomized controlled trial to evaluate an intervention which encourages parents and caregivers to foster human capital accumulation among their children between ages 3 and 5, with a focus on math and phonics skills. Children gain 0.52 and 0.51 standard deviations relative to the control group on math and phonics tests, respectively (p<0.001). A year later effects persist, but math gains dissipate to 0.15 (p=0.06) and phonics to 0.13 (p=0.12). Effects appear to be mediated largely through instructional support by parents and not other parent investment mechanisms, such as more positive parent-child interactions or additional time spent on education at home beyond the intervention. Our results show that parents can be effective conduits of educational instruction even in low-resource settings.

Bone And Body Composition Core, Douglas Maish, Purdue University Office Of Research

University Research Core Facility Boilerplate Descriptions

No abstract provided.

2024-2025 Philharmonia Season Program, Lynn University Philharmonia, Guillermo Figueroa, Jon H. Robertson, Kenneth Amis, Andres Cardenes, Sheila Browne, Jon Manasse, Whitney Crockett, Tim Brumfield

Philharmonia

Lynn University Wind Ensemble

• Date & Time: September 14, 2024 at 7:30 p.m.
• Kenneth Amis, conductor

Philharmonia No. 1

• Date & Time: September 28, 2024 at 7:30 p.m. and September 29, 2024 at 3:00 p.m.
• Guillermo Figueroa, conductor

Philharmonia No. 2

• Date & Time: November 9, 2024 at 7:30 p.m. and November 10, 2024 at 3:00 p.m.
• Guillermo Figueroa, conductor
• Featuring the winners of the 2024 Concerto Competition

Philharmonia No. 3

• Date & Time: January 18, 2024 at 7:30 p.m. and January 19, 2024 at 3:00 p.m.
• Jon Robertson, conductor
• Andrés Cárdenes, violin

Philharmonia No. 4

• Date & Time: February …

A Novel Non-Invasive Murine Model Of Neonatal Hypoxic-Ischemic Encephalopathy Demonstrates Developmental Delay And Motor Deficits With Activation Of Inflammatory Pathways In Monocytes, Elise A Lemanski, Bailey A Collins, Andrew T Ebenezer, Sudha Anilkumar, Victoria A Langdon, Qi Zheng, Shanshan Ding, Karl Royden Franke, Jaclyn M Schwarz, Elizabeth Wright-Jin

Department of Medicine Faculty Papers

Neonatal hypoxic-ischemic encephalopathy (HIE) occurs in 1.5 per 1000 live births, leaving affected children with long-term motor and cognitive deficits. Few animal models of HIE incorporate maternal immune activation (MIA) despite the significant risk MIA poses to HIE incidence and diagnosis. Our non-invasive model of HIE pairs late gestation MIA with postnatal hypoxia. HIE pups exhibited a trend toward smaller overall brain size and delays in the ontogeny of several developmental milestones. In adulthood, HIE animals had reduced strength and gait deficits, but no difference in speed. Surprisingly, HIE animals performed better on the rotarod, an assessment of motor coordination. …

Hif-2Α-Dependent Induction Of Mir-29a Restrains Th1 Activity During T Cell Dependent Colitis, Agnieszka K Czopik, Eóin N Mcnamee, Victoria Vaughn, Xiangsheng Huang, In Hyuk Bang, Trent Clark, Yanyu Wang, Wei Ruan, Tom Nguyen, Joanne C Masterson, Eunyoung Tak, Sandra Frank, Colm B Collins, Howard Li, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Mark E Gerich, Glenn T Furuta, Xiaoyi Yuan, Anil K Sood, Edwin F De Zoeten, Holger K Eltzschig

Faculty, Staff and Student Publications

Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases. We hypothesize that HIF could be stabilized in CD4+ T cells during intestinal inflammation and alter the functional responses of T cells via regulation of microRNAs. Our assays reveal markedly increased T cell-intrinsic hypoxia and stabilization of HIF protein during experimental colitis. microRNA screen in primary CD4+ T cells points us towards miR-29a and our subsequent studies identify a selective role for HIF-2α in CD4-cell-intrinsic induction of miR-29a during hypoxia. Mice with T cell-intrinsic HIF-2α deletion display elevated T-bet (target …

Bomani Jones, Deesha Philyaw

PoemMemoirStory (literary magazine)

pp. 156-161

From The Old Slave Shack, Trellie James Jeffers

PoemMemoirStory (literary magazine)

pp. 119-128

Segregation, Forever, Nikky Finney

PoemMemoirStory (literary magazine)

pp. 66-68

Optimization, Physicochemical Stability And In Vivo Study Of Alginate-Chitosan Composites As Nanocarriers For Low Molecular Weight Angiotensin I-Converting Enzyme (Ace)-Inhibitory Peptide, Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari

Journal of Food and Drug Analysis

Chitosan and alginate, are non-toxic and biodegradable polymers used to enhance the stability of biotherapeutics by loading them into nanocarriers. In this study, the stone fish-derived low molecular weight peptide (Ala-Leu-Gly-Pro-Gln-Phe-Tyr), exhibited an in vitro ACE-inhibitory activity of 94.43 ± 2.05% and an IC₅₀ of 0.012 ± 0.001 mM. The peptide was encapsulated via ionic gelation with alginate followed by polyelectrolyte complexation with chitosan. The resulting ACE-inhibitory peptide-loaded alginate-chitosan nanoparticles (ACE-I-ALG-CS NPs) were optimized to achieve small particle size (212.60 nm) and high encapsulation efficiency (EE, 74.48%). This was based on an optimum chitosan concentration (0.420%w/v), homogenization speed (6000 …

Production And Characterization Of Encapsulated Thymoquinone Loaded Bacterial Cellulose/Chitosan Composite Nano Film And Investigation Of Its In Vitro Antibacterial Activity, Aytul Bayraktar, Tunc Tuba

Journal of Food and Drug Analysis

In this study, nanostructured thin films were produced from thymoquinone (TQ)-loaded composites encapsulated with different ratios of bacterial nanocellulose (BNC) to chitosan (CS). The study aimed to investigate their characterization, antibacterial effects, and potential as drug film coating materials. Chemical features and morphological characteristics were determined, and release tests and antibacterial assays were conducted on the thin film layers. As a result, BNC/CS-thymoquinone composite films obtained at different ratios were found to exhibit the highest antibacterial effect, particularly films with a 70% BNC/CS to 30% thymoquinone ratio, against Salmonella typhimurium bacteria.

Harnessing Gold Nanomaterials For Advanced Multicolor Colorimetric Biosensors In Food Hazards Detection, Longyingzi Xie, Chenxi Guo, Lu Yang, Yue He

Journal of Food and Drug Analysis

Hazards such as pathogenic bacteria, mycotoxins, pesticides, antibiotics, heavy metal ions, etc., cause serious food safety problems worldwide due to their toxicity and frequent contamination. Rapid screening is an effective way for food safety control, which highly relies on the development of sensitive, specific, and convenient detection methods. The multicolor colorimetric biosensors based on gold nanomaterials have evolved into advanced tools for detecting various hazards in food, with intuitive readout. The excellent localized surface plasmon resonance (LSPR) properties of gold nanomaterials enable them to exhibit bright colors when used as chromophores. In addition, the small changes in the morphology of …

Functional Gold Nanoparticles For Analysis And Delivery Of Nucleic Acids, Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang

Journal of Food and Drug Analysis

Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects …

Cgm-Induced Extracellular Trap Formation Augments Inflammation, Joseph Cavataio, Kenneth Wood B.S., Jean Gabriel De Souza Ph.D., Ulrike Klueh Ph.D.

Medical Student Research Symposium

Background and Aims: Subcutaneous continuous glucose monitoring (CGM) devices serve an important role in diabetes management but are prone to biofouling and ensuant device failure. CGM Implantation of CGM devices incites an inflammatory response with initial skin penetration. One specific response is NETosis, in which leukocytes, (e.g. neutrophils), release nuclear DNA to ensnare foreign antigens designated. This study aimed to determine the factors responsible for CGM-induced NETosis.

Methods: In vitro commercial Libre 2 glucose sensors were evaluated for their ability to induce NETosis. These studies utilized flow cytometry and time-lapse imaging, multiplex cytokine panel assessment, and scanning electron …

The War With The Squirrels, Tally Brennan

PoemMemoirStory (literary magazine)

pp. 111-121

Unfinished, Kim Aubry

PoemMemoirStory (literary magazine)

pp. 101-110

Cracking Open, Patricia Brieschke

PoemMemoirStory (literary magazine)

pp. 64-76

There Was Loneliness Before, Colette Jonopulos

PoemMemoirStory (literary magazine)

p. 27

Pms 7 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

Gesture-Driven Attribute Transfer For Visual Assets Using Generative Artificial Intelligence, Manasa Babu

Defensive Publications Series

This disclosure describes techniques that use generative artificial intelligence (gen-AI) to enable the rapid merging of visual assets using drag/pinch gestures to create an output visual that draws on individual attributes of the constituent visual assets. The techniques, effectively a design paradigm, enable non-technical users with little or no design skills to combine a reference visual (asset) with an original asset to create a new, merged asset. The techniques can accelerate productivity, reduce design time, increase design possibilities, increase decision-making speed, and democratize the design and management of visual assets. Example use cases include user interface design, photo editing, icon …