Digital Commons Network^™

Oncolytic Virotherapies And Adjuvant Gut Microbiome Therapeutics To Enhance Efficacy Against Malignant Gliomas, Natalie M Meléndez-Vázquez, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most prevalent malignant brain tumor. Current standard-of-care treatments offer limited benefits for patient survival. Virotherapy is emerging as a novel strategy to use oncolytic viruses (OVs) for the treatment of GBM. These engineered and non-engineered viruses infect and lyse cancer cells, causing tumor destruction without harming healthy cells. Recent advances in genetic modifications to OVs have helped improve their targeting capabilities and introduce therapeutic genes, broadening the therapeutic window and minimizing potential side effects. The efficacy of oncolytic virotherapy can be enhanced by combining it with other treatments such as immunotherapy, chemotherapy, or radiation. Recent studies …

The Effects Of Full-Body Photo-Editing On Female Body Image, Claire E. Mcelhern

Master's Theses

Over the past decade, the use of photo-based social media sites has seen an exponential increase. Although these sites can be beneficial for connecting with others, the editing and modification of images posted to social media has also produced adverse effects on some who use them. The aim of the present study was to assess whether partaking in a full-body photo-editing task would have a significant effect on weight dissatisfaction, appearance dissatisfaction and body confidence, compared to a control condition. Female college participants were first asked about their general Instagram use, and then were given a baseline Visual Analog Scale …

The Grizzly, November 14, 2024, Kate Horan, Connor Mccarney, Sidney Belleroche, Caitlin Cunnane, Sophia Kumar, Stella Bower, Emily Veasey, Mary Lauren Franz, Kylie Ruggiero

Ursinus College Grizzly Newspaper, 1978 to Present

"Keep Moving Forward" • Hora De Café • Bears on Trial • A Dorm Cat's Story • The Yap: A Recession of "Meet-Cute" Stories? • Bears' Zelinske Defies the Odds • Gymnastics Coach DeLorme Does It All

November 14, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Swim Bladder Morphology Influences The Responses Of Nearshore Rockfishes To Barotrauma, Molly K. Alvino

Master's Theses

Rockfishes (Sebastes spp.) are ecologically and economically important fishes in the continental shelf and slope regions of the Eastern Pacific Ocean. All species within the Sebastes genus have a buoyancy organ, the swim bladder, which is sensitive to rapid changes in pressure that occur when fish are caught and brought up to the surface. Although all rockfishes have swim bladders, pressure-related injuries (barotrauma) affect rockfish species differently. I determined whether swim bladder morphology can explain differences in barotrauma among semi-pelagic (Blue and Olive rockfish) and benthic (Gopher and Vermilion rockfish) species that occupy different habitat zones. Seven different swim bladder …

The Impacts Of Recreational Infrastructure On Mammal Use Of Riparian Zones In Northern California Regional Parks, Emily A. Matthews

Master's Theses

Public lands have been important for the protection of riparian habitats; however, many public lands are also used for recreation, which can reduce mammal habitat use. Understanding how mammals are affected by recreation in riparian areas can help guide management decisions. The goal of this research is to understand the effect of recreation on mammal use of riparian habitats in two popular East Bay Regional Parks, Charles Lee Tilden and Wildcat Canyon, and to map the extent of that impact. Cameras were deployed in the riparian areas of a high, moderate, and low development site (Alvarado, Tilden, and Wildcat Canyon) …

An Assessment Of Anthropogenic Injuries On White Sharks (Carcharodon Carcharias) In Central California, Kaitlyn Yee

Master's Theses

As human activities increasingly impact marine ecosystems, understanding the effects of anthropogenic activity on white sharks is important for their continued conservation. Human-induced injuries are observed in many shark species. Such injuries have been found to have physiological and ecological impacts. Four sites in Central California off the coasts of Aptos, Año Nuevo Island, Southeast Farallon Island, and Point Reyes are all known areas of white shark aggregation with varying levels of human use and protection. Utilizing a vast video database, this study evaluated the effects of natural and non-natural anthropogenic shark injury types across all locations, age classes, and …

Creatine And Depression In Rodents: A Meta-Analysis, Ruchika S. Tirupachur

Master's Theses

Traditional treatments for major depression are based on the monoamine deficiency hypothesis, and they fail to achieve remission in a substantial portion of patients. Newer evidence suggests the pathophysiology of depression is a more complex story, highlighting a need for research in alternative therapies. Mounting evidence shows a linkage between depression and the supplement creatine monohydrate (CRMH). Research in rodent models suggests that CRMH may both alleviate depressive symptoms and enhance the efficacy of standard antidepressants like SSRIs. The following study describes findings from a combined fixed- and random-effects meta-analysis based on four empirical studies investigating the effect of CRMH …

Best Practices For The Naming Of Species, Luis A. Ruedas, Ryan W. Norris, Robert M. Timm

Biology Faculty Publications and Presentations

The process of describing a species has evolved considerably since the modern age of taxonomy was initiated with the publication of the 10th edition of Linnaeus’ Systema Naturæ in 1758. Nevertheless, the basic unit of the taxonomic framework remains the species group (species and subspecies). As a result, it is incumbent upon individuals undertaking species-group descriptions to strive for the highest standards, just as it is for reviewers and editors to hold authors to those same standards. The clear and mounting biodiversity crisis, the increasing proliferation of journals, the multiplication of journals publishing only in electronic format, the decline in …

Evidence That Crispr-Cas9 Y537s-Mutant Expressing Breast Cancer Cells Activate Yes-Associated Protein 1 To Driving The Conversion Of Normal Fibroblasts Into Cancer-Associated Fibroblasts, Luca Gelsomino, Amanda Caruso, Emine Tasan, Adele Elisabetta Leonetti, Rocco Malivindi, Giuseppina Daniela Naimo, Francesca Giordano, Salvatore Panza, Guowei Gu, Benedetta Perrone, Cinzia Giordano, Loredana Mauro, Bruno Nardo, Gianfranco Filippelli, Daniela Bonofiglio, Ines Barone, Suzanne A W Fuqua, Stefania Catalano, Sebastiano Andò

Faculty, Staff and Students Publications

BACKGROUND: Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast cancer (BC) patients, even though resistance to ET remains a clinical issue. Mutations in the hormone-binding domain of ERɑ represent an acquired intrinsic mechanism of ET resistance. However, the latter also depends on the multiple functional interactions between BC cells and the tumor microenvironment (TME). Here, we investigated how the most common Y537S-ERɑ mutation may influence the behavior of fibroblasts, the most prominent component of the TME.

METHODS: We conducted coculture experiments with normal human foreskin fibroblasts BJ1-hTERT (NFs), cancer-associated fibroblasts (CAFs), isolated from …

Faint Glimmers: Redrawing The Housewife In Yamada Murasaki's Talk To My Back, Ceres Lovelace

Dissertations and Theses

Yamada Murasaki's seminal manga collection Talk to My Back, originally titled Shinkirari, tells a story of a woman's gradual journey toward agency within the constraints of a nuclear patriarchal family. Set within the everyday suburban life of Chiharu in 1980s Japan, Yamada uses subtle visual cues and restrained narrative techniques to illustrate her protagonist's struggles and quiet breakthroughs as she questions her identity and renegotiates her role as a housewife and mother.

By exploring the often-overlooked inner world of a housewife, Yamada scrutinizes traditional gender roles and reveals the burden and psychological toll of the emotional labor imposed on …

Vol. 40, No. 12 - Whole No. 261, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 11 - Whole No. 260, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 7 - Whole No. 256, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 6 - Whole No. 255, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 5 - Whole No. 254, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 3 - Whole No. 252, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 40, No. 1 - Whole No. 250, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Observing The Impacts Of Different Diets On Clinical Outcomes In Patients With Alzheimer's Disease: A Scoping Review, Erjola Toska, Alessandra Ottley, Quinn Jackson, Rachel Fricker, Alexa Carleo, Gabriella Cutrali, Olivia D’Alessio, Raquel Rossman, Samuel Kruchakov, Abraham Edelstein, Lubov Nathanson

HCA-NSU MD Research Day

Observing the Impacts of Different Diets on Clinical Outcomes in patients with Alzheimer's disease: A Scoping Review Authors: Quinn Jackson, OMS-III; Rachel Fricker,OMS-III; Erjola Toska, OMS-III; Alessandra Ottley,OMS-III; Alexa Carleo,OMS-III; Gabriella Cutrali, OMS-III; Olivia D’Alessio, OMS-III; Raquel Rossman, OMS-III; Samuel Kruchakov, OMS-III; Abraham Edelstein,OMS-III; Lubov Nathanson, Ph.D. Program: Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Florida Objectives: This study aimed to assess the literature published from 2013 to 2023 on the impact of diet on Alzheimer’s Disease (AD). Background: AD is primarily marked by β-amyloid plaques and neurofibrillary tangles, which impair neuronal synapses, leading to memory …

Importance Of Tropical Pasture Seed Quality And Factors Affecting It In Smallholder Farming System, H F. Chin, C C. Wong

IGC Proceedings (1977-2023)

Most tropical pastures are associated with and confined to smaJlholder animal production in developing countries of the tropics, with the exception of Australia. At present, tropical pasture seeds are very variable and poor in quality, as tropical herbage seed production is relatively new compared with that for temperate systems. Many tropical species are relatively wild and have yet to be domesticated and selected for pasture use, let alone for seed production characteristics. The unfavourable production and storage environment of the wet tropics, coupled with a lack of appropriate technology, also contributes towards poor quality in tropical pasture seeds. In this …

Integration Of Pastoral And Non-Pastoral Uses On Temperate Rangelands With Cold Winters In Developed Countries, T J. Maxwell, W A. Laycock

IGC Proceedings (1977-2023)

The demands of the relatively wealthy and sophisticated societies of developed countries, with their substantial amounts of leisure time and discretionary income, are having an increasing impact on temperate rangelands in a variety of ways. Some parts of these societies are concerned to protect the landscapes, habitats, wildlife and solitude that can be found there, and wish to constrain any further development within these ecosystems; others also wish .to gain ready access to these resources for hunting, recreation and sport and believe that this requires the exclusion of domesticated livestock. Temperate rangelands are frequently used as water catchments and some …

Harvesting And Processing Techniques Of Tropical Grass And Legume Seeds For Smallfarmers, Lumyai Kowithayakorn, Chaisang Phaikaew

IGC Proceedings (1977-2023)

For smallfarmers of forage legumes and grasses in Thailand, manual harvesting and cleaning of leguminous seeds have been widely practised because of cheap and available labour. Tropical grasses produce more seeds than can be harvested; hence it is necessary to find means to improve harvesting and processing techniques in order to obtain high standards of both quality and quantity of seed. The main obstacles could be due to prolonged flowering nnd grain filling periods of individual seedheads resulting in the uneven ripening of seeds at harvest. Premature seeds cause low yields and low quality nt harvests in many species. Flowering …

Control Of Oxytropis Ochrocephala Bge. On The Mountainous Pasture Of Southern Ningxia, China, Guo Sijia, Chen Yizhong, Li Kechang, Xu Rong

IGC Proceedings (1977-2023)

Oxytropls ochrocephala Bge., the main poisonous plant on the mountainous pasture in southern Ningxia, has Increased dramatically as a result of overgrazing, The results of a series of studies on control of this plant show the following 3 ways are effective, (1) Spraying selective herbicide Butylate which makes the unpalatable dicotyledons drop by 37% and poisonous plant drop by 86.8% while the palatable grasses increase by 230%; the total yield is raised by 5.4%. This method can both control the poisonous plant and improve the pasture. (2) Spraying herbicides Starane, T-101, D-250, etc., which can specifically kill Oxytropis ochrocephala …

Commercial Seed Production Of Tropical Forage Grasses And Legumes In Costa Rica, Rosemary Sylvester-Bradley, J E. Ferguson

IGC Proceedings (1977-2023)

ABSTRACT A commercial seed enterprise with the initial objective of producing and marketing seeds of recently selected pasture species (Brachriaria dictyoneura and Arachis pintoi) oo small farms in the south west of Costa Rica is described. Farmers provide land and fencing and use the seed plots for grazing when not In the flowering period. The enterprise provides labour and technical organisation for establishment and seed production. Costs of organisation, and research and development work were greater than production costs; To achieve profitability the enterprise needs to increase net income possibly through share-cropping including animal production, and diversification into …

Ruzi Grass (Brachiaria Ruziziensis) Seed Production In North-East Thailand, Chaisang Phaikaew, Chanchai Manidool, Pimpaporn Devahuti

IGC Proceedings (1977-2023)

The recent expansion of beef and dairy production in Thailand has increased demand for pasture seed. Ruzi grass (Brachiaria ruziziensis) seed production has increased from 18 tin 1983 to 466 tin 1991. The; production sites are in the north east, where soils and climate are most suitable for seed production. 60% of all ruzi seed is being produced by smallfarmers; the rest is produced by government stations. Average farmer yield of rilzi is 400 kg • seed/h'a, with each farmer contracted 'to grow 0.32 h�� of ruzi grass, at a guaranteed price of US$2/kg; Abo·ut 2700 farmers are …

Model Herbage Seed Farm Establishment In South-West China, Guizhou Province, M P. Rolston, G W. Lill, R W. Brougham, Xie Jishi

IGC Proceedings (1977-2023)

A model herbage seed farm was established during 1983-1988 in Guizhou to provide a base for research, training and the product.ion of quality seed for smallholder pasture development. The site is at 26°N in a monsoonal subtropical zone at 1000 m asl. Mean monthly temperatures range from 4°C in winter to 25°C in summer. Seed yield potential of cultivars of perennial ryegrass (Lolium perenne), cocksfoot (Dactylis glomerata), white clover (Trifolium repens) and red clover (Trifolium pratense) was evaluated. Major nutrient limitations were identified, including responses to K and P. Management strategies to …

Efficiency Of Grassland Areas Of Desert Steppe In North China, Wang Ning, Wang Kezhi

IGC Proceedings (1977-2023)

On the desert steppe of Yanchi County of Ningxia Province, where 1he annual precipilalion is only 300 mm, some methods, including reducing unirrigated land, exploiting water resources, cultivating grasses, planting trees and developing animal husbandry, have been used to improve production. After 10 years the poor villages have become richer; the cultivated grassland is up to 44% of the total arable area and the forest cover to 15%; value of livestock farming output has increased by as much as 5 times, gross yields of grain have increased 1.5-fold, and the average income per capita increased more than 5-fold.

Breeding Switchgrass For Improved Animal Performance, K P. Vogel, K J. Moore, A A. Hopkins

IGC Proceedings (1977-2023)

Studies on breeding and evaluating switchgrass (Panicum virgatum L.) for improved animal performance have been conducted for the last 18 years. !ti vitro dry matter digestibility (IVDMD) has been increased 3 8 g/kg after 3 cycles of selection; demonstrating· that IVDMD of switchgrass can be improved using recurrent, phenotypjc selection. Digestibility of plant tillers collected at panicle emergence was an excellent predictor of IVDMD of progeny in pastures or swards during the growing season. Small improvements in IVDMD (20-30 g/kg} significantly improved average daily gains and gains/ha (17-24 %) of beer cattle (Bos taurus) grazing switchgrass. It should …

Small-Grain Forage For Winter Pastures, D J. Undersander, D P. Hutchenson

IGC Proceedings (1977-2023)

The paper summarises 2 studies comparing wheal (Triticum aestivum), barley (Horderim vulgare), rye (Triticale secale), and triticale (x Triticoseca/e) for fornge production and animal performance. Wheat, rye and triticale were planted in 10, 20 and 30 cm row spacings and grown over 2 winters in South Carolina. Porage yield from early­October plantings ranged from 2961 to 5000 kg/ha in 1986-87 and from l012 to 3400 kg/ha in 1987-88. Porage yield was highest from rye, most of the forage growth occurring in autumn. Wheat produced forage growth most uniformly throughout autumn and spring. In the …

Effects Of Lime And Fertilizer On The Establishment Of White Clover In The Falkland Islands, J A. Kerr, Rosie Poultney

IGC Proceedings (1977-2023)

White clover (Trifolium repens L.)-based pastures could improve low pasture and animal production in the Falkland Islands. However, establishment is difficult and expensive. Effects of lime and fertilisers containing nitrogen (N), phosphorus (P) and potassium (K) on white clover dry matter yield and root nodulation were experimentally assessed between 1986-88. Lime at 1 t/ha and 30 kg/ha P as triple superphosphate, separately improved clover yield. Nodulation was improved only by lime. Neither N nor K fertilisers affected on white clover establishment yields,