Digital Commons Network^™

Introducing Biosimilar Competition For Cell And Gene Therapy Products, Brian Canter, Sabine Sussman, Stephen Colvill, Nitzan Arad, Elizabeth Staton, Arti Rai

Faculty Scholarship

This article provides an early analysis of the potential for creating future biosimilar competition for cell and gene therapies (CGTs) to lower prices and improve patient access, building on a unique set of interviews with relevant experts. Our discussion addressed regulatory, manufacturing, intellectual property, and market size challenges. Due to CGTs’ complexity, meeting the regulatory requirement of ‘high similarity with no clinically meaningful differences’ will be difficult. Gene therapies are likely better candidates for biosimilar development than cell therapies. Biosimilarity should be met when gene therapy biosimilars contain the same genetic sequence as a reference product, and the variability in …

Lysophosphatidylcholine Acyltransferase-2 (Lpcat-2) & Protein S-Acylation In Macrophage Innate Immunity, Christian Good

School of Biomedical Sciences Theses

Lysophosphatidylcholine acyltransferase (LPCAT)2 is an enzyme involved in remodelling glycerophospholipids within cell membranes and the generation of platelet-activating factor. LPCAT2 also mediates lipopolysaccharide (LPS)-induced cytokine responses in both murine and human macrophages. Investigations into the mechanism behind LPCAT2 involvement into LPS-induced cytokine responses identified that LPCAT2 translocates to membrane lipid raft domains and associates with toll-like receptor (TLR)4 following activation by LPS. The mechanism behind this is not known, however LPCAT2 appears to have a role in regulating innate immune responses via lipid raft signalling complexes and understanding the molecular details of these mechanisms could help in the development of …

Delphi Panel For Establishing Land Use Compatibility Areas And Standards For Vertiports, David C. Ison

International Journal of Aviation, Aeronautics, and Aerospace

This study aimed to determine land use compatibility guidelines for vertiports, which are locations where vertical take-off and landing (VTOL) aircraft operate. The study employed a three-round e-Delphi panel to establish vertiport land use compatibility zones and standards. The results reached a consensus of at least 70%, providing comprehensive land use compatibility recommendations for vertiports. The study provides a foundation for vertiport land use compatibility planning, ensuring the integration of vertiports in existing communities. The findings can also increase public and local officials' awareness of the needs and requirements of Advanced Air Mobility (AAM) infrastructure development. The uniformity between existing …

Non-Technical Skills Proficiency In Aviation Pilots: A Systematic Review, Seda Ceken

International Journal of Aviation, Aeronautics, and Aerospace

This systematic review aims to examine the role of non-technical competencies in pilot selection and flight operations, and explore the methods used for their assessment. It has been discerned that relying solely on technical flying skills is insufficient for a pilot; there is a growing understanding that a pilot candidate must possess and adeptly employ non-technical skills, commonly referred to as Crew Resource Management (CRM) skills. This systematic review was designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. For this review, a systematic search was conducted across seven databases. Seventeen publications were included in …

Annual Report Of The Selectmen/Auditors, Town Clerk/Tax Collector, Town Treasurer, Road Agent/Trustees Of The Trust Funds, Trustees Of The Library, Planning Board, Police And Fire Departments, Board Of Education, Town Of Hampstead, New Hampshire For The Year Ending December 31, 2023, Together With The Vital Statistics For The Year As Prepared By The Town Clerk, Hampstead Town Representatives

Hampstead, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Nekton Community Responses To Living Shoreline Restorations In Alabama, Shelby Kuck, Christopher Grant, Matheus De Barros, Alexandra Rodriguez, Ronald Baker

Gulf and Caribbean Research

No abstract provided.

Senate Journal, Colorado General Assembly

Colorado House and Senate Journals

No abstract provided.

Warwilding: A Weapon And A Shield In The Midst Of Conflict, Lynn Ma

UC Law Environmental Journal

War disrupts the lives of people, governments, and the wider environment. The purpose of this article is to examine how rewilding and ecological planning could be applied to military logistics to enhance peace and security amid war and post-war periods. This is explored through a concept that conservationists have coined “WarWilding.” I will develop my conclusions by analyzing WarWilding case studies from active warfare and post-war zones. To evaluate the boundaries in the ethics of WarWilding, this paper will frame the analyses around provisions in the Convention on the Prohibition of Military or Any Other Hostile Use of Environmental Modification …

Carbon Storage Capacity Of Forests In New Jersey, Charles R. Harman, Meiyin Wu, Paul Bovitz, Elizabeth Ravit, Elizabeth Burke Watson, Daniel Gimenez

New Jersey Center for Water Science & Technology Reports

This report of the NJ Science Advisory Board Ecological Processes Standing Committee (EPSC) addresses charge questions focused on researching how the NJ Department of Environmental Protection might manage issues related to carbon content found within soil and its relationship to climate change. Whereas forests of New Jersey play a critical role in sequestering carbon which plays a direct role attempts to combat climate change, our forests are under constant pressure from a variety of natural and anthropogenic factors including damaging insects, overpopulation of browse species such as white-tailed deer, the influx of invasive plant species and impacts from development. The …

Harmful Algal Bloom Lake Management Guidance, Mike Danko, Jason Adolf, Chris Doyle, Nicole Fahrenfeld, Bob Kortmann, Fred Lubnow, Ling Ren, Nathan Ruhl, Stephen Souza, Meiyin Wu

New Jersey Center for Water Science & Technology Reports

Executive Summary: In 2021, the Division of Water Monitoring and Standards and Pesticide Control (DWMSPC) and the New Jersey Sea Grant Consortium (NJSGC) recruited a team of lakes management and cyanobacterial HAB experts to address the second component of the Governor’s HAB initiative focusing on enhancing scientific expertise and building the state’s capacity for HAB response. The HAB Expert Team’s primary objective is to provide guidance to DEP on HAB prevention, mitigation and management for NJ lakes and other waterbodies. The team has compiled a comprehensive literature review as a resource guide available here: NJDEP | Harmful Algal Blooms | …

Juvenile Dungeness Face High Predation Risk From Green Crabs Across Increased Temperatures At Different Salinities, Trever Gelling

Environmental Science and Management Undergraduate Departmental Honors Theses

Marine heatwaves, altered precipitation regimes, and other changing climate conditions are altering the abiotic conditions of Oregon's estuaries. Furthermore, warmer water temperatures are correlated with the range expansion and population growth of the invasive and broadly tolerant Carcinus maenas, the green crab, in Oregon. Metacarcinus magister, Dungeness crab, one of Oregon’s most valuable fishery species, is also facing these climate stressors, and their young that recruit to estuaries overlap with C. maenas adults. Therefore, we wanted to determine impacts of C. maenas on young-of-the-year (YOTY) M. magister and the roles of salinity, temperature, and predator size in mediating …

Breathe, Renee J Flores

Faculty and Staff Publications

This is a personal essay about breasts. It focuses on my experiences as a young girl, moving through adolescence to a history of breast cancer in my family, including my mother's breast cancer diagnosis. As a physician, patient, and wife, I reflect on the choices that I have to make and what this means for my identity as a woman and mother.

Translational Neuroscience Contributes To Understanding Neurodevelopmental Outcomes Of Dostoyevsky's "Brothers Karamazov" With Treatment Implications, Stephen I. Deutsch, Jessica A. Burket, Jeffrey Elikan Jd, David R. Spiegel

Department Psychiatry & Behavioral Science Faculty Publications

Dostoyevsky's novels raise profound ethical, moral, philosophical and theological issues and, as a result, both he and his novels serve as fertile subjects of scholarly inquiry across a variety of academic disciplines. In particular, major characters in "The Brothers Karamazov" lend themselves to classical psychodynamic formulations, such as the influence of adverse childhood experiences on adult social and occupational outcomes, which in the case of Dmitry, the eldest son of Fyodor Pavlovich Karamazov, are considered in exquisitely fine detail. Prosecutor and defense attorney provide differing interpretations of how early traumas, largely due to paternal neglect and abuse, affected Dmitry's adult …

Parting Thoughts Xxx: My Struggle With Disney And Cognitive Dissonance, Robin Lizzo

Faculty Publications - Kinesiology and Recreation

No abstract provided.

“Criminalizing” Depositions In Arbitration, Mitch Zamoff

Articles

Civil litigation–style deposition practice is preventing commercial arbitration from reaching its full potential as an economical, efficient alternative to a civil lawsuit. Although there is consensus among alternative dispute resolution experts that meaningful limits must be imposed on arbitration discovery to unlock the efficiency benefits of arbitration, depositions continue to feature prominently in commercial arbitrations for at least three reasons. First, civil litigators are addicted to depositions. They reflexively propose overdone deposition practice in arbitrations that replicates their litigation experience. Second, arbitrators may hesitate to disallow deposition discovery out of fear that their awards will be vacated for failure to …

Shareholders All The Way Down: Eu Corporate Sustainability Reforms And The Structure Of Corporate Governance, Matthew Bodie

Articles

The laws and norms of corporate law are changing across the globe. Gone are the days when scholars could confidently predict that shareholder wealth maximization would be the universal metric of corporate success. Instead, corporate leaders, governments, workers, activists, and even shareholders are looking beyond simplistic models of shareholder primacy to a broader understanding of corporate responsibility. This new approach has taken its firmest hold in the European Union, where three directives over the last decade have reshaped reporting requirements and directors’ duties in significant ways, pushing for greater accountability and attention to the needs of stakeholders.

Changes to company …

Planning For Pandemic And Epidemic-Related Scarcity Of Medicines, Sapna Kumar

Articles

This chapter proposes an ex ante approach to tackling drug scarcity. Entities funding pandemic- and epidemic-related research should contractually require recipients to produce sufficient quantities of resulting medicines. The recipient would agree in the event of a future shortage to share its technology and know-how with a qualified third-party manufacturer, in exchange for compensation. Alternatively, funding entities could more broadly utilize dormant licenses, which activate in the event of a pandemic or epidemic, and which require rights holders to license out technology and know-how to alleviate shortages. Such provisions could go even further, integrating reasonable pricing assurances and ensuring access …

Presidential Investment In The Administrative State, Nicholas Bednar, David E. Lewis

Articles

In this paper, we explain how presidents strategically invest in administrative capacity, noting that presidents have few incentives to invest effort in capacity building in most agencies. We test our account with two analyses. First, we examine the time it took for the Bush, Obama, Trump, and Biden Administrations to nominate individuals to appointed positions. We find that presidents prioritize appointments to policy over management positions and that nominations occur sooner in agencies that implement presidential priorities. Second, we examine the responses of federal executives to the 2020 Survey on the Future of Government Service to see whether perceptions of …

Pioneer Tales (Vol. 8, No. 1), San Bernardino Historical & Pioneer Society

Pioneer Tales

No abstract provided.

Pioneer Tales (Vol. 8, No. 2), San Bernardino Historical & Pioneer Society

Pioneer Tales

No abstract provided.

Pioneer Tales (Vol. 8, No. 4), San Bernardino Historical & Pioneer Society

Pioneer Tales

No abstract provided.

Long-Term Cardiometabolic Effects Of Preconceptional And Prenatal Opioid Exposure In The Adult Offspring, Nermin Hassan Mohamed Selim Ahmed

Theses and Dissertations--Pharmacology and Nutritional Sciences

Opioid use disorder (OUD), one of the greatest public health threats in the US, requires urgent attention. In 2022, the CDC reported 107,941 overdose deaths, over 70% attributed to synthetic opioids such as fentanyl (FEN). An alarming increase in opioid use disorder (OUD) diagnoses in pregnant people resulted in a 5-fold rise in cases of neonatal opioid withdrawal syndrome (NOWS). This condition elicits sympathetic overactivity, neural hyperexcitability, and a stress reaction characterized by tachycardia and hypertension. Whether prenatal exposure to fentanyl induces cardiovascular dysfunction in the offspring remains undetermined, impeding the timely development of strategies to mitigate OUD-related health risks …

Feeding Systems And Fresh Lamb Color Stability, Koushik Mondal

Theses and Dissertations--Animal and Food Sciences

Consumers consider the surface color of fresh lamb as the indicator of freshness and wholesomeness, which affects their purchase decisions. The redox chemistry of myoglobin (Mb) determines the color of fresh lamb. Artificial raising on milk replacer (a pre-weaning strategy) as well as red clover supplementation are management strategies used in lamb production. This thesis focuses on the effects of artificial raising on milk replacer and red clover supplementation on the color and oxidative stability of fresh lamb.

In the first experiment, the effect of pre-weaning with milk replacer on the carcass attributes, color stability and lipid oxidation of lamb …

Documented Outcomes Of Informal Caregivers Delivering Home-Based Interventions To Persons Living With Dementia: A Scoping Review, Andrea H. Meller

Social Work Theses - Archive

Most people living with dementia in the United States reside at home with informal caregivers. Yet research regarding non-pharmacological interventions for persons living with dementia is mainly conducted in institutional settings. Also, research into the impacts of interventions for persons with dementia on informal caregivers is scarce. This scoping review aims to map the breadth of literature on outcomes of informal caregivers delivering home-based interventions to people with dementia through the lens of the stress process model. Using the Arskey & O’Malley framework, an initial database search yielded 3,977 studies of which 22 were included in this review. Results revealed …

A Little Less Conversation, A Little More Action: How American Unwillingness To Escalate Emboldens Mexico’S Populist Ambitions, David Montero

American University International Law Review

Part II of this Comment will explain the history of Mexico’s relationship with trade, as well as the finer details of the dispute resolution provisions of the USMCA that are of note. Part III will analyze two key violations of the USMCA by AMLO’s administration, contrasting the American response between the two and demonstrating the cycle of violations that has largely been created as a result of the failure to act. Part IV provides a simple recommendation to the U.S. administration for how to effectively halt its southern neighbor’s decline into unfettered populism that harms U.S. trade interests: employ the …

Policing The Strait: How China’S Policing Of The Taiwan Strait Violates The U.N. Convention On The Law Of The Sea, Elizabeth C. Parker

American University International Law Review

As tensions continue to grow across the Taiwan Strait, China is using domestic maritime law to justify an expansion of police power in the international waters of the Taiwan Strait in violation of international law. This Comment will argue that the People’s Republic of China has violated the UN Convention on the Law of the Sea (“UNCLOS”) by implementing non-resource-related police power in waters meant only for resource exploration and management. In comparing the language of China’s domestic maritime law with that of UNCLOS, this Comment will show that the People’s Republic of China has used domestic law to reinterpret …

An Efficient And High-Throughput Method For The Evaluation Of Mitochondrial Dysfunction In Frozen Brain Samples After Traumatic Brain Injury., Hemendra J Vekaria, Olivia J. Kalimon, Paresh Prajapati, Gopal V. Velmurugan, Patrick G Sullivan

Neuroscience Faculty Publications

Mitochondrial function analysis is a well-established method used in preclinical and clinical investigations to assess pathophysiological changes in various disease states, including traumatic brain injury (TBI). Although there are multiple approaches to assess mitochondrial function, one common method involves respirometric assays utilizing either Clark-type oxygen electrodes or fluorescent-based Seahorse analysis (Agilent). However, these functional analysis methods are typically limited to the availability of freshly isolated tissue samples due to the compromise of the electron transport chain (ETC) upon storage, caused by freeze-thaw-mediated breakdown of mitochondrial membranes. In this study, we propose and refine a method for evaluating electron flux through …

Ironic And Absurd Discourse Of Dress And Appearance On Social Media, Craig Hobin

Major Papers by TMD Master of Science Students

The purpose of this paper is to interpret how absurdity can be ironic through dress and appearance. By using two popular culture examples, one contemporary and one from the 1990’s, I look at how existential philosophies impact comparisons to society and how their reactions of dress and appearance can be ironic. This paper discusses Lee Alexander McQueen and Austin Babbitt (AssPizza) to find the intersection of irony, absurdism, social comparison, and dress and appearance. These two examples prove irony can be interpreted through an understanding of existentialism and how one views society and if they draw comparisons to their peers. …

The Influence Of Ecoregions And Land Use/Land Cover On Fish Assemblages In Southern Minnesota, Masaki Hara

All Graduate Theses, Dissertations, and Other Capstone Projects

Level III ecoregions of the conterminous United States provide a framework for facilitating environmental understanding and aiding environmental management practices. In southern Minnesota near Mankato, there are two level III ecoregions: to the east is North Central Hardwood Forest (NCHF) and to the west are Western Corn Belt Plains (WCBP). They contained a combined 104 fish species in local lakes. However, little is known about how land use and land cover affect fish assemblages in these lakes, which are indicator fish species, and if any invasive fish species are adversely impacting native fish populations. This study addresses these issues through …

Marielle Calanza Honors Portfolio, Marielle Calanza

Honors Capstone Portfolios

Marielle Calanza's Honors Porfolio captured in December 2024.