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Cas Connections- 2024 Fall Term - October, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Fabrication And Optimization Of A Silodosin In Situ-Forming Plga Implants For The Treatment Of Benign Prostatic Hyperplasia: In Vitro And In Vivo Study, Eman Gomaa

Nanotechnology Research Centre

Lower urinary tract symptoms (LUTSs) related to benign prostatic hyperplasia (BPH) are common in older men, and alpha-adrenoceptor blockers continue to be a key part of managing these symptoms. This study aimed to formulate injectable poly (lactic-co-glycolic acid) (PLGA) in situ-forming implants (ISFIs) loaded with silodosin (SLD) to address symptoms associated with BPH. This method, which ensures prolonged therapeutic effects of SLD, is intended to decrease dosing frequency and improve treatment outcomes, leading to better patient adherence. Methods: An appropriate solvent with favorable PLGA solubility, viscosity, and in vitro release profile was selected. Additionally, an I-optimal design was employed as …

The Primacy Of Density-Mediated Indirect Effects In A Community Of Wolves, Elk, And Aspen, Elaine M. Brice, Eric J. Larsen, Daniel R. Stahler, Daniel R. Macnulty

Aspen Bibliography

The removal or addition of a predator in an ecosystem can trigger a trophic cascade, whereby the predator indirectly influences plants and/or abiotic processes via direct effects on its herbivore prey. A trophic cascade can operate through a density-mediated indirect effect (DMIE), where the predator reduces herbivore density via predation, and/or through a trait-mediated indirect effect (TMIE), where the predator induces an herbivore trait response that modifies the herbivore's effect on plants. Manipulative experiments suggest that TMIEs are an equivalent or more important driver of trophic cascades than are DMIEs. Whether this applies generally in nature is uncertain because few …

October 23, 2024 (Vol. 109, No. 9), Daily Eastern News

Daily Eastern News: 2024-2025

No abstract provided.

Mutual Recognitions Across Generations, Steven L. Winter Walter S. Gibbs Distinguished Professor Of Constitutional Law

Law Faculty Research Publications

“Sovereignty,” Arendt says, “is contradictory to” the human condition. It is not, in any event, the kind of thing that can be shared across generations. Subsequent generations lack sovereignty to the precise degree that they are bound by the decisions of their predecessors. It is no answer to say that contemporary citizens participate in the sovereignty of a whole, transgenerational people. To paraphrase de Tocqueville, later generations are not free because they are not entirely equal, and they are not equal because they are not entirely free.

Where “sovereignty” is a metaphysical concept that transcends time, recognition is an act …

Study Of Chick Peeps Could Improve Understanding Of Animal Emotions, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Understanding animal emotions has been a long-running question at the forefront of welfare studies, but a University of Mississippi professor's work may hold the key to decoding the chatter.

Office Of Research, Economic Engagement And Outreach Update, October 23, 2024, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis And Regulates A Schizophrenia Susceptibility Gene Network Within The Mouse Dentate Gyrus, Prithviraj Rajebhosale, Alice Jone, Kory R Johnson, Rohan Hofland, Camille Palarpalar, Samara Khan, Lorna W Role, David A Talmage

Faculty, Staff and Student Publications

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by γ-secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V

Feasibility Of The Mind+Soul Culturally Tailored Brain Healthy Diet: A Pilot Study, Ashley R Shaw, Robyn Honea, Dinesh Pal Mudaranthakam, Kate Young, Eric D Vidoni, Jill K Morris, Sandra Billinger, Mickeal N Key, Jannette Berkley-Patton, Jeffrey M Burns

Faculty, Staff and Student Publications

Alzheimer’s disease (AD) disproportionately impacts Black Americans, who are three times more likely to develop AD. While heart-healthy diets have shown potential in reducing AD risk, research on adapted dietary interventions for Black American communities remains limited. This pilot study assessed the feasibility and acceptability of an adapted brain healthy diet intervention (MIND + SOUL) and explored changes in cardiometabolic risk and cognition. Twenty-nine participants completed the 12-week intervention, which included culturally tailored health education, cooking classes, health coaching, and groceries. Feasibility was assessed by attendance and retention rates, while acceptability was measured by two questionnaires. Participants had a mean …

A Trans-Theoretical Systematization Of Clinical Interventions Based On Dynamical Systems Research (Dsr), Giulio De Felice, David Pincus

Psychology Faculty Articles and Research

The scientific literature focused on the categorization of therapists’ interventions in clinical sessions, and their effects on patients, is not very extensive and often autoreferential. The most relevant findings clearly show the eclecticism of clinicians, grounding only 10–14% of their interventions on the specific theoretical approach to which they belong. Despite that, a trans-theoretical systematization of clinical interventions is lacking. The present work aims to verify the feasibility of a trans-theoretical categorization of clinical interventions based on Dynamical Systems Research in psychotherapy (DSR). For this purpose, the authors present the results of three literature reviews. The first sections of this …

Psychosocial Influences On African American Men Who Viewed Videos Of Police Killing Unarmed African American Men, Shaterrica Denae Maloney

Walden Dissertations and Doctoral Studies

The strained relationship between the African American community and law enforcement is not a new phenomenon. However, these interactions have become a focal point in research given the current use of smartphones and other technologies that capture video footage of these interactions, including those that result in the fatality of an African American male. The purpose and research questions of this phenomenological study explored the lived experiences of African American men and how their psychosocial development is influenced by watching videos of unarmed African American men being killed by police. The research questions were: What is the experience of African …

How Can Nature-Based Early Childhood Learning Environments Support Whole Child Development?, Greta Miller

Graduate Teacher Education

Learning experiences and environments have a profound influence on young children’s learning and development (National Association for the Education of Young Children, 2022; Zosh et al., 2022). When young children are afforded inadequate opportunities to engage with and explore a nature-based outdoor learning environment, children’s growth, learning, and development can be negatively impacted (Louv, 2008; Suttie, 2016). Current research and literature regarding how nature-based early learning environments support whole child development was analyzed. Research indicated that when children spent more time exploring nature, children had improved learning outcomes (American Academy of Pediatrics, 2022). Outdoor play promoted creativity, curiosity, and critical …

Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson

McKelvey School of Engineering Graduate Student Theses & Dissertations

A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …

Subjective Well-Being Across The Life Course Among Non-Industrialized Populations, Michael Gurven, Yoann Buoro, Daniel Eid Rodriguez, Katherine Sayre, Benjamin Trumble, Aili Pyhälä, Hillard Kaplan, Arild Angelsen, Jonathan Stieglitz, Victoria Reyes-Garcia

ESI Publications

Subjective well-being (SWB) is often described as being U-shaped over adulthood, declining to a midlife slump and then improving thereafter. Improved SWB in later adulthood has been considered a paradox given age-related declines in health and social losses. While SWB has mostly been studied in high-income countries, it remains largely unexplored in rural subsistence populations lacking formal institutions that reliably promote social welfare. Here, we evaluate the age profile of SWB among three small-scale subsistence societies (n = 468; study 1), forest users from 23 low-income countries (n = 6987; study 2), and Tsimane’ horticulturalists (n = …

Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson

McKelvey School of Engineering Graduate Student Theses & Dissertations

A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …

At Harvard Mgh’S Mouro Pinto Lab, Deploying Crispr In The Quest To Cure Huntington’S Disease, Kenneth P. Serbin Phd

At Risk for Huntington's Disease

No abstract provided.

The Dleu2/Mir-15a/Mir-16-1 Cluster Shapes The Immune Microenvironment Of Chronic Lymphocytic Leukemia, Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A Calin, Michael J Keating, Maria Teresa Sabrina Bertilaccio

Faculty, Staff and Student Publications

The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2-/-γc-/- MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the …

[Keynote Presentation] Why Open Access & What Is It?, Abbey Elder

Open Access Week Events

Attend this keynote presentation to learn about what Open Access is and why it’s important.

A Primer On Artificial Intelligence And Ai-Powered Financial Analysis, Zain Kalson

Ohio Northern University Law Review

No abstract provided.

Review Of "Enduring Alliance: A History Of Nato And The Postwar Global Order" By Timothy Andrews Sayle, Jean-Michel Turcotte

Canadian Military History

Review of Enduring Alliance: A History of NATO and the Postwar Global Order by Timothy Andrews Sayle

Review Of "The Spanish Blue Division On The Eastern Front, 1941-1945: War, Occupation, Memory" By Xosé M. Núnez Seixas, Ben H. Shepherd

Canadian Military History

Review of The Spanish Blue Division on the Eastern Front, 1941-1945: War, Occupation, Memory by Xosé M. Núnez Seixas

Review Of "Battlefield Emotions In Late Antiquity: A Study Of Fear And Motivation In Roman Military Treatises" By Łukasz Różycki, Lucas Mcmahon

Canadian Military History

Review of Battlefield Emotions in Late Antiquity: A Study of Fear and Motivation in Roman Military Treatises by Łukasz Różycki

Bringing Servicewomen Into Focus: Exploring Methods For Indexing Second World War Archival Photographs At Library And Archives Canada, Rebecca Murray

Canadian Military History

The Second World War saw women officially serving in the Canadian military in capacities other than nursing, breaking into roles historically held by men. The service of over fifty thousand Canadian women is documented in photographs held at Library and Archives Canada; photographs that allow historians to widen the lens on the traditional narrative, but only if they can find them. This article presents two methods for indexing archival photographs and highlights the particular challenges of identifying servicewomen in the archival record and bringing our aunties and grandmas into focus.

San Diego Collaboration For Conservation: Sustaining The Region's Legacy Of Biodiversity Conservation, Tessa Tinkler, Darbi Berry, A-Bel Gong, Bryan Cardenas, Daniela Olguin, Connelly Meschen, Eo Hanabusa

Environment

We are living through significant environmental, social, political, and economic challenges. These challenges have strained our communities and humanbuilt systems, as well as our interconnected habitats, wildlife, and natural systems. Lack of adequate infrastructure to withstand natural disasters and climate change, as well as historical and presentday inequities in resources across neighborhoods, are examples of the multifaceted and interconnected threats contributing to the accelerated loss of our rich biodiversity. This natural abundance is integral to our region’s health, history, and continued prosperity.

The Perception Of Waste Management Of Hikers At Bulusaraung Mountain Area Of Bantimurung Bulusaraung National Park, Alya Heldayanti, Asrianny Asrianny, Risma Illa Maulany

Jurnal Penelitian Kehutanan Wallacea

Waste management in tourist destinations is a serious problem because of its non-biodegradable nature and the volume of waste produced each year continues to increase along with the increasing number of visitors to the tourist area. The existence of climbing activities in the Bulusaraung Mountains area has an impact on the waste problem that arises due to hikers activities in the area. This study aims to examine the effectiveness of waste management in the Bulusaraung Mountains, Bantimurung-Bulusaraung National Park (South Sulawesi), Indonesia from the perspective of hikers, a survey was conducted on 100 hikers with a focus on their perceptions, …

Ethnoecology: The Community Adaptation Patterns Of Forest Management In Grobogan Central Java, Noor Fatmawati, Sanusi

Jurnal Penelitian Kehutanan Wallacea

The aims of this research are to describe community adaptation patterns and determine community perceptions regarding forest environmental management. This qualitative research was studied using an ethnoecological approach with the research focus being the people of the Perhutani area of ​​Grobogan Regency. This research carried out the data collection through interviews, observation and documentation, with the main informant being Pesanggem as a forest land manager. This research produced the first findings in the form of community adaptation patterns in managing the environment covering three aspects, namely ecological adaptation, economic adaptation and social adaptation in the Pesanggem community in Gedangan Village, …

Differential Hepatic Expression Of Mirna In Response To Aflatoxin B1 Challenge In Domestic And Wild Turkeys, Kade Jorud, Kristelle M. Mendoza, Thomas Kono, Roger A. Coulombe, Kent M. Reed

Animal, Dairy, and Veterinary Science Faculty Publications

Aflatoxin B1 (AFB₁) is a major foodborne mycotoxin that poses a significant economic risk to poultry due to a greater degree of susceptibility compared to other agricultural species. Domesticated turkeys (Meleagris gallopavo) are especially sensitive to AFB₁; however, wild turkeys (M. g. silvestris) are more resistant. A lack of functional isoforms of hepatic glutathione S-transferases (GSTs), an enzyme that plays a role in the detoxification of aflatoxin, is suspected as the reason for the increased sensitivity. Previous studies comparing the gene expression of domesticated and wild turkeys exposed to AFB₁ identified …

Minutes, Curriculum Committee Meeting, Tuesday, October 22, 2024, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Preparation And Efficacy Evaluation Of Chicken Egg Yolk Sourced Igy Against The Venoms Of Cobra, Krait, Russell’S Viper, And Saw-Scaled Viper, Gayathri G

Theses and Dissertations

Envenomation resulting from snakebites is widely recognized as an alarming health risk in tropical and sub-tropical areas. The big four snakes including Naja naja, Bungarus caeruleus, Daboia russelli, Echis carinatus are responsible for most of the envenomation in India. The current therapy for snake envenomation is immunoglobulins, produced from serum or plasma of horses or sheep. To overcome the drawbacks of current antivenom, chicken egg yolk (IgY) antibodies have recently emerged as one of the most promising research avenues.

In this study, the efficacy of chicken egg yolk sourced antisnake venom (ASV) IgY against the big four venoms was evaluated …

Garnet & Black: Fall 2024, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.