Digital Commons Network^™

202401-02, 01/27/2024, I-69 N, Mm 263, Grant Co., Myles W. Overall, Rahul Suryakant Sakhare, Justin Mukai, Jairaj Desai, Deborah Horton, Darcy M. Bullock

After-Action Reports for Traffic Incident Management (TIM)

No abstract provided.

Oral Rabies Vaccination Of Raccoons (Procyon Lotor) Across A Development Intensity Gradient In Burlington, Vermont, Usa, 2015–2017, Emily M. Beasley, Kathleen M. Nelson, Dennis Slate, Amy T. Gilbert, Frederick E. Pogmore, Richard B. Chipman, Amy J. Davis

United States Department of Agriculture Wildlife Services: Staff Publications

Management of the raccoon rabies virus variant in North America is conducted primarily using oral rabies vaccination (ORV). When a sufficient proportion of the population is vaccinated (60%), rabies transmission can be eliminated. To date, ORV programs have successfully controlled and eliminated raccoon rabies in rural areas, but there has been less success in urban areas. We studied the proportions of rabies virus neutralizing antibodies (RVNA) in a raccoon (Procyon lotor) population during a 3-year ORV trial in developed areas of Burlington, Vermont, United States. We used a modified N-mixture model to estimate raccoon abundance, RVNA seroprevalence, and …

Distribution And Prevalence Of Antibodies To Trichinella Spp. And Toxoplasma Gondii In Wild Pigs (Sus Scrofa) In The United States, Christopher A. Cleveland, Ellen Haynes, Katherine C. Callaghan, Alinde Fojtik, Sarah Coker, Emily Doub, Vienna R. Brown, Ania A. Majewska, Michael J. Yabsley

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive wild pigs (Sus scrofa) are a reservoir for over 100 viral, bacterial, and parasitic pathogens that are transmissible to humans, livestock, domestic animals, and wildlife in North America. Numerous historical local surveys and results from a nation-wide survey (2006–2010) indicated that wild pigs in the United States act as reservoirs for Trichinella spp. and Toxoplasma gondii, two zoonotic pathogens of importance for human and animal health. Since that time, wild pig populations have expanded and increased in density in many areas. Population expansion of wild pigs creates opportunities for the introduction of pathogens to new areas …

Ethyl-Iophenoxic Acid As A Serum Marker For Oral Baiting Of Tasmanian Devils, Ruth Pye, David Nichols, Sally A. Nofs, Amy T. Gilbert, Andrew S. Flies

United States Department of Agriculture Wildlife Services: Staff Publications

Oral baits containing vaccines, medicants or toxicants have been delivered to a broad range of wildlife species to protect against or treat disease, or suppress populations. Ethyl-Iophenoxic acid (Et-IPA) is used as a biomarker to determine oral bait consumption by wildlife species to assess and refine baiting strategies. Et-IPA is a persistent biomarker in many eutherian mammal species but not in the two marsupial species, swamp wallaby (Wallabia bicolor) and brushtail possum (Trichosurus vulpecula), tested to date. Et-IPA has not previously been evaluated in carnivorous marsupials. The Tasmanian devil (Sarcophilus harrisii), the largest extant …

Estimating Landscape Spread Of A Low-Prevalence Disease Using Multiple Surveillance Methods, Abigail Feuka, Aakash Pandey, Melinda Cosgrove, Megan Moriarty, Anthony Duffiney, Henry Campa Iii, Kurt C. Vercuteren, Kimberly M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

1. Diseases occurring at low prevalence in free-ranging wildlife can be difficult to study and predict at a landscape scale. This problem is compounded by imperfect pathogen detection.

2. We used data from multiple surveillance methods to determine factors influencing spread of a low-prevalence disease, bovine tuberculosis (bTB), among white-tailed deer (Odocoileus virginianus) in a bTB endemic area over a 10-year period. We fit dynamic occupancy models to predict spatial spread of bTB through a county in Michigan, USA, within the bTB endemic area, while accounting for imperfect detection and a suite of ecological processes potentially driving bTB …

Effects Of The Immunocontraceptive Gonacon On Pregnancy In Brucella-Seropositive American Bison (Bison Bison), Rebecca K. Frey, Morgan E. Wehtje, Pauline Nol, Patrick R. Clarke, Jack C. Rhyan, Matthew P. Mccollum, Lowell A. Miller, Douglas C. Eckery

United States Department of Agriculture Wildlife Services: Staff Publications

The purpose of this study was to determine if the number of pregnancies in naturally infected Brucella abortus-positive bison (Bison bison) cows would be reduced over a period of 5 yr after one treatment with 3000 mg gonadotropin-releasing hormone immunocontraceptive (GonaCon) compared to a similar group of naturally infected B. abortus-positive bison cows not treated with GonaCon. In each of the 5 yr, GonaCon-treated cows produced fewer offspring in relation to number of cows than the nontreated cows. Fisher’s Exact test comparing offspring produced during the first reproductive season showed a significant difference between the …

Efficacy Of X-Ray Phytosanitary Irradiation On The Infectivity And Reproduction Of Angiostrongylus Cantonensis In Experimentally Infected Rats, Susan I. Jarvi, Lisa M. Kaluna, Steven C. Hess, Lindsey Hamilton, Carmen Antaky, Robert T. Sugihara, Israel L. Leinbach, Yaeko Tagami, Argon Steel, Kathleen Howe, Steven Jacquier, Forrest Cookman, Jocelyn Diaz, John Jacob, Peter Follett

United States Department of Agriculture Wildlife Services: Staff Publications

Angiostrongylus cantonensis is a globally distributed nematode and the leading cause of eosinophilic meningitis in humans. As a global hotspot for this disease, Hawaii’s agricultural exports may be contributing to the spread of A. cantonensis. Phytosanitary irradiation doses of 150 or 400 Gy provide quarantine security against multiple insect pests. We evaluated the in vitro and in vivo effects of phytosanitary irradiation on infectious, third-stage A. cantonensis juveniles. In vitro experiments directly exposed juveniles to irradiation doses ranging from 200 to 1,000 Gy. Results showed low mortality and no dose response across all treatments 27 days post-irradiation. …

A Different Approach To Agency Theory And Implications For Esg, Jonathan Bonham, Amoray Riggs-Cragun

Seattle University Law Review

In conventional agency theory, the agent is modeled as exerting unobservable “effort” that influences the distribution over outcomes the principal cares about. Recent papers instead allow the agent to choose the entire distribution, an assumption that better describes the extensive and flexible control that CEOs have over firm outcomes. Under this assumption, the optimal contract rewards the agent directly for outcomes the principal cares about, rather than for what those outcomes reveal about the agent’s effort. This article briefly summarizes this new agency model and discusses its implications for contracting on ESG activities.

Overseeing The Administrative State, Jill E. Fisch

Seattle University Law Review

In a series of recent cases, the Supreme Court has reduced the regulatory power of the Administrative State. Pending cases offer vehicles for the Court to go still further. Although the Court’s skepticism of administrative agencies may be rooted in Constitutional principles or political expediency, this Article explores another possible explanation—a shift in the nature of agencies and their regulatory role. As Pritchard and Thompson detail in their important book, A History of Securities Law in the Supreme Court, the Supreme Court was initially skeptical of agency power, jeopardizing Franklin Delano Roosevelt (FDR)’s ambitious New Deal plan. The Court’s acceptance …

The Sec, The Supreme Court, And The Administrative State, Paul G. Mahoney

Seattle University Law Review

Pritchard and Thompson have given those of us who study the SEC and the securities laws much food for thought. Their methodological focus is on the internal dynamics of the Court’s deliberations, on which they have done detailed and valuable work. The Court did not, however, operate in a vacuum. Intellectual trends in economics and law over the past century can also help us understand the SEC’s fortunes in the federal courts and make predictions about its future.

A Hard Pill To Swallow: The Abysmal Mental Health Standards Of Detained Immigrant Children In The United States, Rama Bankesly

Seattle University Law Review

After setting foot into the U.S., unaccompanied children must learn to navigate academic and legal systems while receiving little support and carrying the heavy burden of effects of trauma on their mental health. They need access to mental health care from qualified professionals, but as this Comment will explain, they systematically fail to receive care, as can be seen in cases like Doe v. Shenandoah Valley Juv. Ctr. Comm’n. In Shenandoah, an unaccompanied child arrived in the U.S. and was placed in a facility that failed to provide remotely adequate mental health care and in fact was subjected …

The Influence Of Genes On The Migratory Timing Of Great Reed Warblers, Emily Fackler

Honors Undergraduate Theses

Many organisms migrate; however, there is a lack of knowledge on the mechanisms that drive migration timing, including which genes play a role. The great reed warbler (Acrocephalus arundinaceus), a migratory bird that breeds in Eurasia and overwinters in sub-Saharan Africa, is an excellent model to study the genetics of migration. Each season, some individuals migrate early, whereas others migrate later in the season. In other words, they exhibit differences in their migratory chronotypes. Past research has identified three candidate genes (TOP1, PEAK1, and CPNE4) that influence the migratory chronotypes of another avian species, …

What Does It Mean To Stand Out? How Visual Design And Presentation Affects Attention And Memory In A Warning Message., Nichlas Waugh, Jeannette Sutton, Laura M. Fischer, Ginder Orton

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

In emergency communication, it is essential to call attention to key information that can be interpreted quickly and remembered easily. Individuals possess a limited number of cognitive resources to allocate to message processing in an emergency. Because of this, they are more likely to allocate attention to messages they are motivated to care about, or to message attributes that stand out. In this study, we focus on how warning messages are attended to when they are viewed in a busy media environment and ask the question: “What does it mean to stand out?” To address the research questions, we used …

Dendritic Cell Subsets And Implications For Cancer Immunotherapy, Michael Y Chen, Felicia Zhang, Simon Peter Goedegebuure, William E Gillanders

2020-Current year OA Pubs

Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory milieu all impact DCs with regard to promoting or inhibiting tumor immunity. The following review introduces important facets of DC function, and how subset and phenotype can affect the interplay of DCs with other factors in the tumor microenvironment. It will also discuss how current cancer treatment relies on DC function, and survey the myriad ways with which immune therapy can more directly harness DCs to enact antitumor …

Identification Of Constrained Sequence Elements Across 239 Primate Genomes, Lukas F K Kuderna, Jacob C Ulirsch, Sabrina Rashid, Mohamed Ameen, Laksshman Sundaram, Glenn Hickey, Anthony J Cox, Hong Gao, Arvind Kumar, Francois Aguet, Matthew J Christmas, Hiram Clawson, Maximilian Haeussler, Mareike C Janiak, Martin Kuhlwilm, Joseph D Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rouselle, Felipe Ennes Silva, Lidia Agueda, Julie Blanc, Marta Gut, Dorien De Vries, Ian Goodhead, R Alan Harris, Muthuswamy Raveendran, Axel Jensen, Idriss S Chuma, Julie E Horvath, Christina Hvilsom, David Juan, Peter Frandsen, Joshua G Schraiber, Fabiano R De Melo, Fabrício Bertuol, Hazel Byrne, Iracilda Sampaio, Izeni Farias, João Valsecchi, Malu Messias, Maria N F Da Silva, Mihir Trivedi, Rogerio Rossi, Tomas Hrbek, Nicole Andriaholinirina, Clément J Rabarivola, Alphonse Zaramody, Clifford J Jolly, Jane Phillips-Conroy, Gregory Wilkerson, Christian Abee, Joe H Simmons, Eduardo Fernandez-Duque, Sree Kanthaswamy, Fekadu Shiferaw, Dongdong Wu, Long Zhou, Yong Shao, Guojie Zhang, Julius D Keyyu, Sascha Knauf, Minh D Le, Esther Lizano, Stefan Merker, Arcadi Navarro, Tilo Nadler, Chiea Chuen Khor, Jessica Lee, Patrick Tan, Weng Khong Lim, Andrew C Kitchener, Dietmar Zinner, Ivo Gut, Amanda D Melin, Katerina Guschanski, Mikkel Heide Schierup, Robin M D Beck, Ioannis Karakikes, Kevin C Wang, Govindhaswamy Umapathy, Christian Roos, Jean P Boubli, Adam Siepel, Anshul Kundaje, Benedict Paten, Kerstin Lindblad-Toh, Jeffrey Rogers, Tomas Marques Bonet, Kyle Kai-How Farh

Faculty, Staff and Students Publications

Noncoding DNA is central to our understanding of human gene regulation and complex diseases1,2, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome3–9. Identifying the genomic elements that have become constrained specifically in primates has been hampered by the faster evolution of noncoding DNA compared to protein-coding DNA10, the relatively short timescales separating primate species11, and the previously limited availability of whole-genome sequences12. Here we construct a whole-genome alignment of 239 species, representing nearly half of …

Factors Influencing Metal Concentrations In Hair And Nails During Longitudinal Follow-Up Of Apprentice Welders, Jairo Buitrago-Cortes, Philippe Sarazin, Denis Dieme, Naïma El Majidi, Michèle Bouchard

Études primaires

The aim of this study was to determine factors influencing observed increased metal biomarkers of exposure levels in a group of 116 Quebec apprentice welders during a longitudinal follow-up of exposure. Analysis of 14 metals was carried out in hair, fingernail, and toenail samples taken from participants over the course of their welding curriculum at 6 different times. Personal and socio-demographic characteristics, lifestyle habits, and other potential confounding factors were documented by questionnaire. Multivariate linear mixed-effect models were used to assess main predictors of metal concentrations in each biological matrix including increasing time of exposure throughout the curriculum (defined as …

A Roadmap For Sex Workers’ Rights Reform: Lessons Learned From Recent Legal Advancements, Chi Adanna Mgbako

Faculty Scholarship

The past decade has witnessed unprecedented growth in the legal recognition of sex workers’ rights. Recent legislation and court judgments strengthening sex workers’ rights protections have occurred in the Australian jurisdictions of the Northern Territory, Queensland, and Victoria, as well as in Belgium, India, and Malawi. These legal advancements conform with the goals of the global sex workers’ rights movement. They include newly decriminalized legal frameworks governing sex work, groundbreaking labor and anti-discrimination protections for sex workers, the striking down of vagrancy laws that indirectly target sex workers, and judicial directives on state protection of sex workers’ rights. Despite the …

Immunohistochemical Analysis Of Dentigerous Cysts And Odontogenic Keratocysts Associated With Impacted Third Molars—A Systematic Review, Luis Eduardo Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto

School of Dentistry Faculty Research and Publications

Objective: This systematic review investigates the diagnostic, prognostic, and therapeutic implications of immunohistochemical markers in dentigerous cysts (DCs) and odontogenic keratocysts (OKCs) associated with impacted third molars.

Materials and Methods: A comprehensive search strategy was employed across major databases including MEDLINE/PubMed, EMBASE, and Web of Science, from the inception of the databases to March 2024. Keywords and Medical Subject Heading (MeSH) terms such as “dentigerous cysts”, “odontogenic keratocysts”, “immunohistochemistry”, “Ki-67”, and “p53” were used. The PRISMA 2020 guidelines were followed to ensure methodological rigor. Inclusion criteria encompassed studies on humans and animals providing definitive diagnoses or specific signs and symptoms …

Reactive Aldehyde Species (Rasp) Inhibitors Sequester Maa-Adducts And Reduce Pro-Inflammatory Cytokines, Duncan Works

Posters and Presentations: College of Medicine Students

Background: Post-translational modifications of self-proteins have been implicated in the pathogenesis of Rheumatoid Arthritis (RA). One of these protein modifications termed malondialdehyde-acetaldehyde-adduct (MAA) has recently gained interest for its involvement in RA. This protein adduct contributes to inflammation by inducing immune cells to generate pro-inflammatory cytokines, T-cell specific responses, responses and circulating autoantibodies. Recently, novel reactive aldehyde species (RASP) inhibitors (ADX-629 and ADX-246) became available that have been shown to prevent the formation of MAA adducts by covalently binding and sequestering MDA and AA in a mouse model of alcoholic liver disease. These inhibitors prevented the release of key inflammatory …

Marine Protection And Environmental Forcing Influence Fish-Derived Nutrient Cycling In Kelp Forests, June Shrestha, Joseph R. Peters, Jennifer E. Caselle, Scott L. Hamilton

Faculty Research, Scholarly, and Creative Activity

Animal consumers excrete dissolved inorganic nitrogen, an essential nutrient for regulating primary production and macroalgal growth in the ocean. Often overlooked in attempts to explain kelp forest productivity, relatively little is known about the role of consumers in nutrient cycling in temperate systems, such as the magnitude of nutrients excreted and the factors that influence spatial and temporal variability in consumer-derived nutrients. To investigate the supply of ammonium (NH4+) excreted by the dominant members of the nearshore rocky reef fish community, we combined empirically-measured relationships between excretion rate and body mass with data on fish density and size structure from …

Density And Abundance Estimation Of West Indian Manatee, Trichechus Manatus, Between The States Of Ceará And Piauí, Northeast Brazil, Using Active Acoustics, Katherine Fiedler Choi Lima, Denis Moledo De Sousa Abessa, Daniel Gonzalez-Socoloske, Renata Sousa-Lima, Ana Carolina Oliveira De Meirelles, Cristine Pereira Negrão Silva

Faculty Publications

The West Indian manatee is one of the most threatened species in Brazil. The species has currently a patchy distribution from the state of Alagoas to the state of Amapá. The difficulty of observing manatees, especially in estuarine waters, is a challenge for conservation. Therefore, it is necessary to use new methodologies and technologies to solve manatee detection problems in their natural habitats. The goal of this study was to use an active acoustic method of detection to estimate manatee density and abundance in the estuarine complex of the Timonha and Ubatuba rivers, between the states of Ceará and Piauí, …

Multimodal Prediction Of Obsessive-Compulsive Disorder And Comorbid Depression Severity And Energy Delivered By Deep Brain Electrodes, Saurabh Hinduja, Ali Darzi, Itir Onal Ertugrul, Nicole Provenza, Ron Gadot, Eric A Storch, Sameer A Sheth, Wayne K Goodman, Jeffrey F Cohn

Faculty, Staff and Students Publications

To develop reliable, valid, and efficient measures of obsessive-compulsive disorder (OCD) severity, comorbid depression severity, and total electrical energy delivered (TEED) by deep brain stimulation (DBS), we trained and compared random forests regression models in a clinical trial of participants receiving DBS for refractory OCD. Six participants were recorded during open-ended interviews at pre- and post-surgery baselines and then at 3-month intervals following DBS activation. Ground-truth severity was assessed by clinical interview and self-report. Visual and auditory modalities included facial action units, head and facial landmarks, speech behavior and content, and voice acoustics. Mixed-effects random forest regression with Shapley feature …

Adolescence: A Collection Of Short Stories ; Title Pending: A Novel, Dylan Siegel

EWU Masters Thesis Collection

No abstract provided.

Improving The Most Gg Model To Predict Environmental Impact And Improve On Farm Grass Growth Prediction, Laeticia Bonnard

Theses

The increasing need for highly productive and eco-friendly agriculture is driving demand for decision-support tools to assist agricultural operators in managing systems more precisely and sustainably. Although grasslands provide a cost-effective option for ruminant production and can offer many environmental benefits (biodiversity, carbon storage etc.), grasslands management is challenging due to the inherent climate and soil sensitivities and their potential negative impact on water quality. In Ireland, the Moorepark Saint Gilles Grass Growth (MoSt GG) model was developed for the dual purposes of research-based simulations and on-farm grass growth prediction for farmers. The objective of this thesis was to improve …

Field And Laboratory Evaluation Of The Interactions Between Pesticides And The Gut Microbiome In Honey Bees (Apis Mellifera), Macee R. Mitchell

EWU Masters Thesis Collection

Western honey bees (Apis mellifera) are important pollinators yet are threatened by a combination of factors such as poor nutrition, pathogens, parasites, and pesticide use. Bees encounter numerous pesticides while foraging (e.g. imidacloprid, a neonicotinoid insecticide) or in the hive colony (e.g. Tau-fluvalinate, a miticide commonly used to treat Varroa mite parasites). Similar to most organisms, the gut microbiome is important for bee health, metabolism, and behavior, however it is not well known how environmental factors like pesticides impact their gut bacterial symbionts. I hypothesized that 1) pesticide concentrations in bees are correlated with gut bacterial community structure, and 2) …

Envisioning Munster Technological University As A Trauma-Sensitive University, Marie Singleton

Theses

Trauma-informed care works on the assumption that individuals utilizing relevant services have experienced trauma (Palmer, 2020). The trauma-informed approach focuses on providing empathy and compassion to create healing relationships and ensure accessibility for all service users. This approach is aimed at understanding, identifying, and addressing trauma in organisations by making changes to practices, policies, and procedures (Champine et al., 2022). Substance Abuse and Mental Health Services Administration (SAMHSA) (2014:10) states that ‘trauma results from an event, serie s of events, or set of circumstances that is experienced by an individual as physically or emotionally harmful or threatening and that has …

Optima: Optimal Protein For Optimal Ageing, Eunice Ti-Oluwani Olaniyan

Theses

The older adult population is increasing globally, and this is associated with an increased prevalence of chronic diseases. This, together with increased consumer concern regarding the overconsumption of animal proteins, has led to a need to consider alternative dietary strategies for older adults. This study developed novel plant protein blends using combinations of pumpkin, pea ad rice protein isolates, and investigated their amino acid profiles, protein content and bioactive properties to identify optimal blends for functional food formulation. A major objective of this study was to formulate protein-rich products. It was hypothesised that blending multiple sources of plant proteins in …

Strategic Use Of Once-A-Day Milking For Pasture-Based Dairy Cows In Ireland, John Paul Murphy

Theses

The current perception of dairy farming in Ireland is one of long hours, physically demanding work and poor remuneration, especially when compared to that of a modern, high-tech industry with career opportunities and advancement possibilities at many levels (Teagasc, 2018). One of the biggest factors in attracting and retaining people to work on Irish dairy farms is that they must be desirable places to work (Teagasc, 2018). Milking is the most labour demanding task on Irish dairy farms (Deming et al., 2018) and one, which necessitates farmers being present on the farm twice daily if milking twice-a-day (TAD). Altering milking …

The Impact Of Data Quality On Beef Genetics, Shauna Walsh

Theses

Efficiency and profitability in the beef industry are driven by cattle live-weight, therefore, to optimise live-weight data it is essential to maintain consistency across data collection methods. Data for this thesis was collected from 97,780 Irish suckler herds across the years 2019 to 2022, inclusive, with a total of 1,311,870 calf and dam live-weight records available. Live-weight data originated from five different sources including: professionally-recorded, producer recorded using either owned, borrowed or hired weighing scales, or from an unknown recording source. The objectives of this thesis were to: i) identify anomalies within cattle live-weight data for both calf and dam, …

Improving Long-Term Sustainable Profit For Beef Producers And Processors Through Genetic Selection, Stephen Connolly

Theses

The thesis served to quantify the phenotypic performance of animals differing in genetic merit based on the Irish Terminal Breeding Index. The data in the thesis included performance metrics of interest to both the primary producer and the meat processing industry. It is anticipated that the findings of the thesis will instil a level of confidence among primary producers and meat processors whereby the current terminal breeding objective is generating beef cattle with superior carcass performance, and improved farm margins along with a more desirable animal for meat processors. The impact of genetic differences among animals for performance traits on …