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Ccr5-Ligand Decorated Rilpivirine Lipid-Based Nanoparticles For Sustained Antiretroviral Responses, Milankumar Patel

Theses & Dissertations

Antiretroviral therapy (ART) is the standard remedy to improve the health-related quality of life of people living with human immunodeficiency virus (HIV). However, limited access to the viral reservoir has significantly hindered its effectiveness in fully eradicating HIV. Therefore, to improve HIV therapy, here we propose a C-C chemokine receptor type 5 (CCR5)-targeted theranostic lipid Based Nanoparticles (LBNPs) to noninvasively track and specifically deliver the antiretroviral drugs (ARVs) to the viral reservoir. A multi-modular radioactive nanoprobe was synthesized and co-encapsulated with rilpivirine (RPV, an ARV) into the LBNP to achieve a theranostic LBNP that can be tracked by positron emission …

Neurophysiological Indicators Of Neurodevelopmental Outcomes: Examining Discrimination And Habituation Among Children Born Preterm, Erin Stephanie Misato Matsuba

Dissertations - ALL

Children born preterm are at an elevated likelihood for autism (ELA) and intellectual disabilities (ID). Event-related Potentials (ERPs), such as the P1 and the Mismatch Negativity (MMN), can be used to measure underlying neurophysiology, which may aid in the identification of these important neurodevelopmental and cognitive outcomes. Specifically, enhanced P1 and MMN discrimination, measured via the difference between two alternating sounds, is associated with autism while reduced neurophysiological habituation is associated with a lower IQ. The present study sought to examine whether early auditory discrimination and habituation could differentially predict autistic traits and cognitive abilities, respectively, as well as assess …

Regional Differences In Three-Dimensional Fiber Organization, Smooth Muscle Cell Phenotype, And Contractility In The Pregnant Mouse Cervix, Christopher J Hansen, Christine M O'Brien, Et Al.

2020-Current year OA Pubs

The orientation and function of smooth muscle in the cervix may contribute to the important biomechanical properties that change during pregnancy. Thus, this study examined the three-dimensional structure, smooth muscle phenotype, and mechanical and contractile functions of the upper and lower cervix of nongravid (not pregnant) and gravid (pregnant) mice. In gravid cervix, we uncovered region-specific changes in the structure and organization of fiber tracts. We also detected a greater proportion of contractile smooth muscle cells (SMCs), but an equal proportion of synthetic SMCs, in the upper versus lower cervix. Furthermore, we revealed that the lower cervix had infrequent spontaneous …

Epidemiology Of Older Patients Presenting To Irish Emergency Departments: A Subgroup Analysis Of The Egers Dataset, Sean Croughan, Arina Kruis Dr, Kelly Ann Catherine Janssens Dr, Pro Mukerjee Dr, Denys Shchetkovskyy Dr, Áine Mitchell Dr, Mehmet Akif Karamercan Dr, Zerrin Defne Dundar Dr, Anna Slagman Dr, Effie Polyzogopoulou Dr, Sandor Somodi Dr, Andrea Fabbri Dr, Lars Peter Bjornsen Dr, Wilma Beetge, Said Laribi, Rebecca Ann Sealy, Visnja Nesek Adam, Comfort Adedokun Dr, Lucy Gibbons, Pamela O’Brien, Jessica Lynch Dr, Laura Kenny, Conor Deasy Dr, John Ryan Dr, David Menzies Dr, John Cronin Dr, Vijay Narayanan Dr, Nurali Noorani Dr, Waslet Bakhshi Dr, Ahmed Al Rasheed Ahmed Dr, Rosa Mcnamara Dr

Journal of Geriatric Emergency Medicine

Introduction

Within Emergency Medicine, older adults represent a distinct population with unique needs and challenges. There is a scarcity of epidemiologic data on the requirements of Ireland’s older population for, and their utilisation of, emergency care networks. We sought to assess this deficit utilising data from the recently published European Geriatric Emergency Departments Registry Study (EGERS) dataset.

Methodology

A prospective, cohort study of older adult patients (≥65) presenting to Irish Emergency Departments over a 7-day period. The dataset was originally collected as part of the EGERS study. The Irish subpopulation was extracted, analysed in further detail, and compared to the …

Transgenerational Legislative Awareness Issues In Children's Food, Yi Seul Kim

Duke Environmental Law & Policy Forum

No abstract provided.

Disparities In Kidney Care In Vulnerable Populations: A Multinational Study From The Isn-Gkha, Robin L. Erickson, Nivedita Kamath, Arpana Iyengar, Adebowale Ademola

Open Access archive

Vulnerable populations, such as the elderly, children, displaced people, and refugees, often encounter challenges in accessing healthcare. In this study, we used data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) to describe kidney care access and delivery to vulnerable populations across countries and regions. Using data from an international survey of clinicians, policymakers, and patient advocates, we assessed the funding and coverage of vulnerable populations on all aspects of kidney replacement therapies (KRT). Overall, 167 countries or jurisdictions participated in the survey, representing 97.4% of the world’s population. Children had less access …

Efficacy Of Probiotics For Treatment Of Acute Or Persistent Diarrhoea In Children From Birth Till 10 Years: Systematic Review And Meta-Analysis, Anmol Minaz, Ridwa Alam, Uswa Jiwani, Khadija Vadsaria, Ahmad Khan, Aqsa Ishaq, Samar Sultan, Marium Mohsin, Ashraf Sharif, Yasir Bin Nisar, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff

Centre of Excellence in Women and Child Health

Background: Numerous studies have investigated the efficacy of probiotics in treating acute and persistent diarrhoea. However, probiotics have not been established as a recommended management option for diarrhoeal illness by the World Health Organization (WHO). Therefore, we conducted a systematic review of randomised controlled trials to assess the efficacy of probiotics for the management of acute and persistent diarrhoea in children.
Methods: A systematic search on PubMed, CINAHL, Wiley Cochrane Library, Scopus, Clinicaltrials.gov, and WHO International Clinical Trials Registry Platform (ICTRP) was performed. All studies published in the year 2000 and onwards that assessed the use of probiotics in the …

A New Form Of Greenwashing: Why The Implementation Of Carbon Capture Cannot Be Justified For The Public Good Under The Takings Clause Of The Fifth Amendment, Emma Valiante

Seton Hall Law Review

No abstract provided.

Indigenous Metal: Rage, Rejects, And The Reconstruction Of Culture, Louis W. Asbury

Master's Theses

Metal music’s latest frontier is Indigenous metal, combining explorations of Indigenous identity with the heavy and aggressive stylings of the music genre. To explore this new subgenre, this study asks to what extent can metal music be used as a political tool and what are some of the broader effects of metal bands working to better their communities. This thesis utilizes case studies of two notable Indigenous metal scenes, the Rez metal scene in the Navajo Nation and the Māori metal scene in Aotearoa. By collecting data from these scenes, including lyrics, videos, interviews, and audience interactions, this thesis thoroughly …

The Ethical Requirements To Avoid Clinical Error Via Safety, Augustus Nweze, Augustus Ifeanyi Nweze Fr

Electronic Theses and Dissertations

Establishing safety programs across healthcare organizations will help to eliminate clinical errors and promote patient safety goals such as culture of quality and safety. Following the 1999 IOM Report, To Err is Human: Building a Safer Health System, regarding the high rate of injuries and deaths due to medical errors, healthcare institutions and policymakers at all levels have continued to draw attention to patient safety programs. As a result, patient safety programs have been implemented nationally to avoid clinical error in healthcare. Regulatory agencies like The Joint Commission, which oversees the voluntary accreditation of hospitals in the U.S. continues to …

Body Study, Annaliese "Ace" Taylor

Theses

A paper chronicling the creation of my graduate thesis film, Body Study.

The Impact Of Artificial Light At Night On The Distribution Of Sea Turtles In The Mediterranean, Molly R. Blyth

The Plymouth Student Scientist

Artificial light at night (ALAN) poses a significant threat to a wide array of species across the world. In coastal areas, artificial lighting is known to disrupt sea-finding behaviour of sea turtle hatchlings and to deter females from nesting beaches. Yet, sea turtles spend the majority of their lifetimes in the sea, where the influence of ALAN on sea turtle distribution has not previously been studied. Using a recently published atlas of ALAN under the sea, this study analysed an online dataset of sea turtle sightings throughout the Mediterranean Sea, to look for a relationship using a binomial generalised linear …

Measurement Of The Mechanical Properties Of Blood Vessels Using A Vascular Simulation Rig, Jack Lockyer

The Plymouth Student Scientist

Understanding the mechanical properties of blood vessels is crucial for reconstructive surgeons who connect donor tissue flaps to recipient sites. This paper describes the development of a vascular simulation test rig that delivers pulsatile flow to a blood vessel sample while continuously monitoring system pressure and sample diameter. These measurements allow for the calculation of the viscous coefficient, an important mechanical property for comparing blood vessels. A pilot test using the rig demonstrates its ability to measure pressure and diameter and highlights necessary improvements to enhance data quality. The pilot test shows that the current rig can measure 5 mm …

Rooting For Resilience: Investigating The Success Of Seagrass Restoration Methods, Olivia K. Stockdale

The Plymouth Student Scientist

Seagrasses generate vital ecosystem services to coastal communities, whilst also protecting marine biodiversity. Despite their significance, seagrass ecosystems face a plethora of threats from both anthropogenic and natural sources, causing a 20 % loss of seagrass area over the last century. To combat this, numerous restoration methods exist for seagrass habitats globally, with varying degrees of success. Through a comprehensive systematic review and subsequent meta-analysis, this study illustrates the varying success rates of different transplant and seed-based restoration methods over differing timescales. Accounting for varying timescales, results showed that restoration method had a significant effect on success rate (χ^{2 …}

Development Of A Climbing Performance Analysis Tool Using Computer Vision, Guy Ludford

The Plymouth Student Scientist

Indoor bouldering, a rapidly growing sport in the UK and globally, has seen a significant rise in participation, paralleled by an increase in the use of fitness apps and wearable trackers. Despite this growth, tracking and recording metrics for indoor climbing remains a challenge. This paper proposes an automated tool utilising computer vision and a gym-wide camera system to collect data on routes climbed and attempts made, without the need for manual logging. This tool aims to provide climbers with detailed performance analysis and support climbing gyms in optimising route setting and member engagement. Initial market research and discussions with …

Influence Of Patch Characteristics On Pollinator Behavior And Seed Production In Centaurea Stoebe, Abigail Hiltke

Theses - ALL

Discontinuous, or patchy, landscapes may affect pollinator foraging behaviors and could potentially lower the fitness of isolated plant communities by limiting and/or altering pollination services. I tested this idea by examining changes in pollinator behavior in patches of spotted knapweed of different size, flower density, and distance from one another. Based on predictions from optimal foraging theory, I identified and measured key pollination promoting behaviors that may change when foragers are exposed to discontinuous landscape. These behaviors were pollinator visitation rates to patches, the number of visits to individual flowers within patches, and the handling time per flower. These factors …

The Ghostly Angel In The Haunted Home: The Haunted House As A Metaphor For A Woman's Body In Crimson Peak, Andrea I. Amado-Fajardo

Theses and Dissertations

Crimson Peak (2015, dir. Guillermo del Toro), often overshadowed by del Toro's more critically acclaimed filmography, deserves to be acknowledged for its central trauma metaphor and its nuanced approach to gender. Far from being merely a horror movie fueled by disturbing sequences such as those found in contemporary supernatural horror films, Crimson Peak slowly unravels how Allerdale Hall parallels the film's female leads as they house and live with ghosts, revenants of a traumatic past. This essay explores the personification of the haunted house as a metaphor for the personified trauma that resides in a woman's body using Crimson Peak …

Toward A Broader Theocentric Environmentalism, Melvin L. Otey

Duke Environmental Law & Policy Forum

No abstract provided.

Altruistic Arbitrage And Climate Change Mitigation:Rethinking The Role Of Cap And Trade Policies, Fatjon Kaja, Matthew G. Nagler

Duke Environmental Law & Policy Forum

We examine the implications for efficient public goods provision by exploring the relationship of altruism to the endowment effect, focusing our analysis on the problem of climate change mitigation. We argue that the reduction in distortionary valuation (i.e., willingness-to-accept departing from willingness-to-pay) experienced by altruistic market participants implies an ability to mediate ignored trades and extract the gains from trade — an activity we call "altruistic arbitrage" — thereby improving the efficiency of markets. This activity, broadly speaking, restores the Coase Theorem in the context of WTA-WTP disparities. Moreover, it leads to previously unidentified benefits to when markets are employed …

On The Brink: Red Wolves On The Albemarle Peninsula, Jessica Hardee

Duke Environmental Law & Policy Forum

No abstract provided.

Population Dynamics In Myxococcus Xanthus Developmental Biofilm, Trosporsha Tasnim Khan

Dissertations - ALL

Myxococcus xanthus, a soil-dwelling bacterium, exhibits complex multicellular behaviors through self-organization into biofilms. M. xanthus cells traverse agar surfaces, forming either predatory biofilm or vegetative swarm that expands outward in the presence of nutrients. Upon nutrient depletion, the swarm reorganizes as cells “stream” inward, coalescing into aggregates that mature into spore-filled fruiting bodies. This starvation-induced biofilm development is a complex process, governed by stringent genetic controls and coordinated population interactions. Despite extensive research into the dynamics of this development, from the onset of starvation to fruiting body maturation, a comprehensive understanding is still missing. This dissertation sheds light on the …

Protocol For A Non-Surgical Model Of Perineural Invasion For Assessing Neural Drivers Of Cancer Aggressiveness In Mice, Tiago H Zaninelli, Telma Saraiva-Santos, Brielle H Patlin, Michael Slade Stratton, David Y Chen, Felipe A Pinho-Ribeiro

2020-Current year OA Pubs

Perineural invasion (PNI) is a significant risk factor for cancer recurrence and metastasis; however, its mechanisms relating to cancer aggressiveness remain poorly understood. Here, we present a protocol for a non-surgical model of PNI in mice using a neurotropic melanoma cell line that migrates from the skin to the sciatic nerve. We describe the steps for cell culture and injection, tumor burden measurements, mouse euthanasia, and tissue dissection. We then detail procedures for sample cross-section and confocal imaging.

Native Freshwater Mussel Communities In The Lower Grand River, Michigan: Assessing Tributary Confluence Effects And Updating Survey Information, Grayson L. Kosak

Masters Theses

Freshwater mussels (Unionidae) are ecosystem engineers and keystone species vital to stream ecosystems yet represent the most imperiled group of freshwater fauna. Conservation of unionids necessitates further understanding how assemblages interact with watershed features. This study investigates mussel occupancy, distribution, and assemblage structure upstream and downstream of tributary confluences in the lower Grand River, Michigan, alongside updated surveys of the unionid community with comparisons to previous assessments conducted by Michigan Natural Features Inventory (MNFI) in 2002–2003. Unionid density, richness, and diversity were greater upstream of confluences. No significant distance-gradient effects were observed. Assemblage structure differed between upstream and downstream reaches …

Disgusted Judges And Domestic Violence, Jessica Miles

Seton Hall Law Review

No abstract provided.

Peptides And Metalloproteins: Evolution, Catalysis And Material Design, Dona Imanga Upamadi Edirisinghe

Dissertations - ALL

Peptide hydrogels are an important class of biomaterials that have gained significant attention in recent years. The stimuli responsive materials change their properties in response to pH, redox, temperature and enzymes and this property allowed us to design the materials with tunable properties based on their end application. This dissertation reports the de novo design, synthesis and characterization of short chain peptide sequences and optimizations of those in order to develop them into potential candidates in wound care and drug delivery applications. The investigation of these novel peptide sequences will open up new possibilities to tailor the properties through simple …

Engineering Biomaterial Interfaces For Microbial Control, Yikang Xu

Dissertations - ALL

Since its inception as early as ancient Chinese placing bamboo pegs in place of missing teeth over 4,000 years ago, biomaterials have been an indispensable component of medical tools at human’s disposal. While early implants rely solely on the material properties themselves, modern devices have become much more than just materials. Topographic features, coatings, surface energy, and even embedded electronics have all added dimensions to the complexity of biomaterials and medical devices. Interaction between these materials and host cells and tissues, as well as microbes that can cause infections. Although well recognized for its significance, controlling biomaterial associated infections is …

Governing The Paddies: Emotions, Dispossession, And Gendered Struggles For Resource Access In Rice Farming In Tolima, Colombia, Akemi Inamoto

Dissertations - ALL

Colombia produces nearly one million tons of irrigated rice annually, almost exclusively for domestic consumption, with 72% of this production driven by smallholder farmers. In the department of Tolima, rice farming plays a significant role in both the local political economy and the agrarian landscape. This dissertation engages with feminist political ecology, critical agrarian studies, and debates on agrarian transformation to examine the everyday manifestations of dispossession that shape the lives of smallholder farmers and farmworkers in rural Tolima. I focus on how gender and class dynamics structure access to resources and opportunities, with special attention to the experiences and …

Elementary Science Instruction: A Document Analysis Of Teacher Messaging Across Two Sets Of Curriculum Materials, Jessica Mary Whisher-Hehl

Dissertations - ALL

Elementary teachers are tasked with teaching multiple subjects within an instructional day. One mechanism to support this task is through strong curriculum materials, which lay out a course of instruction aligned with instructional standards. This is helpful when teachers are trying to teach to a new set of standards, such as the Next Generation Science Standards, which require a significant shift in instructional strategies. In cases such as this, educative features embedded in the curriculum materials can assist teachers in making the required shifts in instruction. However, sometimes the instructional time required by curriculum materials, especially in elementary science, is …

Effects Of Negative Poisson’S Ratio On The Mechanics Of Auxetic Carbon Fiber Composites Under Tensile, Buckling And Low Velocity Impact, Wenhua Lin

Dissertations - ALL

Carbon fiber reinforced polymer (CFRP) matrix composites exhibited superior properties, such as high specific stiffness and specific strength, excellent fatigue and corrosion resistance, and low coefficient of thermal expansion, have been popular across various industries including aerospace, marine, automotive, energy, civil infrastructure, and high-end sports over the past decades. However, one significant drawback of CFRP composites is the susceptibility to low velocity impact damage which, for aircraft, can be results of tool drop, runway debris, and bird strike during takeoff and landing. These impact events could lead to external and internal damages of a CFRP composite structure in various damage …

Protocol For Monitoring Clonal Hematopoiesis In Transgenic Mouse Models Using Multispectral Imaging, Priyanka Khanna, Lauren B Ostermann, Shayaun Khazaei, Ran Zhao, Michael Andreeff, Rasoul Pourebrahim

Faculty, Staff and Student Publications

Clonal hematopoiesis involves the clonal expansion of hematopoietic cells, potentially progressing into hematological malignancies. Here, we present a protocol for the development and characterization of two mouse models designed to simulate clonal hematopoiesis and acute myeloid leukemia. We describe steps for model generation, monitoring clonal expansion, harvesting, fixation, and staining of bone marrow and spleen tissues. We specifically focus on the visualization and analysis of p53 mutant clonal expansions, providing a comprehensive protocol for studying these phenomena in mouse models. For complete details on the use and execution of this protocol, please refer to Pourebrahim et al.