Digital Commons Network^™

Mta-Cooperative Prmt5 Inhibitors Enhance T Cell-Mediated Antitumor Activity In Mtap-Loss Tumors, Si Chen, Jiakai Hou, Roshni Jaffery, Ashley Guerrero, Rongjie Fu, Leilei Shi, Ningbo Zheng, Ritu Bohat, Nicholas A Egan, Chengtai Yu, Sana Sharif, Yue Lu, Wei He, Shuyue Wang, Donjeta Gjuka, Everett M Stone, Pooja Anil Shah, Jordi Rodon Ahnert, Taiping Chen, Xinli Liu, Mark T Bedford, Han Xu, Weiyi Peng

Faculty, Staff and Student Publications

BACKGROUND: Hyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, highlighting the possibility of combining PRMT5 inhibitors (PRMT5i) with cancer immunotherapy. However, global suppression of PRMT5 activity impairs the effector functions of immune cells. Here, we sought to identify strategies to specifically inhibit PRMT5 activity in tumor tissues and develop effective PRMT5i-based immuno-oncology (IO) combinations for cancer treatment, particularly for methylthioadenosine phosphorylase (MTAP)-loss cancer.

METHODS: Isogeneic tumor lines with and without MTAP loss were generated by CRISPR/Cas9 knockout. The effects of two PRMT5 inhibitors (GSK3326595 and MRTX1719) were …

Strategic Stabilization Of Arousal Boosts Sustained Attention, Jan Willem De Gee, Zakir Mridha, Marisa Hudson, Yanchen Shi, Hannah Ramsaywak, Spencer Smith, Nishad Karediya, Matthew Thompson, Kit Jaspe, Hong Jiang, Wenhao Zhang, Matthew J Mcginley

Duncan NRI Faculty and Staff Publications

Arousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity to control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how arousal and motivation jointly influence decision computations, including if and how animals, such as rodents, adapt their arousal state to their needs. Here, we developed and show results from an auditory, feature-based, sustained-attention task with intermittently shifting task utility. We use pupil size to estimate arousal across a wide range of states and apply tailored signal detection theoretic, hazard function …

Reducing Food Waste At Home, Makell Corry, Palak Gupta, Jose Brandao

All Current Publications

As food is discarded, resources such as money and water are wasted by producing food that will not be eaten and then transporting it to landfills. There are many solutions for reducing food loss. This fact sheet reviews ways you can build successful habits to address food waste.

Recent Climate Change In Utah, 1870-2023, Scott Hotaling, Kendall Becker

All Current Publications

Climate change is impacting Utah. Forty-five years of temperature data show that Utah is steadily warming, which, in turn, is driving declines in winter snowpack, shifting the timing and amount of available water, increasing fire risk, and causing ecological change. This fact sheet addresses changes in Utah's temperature, precipitation and snowpack, streamflow, wildfire, and ecology.

Synthesis And Characterization Of Uio-66-Nh2 (Zr) Metal–Organic Frameworks: Chitosan And Its Aminated Derivatives To Remove Toxic Cr (Vi) From Industrial Wastewater, Bassma M. Ali, Zainab Ali, Elen Emad, Ragaa Ahmed, Ayat Khasawneh, Khalideh Al Bkoor Alrawashdeh, Rebhi A. Damseh, Jalal A. Al-Tabbal, Kamel K. Al-Zboon, Petros Samaras, Yasser Dessouky, Kareem Tonbol

Blue Economy

This study used adsorbent hydrogel beads on chitosan coated with the commercially prepared metal-organic framework (MOF) and its aminated derivative to chromium (VI) ions from their aqueous solutions. Higher removal (%) and higher adsorption capacity values were recorded using chitosan and its aminated derivatives, UiO-66-NH₂ (Zr) (0.5 % CS) adsorbent (87 % and 95 mgg^-1), respectively, compared with those using CS adsorbent (86% and 93 mg/g using 1% CS); contact time was 180 min, with maximum removal (%) reaching 87% and maximum adsorption capacity of 95 mgg^-1. The pH of the studied medium was in …

Melanism In Polymorphic Terrestrial Snakes: A Meta-Analysis And Systematic Review, Ryan A. Martin

Faculty Scholarship

Background and Aim: Colour polymorphic populations constitute excellent model systems for testing ecological and evolutionary hypotheses, as alternate colourations are associated with differences in various biological, behavioural and life-history traits. Melanism is the most common and most obvious form of polymorphism. In reptiles in general (and snakes in particular), thermal melanism has been a popular hypothesis used to explain the appearance of black individuals. It suggests that a trade-off exists between superior thermoregulation and reduced protection through the loss of crypsis. Surprisingly, despite the growing body of literature available, to date, there are only two qualitative reviews on the evolutionary …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Albohy, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Phytotherapeutic Approach To Enhance The Hepatoprotective Activity Of Some Edible Plants: Molecular Docking And Nanoformulation, Khaled Nematallah, Amgad Abdallah, Noha Swilam

Pharmacy

This study used molecular docking to evaluate phytochemicals from 47 plants against liver fibrosis. It identified potent compounds, prompting further investigation of chamomile, pomegranate, ginseng, and artichoke. Extracts from these plants were characterized and formulated into a self-microemulsifying drug delivery system (SMEDDS). Studies on the herbal formula exhibited around 150% higher flavonoids, 50% higher polyphenols, 178% higher antioxidant activity, and synergistic In-vitro hepatoprotective effects compared to the average results of individual extracts. Both the aqueous suspension and the nanoformulation of the formula offered in-vivo protection against paracetamol-induced hepatotoxicity in mice. The SMEDDS group showed superior outcomes, with no significant differences …

Group Dynamics, Gender, And Field : An Ethnographic Study Of The Yo-Yoing Sport Subculture In Hong Kong, Ho Wang Kwong

Lingnan Theses (MPhil & PhD)

This research explores the yo-yoing sport subculture in Hong Kong, tracing its evolution from a popular pastime to a recognized sport with a global competition structure led by the International Yo-Yo Federation. By situating yo-yoing within lifestyle sports literature, this study offers a sociological understanding of yo-yo players’ experiences and challenges in Hong Kong. Yo-yoing is an interesting case to study because of its prevailing label as a toy hobby, thus players are generally positive to mainstreaming which differs from many lifestyle sports participants’ reluctant attitude. The central question of this study is: How does a subculture gain legitimation as …

Contaminant Exposure And Liver And Kidney Lesions In North American River Otters In The Indian River Lagoon, Florida, Ami Krasner, Megan Stolen, David Rotstein, Spencer Fire

Ocean Engineering and Marine Sciences Student Publications

The harmful algal bloom (HAB) liver toxin microcystin (MC) and trace element biomagnification were previously detected in organisms in the Indian River Lagoon (IRL), Florida. Since there are no routine screening programs for these contaminants, liver tissue from North American river otters (Lontra canadensis), an important sentinel species in the IRL, was screened for MC via enzyme-linked immunoassay (ELISA), followed by confirmatory analyses via liquid-chromatography/mass spectrometry methods (LC-MS/MS). Liver and kidney samples were evaluated for trace element (As, Cd, Co, Cu, Fe, Hg, Mn, Mo, Pb, Se, Tl, and Zn) bioaccumulation via inductively coupled plasma mass spectrometry (ICP-MS). Histopathologic evaluation …

Prediction Of Mooring System Characteristics Of The Floating Barge Using Deep Neural Networks, Janghoon Seo, Dong-Woo Park

Journal of Marine Science and Technology–Taiwan

The present study establishes deep learning models to predict the tensions and inclinations of mooring lines of a floating barge and verifies applicability of these models. Hydrodynamic and mooring analyses are conducted on the dataset used for the deep learning models. Three types of neural network models include a deep neural network (DNN) with input data representing the six degrees of freedom motions of a floating barge, convolutional neural network (CNN) with input images of the floating barge and mooring lines on a horizontal plane, and hybrid neural network (HNN) that consolidates the characteristics of DNN and CNN models. The …

Monitoring Avian Productivity And Survivorship (Maps) At Strawberry Plains Audubon Center: 2017-2018, Kristina Mitchell

Mississippi Kite

No abstract provided.

Aberrant Song Of A Field Sparrow, J. R. Rigby, Gene C. Knight

Mississippi Kite

No abstract provided.

Cooper's Hawk Feeding At A Deer Carcass, W. Marvin Davis

Mississippi Kite

No abstract provided.

An Interspecific Interaction Between A European Starling And A Green-Winged Teal, Jonathan D. Maul

Mississippi Kite

No abstract provided.

European Starling "Helper" At Late Season Red-Bellied Woodpecker Nest, Barbara Qualls

Mississippi Kite

No abstract provided.

The First Annual Mississippi Colonial Waterbird Count, Allan J. Mueller

Mississippi Kite

No abstract provided.

Spring Diet Of The Barn Owl In North Mississippi, James L. Key

Mississippi Kite

No abstract provided.

Red-Bellied Woodpecker Predation On A Green Anole, Gregory A. Smith, Jerome A. Jackson

Mississippi Kite

No abstract provided.

Reviews, Mississippi Kite

Mississippi Kite

No abstract provided.

Reviews, Mississippi Kite

Mississippi Kite

No abstract provided.

Reviews, Mississippi Kite

Mississippi Kite

No abstract provided.

Black Vultures Kill Skunk In Mississippi, Dena D. Dickerson

Mississippi Kite

No abstract provided.

Reviews, Mississippi Kite

Mississippi Kite

No abstract provided.

Reviews, Mississippi Kite

Mississippi Kite

No abstract provided.

Reviews, J. A. Jackson, J. A. Toups

Mississippi Kite

No abstract provided.

An Unusual Instance Of Mortality In The Barn Swallow, Ren Lohoefener

Mississippi Kite

No abstract provided.

Requests For Information: Sightings Of Color-Banded Killdeer, Bette J. Schardien

Mississippi Kite

No abstract provided.

Extensive Ground Foraging By Pileated Woodpeckers In Recently Burned Pine Forests, Bette J. Schardien, Jerome A. Jackson

Mississippi Kite

No abstract provided.

Reviews, J. A. Jackson, Ray E. Weeks, Dave Werschkul

Mississippi Kite

No abstract provided.