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Vitamin D3 Alleviates Intestinal Injury In Necrotizing Enterocolitis And Lipopolysaccharide-Induced Inflammatory Response In Dendritic Cells In Rats, Bo Ke, Chaoyu Li, Song Li, Jingjing Yan, Leke Sun

Turkish Journal of Medical Sciences

Background/aim: Necrotizing enterocolitis (NEC) is a serious condition that predominantly affects premature infants and involves an aberrant immune response and inflammatory cytokine release resulting in intestinal epithelial damage. The current study investigated the immunoregulatory effects of vitamin D3 on the maturation and activation of dendritic cells (DCs) and the antiinflammatory impact on the intestines in a neonatal rat model of NEC.Materials and methods: Inflammatory damage to intestinal tissue was assessed via morphological changes and apoptosis and DC expression of costimulatory molecules, inflammatory factors, and immunoregulatory factors by immunohistochemical staining, quantitative real-time PCR, and immunofluorescence. The fluorescein isothiocyanate-ovalbumin (FITC-OVA) uptake assay …

Discovery Of Genes That Positively Affect Biomass And Stress Associated Traits In Poplar, Tatyana Georgieva, Yordan Yordanov, Elena Yordanova, Md Rezaul Khan, Kaiwen Lyu, Victor Busov

Michigan Tech Publications

Woody biomass serves as a renewable resource for various industries, including pulp and paper production, construction, biofuels, and electricity generation. However, the molecular mechanisms behind biomass traits are poorly understood, which significantly curtails the speed and efficiency of their improvement. We used activation tagging to discover genes that can positively affect tree biomass-associated traits. We generated and screened under greenhouse conditions a population of 2,700 independent activation tagging lines. A total of 761 lines, which had significantly and positively affected at least one biomass-associated trait, were discovered. The tag was positioned in the genome for forty lines which were affected …

Hydrodynamic Exposure – On The Quest To Deriving Quantitative Metrics For Mariculture Sites, Oliver Lojek, Nils Goseberg, Heidi Moe Føre, Tobias Dewhurst, Thea Bölker, Kevin Gerald Heasman, Bela H. Buck, David W. Fredriksson, Samuel Rickerich

Faculty Publications

This work attempts to define metrics for hydrodynamic exposure, using known oceanographic variables to provide a universal site assessment method for mariculture structures. Understanding environmental conditions driving open-ocean mariculture siting is crucial in establishing consistent ocean governance, minimizing adverse environmental impacts, and facilitating economically sustainable farm operations. To provide a metric of oceanic conditions and associated requirements for structural design and operation of aquaculture systems, six Exposure Indices (EI) are proposed that consider physical energy levels related to hydrodynamic forces at a site. Four of the proposed indices consider only environmental conditions, while the other two also consider the dimensions …

Post-Transcriptional Methylation Of Mitochondrial-Trna Differentially Contributes To Mitochondrial Pathology, Sunita Maharjan, Howard Gamper, Yuka Yamaki, Thomas W. Christian, Robert Y. Henley, Nan-Sheng Li, Takeo Suzuki, Tsutomu Suzuki, Joseph A. Piccirilli, Meni Wanunu, Erin L. Seifert, Douglas C. Wallace, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their fragile structures. However, whether a modification that stabilizes a wild-type (WT) mt-tRNA would also stabilize its pathogenic variants is unknown. Here we show that the N¹-methylation of guanosine at position 9 (m¹G9) of mt-Leu(UAA), while stabilizing the WT tRNA, has a destabilizing effect on variants associated with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes). This differential effect is further demonstrated, as removal of the m¹G9 …

Marijuana Legalization And Opioid Use Disorder In Ontario, Canada, From 2015 To 2021, Luke Ome Agada

Walden Dissertations and Doctoral Studies

This study examined the trends in opioid-related hospitalizations and deaths in Ontario, Canada, from 2015, to 2021, with a particular focus on the periods before and after cannabis legalization. The social problem addressed was the ongoing opioid crisis, exacerbated by rising opioid-related health issues. Grounded in the harm reduction theory, this research explored whether cannabis legalization could serve as a substitute to mitigate opioid use disorder. Data were extracted from the Discharge Database, Emergency Department Database, National Ambulatory Care Reporting System, and Hospital Morbidity Database. Analysis using the generalized estimation equation (GEE) method revealed a significant increase in opioid-related hospitalizations, …

Nonclinical Profile Of Pf-06952229 (Mdv6058), A Novel Tgfβri/Activin Like Kinase 5 Inhibitor Supports Clinical Evaluation In Cancer, Mausumee Guha, Stephane Thibault, Son Pham, Sebastian Bernales, Rama Pai, Francisco J Herrera, Theodore R Johnson, Allison Vitsky, Tina Fernando, Martin Finkelstein

Faculty, Staff and Student Publications

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic …

Association Between Systemic Zinc And Oxidative Stress Levels And Periodontal Inflamed Surface Area, Ayşegül Sari, Serdar Doğan, Luigi Nibali

Turkish Journal of Medical Sciences

Background/aim: Zinc is a structural component of some enzymes. The aim of this study was to evaluate the potential associations between serum zinc and oxidative stress levels and periodontal inflamed surface area (PISA).Materials and methods: This study included 90 patients divided into three groups: a periodontitis group (P; n = 30), a gingivitis group (G; n = 30), and a periodontal health group (PH; n = 30). Periodontal parameters were recorded and PISA values were calculated. Serum total antioxidant status (TAS), total oxidant status (TOS), and zinc levels were examined biochemically. Oxidative stress index (OSI) levels were calculated.Results: All clinical …

Thoracic Trauma In The Geriatric Population And Possible Preventive Measures: A Retrospective Analysis Of 261 Cases, Mehmet Çeti̇n, Necati̇ Solak, Büşra Özdemi̇r Çi̇fli̇k, İlteri̇ş Türk, Sebahatti̇n Sefa Ermancik, Koray Aydoğdu

Turkish Journal of Medical Sciences

Background/aim: The rise in the proportion of the elderly population within society is concurrently escalating their vulnerability to traumas, notably falls associated with age-related comorbidities.Materials and Methods: The retrospective analysis involved the examination of data pertaining to patients aged 65 and above who were admitted to our clinic for inpatient treatment following thoracic trauma. Various parameters were statistically compared between the groups with indoor and outdoor traumas.Results: 59.4% of the 261 patients included in the study were male, and the average age in the entire sample was calculated as 75.52±7.79. 136 patients (52%) had indoor trauma, while 125 (48%) had …

The Socioeconomic And Environmental Niche Of Protected Areas Reveals Global Conservation Gaps And Opportunities, David Mouillot, Laure Velez, Camille Albouy, Nicolas Casajus, Joachim Claudet, Vincent Delbar, Rodolphe Devillers, Tom B Letessier, Nicolas Loiseau, Stéphanie Manel, Laura Mannocci, Jessica Meeuwig, Nicolas Mouquet, Ana Nuno, Louise O'Connor, Valeriano Parravicini, Julien Renaud, Raphael Seguin, Marc Troussellier, Wilfried Thuiller

School of Biological and Marine Sciences

The global network of protected areas has rapidly expanded in the past decade and is expected to cover at least 30% of land and sea by 2030 to halt biodiversity erosion. Yet, the distribution of protected areas is highly heterogeneous on Earth and the social-environmental preconditions enabling or hindering protected area establishment remain poorly understood. Here, using fourteen socioeconomic and environmental factors, we characterize the multidimensional niche of terrestrial and marine protected areas, which we use to accurately establish, at the global scale, whether a particular location has preconditions favourable for paestablishment. We reveal that protected areas, particularly the most …

Inshore Fisheries And Conservation Authorities: Fisheries Regulator Or Environmental Backstop? The Complexities Of Section 153 Marine & Coastal Access Act 2009, Emma Bean, Jason Lowther, Mike Williams

School of Law, Humanities and Social Sciences

Since the introduction of the Marine and Coastal Access Act 2009 (‘MCAA'), fishing within England's inshore marine area has been managed by Inshore Fisheries and Conservation Authorities (IFCAs). The powers and duties of IFCAs are contained in section 153 of MCAA and include a conservation remit; requiring IFCAs to have regard to the sustainability of fisheries activities and to conservation of the inshore marine environment. The inclusion of conservation in the name of these bodies and references to sustainability in their duties leads to questions as to the scope of IFCAs’ remit in relation to conservation. An examination of the …

Maritime Behaviour Anomaly Detection With Seasonal Context, Travis Rybicki, Martin Masek, Chiou Peng Lam

Research outputs 2022 to 2026

Monitoring maritime traffic has become an important task for ensuring the safety of vessels, as well as the goods, and persons that they may be transporting. An active area of research is the modelling of expected normal vessel behaviour so as to detect subsequent anomalies in new data. Anomalies indicate that a vessel is not behaving in an expected manner and their detection can be flagged for further investigation to identify whether the vessel needs assistance or intervention. An important factor for some vessels in determining normal behaviour is seasonal context. However, current approaches typically do not incorporate seasonality into …

Expanding Public Access By Codifying The Public Trust Doctrine: The Massachusetts Experience, William L. Lahey, Lauren Sandler Zurier, Kenneth W. Salinger

Maine Law Review

The Commonwealth of Massachusetts is dramatically expanding public access to the coast through statutory and regulatory codification of the public trust doctrine. Is this legislative and administrative experiment relevant to other states, particularly to Maine? The initial answer to this question may depend on the meaning of the Bell v. Town of Wells decision. For better or for worse, Massachusetts jurisprudence set the course followed by the majority of the Maine Supreme Judicial Court in Bell. To some, including several of the authors in this symposium, the bearing of the Massachusetts courts leads to a civic wasteland where the public's …

China’S Naval Diplomacy In The Baltic Sea At The Beginning Of The Twenty-First Century—A Lost Window Of Opportunity, Tobias Kollakowski

Naval War College Review

The PLA Navy engaged Baltic Sea states heavily in the first and second decades of the twenty-first century, but these cooperative efforts ultimately failed as the contradiction with more-aggressive and concerning Chinese policies overall became untenable.

Road Signs Detection Using Ssd Mobilenetv2, Zahraa Salah Dhaif, Nidhal K. El Abbadi

Karbala International Journal of Modern Science

One of the most critical challenges for self-driving vehicles is accurately identifying traffic signs, which are essential for self-navigation and decision-making. Systems for the detection and recognition of road signs play a crucial role in this process by providing vital information for the vehicle's decision-making. This study proposes an approach for road sign identification and recognition utilising the TensorFlow Object Detection API and the SSD MobileNet V2 FPN Lite model.

In this proposal, we combine the efficiency and accuracy of SSD with the lightweight architecture of MobileNet to achieve excellent performance in object detection benchmarks while maintaining a small model …

A Saudi Heart Association Position Statement On Obesity And Cardiovascular Disease, Waleed Alhabeeb, Abdulhalim J. Kinsara, Abeer Bakhsh, Adel Tash, Afaf Alshammary, Ali Almasood, Kamal Alghalayini, Mohammed Arafah, Osama Hamdy, Saud Alsifri, Suleiman M Kharabsheh, Wail Alkattan

Journal of the Saudi Heart Association

Objectives: The obesity pandemic is a major public health concern in Saudi Arabia, with significant impact on cardiovascular disease (CVD). This position statement aims to provide an overview of available evidence as well as the recommendations of the Saudi Heart Association on the management of obesity associated with CVD.

Methods: Under the auspices of the Saudi Heart Association, a multidisciplinary expert panel comprised of cardiologists and endocrinologists discussed available evidence and provided recommendations on the management of obesity in CVD. The expert panel discussions occurred between September of 2023 and May of 2024 and also took into consideration …

Iridoid Glucosides Against Staphylococcus Aureus Infection And Inhibit Inflammation On Bovine Mammary Epithelial Cells, Yanfang Zhang, Ping Xu

The Thai Journal of Veterinary Medicine

Staphylococcus aureus can cause diseases in humans and livestock, destroy the body barrier, exacerbate inflammation, and seriously threaten human health and animal husbandry development. Iridoid glucosides isolated from Rehmannia glutinosa, is an important Chinese tradition medicine widely used in various diseases. The aim of this study was to investigate whether the iridoid glucosides was effective against S. aureus infection, and inhibits inflammation on bovine mammary epithelial cells. The antibacterial potential was determined using the in vitro broth microdilution assay against S. aureus. Then, the antibiofilm activity was tested by BCA protein assay, electric conductivity assay and scanning electron …

Molecular Detection And Characterization Of Histomonas Meleagridis In Fighting Cocks Thailand, Piyanan Taweethavonsawat, Mangsatabam Norjit Singh, Sawang Kesdangsakonwut, Wanarit Jitsamai, Chongtham Sonia, Cherdpong Phupolpan

The Thai Journal of Veterinary Medicine

Histomoniasis caused by the protozoa Histomonas meleagridis is a disease of gallinaceous birds which is of special importance to the poultry industry. The turkey is highly susceptible and results in high mortality. However, the disease is less severe in chickens but sometimes leads to mortality especially in those reared in the free-range system. During the present study, four dead fighting cocks were presented to the Veterinary Diagnostic Laboratory, Livestock Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University for post-mortem examination. Based on history and pathological changes, it was preliminarily diagnosed as histomoniasis. The affected livers and caeca samples were collected …

Improved Process For The Preparation Of Metal Gluconate, Anonymous

Defensive Publications Series

The present publication relates to an improved process for the preparation of metal gluconate such as sodium gluconate, potassium gluconate, zinc gluconate, calcium gluconate and the like.

Spartan Daily, October 17, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 163, Issue 24

All Things Marian: Las Cantigas De Santa Maria—A Medieval Synthesis Of Marian And Religious Culture, University Of Dayton. International Marian Research Institute, Michele Foley, Johann G. Roten S.M.

Podcast: All Things Marian

Transcript is available using the "Download" button.

Learning Outcomes, Benefits, And Challenges Of International Research Experiences For Students (Ires): An Exploratory Study Of An Ires Program In China, Yousef Jalali, James Barilla, Kirsten Davis, Vinod Lohani, Rolf Müller

Journal of International Engineering Education

Despite the increasing number of international programs targeting students’ learning of research and intercultural skills, there has been limited holistic investigation of students’ experiences employing both qualitative and quantitative methods. In this study, we incorporated several measures to explore students’ experiences in an International Research Experiences for Students (IRES) program, which benefited from the existing partnership between Virginia Tech in the U.S. and Shandong University in China. We examined students’ intercultural competence and interdisciplinary research skills and explored students’ stories of their lived experiences across three cohorts, each with five students, who completed the IRES program. Both open-ended survey responses …

Spectator 2024-10-17, Editors Of The Spectator

The Spectator

No abstract provided.

Montana Kaimin, October 17, 2024, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Therapeutic Targeting Of Differentiation-State Dependent Metabolic Vulnerabilities In Diffuse Midline Glioma., Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis

Manuscripts, Articles, Book Chapters and Other Papers

H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells. Here, we establish in vitro models that recapitulate DMG-OPC-like and AC-like phenotypes and perform transcriptomics, metabolomics, and bioenergetic profiling to identify metabolic programs in the different cellular states. We then define strategies to target metabolic vulnerabilities within specific tumor populations. We show that AC-like cells exhibit a mesenchymal phenotype and are sensitized to ferroptotic cell death. In contrast, OPC-like cells upregulate cholesterol biosynthesis, have diminished mitochondrial oxidative phosphorylation (OXPHOS), and are accordingly more …

Diagnosis And Management Of Shrimp Allergy, Brenda Bin Su, Warren Blackmon, Chun Xu, Christopher Holt, Nathaniel Boateng, Darren Wang, Vibha Szafron, Aikaterini Anagnostou, Sara Anvari, Carla M. Davis

Health & Biomedical Sciences Faculty Publications

Shrimp allergy, the most common food allergy in the United States, affects up to 2% of the population. Its etiology is multi-factorial with the combination of genetic predisposition and environmental exposures. This review summarizes the latest diagnosis and management strategies for shrimp allergy. Currently, the double-blind, placebo-controlled food challenge is the gold standard for diagnosis. Moreover, mainstream and experimental management strategies include food allergen avoidance, the FDA-approved omalizumab, and oral immunotherapy. Herein, we emphasize the urgent need to develop more effective diagnostic tools and therapies for shrimp allergy.

Differences In Susceptibility To Sars-Cov-2 Infection Among Transgenic Hace2-Hamster Founder Lines, Scott A. Gibson, Yanan Liu, Rong Li, Brett L. Hurst, Zhiqiang Fan, Venkatraman Siddharthan, Deanna P. Larson, Ashley Y. Sheesley, Rebekah Stewart, Madelyn Kunzler, Irina A. Polejaeva, Arnaud J. Van Wettere, Stefan Moisyadi, John D. Morrey, E. Bart Tarbet, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Animal models that are susceptible to SARS-CoV-2 infection and develop clinical signs like human COVID-19 are desired to understand viral pathogenesis and develop effective medical countermeasures. The golden Syrian hamster is important for the study of SARS-CoV-2 since hamsters are naturally susceptible to SARS-CoV-2. However, infected hamsters show only limited clinical disease and resolve infection quickly. In this study, we describe development of human angiotensin-converting enzyme 2 (hACE2) transgenic hamsters as a model for COVID-19. During development of the model for SARS-CoV-2, we observed that different hACE2 transgenic hamster founder lines varied in their susceptibility to SARS-CoV-2 lethal infection. The …

Fluidity Of Time, Phoebe Huey

Theses

Fluidity of Time is a digital clock installation that uses particle simulations to symbolize the fluctuating nature of human emotions throughout the day. Inspired by the concept of entropy—the natural shift from order to disorder—the clock’s particle-based digits flow, collapse, and rebuild, mirroring emotional cycles. The project addresses the issue of disconnection in a post-pandemic, technology-driven world, aiming to captivate viewers and create shared experiences that foster community. Through experimentation in X-Particles, I developed fluid, life-like motion in a digital clock that engages viewers on both aesthetic and emotional levels. The installation received positive feedback for its mesmerizing and satisfying …

Data-Driven Sparse Sensor Placement Optimization On Wings For Flight-By-Feel: Bioinspired Approach And Application, Alex C. Hollenbeck, Atticus J. Beachy, Ramana V. Grandhi, Alexander M. Pankonien

Faculty Publications

Flight-by-feel (FBF) is an approach to flight control that uses dispersed sensors on the wings of aircraft to detect flight state. While biological FBF systems, such as the wings of insects, often contain hundreds of strain and flow sensors, artificial systems are highly constrained by size, weight, and power (SWaP) considerations, especially for small aircraft. An optimization approach is needed to determine how many sensors are required and where they should be placed on the wing. Airflow fields can be highly nonlinear, and many local minima exist for sensor placement, meaning conventional optimization techniques are unreliable for this application. The …

Targeted Therapy In Breast Cancer: Advantages And Advancements Of Antibody-Drug Conjugates, A Type Of Chemo-Biologic Hybrid Drugs, Attrayo Mukherjee, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Cancer is a significant health challenge globally, with millions of people affected every year, resulting in high morbidity and mortality. Although other treatment options are available with limitations, chemotherapy, either standalone or combined with other therapeutic procedures, is the most commonly used practice of treating cancer. In chemotherapy, cancer cells/malignant tumors are targeted; however, due to less target specificity, along with malignant cells, normal cells are also affected, which leads to various off-target effects (side effects) that impact the patient quality of life. Out of all the different types of cancers, breast cancer is the most common type of cancer …

Effect Of Electronegativity On Environmentally Persistent Free Radical (Epfr) Formation, Persistence, And Toxicity On Transition Metal Oxides, Syed Monjur Ahmed

LSU Doctoral Dissertations

Environmentally persistent free radicals (EPFRs) are a group of emerging environmental pollutants. Owing to their resonance structures, EPFRs have significantly higher lifetimes than typical free radicals, and can induce the formation of reactive oxygen species (ROS) known to cause pulmonary and cardiovascular dysfunction. EPFRs form by the adsorption of organic precursors on a transition metal oxide (TMO) surface and exhibit enough stability to cause negative health and environmental effects. While aromatic and substituted aromatic precursors form EPFRs on TMO surface at elevated temperatures and numerous substituted organics are ubiquitous in various industrial processes and household products, studies have largely overlooked …