Digital Commons Network^™

Machine-Guided Design Of Cell-Type-Targeting Cis-Regulatory Elements., Sager J Gosai, Rodrigo Castro, Natalia Fuentes, John C Butts, Kousuke Mouri, Michael Alasoadura, Susan Kales, Thanh Thanh L Nguyen, Ramil R Noche, Arya S Rao, Mary T Joy, Pardis C Sabeti, Steven K Reilly, Ryan Tewhey

Faculty Research 2024

Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing and stimulus responses, which collectively define the thousands of unique cell types in the body1–3 . While there is great potential for strategically incorporating CREs in therapeutic or biotechnology applications that require tissue specificity, there is no guarantee that an optimal CRE for these intended purposes has arisen naturally. Here we present a platform to engineer and validate synthetic CREs capable of driving gene expression with programmed cell-type specificity. We take advantage of innovations in deep neural network modelling of CRE activity across three cell types, efficient in silico …

Natasha, Pierre, & The Great Comet Of 1812, Otterbein Theatre And Dance Department

2024-2025 Season Productions

No abstract provided.

Neurosteroids For The Treatment Of Major Depressive Disorder (Mdd) And Chronic Pain (Paper), Meghan Haan

Honors Capstone Projects

Neurosteroids are endogenous steroids within the brain that act as modulators in neurotransmission. Among their targets are the gamma-aminobutyric acid (GABA) receptors, which are responsible for inhibitory signaling in the brain. The interaction between neurosteroids and GABA receptors is complex, influencing mood regulation and pain perception. Endogenous neurosteroids have been used in conditions such as postpartum depression (PPD), where fluctuation in neurosteroid levels contribute to the onset of depressive systems. Conversely, exogenous neurosteroids, such as brexanolone and zuranolone, have emerged as therapeutic agents for PPD. These compounds act as positive allosteric modulators (PAMs) on GABA receptors, enhancing inhibitory neurotransmission and …

Stockfeed Labelling In Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

The Department of Primary Industries and Regional Development (DPIRD) is responsible for regulating the labels of stockfeed supplied in Western Australia (WA) to ensure they provide the required information to people feeding it to their livestock. This factsheet contains information to help stockfeed retailers and manufacturers meet WA’s labelling requirements.

Cultural Perspectives On Psychoactive Substances: A Study Of Psilocybin In Indonesia, Parmis Mazdeh

Indonesia: Arts, Religion, and Social Change

This study examines the various cultural views on psilocybin in Indonesia, emphasizing its role in religious, spiritual, and cultural contexts. It investigates both the historical and present-day use of psychoactive substances, specifically psilocybin, in connecting with the divine, attaining transcendental enlightenment, and shaping identity within specific civilizations. Although psilocybin is illegal in Indonesia, these mushrooms can be found in the Gili Islands, raising questions about how they fit into local spiritual traditions and the legal loopholes that allow their use. Field research in the Gili Islands reveals how religious beliefs and practices influence the cultural acceptance of magic mushrooms, while …

Issue 11: Pulmonary & Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth-Hoffman Mls, Dustin D. Linn Pharmd, Payal Shukla Md, Ms, Patricia Rich Md, Morgan Crites Np-C

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 11

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

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Topics:

VIEWPOINTS:

Blood Pressure Measurement

Home Noninvasive Ventilation

ORIGINAL STUDY SUMMARY

Acute Pulmonary Embolism

The PEXIVAS trial

Respiratory Failure in hemorrhagic shock

SNAPSHOTS:

RBC Transfusions

New Small cell lung cancer Treatment.

Board Of Pharmacy, Catherine Santos, Marcus Friedman

California Regulatory Law Reporter

No abstract provided.

2024-2025 Book-In-Common Teaching Guide, Collin College

Book in Common

EDITOR’S INTRODUCTION

As always, the 2024 - 2025 Teaching Guide exemplifies the Collin College Book-in Common Committee’s commitment to the goal of a year-long, college-wide engagement with an important book and its author. This dystopian novel discusses themes of art, culture, survival, relationships, health, and memory. Highlights of this year’s Guide include:

• New for 2024 – 2025
• Fall 2024 Assessment-aligned activities for COAT Core Objective Personal Responsibility
• Review the interactive teaching strategies and access scaffolding activities
• Responses to the text including explorations of the major themes in Station Eleven, reflection prompts, subject assignments, and connections to art, biology, and …

The Chronicle, Lara Jones, Taysia Bettis, Bella Perez, Joyanna Huang, Kasey Andrews, Emily Riley, Samantha Russell, Corey Suckow, Andy Langager

Campus Chronicle

No abstract provided.

Ua64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 57 Fall 2024), Elizabeth Joyce Editor

Gifted Studies Publications

Magazine created by and about the WKU Center for Gifted Studies.

Torture And Its Sequelae Among Prostituted Women In The United States, Melissa Farley, M. Alexis Kennedy

Criminal Justice Faculty Research

Background: Extreme violence and psychological abuse have been extensively documented and are pervasive in prostitution. Survivors of prostitution report high levels of posttraumatic stress disorder, dissociation, depression, and self-loathing. These are the same sequelae reported by torture survivors.

Objective: Severe forms of violence have been categorized as torture by experts. The authors note that torture is commonly suffered during prostitution and should be appropriately named.

Method: Using standardized measures and including a new measure of torture, we interviewed 45 women in the United States about their torture experiences in prostitution and their symptoms of PTSD, dissociation, childhood trauma, health status …

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Protecting Coastal Communities And Marine Biodiversity Under The Coastal Zone Management Act, Eric V. Hull

South Carolina Law Review

No abstract provided.

2024 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2024.

Personality (O.C.E.A.N) Driven Data Augmentation For Post-Trial Interviews In A Three-Arm Chronic Back Pain Randomized Clinical Trial, Kamakshi Moparthi

Dartmouth College Master’s Theses

This case study investigates the use of Large Language Models (LLMs) and prompt engineering techniques for data augmentation,in the context of post-trial inter- view data (low-resource natural language data) from a randomized clinical trial on Pain Reprocessing Therapy (PRT) for chronic back pain. The limited sample size from the original study necessitates the generation of synthetic interview samples, needed to draw meaningful inferences from the data and to further extend the study. This study explores the efficacy of various prompting techniques in different approaches such as sentiment inversion and personality-based augmentation. The goal is to elicit desired responses from LLMs …

On The Pathogenesis Of Obesity: Causal Models And Missing Pieces Of The Puzzle, Faidon Magkos, Thorkild I.A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J.F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup

Clinical Research Faculty Publications

Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate–insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century. Here, we summarize outcomes of a …

Metabolic Crossroads: Gaba Synthesis In Trichomonas Vaginalis Infection, Yesha Dhruv

Biochemistry and Molecular Biology

This study examines the gamma-aminobutyric acid (GABA) synthesis pathway in Trichomonas vaginalis infection of human HCT-8 cells, focusing on key enzymatic processes in glutamate conversion to GABA and metabolic adaptations. The hypothesis tested was that T. vaginalis modulates GABA metabolism to enhance host cell invasion and adaptation. Infection time-point studies, RNA sequencing, and aldehyde dehydrogenase (ALDH) assays were conducted. Comparisons between T. vaginalis strains Casu 2 and Casu 2/MOZ 2 revealed distinct infection dynamics. Casu 2 rapidly attached and replicated within an hour, peaking at 24 hours, while Casu 2/MOZ 2 exhibited delayed replication, peaking at 48 to 72 hours, …

An Efficient Fourier Caching Algorithm For Walk On Spheres, Zihong Zhou

Dartmouth College Master’s Theses

Walk on Spheres (WoS) is a grid-free Monte Carlo method for solving elliptic partial differential equations (PDEs).
Rather than discretizing the domain, WoS leverages the mean-value principle to obtain Monte Carlo estimates by recursively averaging the solution over the largest contained sphere, terminating upon reaching the boundary.
Unfortunately, WoS requires many independent estimates to achieve noise-free results.

We propose an acceleration technique for WoS, inspired by irradiance caching methods, that computes the solution at a sparse set of locations, and extrapolates these cached values to local neighborhoods. A key insight is that WoS can be extended to compute not only …

Implementing Social Emotional Strategies In An Early Childhood Setting, Susan Mcclain

Master's Theses & Capstone Projects

This research paper provides a comprehensive overview of studies focusing in on social-emotional skill development in early childhood and its impact on long-term outcomes in emotional regulation, interpersonal relationships, and problem-solving strategies. Drawing on a comprehensive review of existing literature and empirical studies, the research highlights the critical developmental milestones in social-emotional learning (SEL) during the early years and explore effective strategies for fostering these skills within various contexts, including home, preschool, and other early learning settings. The findings suggest that targeted interventions, such as play-based activities and structured SEL programs, significantly enhance children’s ability to navigate social interactions with …

Assistive Technology In Early Childhood For Language And Communication, Katherine Kemp

Master's Theses & Capstone Projects

Students with special needs across the country and the world continue to struggle to gain functional language and communication skills, and build a vocabulary to use throughout life. Research shows that augmentative and alternative communication or speech-generating devices can be a special, useful, and powerful tool for students' language skills. Based on a literature review of augmentative and alternative communication devices, early childhood, and assistive technology, an in-class study was performed in a Virginia Early Childhood Special Education classroom. The results indicate that augmentative and alternative communication devices and assistive technology have a positive impact on students' language and vocabulary …

Precision Interventions Targeting The Maternal Metabolic Milieu For Healthy Pregnancies In Obesity, Alexandra M. Niclou, Hannah E. Cabre, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Purpose of Review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight. Recent Findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies …

Long-Term Effects Of Climate Change On Juvenile Bull Shark Migratory Patterns, Philip Matich, Jeffrey D. Plumlee, Walter Bubley, Tobey H. Curtis, J. Marcus Drymon, Lindsay L. Mullins, Oliver N. Shipley, Thomas C. Tinhan, Mark R. Fisher

Faculty Publications

Seasonal variability in environmental conditions is a strong determinant of animal migrations, but warming temperatures associated with climate change are anticipated to alter this phenomenon with unknown consequences. We used a 40-year fishery-independent survey to assess how a changing climate has altered the migration timing, duration and first-year survival of juvenile bull sharks (Carcharhinus leucas). From 1982 to 2021, estuaries in the western Gulf of Mexico (Texas) experienced a mean increase of 1.55°C in autumn water temperatures, and delays in autumn cold fronts by ca. 0.5 days per year. Bull shark migrations in more northern estuaries concomitantly changed, with departures …

A Quantitative Adverse Outcome Pathway For Embryonic Activation Of The Aryl Hydrocarbon Receptor Of Fishes By Polycyclic Aromatic Hydrocarbons Leading To Decreased Fecundity At Adulthood, Jon A. Doering, Justin Dubiel, Eric Stock, Cameron H. Collins, Ian Frick, Hunter M. Johnson, Christopher M. Lowrey-Dufour, Justin G.P. Miller, Zhe Xia, Gregg T. Tomy, Steve Wiseman

Faculty Publications

Quantitative adverse outcome pathways (qAOPs) describe the response–response relationships that link the magnitude and/or duration of chemical interaction with a specific molecular target to the probability and/or severity of the resulting apical-level toxicity of regulatory relevance. The present study developed the first qAOP for latent toxicities showing that early life exposure adversely affects health at adulthood. Specifically, a qAOP for embryonic activation of the aryl hydrocarbon receptor 2 (AHR2) of fishes by polycyclic aromatic hydrocarbons (PAHs) leading to decreased fecundity of females at adulthood was developed by building on existing qAOPs for (1) activation of the AHR leading to early …

Comparative Transcriptomic Analyses Reveal Differences In The Responses Of Diploid And Triploid Eastern Oysters To Environmental Stress, Rujuta V Vaidya, Sarah Bodenstein, Dildorakhon Rasulova, Jerome F La Peyre, Morgan W Kelly

Faculty Publications

Triploid oysters are commonly used as the basis for production in the aquaculture of eastern oysters along the USA East and Gulf of Mexico coasts. While they are valued for their rapid growth, incidents of triploid mortality during summer months have been well documented in eastern oysters, especially at low salinity sites. We compared global transcriptomic responses of diploid and triploid oysters bred from the same three maternal source populations at two different hatcheries and outplanted to a high (annual mean salinity = 19.4 ± 6.7) and low (annual mean salinity = 9.3 ± 5.0) salinity site. Oysters were sampled …

Macroevolution Of The Plant–Hummingbird Pollination System, Elisa Barreto, Mannfred M.A. Boehm, Ezgi Ogutcen, Stefan Abrahamczyk, Michael Kessler, Jordi Bascompte, Agnes S. Dellinger, Carolina Bello, D. Matthias Dehling, François Duchenne, Miriam Kaehler, Laura P. Lagomarsino, Lúcia G. Lohmann, María A. Maglianesi, Hélène Morlon, Nathan Muchhala, Juan Francisco Ornelas, Mathieu Perret, Nelson R. Salinas, Stacey D. Smith, Jana C. Vamosi, Isabela G. Varassin, Catherine H. Graham

Faculty Publications

Plant–hummingbird interactions are considered a classic example of coevolution, a process in which mutually dependent species influence each other's evolution. Plants depend on hummingbirds for pollination, whereas hummingbirds rely on nectar for food. As a step towards understanding coevolution, this review focuses on the macroevolutionary consequences of plant–hummingbird interactions, a relatively underexplored area in the current literature. We synthesize prior studies, illustrating the origins and dynamics of hummingbird pollination across different angiosperm clades previously pollinated by insects (mostly bees), bats, and passerine birds. In some cases, the crown age of hummingbirds pre-dates the plants they pollinate. In other cases, plant …

Louisiana Agriculture Magazine, Fall 2024

Louisiana Agriculture

Questions drive the science behind the LSU AgCenter. Researcher Erin Oberhaus wanted to find data to help educate Louisiana horse owners about the use of an important medication, and a water quality specialist wondered if noneconomic bodies of water, which include agricultural ponds, might help people generate electricity. The research projects that grew from their questions are detailed in this issue of Louisiana Agriculture.

Also in this issue, scientists share the results from important soybean studies, and the AgCenter farm to school team shares success stories from school gardens across the state.

Research is at the core of the LSU …

Fall 2024 Catalog, Lsu Press

LSU Press Seasonal Catalogs

No abstract provided.

Navigating Educational Transformation: Understanding Learning Styles’ Preferences Of Egyptian Students In The Post-Pandemic Era, Wesam Khairy Morsi

English Language and Literature

This study investigated the Learning style preferences of Egyptian EFL learners post COVID-19. It aims to examine differences emerging in multimodal and bimodal learning preferences based on demographic variables of age and gender and consider the cultural educational context in Egypt during and post the pandemic era. Utilizing the VARK Model, Mayor’s Multimodal Learning Theory, and the Connectivism Learning Theory a survey comprising 19 questions was disseminated to 211 Egyptian EFL students from various age groups. Findings reveal a predominant preference for multimodal learning, particularly visual and read/write styles, with significant variations between genders. Female learners exhibited a stronger inclination …

Monarch, Victoria Bourne (Editor)

Monarch Magazine

Fall 2024 issue of Monarch, the Old Dominion University Magazine.

Subtitled: Forward-Focused: ODU & EVMS Make History

2024 Fall Nutshell, Morehead State University. Institutional Research & Analysis.

Office of Institutional Research & Analysis Publication Archive

Fall 2024 issue of the Nutshell.