Digital Commons Network^™

Synthesis And Evaluation Of 5-(Heteroarylmethylene)Hydantoins As Glycogen Synthase Kinase-3Β Inhibitors, Nicholas O. Schneider, Keandra Gilreath, Daniel J. Burkett, Martin St. Maurice, William A. Donaldson

Chemistry Faculty Research and Publications

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increasing number of small organic molecule inhibitors of GSK-3 have been reported. Phenylmethylene hydantoins are known to exhibit a wide range of inhibitory activities including for GSK-3β. A family of fourteen 2-heterocycle substituted methylene hydantoins (14, 17–29) were prepared and evaluated for the inhibition of GSK-3β at 25 μM. The IC50 values of five of these compounds was determined; the two best inhibitors …

Disentangling Cyclic Causality: An Instance-Based Framework For Causal Discovery, Chase A. Yakaboski

Dartmouth College Ph.D Dissertations

Correlation does not imply causation" is one of the fundamental principles taught in science, emphasizing that associations between variables do not necessarily indicate causality. Yet, over the past three decades, extensive research has begun to challenge this perspective by developing sophisticated methods to differentiate causal from correlative relationships. This research suggests that correlations often involve a blend of confounded and causal interactions, which, given certain assumptions, can be disentangled to uncover actionable insights and deepen our understanding of physical, biological, and societal systems.

Accurately discovering causal relationships from data amidst cyclic dynamics remains a challenging open problem in causality research. …

Scalable Methods For Resource-Constrained Adaptive Sampling, Kizito Masaba

Dartmouth College Ph.D Dissertations

As the global community confronts the pressing issues of climate change, the importance of environment monitoring cannot be overstated. This process is essential in identifying and tracking critical environmental trends to facilitate efficient and effective conservation efforts. Traditionally, scientists perform this task using hand-held, in-situ instruments. With the recent robot advancements, this task can be fully automated by applying multi-robot systems to a task referred to as multi-robot adaptive sampling. However, the cost of purchasing and operating robot systems for this application are still prohibitive due to various environmental, technological, and logistical constraints. Some of the outstanding constraints to the …

Estrogen Receptor (Er) Alpha Regulatory Mechanisms And Therapeutic Strategies In Er+ Breast Cancer, Bianca A. Romo

Dartmouth College Ph.D Dissertations

Breast cancer is among the most frequently diagnosed cancers in the U.S. and is one of the leading causes of cancer-related mortalities, second to lung cancer. Estrogen receptor alpha-positive (ER+) breast cancer accounts for 2/3 of diagnosed cases. Patients diagnosed with this subtype of breast cancer typically undergo endocrine therapy that aims to mitigate the growth-promoting effects of estrogen/ER. While therapies are effective, 1/3 of patients will experience recurrence. To begin addressing this drug-resistant patient population, we investigated potential drug targets involved in response to treatment.

Coregulators have been implicated in the regulation of ER transcriptional activity and subsequently affecting …

Biogenesis And Function Of Microglial Extracellular Vesicles In Neuroinflammation And Parkinson’S Disease, Karl E. Biggs

Dartmouth College Ph.D Dissertations

Microglia are subject to chronic proteinaceous and environmental stress during the progression of prevalent neurodegenerative diseases such as Parkinson’s Disease (PD). Chronic stress can activate the NLR family pyrin domain containing 3 (NLRP3) pattern recognition receptor resulting in the formation of the NLRP3 inflammasome, proinflammatory signaling, and pyroptotic cell death. A distinct subset of extracellular vesicles (EVs) are released from cells upon NLRP3 activation. We studied WT and Nlrp3^-/- primary microglia exposed to bacterial stimulating agents and alpha synuclein preformed fibrils (αsyn PFFs), which model Parkinson’s disease and associated synucleinopathies. We identified the NLRP3-dependent release of the endosome fate …

Debt, Race, And Physical Mobility, Kate Sablosky Elengold

Faculty Publications

Residents in every state in the United States can lose their driver’s license or car registration because they owe debt to the state. At least eleven million people across the United States suffer these debt-based driving restrictions at any given time. Because Americans overwhelmingly rely on personal automobiles for transportation, states, by controlling access to driver’s licenses and vehicle registrations, use debt policy to control where and how people travel. And because these laws disproportionately affect people of color, primarily Black people, this kind of regulation props up racial segregation in both location and opportunity. This Article’s first contribution is …

Against Associational Standing, Michael T. Morley, F. Andrew Hessick

Faculty Publications

This Article calls for the abandonment, or at least serious modification, of associational standing. Even without associational standing, groups may still sue to enforce their own rights. And they could continue to help vindicate their members’ rights by providing legal representation for member plaintiffs in individual or class action suits (filed anonymously, if necessary), covering members’ litigation costs, and providing expert witnesses and other guidance. In short, associational standing is a largely unnecessary deviation from both Article III’s injury-in-fact requirement and the fundamental principles underlying our justice system. Eliminating associational standing would not limit public law and other important collective …

The Effects Of Exercise In Cognitive Function In Older Ad, Josephine Sagan

Honors Program Theses

No abstract provided.

The First Amendment To The Constitution, Associational Freedom, And The Future Of The Country: Alabama’S Direct Attack On The Existence Of The Naacp, Helen J. Knowles-Gardner

Seattle University Law Review

Sixty years ago, on Wednesday, April 8, 1964, Professor Harry Kalven, Jr., gave the second of three lectures at The Ohio State University College of Law Forum. These lectures were published two years later in a book entitled The Negro & the 1st Amendment. In the second lecture, Kalven distinguished between direct and indirect threats to the associational freedom of the National Association for the Advancement of Colored People (NAACP). Kalven categorized the 1958 decision in NAACP v. Alabama ex rel. Patterson as an indirect effort to control the NAACP.

With the benefit of material obtained from numerous archival sources, …

What Is In Your Tampon? Increasing Transparency In Menstrual Products, Elianna Spitzer

Seattle University Law Review

The average person who menstruates will bleed for an average of five days, every twenty-four to thirty-eight days, over several decades and could use thousands of disposable menstrual products in their lifetime. Menstrual products line retail shelves. They can be found in homes, bags, and bodies—but until 2021, manufacturers were not required to disclose the ingredients used to make these products to consumers at all. In fact, they still are not federally required to disclose menstrual product ingredients on product packaging. Instead, in recent years, changes to menstrual product labels have largely been the result of state legislation. In 2019, …

Due Process Shaped By The Present Instead Of The Past: The Needed Reinvigoration Of A Lawrence Vision Of Due Process, Azor Cole

Seattle University Law Review

The recognition of unenumerated rights, rights implied from the text of the constitution, is a political battlefield waged through law with profound implications for all Americans. Generally, there have been two prongs for an inquiry into an unenumerated constitutional right under the Fourteenth Amendment. One is to ask whether the right to be found is objectively deeply rooted in this Nation’s history and tradition. The other is to ask whether the right to be found is fundamental to this Nation’s scheme of ordered liberty. The current Supreme Court has effectively done away with this present-day liberty analysis, saying it is …

Sneakers, The Shoes That Talk The Talk And Walk The Walk: How Jack Daniel’S Properties, Inc. V. Vip Products Left Its Footprint On Trademark Law And The Sneaker Industry, Nitya Tolani

Seattle University Law Review

As the fashion industry—including the sneaker industry housed within it—continues to go through the motions of collectively flocking out, and then collectively flocking again to the newest innovations in the world of wearables, the landscape of laws to protect and promote those innovations expands as well, mainly in the area of intellectual property law. Although copyright, trademark, and patent law can cover innovations in the fashion industry, this Note centers its analysis on trademark law. Trademark law has been through notable change in recent years because of the United States Supreme Court’s 2023 decision in Jack Daniel’s Properties, Inc. v. …

Prejudice Standards In Washington’S Appellate Courts, Andrew B. Van Winkle

Seattle University Law Review

When an appellate court finds an error to have occurred during a proceeding, the error is not yet subject to correction. In order to merit a remedy, the error must have been sufficiently prejudicial to the aggrieved party’s case. Drawing the line between correctable and non-correctable errors is not an easy task, for it often requires guessing at what was in the minds of jurors and trial judges. To cope with this task, courts have devised various rules and tests for deciding whether an error was likely prejudicial or not. These standards often go by names such as “harmless error,” …

Table Of Contents, Seattle University Law Review

Seattle University Law Review

Table of Contents

Immediate Repeated Reading Has Positive Effects On Reading Rate For English Language Learners: An Eye-Tracking Study, Jennifer Hemmert Hansen, Grant Eckstein, Troy L. Cox, Steven G. Luke, Krista Rich

Faculty Publications

Fluent and skillful reading in English requires efficient and automatic letter and word recognition. Dysfluent reading can affect motivation for reading in English language learners, thereby limiting access to a wealth of language input from written texts. Extensive research of repeated reading in first language (L1) settings has been shown to increase reading rate, while comparatively little research has been done on repeated reading in second language (L2) settings. The objective of this eye-tracking study was to accurately document early and late reading processes in an immediate repeated reading exercise to observe how repeated reading affects reading rate in adult …

Virtual Gaming, Actual Damage: Video Game Design That Intentionally And Successfully Addicts Users Constitutes Civil Battery, Allison Caffarone

Hofstra Law Faculty Scholarship

In recent years, there has been increased academic interest in both the neurological effects of compulsive gaming and the potential tort liability of game developers who scientifically engineer games in order to addict users. Scholars from various disciplines are currently debating the scope and potential solutions to the problems associated with Gaming Disorder, now a globally recognized illness. This article contributes to this discussion by offering a multidisciplinary analysis of the scope of video game addiction, its neurological bases, and its relation to the legal rights and responsibilities of victims and game developers. In addition, this article explores the practical …

The Repeal Of Religious Accommodations – A Constitutional Analysis, Ronald J. Colombo

Hofstra Law Faculty Scholarship

Under modern Supreme Court jurisprudence, the First Amendment ordinarily imposes no heightened standard of review upon neutral laws of general applicability that coincidentally burden the free exercise of religion. To relieve or minimize this burden, however, lawmakers are generally free to promulgate exemptions from or accommodations to such laws for the benefit of religious adherents. Such exemptions and accommodations are common.

When a law is not neutral with respect to religion, or when the law is not generally applicable, then it will be subject to the exacting test of strict scrutiny to the extent that it burdens the free exercise …

Challenging Medicine: Ivermectin Cases, Medical Futility Cases And The Patient-Physician Relationship, Janet L. Dolgin

Hofstra Law Faculty Scholarship

No abstract provided.

Accountable Ai And Insider Trading: The Other 'Black Box' Problem, J. Scott Colesanti

Hofstra Law Faculty Scholarship

No abstract provided.

How Pizza And Stickers Drove My Kids To Read And Kept Them Reading, Tiya Montaño

Graduate Research Papers

Walk into any English/Language Arts (ELA) classroom across the country and you will find books on bookshelves, students on computers or cellphones, and a teacher struggling to garner the attention of their students long enough to make it through the short story, poem, or novel they are reading. This has become an all too familiar image that ELA teachers struggle with. Why won’t the students engage? Are the readings too difficult? Are the readings too boring? Am I teaching them all wrong? All these questions and more fly through our brains as they work towards trying to get the students …

Fostering Multiliteracies And Engagement With Multimodal Texts In The Secondary English Language Arts Classroom, Amanda J. Hargis

Graduate Research Papers

This study underscores the potential of multimodal texts to enhance student engagement and understanding in high school English Language Arts classrooms. While student preferences for different text formats varied, challenges remain in how to connect classic literature to contemporary students. However, the integration of multimodal resources can offer valuable opportunities for enriching the learning experience. Future research and continued adoption of culturally sustaining pedagogies in instructional practices will be key to maximizing the benefits of multimodal texts in diverse educational settings.

The Effect Of Student Discussion Groups On Music Preference, Abby Steffen

Graduate Research Papers

The purpose of this study was to explore the effect of three different listening conditions on how students rate their preference of musical genre. The preferences of the students could then be analyzed and incorporated into daily teaching. The participants were fifth-grade students of the researcher. Students (N = 44) were divided into three groups: Listening Only, Small Group Discussion and Teacher Info. Students in the Listening Only group listened to a playlist of music representing ten genres and rated each genre on a scale from 1(I don’t like it) to 5 (I like it a lot). Students in the …

Evaluation Of Environmentally Friendly Products For Use Against Ixodes Scapularis And Amblyomma Americanum Ticks (Acari: Ixodidae), Chantal Sengsourinho

Open Access Master's Theses

Ticks are vectors of diseases and are a significant public health concern in the United States. Over the last several decades, two medically important species, the blacklegged tick (Ixodes scapularis) and the lone star tick (Amblyomma americanum) have rapidly expanded their geographic ranges. As the number of ticks increase, so does the chance for disease incidence - especially in areas where ticks were not previously present. Together, these two species carry multiple pathogens that can cause serious diseases including Lyme disease, ehrlichiosis, babesiosis, anaplasmosis, and several viral infections.

One of the most common methods for preventing …

Enhancing Forest Monitoring And Management In Southern New England Through Gis Analysis, Remote Sensing, And Predictive Models: Assessing Tree Mortality And Enhancing Infrastructure Resilience, Liubov Dumarevskaya

Open Access Dissertations

Forests have immense economic value, contributing to industries such as timber production, nontimber forest products, and ecotourism (Wang et al., 2022). Additionally, forest ecosystems play a crucial role in mitigating climate change by acting as carbon sinks (Yingchun et al., 2012). However, forests also pose hazards to humans and infrastructure. Fallen trees, limbs, and contact of tree branches with power lines create numerous hazards to public safety, property damage, and substantial economic losses from power outages. Studies report that the total cost of storm-related power outages in the United States range from $20-150 billion annually (Campbell et al., 2021; Swaminathan …

Max Holland Papers - Accession 738, Max Holland

Manuscript Collection

The Max Holland Papers consists of materials related to the Rock Hill, SC city government and the office of City Manager. Max Holland (1923-1992) was the Rock Hill City Manager from 1965 to 1979. Mr. Holland was involved in the redevelopment of downtown Rock Hill that included the urban renewal clearance program, the new city hall, railroad was relocated, the Train depot was razed, Dave Lyle Boulevard was constructed, a new law center was built, the city limits were expanded, and the Town Center Mall was built. The Town Center Mall experiment, that put a roof on Main Street in …

Perspective: The Evolution Of Hormones And Person Perception-A Quantitative Genetic Framework, Christopher I Gurguis, Tyler S Kimm, Teresa A Pigott

Faculty, Staff and Student Publications

Evolutionary biology provides a unifying theory for testing hypotheses about the relationship between hormones and person perception. Person perception usually receives attention from the perspective of sexual selection. However, because person perception is one trait in a suite regulated by hormones, univariate approaches are insufficient. In this Perspectives article, quantitative genetics is presented as an important but underutilized framework for testing evolutionary hypotheses within this literature. We note tacit assumptions within the current literature on psychiatric genetics, which imperil the interpretation of findings thus far. As regulators of a diverse manifold of traits, hormones mediate tradeoffs among an array of …

2024 Cheshire County Ac Agenda & Minutes, Diane Dugray

Advisory Council

No abstract provided.

Intersectionality Matters In Food And Drug Law, Colleen Campbell

Hofstra Law Faculty Scholarship

Feminist scholars critique food and drug law as a site of gender bias and regulatory neglect. The historical exclusion of women from clinical trials by the FDA prioritized male bodies as the object of clinical research and therapies. Likewise, the FDA’s prior restriction on access to contraceptive birth control illustrates how patriarchal and paternalistic attitudes within the Agency can harm women’s reproductive health. However, there is little analysis of how race and gender intersect in this domain.

This Article uses the regulation of skin-lightening cosmetics products to illustrate why and how intersectionality matters in food and drug law. While the …

Good Apples / Bad Apples: Detection And Classification Of Damage, Angel Star, Conor Pommer, Marius Silaghi

Electrical Engineering and Computer Science Faculty Publications

The sorting of apples in classes of quality using vision, and the detection of bad apples using X-ray and vision have naturally been addressed frequently in the past due to the sheer significance of this fruit. Our novelty consists in going past detection of damage into measuring it and classifying damaged apples for potential usages beyond direct sale, rather than simply deciding if an apple is rotten or not. Size and color of damage stains is assessed to help deciding potential usage of the apples. One can redirect apples towards various usages outside markets for the general population, such as …

Modeling Apparent Pb Loss In Zircon U-Pb Geochronology, Glenn R. Sharman, Matthew A. Malkowski

Geosciences Faculty Publications and Presentations

The loss of radiogenic Pb from zircon is known to be a major factor that can cause inaccuracy in the U–Pb geochronological system; hence, there is a need to better characterize the distribution of Pb loss in natural samples. Treatment of zircon by chemical abrasion (CA) has become standard practice in isotope dilution–thermal ionization mass spectrometry (ID-TIMS), but CA is much less commonly employed prior to in situ analysis via laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) or secondary ionization mass spectrometry (SIMS). Differentiating the effects of low levels of Pb loss in Phanerozoic zircon with relatively low-precision in situ U–Pb …