Digital Commons Network^™

Identification Of A New Human Disease Gene For Dilated Cardiomyopathy (Dcm), Rutairat Wongong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pathogenic BAG5 variants recently linked to dilated cardiomyopathy (DCM) prompt further investigation into phenotypic, mutational, and pathomechanistic aspects. We explored the clinical and molecular characteristics of DCM associated with BAG5 variants, uncovering the consistently severe manifestation of the disease and its impact on the endoplasmic reticulum (ER) stress response. Analysis involved three siblings affected by DCM, along with their four unaffected siblings and consanguineous parents. Exome and Sanger sequencing identified a novel BAG5 variant, c.444_445delGA (p.Lys149AsnfsTer6), homozygous in affected siblings and heterozygous in parents and unaffected siblings. We generated heterozygous and homozygous Bag5 point mutant knock-in (KI) mice and evaluated …

A Chemistry-Transport Model Study For Source Contributions Of Pm2.5 And Its Implications For Southeast Asia Regional Haze Management Policy, Abdul Wahab

Chulalongkorn University Theses and Dissertations (Chula ETD)

PM2.5 pollution is a persistent issue in Southeast Asia. In response, the Association of Southeast Asian Nations (ASEAN) launched the Second Hazefree Roadmap (2023-2030) to alleviate this issue. This roadmap can be an important institutional measure to reduce PM2.5 pollution regionally; however, it largely centres on biomass burning and does not comprehensively tackle other sources. This study aims to quantify the contributions of three key sectors—biomass burning, transport, and industry—to PM2.5 pollution. In addition, for the focus of Thailand, the study assesses transboundary PM2.5 pollution coming into Thailand. We employ the GEOS-Chem chemistry transport model, a widely used global model …

การพัฒนาแพลตฟอร์มเมตาเวิร์สแบบเว็บที่มีระบบสนับสนุนปัญญาประดิษฐ์, สืบพงศ์ น้อยศรี

Chulalongkorn University Theses and Dissertations (Chula ETD)

วิทยานิพนธ์ฉบับนี้นำเสนอการพัฒนาต้นแบบแพลตฟอร์มเมตาเวิร์สที่มีขีดความสามารถขั้นพื้นฐานครอบคลุมระบบอวาทาร์ ระบบผู้ใช้หลายราย ระบบสื่อสารตามเวลา ระบบการเชื่อมต่อแชตบอต และฉากโลกเสมือนจริงสามมิติที่เหมือนจริง แพลตฟอร์มที่พัฒนาขึ้นนี้ถูกนำไปใช้ประโยชน์กับหน่วยงานภาคการศึกษาและภาคธุรกิจ ทั้งหน่วยงานภายในจุฬาลงกรณ์มหาวิทยาลัยและสถาบันการศึกษาทั้งในประเทศและระดับนานาชาติ ผลการทดสอบพบว่าระบบทำงานได้ให้ผลสัมฤทธิ์ที่ดีและมีคุณภาพตามความต้องการใช้งานในทางปฏิบัติ สามารถประยุกต์ใช้กับการสร้างห้องเรียนเสมือนออนไลน์ในโลกเสมือนจริง รองรับระบบการสื่อสารระหว่างผู้ใช้ทั้งภาพ เสียง และข้อความ อีกทั้งยังสามารถใช้งานร่วมกับระบบแชตบอตจากภายนอกได้ผ่านระบบเอพีไอที่พัฒนาขึ้น ผลการทดสอบบนระบบคลาวด์ของบริษัท โทรคมนาคมแห่งชาติ จำกัด แสดงให้เห็นว่าระบบสามารถรองรับปริมาณผู้ใช้งานได้ไม่น้อยกว่า 30 รายพร้อมกัน ผลการทดสอบในเชิงประสบการณ์การใช้งานมีระดับความพึงพอใจในเชิงบวก งานวิจัยและพัฒนาจึงให้ประโยชน์และเป็นจุดเริ่มต้นของการประยุกต์ใช้เทคโนโลยีเมตาเวิร์สในวงกว้าง

Author Bios, Author Bios

Intertidal

No abstract provided.

The Unconscious Mind: Psychoanalysis And Art, Carlie Hoffer

MA Theses

The insights brought to society about the unconscious mind can be solely credited to Sigmund Freud’s groundbreaking works that were published in the early 1900’s. Specifically, the concept of the unconscious mind being a driver for human behavior was a unique theory that Freud introduced to a society that had never considered this possibility before this. The realization and acknowledgement of the unconscious mind as relevant to analyzing human behavior including art inspired other scholars and individuals in the field of psychology to explore a more nuanced understanding of human motivations. His novel ideas about human behavior emerged at a …

Growing Up Sustainable? Politics Of Race And Youth In Urbanplan, Copenhagen, Max Ritts, Rebecca Rutt

Geography

This paper considers how racialized youth in Denmark negotiate sustainability amid contexts marked by intersecting forms of economic restructuring, progressive neoliberalism, white ethno-nationalism, and green urban planning. Urbanplan is a low-income, notoriously “troubled” Copenhagen neighborhood where we conducted fieldwork for 7 months (2019-2020) with fifteen male youth, aged 17-21. Using ethnography, policy reviews, and interviews with city social workers, we explore how intimate experiences of nature, group-identity, and place attachment here relate to and depart from the structural forces actively reshaping the neighborhood. Our analysis combines Cindi Katz's intersectional political economy approach with recent work on green gentrification, Critical Utopian …

Do Generations Matter? The Moderating Role Of Media In Adherence To Covid-19 Quarantine Protocol, Luz Suplico Jeong, Reynaldo Bautista Jr., Nelson B. Guillen Jr., Solomon Oluyinka

DLSU Business & Economics Review

This study examined the perceptions of Filipinos from Generations X, Y, and Z towards adherence to COVID-19 quarantine protocol. Of the 400 Filipino respondents, 55 were Generation Xers, 86 were from Generation Y, whereas 259 were from Generation Z. Using the theory of planned behavior, the results suggest that there were no significant differences in how Generations X, Y, and Z responded to the quarantine protocol even if media moderated the relationship between self-efficacy and adherence to quarantine protocol. Thus, marketers can use a standardized campaign to encourage Generations X, Y, and Z to adhere to the quarantine protocol.

Impossibility Of Artificial Inventors, Mateusz Blaszczyk

Scholarly Works

Recently, the United Kingdom Supreme Court decided that only natural persons can be considered inventors. A year before, the United States Court of Appeals for the Federal Circuit issued a similar decision. In fact, so have many of the courts all over the world. This Article analyzes these decisions, argues that the courts got it right, and finds that artificial inventorship is at odds with patent law doctrine, theory, and philosophy. This Article challenges the intellectual property (IP) post-humanists, exposing the analytical and normative perils of their argumentation, and recommends against getting rid of the nominally central place of humans …

Using Mechanical Interventions To Enhance Drug Transport To Bone Tumors, Michelle Gelbs

Dissertations and Theses

Bone metastasis occurs when cancer cells spread from a primary site to a secondary location in bone. Current treatments for metastatic bone tumors typically involve systemic chemotherapy, bisphosphonates, radiotherapy, or surgery; however, due to morphological changes in the tumor microenvironment and elevated interstitial fluid pressure, tissue penetration of therapeutic agents is often more limited in cancerous tumors compared to normal tissue. Weight-bearing mechanical loading applied to bone, as well as other mechanical stimulations such as vibration, have been shown to cause loading-induced bone deformations that increase convective transport via interstitial fluid flow. We hypothesize that mechanical loading can increase the …

Modulation Of Motor Learning With High-Intensity Transcranial Electric Stimulation, Gavin Hsu

Dissertations and Theses

Research thus far on noninvasive, transcranial electric stimulation have produced mixed results from in vivo human experiments. This work tests the hypothesis that applying higher stimulation intensities would induce intracranial electric fields that more closely match the higher magnitudes used in animal and in vitro studies and subsequently yield more robust effects. As done commonly in the literature, we targeted the motor cortex (M1), specifically in the context of neuroplastic changes taking place during motor learning in healthy adult humans. This work also seeks a better understanding of the neural correlates underlying motor skill learning.

Through multiple large-sample studies, this …

Ecological Factors Influencing The Evolution Of Jamestown Canyon Virus In The Northern United States, Ellie Bourgikos

Public Health Theses

Jamestown Canyon virus (JCV) is a re-emerging arthropod-borne virus in the midwest and northeast United States, infecting mosquitoes and white-tailed deer in a seasonal transmission cycle. Its spread may contribute to thousands of asymptomatic human infections, with 194 total cases of neuroinvasive disease diagnosed. However, very little is known about the virus’s evolutionary history, transmission patterns, and lineage distribution. For this project, we sequenced 689 JCV samples collected from mosquito pools in the northern U.S., increasing the availability of this species’ genomes. Using maximum likelihood estimation on surveillance data, we found that JCV is maintained through the overwintering of single-brood …

A History Of Cioms (Council For International Organizations Of Medical Sciences) And The Creation Of Multinational Consensus For Human Subjects Research Ethics, Abigail Belle Cheung

Public Health Theses

N/A

Unveiling Chagas Disease: An In-Depth Analysis Of Epidemiological Patterns In High Burden Latin American Nations, Nicole Del Castillo

Public Health Theses

Background: Chagas Disease, endemic to 21 countries in Latin America, is transmitted by triatominae insects infected with parasites known as Trypanosoma cruzi.1–3 It is the most prevalent tropical disease in Latin America, affecting about 6 million individuals across the Americas.1 This literature review aims to summarize unique epidemiological patterns over a 9-year time period from 2010 to 2019 across three nations in South America that experienced the highest Chagas Disease burden in 2019: Bolivia, Venezuela, and Argentina.4

Methods: For this rapid literature review, one independent reviewer extracted all data for publications reviewed within a 9-year time period: 2010 to 2019. …

Evaluation Of One Health Education Materials: A Scoping Review And Quality Assessment, Sydney Jones

Public Health Theses

The increasing risk of zoonotic spillover, driven by climate change and evolving human behaviors, requires a systematic shift in pandemic prevention strategies towards a One Health approach. Central to this approach is effective health communication intended to translate knowledge into actionable recommendations for the most vulnerable populations. This thesis aims to systematically evaluate the quantity and quality of existing One Health communication materials through a scoping review and two distinct methods of quality evaluation: the CDC Clear Communication Index and content analysis. Among 82 communication materials identified in the scoping review, the median overall CDC Clear Communication Index score was …

Light At Night And Cancer Incidence: A Gis-Based Study In The Us, Linshuoshuo Lyu

Public Health Theses

Aims: Light at night (LAN) can cause circadian disruption and was found to be a potential risk factor for several cancers. This study aims to confirm the adverse effect of LAN on hormone-related cancers and explore the association between LAN and the prevalence of various cancer types under an ecological study design. Methods: County-level age-adjusted cancer incidence data was obtained from the CDC Cancer Statistics (2016 to 2020), while LAN data (1996 to 2000) was obtained from the satellite imagery of Version 4 Defense Meteorological Satellite Program. Linear mixed effect regression models (LMMs) were performed to assess the relationship of …

Effect Of A Weight-Loss Intervention On Oxidative Stress Biomarkers Among Breast Cancer Survivors In The Lifestyle, Exercise, And Nutrition (Lean) Study, Yiyi Li

Public Health Theses

Introduction: As the number of breast cancer survivors increases, ensuring quality of life during the survivorship period is important. Obesity may induce oxidative stress, which may be relevant mechanistically for adverse health outcomes among breast cancer survivors. Diet, exercise, and weight loss may mitigate oxidative stress, yet few lifestyle trials have investigated if these interventions have impacted oxidative stress. Therefore, we conducted a secondary analysis in a 6-month weight loss randomized controlled trial, the Lifestyle, Exercise, and Nutrition (LEAN) study, among breast cancer survivors with a body mass index (BMI) ≥ 25 kg/m2 to evaluate the effect of the intervention …

Emerging Contaminants In Long Island Public Drinking Water, Clare Loughlin

Public Health Theses

Thousands of federally unregulated ‘emerging’ contaminants are entering and persisting in our environment, potentially adversely impacting public health. Drinking water is a major exposure pathway for some of these emerging contaminants. In 2020, New York State set maximum contaminant level (MCL) drinking water standards for three emerging contaminants: 1,4-dioxane: 1 ppb, perfluorooctanoic acid (PFOA): 10 ppt, and perfluorooctanesulfonic acid (PFOS): 10 ppt. Databases of public drinking water exist but generally do not contain comprehensive and ancillary data reported by annual public drinking water reports, or the data may not be aggregated or readily available in a format suitable for data …

Analysis Of Mercury Exposures In The United States Reported To The National Response Center (2018-2022), Abigail E. Mcdonald

Public Health Theses

Introduction

The frequency and extent of environmental elemental mercury exposures in the U.S. are unknown. Due to its marked toxicity, elemental mercury has been phased out of many newer commercial products. However, mercury-containing products are still available, and a variety of religious, cultural, decorative, cosmetic, and illicit uses have been reported in the community. Small quantities of mercury can be highly toxic, and mercury toxicity can present nonspecifically and multi-systemically with the potential to be easily missed. Therefore, it is important to characterize the settings where mercury exposures occur and the extent of such exposures. The overall aim of this …

Indoor Air Pollution In Nomadic Himalayan Highlander Communities, Charles Minicucci

Public Health Theses

Indoor air pollution (IAP) from burning solid biomass fuel is a major global health challenge, especially in resource-limited settings without access to electricity or reliable fuel sources. In the Kingdom of Bhutan, where, despite a reported 99% of households having access to electricity, the vast majority of rural households still use biomass fuels for cooking and indoor heating. Given the resource limitations and access challenges associated with Bhutan’s remote highlander and herding communities, few solutions for or details about their exposure to IAP are available – especially during nomadic periods where families may spend months beyond the reach of infrastructure …

Exploring The Connections Between The Arts And Mental Health In The Face Of Climate Change, Marla Joy Minkoff

Public Health Theses

Objective: This study aims to explore how engagement with art may shape emotions related to the climate crisis and expand the conception of art as a mechanism of public health practice.Background: Climate change impacts human health not only physically but also psychologically, manifesting in symptoms of climate emotions (e.g., ecological grief, eco-anxiety, eco-paralysis) that arise as a result of changes to the earth and our relationship to the natural world. These symptoms are among the pressing mental health effects of climate change. Methods: A qualitative approach utilizing the Rapid Assessment Process (RAP) was employed to conduct semi-structured interviews (N=10) with …

Assessing The Correlation Between Per- And Polyfluoroalkyl Substances (Pfas) Exposure And Cancer Incidence In The U.S., Xiaoqing Zhang

Public Health Theses

AbstractThe study seeks to understand the relationship between key PFAS contaminants and their potential to cause cancer in the United States. It also aims to find out how different PFAS exposures affect different types of cancer and how food can increase or decrease the risk of getting cancer. The study used secondary data from the government and other reliable sources. The process looked at PFAS exposure, food malnutrition, and cancer rates in the population by using both descriptive and inferential statistics. After looking at socio-economic factors and their health effects on the public, the results showed that PFOS, PFHxS, and …

Trauma-Informed Digital Health Interventions: A Scoping Review, Amelea Lowery

Public Health Theses

Background: Trauma exposure is a pervasive issue around the world and the impacts of trauma can be long lasting and detrimental to individual and population health outcomes. Trauma responses can influence and determine an individual or community’s approach in seeking supportive resources. Given the critical role of supportive resources and the prevalent use of technology and internet use, it is essential to understand how digital health interventions contribute to addressing trauma explicitly. This scoping review aims to explore the landscape of trauma-informed digital health interventions for adults, assess their outcomes, and identify their measurable impacts across various settings.Methods: A scoping …

Exploring The Role Of Bacteroidales In Human Health: A Comprehensive Literature Review On Their Associations With Selected Diseases, Tingyue Wang

Public Health Theses

Bacteroidales are a vital group of gut bacteria that significantly contribute to human health by maintaining gut balance. However, their abundance is often altered in various diseases, indicating a strong association with disease progression and immune responses. This review categorizes Bacteroidales into clusters based on metabolic phenotypes, suggesting similarities in their metabolic pathways.

To explore the relationship between Bacteroidales species and human health, we conducted a comprehensive literature review. We compiled a list of 16 Bacteroidales species and performed targeted searches in PubMed using keywords related to inflammation and immunity. This process helped us identify relevant diseases, focusing on those …

Still Problematic, Even Post-Settlement: Florida’S “Don’T Say Gay” Law And The Federal Constitution, Catherine Jean Archibald

Chapman Law Review

Florida’s “Don’t Say Gay” Law, officially part of the Parental Rights in Education Act, came into force in 2022. As amended in 2023, this law prohibits classroom instruction on sexual orientation or gender identity for children in pre-kindergarten through the eighth grade, and forbids any instruction on sexual orientation or gender identity that is not “age-appropriate or developmentally appropriate” for children in any grade.

From the start, this law was controversial and was challenged in court as a violation of the U.S. Constitution. In March 2024, a settlement agreement was reached in a lawsuit challenging the law, providing clarification on …

Travel Literature. Mircea Eliade’S Occidental View In The Himalayan Journal And The Portugal Journal, Irina Armianu

Literatures and Cultural Studies Faculty Publications

This article retraces Mircea Eliade’s mystical travel through the Himalayas as shown in his Himalayan Journal and his struggle to survive as a writer under the weight of brutal historical events in his Portugal Journal. The two travel journals reveal the influence of geographical and historical elements on Eliade's mystical writing. A deeper analysis of these journals is necessary to link travel genre to mystical thought. The next pages will show (1) how these journals fit into the category of existential travel, as theorized by Erik Cohen in "The Phenomenology of Tourist Experiences" (179-201), (2) Eliade’s own transcendence of his …

Maps As Rhetorical Tools Of Colonial Power And Alternative Cartographies: The Americas’ Cartographic Invention, Eda Özyeşilpınar

Faculty Publications – English

This essay focuses on two historical maps as rhetorical artifacts: The Piri Reis Map of 1513 produced by the Turkish admiral Piri Reis in 1513, the Reis map, and the Map of the Island of Cuba and Surrounding Territories produced by the Cuban geographer, historian, and educator José María de la Torre y de la Torre in 1841, the de la Torre map. The Reis map demonstrates the colonial logic of Americas’ cartographic invention while the de la Torre Map is an alternative cartographic artifact disrupting the Reis map’s celebratory discourse and the settler-colonial legacy of the world heritage memory.

Mechanisms For Regenerative Intervertebral Disc Healing During Early Growth In Mice, Danielle N. D'Erminio

Dissertations and Theses

Annulus Fibrosus (AF) defects of intervertebral discs (IVDs) cause painful disability, for example when herniated tissue compresses against adjacent nerves. Discectomy, the current standard of treatment to address herniation, does not repair AF defects and can result in re-herniation and recurrent pain. As such there is a need for improved AF repair strategies. It has previously been established that neonatal mice functionally regenerate following severe AF injury providing a model of successful innate AF repair processes that contrasts the poor healing of adult mice. This dissertation focuses on identifying mechanisms of AF regenerative healing in neonatal mice subjected to severe …

Understand The Structure-Water-Responsive Relationship By Engineering Silk Materials, Yeojin Jung

Dissertations and Theses

Water-responsive (WR) materials mechanically swell and shrink in response to changes in relative humidity, and they have demonstrated the capability to exert higher actuation energy than conventional actuators and artificial muscles. As a result, WR materials have recently gained attention as potential high-energy actuating components for engineering applications. Despite the growing interest in this emerging category of WR materials, the fundamental WR mechanism of their significant performance is still not fully understood, limiting the ability to rationally design engineered systems. This dissertation presents three approaches for understanding the water-responsiveness of materials by engineering Bombyx (B.) mori silkworm silk protein. First, …

Exploring Spatial Operations Of Distractor Suppression In The Sense Of Touch, Nicole A. Serino

Dissertations and Theses

The ability to select sensory information in our environment is key to facilitating goal-directed actions. Sensory selection mechanisms are prevalent in all sensory modalities, and can be implemented by enhancing information at the relevant location and/or suppressing neural information outside the focus of attention (a mechanism known as distractor suppression). Although we have a decent understanding of how the brain enhances information within the focus of attention, less is known about the mechanisms that mediate suppression of distractors, especially in sensory modalities outside vision. In this study, we conducted a series of behavioral experiments to investigate the spatial flexibility of …

The Menstrual Cycle In Psychotherapy: Interventions, Therapist Engagement, And Blind Spots, Rozita Alaluf

Dissertations and Theses

There is a dearth of literature on psychotherapy and menstruation, except for the treatment and diagnosis of issues associated with premenstrual distress. This study aimed to bridge this gap by investigating the frequency and context of discussions about the menstrual cycle, the factors influencing therapists’ engagement with this topic, and the therapeutic approaches utilized to address the menstrual cycle within psychotherapy.

In phase 1, 118 psychotherapists from various theoretical backgrounds completed a survey on menstruation in clinical practice. The data was analyzed using descriptive statistics. In phase 2, semi-structured interviews were conducted with 7 psychotherapists, primarily identifying their theoretical orientation …