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2024

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The Structure Of U.S. Climate Policy, Michael Pappas Jan 2024

The Structure Of U.S. Climate Policy, Michael Pappas

Maryland Law Review

No abstract provided.


Climate Change And Its Hidden Victims: A Review Of The Link Between Climate Change Impacts And Sexual And Gender-Based Violence In East Africa, Ezinwa Osuoha Jan 2024

Climate Change And Its Hidden Victims: A Review Of The Link Between Climate Change Impacts And Sexual And Gender-Based Violence In East Africa, Ezinwa Osuoha

Public Health Theses

Introduction: Climate change is having profound and disproportionate impacts on East Africa. Rising temperatures, unpredictable rainfall patterns, and prolonged droughts have become prevalent, leading to profound humanitarian challenges. The effects of climate change in East Africa span beyond those related to agriculture, food insecurity, and economic well-being. Sexual and gender-based violence (SGBV) is only proliferated in the climate change context. In the event of natural disasters, sexual and gender-based violence increases in tandem with the increase in vulnerability and instability in affected communities. Due to its myriad health consequences, SGBV requires the attention of public health professionals, policymakers, and those …


Evaluating The Susceptibility Of The Lew.1wr1 Rat To Glucose Intolerance, Insulin Resistance, And Masld : Is Fat10 The Key?, Quiana Claudette Wilkerson Vidal Jan 2024

Evaluating The Susceptibility Of The Lew.1wr1 Rat To Glucose Intolerance, Insulin Resistance, And Masld : Is Fat10 The Key?, Quiana Claudette Wilkerson Vidal

Dissertations

Obesity is an epidemic that affects over 40% of adults in America. Obesity can be divided into metabolically healthy and metabolically unhealthy obesity, with the latter being characterized by symptoms closely associated with metabolic syndrome, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). What causes the transition from metabolically healthy to metabolically unhealthy obesity is not fully known. Further, it is unclear how this transition correlates with the onset of co-morbid conditions. We propose that Ubiquitin D (FAT10) may play a role in transitioning into a metabolically unhealthy state in response to obesity. This dissertation evaluated two main …


Crowdsourcing Geospatial Data For Earth And Human Observations: A Review, Xiao Huang, Siqin Wang, Di Yang, Tao Hu, Meixu Chen, Mengxi Zhang, Guiming Zhang, Filip Biljecki, Tianjun Lu, Lei Zou, Connor Y. H. Wu, Yoo Min Park, Xiao Li, Yunzhe Liu, Hongchao Fan, Jessica Mitchell, Zhenlong Li, Alexander Hohl Jan 2024

Crowdsourcing Geospatial Data For Earth And Human Observations: A Review, Xiao Huang, Siqin Wang, Di Yang, Tao Hu, Meixu Chen, Mengxi Zhang, Guiming Zhang, Filip Biljecki, Tianjun Lu, Lei Zou, Connor Y. H. Wu, Yoo Min Park, Xiao Li, Yunzhe Liu, Hongchao Fan, Jessica Mitchell, Zhenlong Li, Alexander Hohl

Earth and Environmental Sciences Faculty Publications

The transformation from authoritative to user-generated data landscapes has garnered considerable attention, notably with the proliferation of crowdsourced geospatial data. Facilitated by advancements in digital technology and high-speed communication, this paradigm shift has democratized data collection, obliterating traditional barriers between data producers and users. While previous literature has compartmentalized this subject into distinct platforms and application domains, this review offers a holistic examination of crowdsourced geospatial data. Employing a narrative review approach due to the interdisciplinary nature of the topic, we investigate both human and Earth observations through crowdsourced initiatives. This review categorizes the diverse applications of these data and …


2024 Nebraska Beef Cattle Report Jan 2024

Predicting Live Body Wight Of Yearling Beef Heifers Using 3d Imaging, Dalton J. Anderson, Yijie Xiong, Andrea K. Watson, J. Travis Mulliniks Jan 2024

Predicting Live Body Wight Of Yearling Beef Heifers Using 3d Imaging, Dalton J. Anderson, Yijie Xiong, Andrea K. Watson, J. Travis Mulliniks

Nebraska Beef Cattle Reports

This study was conducted to determine the accuracy of using 3D imaging technology as a method to predict shrunk body weight (BW) of growing yearling beef heifers. Red Angus x SImmental heifers (n = 69, BW = 726 ± 62 lbs; 12 months of age) were utilized for data collection. A time-of-flight depth camera (Azure Kinect, Microsoft) was used to collect depth videos as heifers walked out of the chute. Ideal image frames were identified from videos and used to determine the body volume of each heifer. Prediction of BW using images produced an R2 (estimate of model fit) …


Impact Of Varying Inclusion Of Modified Distillers Grains Plus Solubles Compared To Constant Inclusion On Feedlot Cattle Performance And Carcass Characteristics, Debora G. Sousa, Rebecca Mcdermott, Mitch M. Norman, J. C. Macdonald, Rick A. Stock, Galen E. Erickson Jan 2024

Impact Of Varying Inclusion Of Modified Distillers Grains Plus Solubles Compared To Constant Inclusion On Feedlot Cattle Performance And Carcass Characteristics, Debora G. Sousa, Rebecca Mcdermott, Mitch M. Norman, J. C. Macdonald, Rick A. Stock, Galen E. Erickson

Nebraska Beef Cattle Reports

An experiment was conducted to evaluate the effect of varying inclusion of modified distillers grains plus solubles on a weekly basis with two inclusions of grass hay on the performance of finishing steers. no interaction was observed between modified distillers grains plus solubles inclusion (0%, 25% constant, or 25% varying from 15-35%) and hay inclusion (6% or 12%). When evaluating the effect of hay inclusion on performance, cattle fed 6% grass hay had less dry matter intake than those fed 12% grass hay, and there was a tendency for gains to be greater for cattle fed 6% grass hay. Adding …


Impact Of Feeding New Fractioinated Distillers Grains (Fiber Plus Syrup) On Feedlot Cattle Performance And Carcass Characteristics, Debora G. Sousa, Rebecca L. Mcdermott, Mitch M. Norman, James C. Macdonald, Rick Stock, Ryan A. Mass, Galen E. Erickson Jan 2024

Impact Of Feeding New Fractioinated Distillers Grains (Fiber Plus Syrup) On Feedlot Cattle Performance And Carcass Characteristics, Debora G. Sousa, Rebecca L. Mcdermott, Mitch M. Norman, James C. Macdonald, Rick Stock, Ryan A. Mass, Galen E. Erickson

Nebraska Beef Cattle Reports

Fractionation processes are being explored to supply higher protein distillers grains for premium markets. Resulting distillers grains after a fraction is isolated will still be marketed as a cattle feed so knowing the impact on performance is important. This study evaluated feeding wet or dry conventional distillers grains with wet and dry fractionated distillers (fiber plus syrup) fed at 0, 20, or 40% of diet DM. When compared to the corn control, intake and gain increased for each of the four distillers types were fed, but feed conversion was poorer (i.e., increased) for dry distillers grains and dry fiber plus …


Comparison Of Corn Silage And Earlage In Finishing Diets When Fed As A Roughage On A Neutral Detergent Fiber Basis, Garrett N. Lemon, Rebecca Mcdermott, Alfredo Dicostanzo, Galen E. Erickson, Pablo L. Loza Jan 2024

Comparison Of Corn Silage And Earlage In Finishing Diets When Fed As A Roughage On A Neutral Detergent Fiber Basis, Garrett N. Lemon, Rebecca Mcdermott, Alfredo Dicostanzo, Galen E. Erickson, Pablo L. Loza

Nebraska Beef Cattle Reports

The finishing trial was conducted to evaluate the ability of earlage to serve as a roughage source compared to corn silage when both sources were balanced on an NDF basis. Steers were fed in a randomized block design with a 2x2 treatment arrangement, with one factor being NDF source (corn silage or earlage) and the other factor being inclusion ("normal" amount of roughage provided by corn silage or earlage as the only grain source and roughage source). No significant interactions were observed between roughage source and inclusion level on steer performance. Steers fed corn silage and grain had greater intakes …


Nebraska Producer Perceptions On The Role And Implications Of Negotiations In Fed Cattle Transactions, Taralee Hudson, Elliott James Dennis, Brad D. Lubben, James C. Macdonald Jan 2024

Nebraska Producer Perceptions On The Role And Implications Of Negotiations In Fed Cattle Transactions, Taralee Hudson, Elliott James Dennis, Brad D. Lubben, James C. Macdonald

Nebraska Beef Cattle Reports

A survey of ten feelot operators, as identified through the Nebraska Department of Agriculture's (NDA) 2019-2020 Cattle Feeder's Directory was conducted to identify the important concepts related to negotiated transactions and price discovery within the fed cattle market. The surveyed feedlots account for approximately 10 percent of the cattle on feed identified within the directory, on a one time capacity basis. Conducted in April of 2023 via phone conversation, the questions were related to 1) negotiated cash transactions, 2) the bidding process, and 3) thinning cash trade. Such results lend insight into the marketing practices that currently dominate the fed …


Evaluation Of Gas Emissions From Cattle On Different Diet Adaptation Strategies Using Either Forage Or Ramp, Cindy D. Mansfield, Rebecca Mcdermott, Braden C. Troyer, Mitchell M. Norman, Maggie Youngers, Andrea K. Watson, Rick Stock, Galen E. Erickson Jan 2024

Evaluation Of Gas Emissions From Cattle On Different Diet Adaptation Strategies Using Either Forage Or Ramp, Cindy D. Mansfield, Rebecca Mcdermott, Braden C. Troyer, Mitchell M. Norman, Maggie Youngers, Andrea K. Watson, Rick Stock, Galen E. Erickson

Nebraska Beef Cattle Reports

A 173-day finishing experiment was conducted to evaluate the effects of feeding RAMP (Cargill Corn Milling, Blair, NE) during diet adaptation compared to a traditional forage adaptation program on methane and carbon dioxide emissions, animal performance and carcass traits in beef steers. Cattle were monitored using a calorimetry emission barn to quantify production of methane and carbon dioxide during step 1 of grain adaptation and at two subsequent times while fed a common finishing diet. Feeding RAMP reduced methane by 12% during the initial diet (step 1) compared to a traditional diet that contained 43% forage. When cattle were fed …


Rethinking Corn Residue: Effects Of Grain Yield On Quality And Quantity Of Residue, Kaylee E. Wheeler, Jessica Miller, Sadie Ference, Stephan Geu, Bill Struckmeyer, Amanda Easterly, Cody F Creech, Brian Maust, Daren D. Redfearn, Jay Parsons, Mary E. Drewnoski Jan 2024

Rethinking Corn Residue: Effects Of Grain Yield On Quality And Quantity Of Residue, Kaylee E. Wheeler, Jessica Miller, Sadie Ference, Stephan Geu, Bill Struckmeyer, Amanda Easterly, Cody F Creech, Brian Maust, Daren D. Redfearn, Jay Parsons, Mary E. Drewnoski

Nebraska Beef Cattle Reports

A two-year experiment evaluated the effects of corn grain yield on the resulting quality and quantity of corn residue. Among the wide variety of corn hybrids, locations, and growing conditions, observed grain yields ranged from 120 to 350 bushels per acre. As corn yield increased, the total pounds of residue increased. However, the amount of reside relative to grain decreased. Within the residue, the proportion of leaf increased from 10 to 28% as corn yield increased while husk remained unchanged at 13%. Overall, the yield of leaf and husk per bushel of corn grain was not affected by grain yield …


Survey Of Current Management Practices And Evaluation Of Their Impact On Nutrient Content Of Small Cereal Silage In Nebraska, Alexa R. Johnson, Mary E. Drewnoski, Daren D. Redfearn, Susan Vanderplas, Jenny Rees, Ben Beckman, Erin Laborie, Todd Whitney, Kim Clark, Brad Schick, Gary Lesoing, Conner Biehler Jan 2024

Survey Of Current Management Practices And Evaluation Of Their Impact On Nutrient Content Of Small Cereal Silage In Nebraska, Alexa R. Johnson, Mary E. Drewnoski, Daren D. Redfearn, Susan Vanderplas, Jenny Rees, Ben Beckman, Erin Laborie, Todd Whitney, Kim Clark, Brad Schick, Gary Lesoing, Conner Biehler

Nebraska Beef Cattle Reports

The nutrient content of small cereal silage from 16 producers in Nebraska was measured at harvest and post-fermentation. At packing, 42% of the samples were below the target dry matter of 30-35%. Samples with dry matter percentage below 30% had a significant increase in the loss of energy (total digestible nutrient) content of the silage. The wetter silage appeared to have increased rates of clostridial fermentation as indicated by production of butyric acid. These data suggest that moisture management is a challenge and increased attention to ensuring the target dry matter content is achieved before packing could improve the quality …


Cereal Rye, Winter Triticale Or Winter Wheat: Which Is Best For Early Spring Grazing?, Alyssa K. Hall, Abigail M. Sartin, Kallie J. Calus, Morgan T. Grabau, Daren D. Redfearn, Robert B. Mitchell, Mary E. Drewnoski Jan 2024

Cereal Rye, Winter Triticale Or Winter Wheat: Which Is Best For Early Spring Grazing?, Alyssa K. Hall, Abigail M. Sartin, Kallie J. Calus, Morgan T. Grabau, Daren D. Redfearn, Robert B. Mitchell, Mary E. Drewnoski

Nebraska Beef Cattle Reports

A study was conducted to determine which winter-hardy small cereal grain was best suited for early spring grazing. Three species were evaluated: winter wheat, cereal rye, and winter triticale, as a double-cropped forage in a continuous soybean rotation. Within this rotation the number of grazing days is limited, but all three species provided high rates of cattle weight gain, with an average daily gain (ADG) of 3 lb/d in April. However, in a year where freezing conditions occurring after cattle started grazing, cattle grazing cereal rye had the greatest ADG, likely due to greater forage growth. Thus, cereal rye may …


Vitamin A In Cow-Calf Production: Impacts Of Maternal Supplementation And Status On Offspring, Hannah F. Speer, Harvey C. Freetly, Karla H. Jenkins, Mary E. Drewnoski Jan 2024

Vitamin A In Cow-Calf Production: Impacts Of Maternal Supplementation And Status On Offspring, Hannah F. Speer, Harvey C. Freetly, Karla H. Jenkins, Mary E. Drewnoski

Nebraska Beef Cattle Reports

The young calf is at greatest risk of vitamin A deficiency when cow vitamin intake is low in late pregnancy. Two studies were conducted to evaluate the relationship between cow and calf vitamin A status and how vitamin A status of cow-calf pairs was influence by maternal vitamin A supplementation. In general, calves did not have adequate liver vitamin A concentrations despite cows having adequate liver vitamin A stores following calving. Both cow iver stores and cow vitamin A intake during late gestation influence the amount of vitamin A in colostrum, so it benefits the calf if the cow has …


The Effect Of Postpartum Supplementation Strategy On Performance In May-Calving 2- And 3-Yr-Old Range Cows, Nicole M. Woita, Selby L. Boerman, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks Jan 2024

The Effect Of Postpartum Supplementation Strategy On Performance In May-Calving 2- And 3-Yr-Old Range Cows, Nicole M. Woita, Selby L. Boerman, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks

Nebraska Beef Cattle Reports

Reproductive performance in young 2- and 3-yr-old cows are often the lowest in the cow herd, which is due to their inability to consume enough energy and protein to meet their requirements for growth and lactation. A 3-yr study was conducted to evaluate the effects of postpartum supplementation strategy on reproduction, cow body weight, and calf performance in lactating young 2- and 3-yr-old May-calving range cows. Supplementation was initiated 20 d prior to the start of the breeding season (45-d postpartum) and continued throughout the 45-d breeding season (125-d postpartum). Supplementation was provided daily with treatments being 1) mineral supplement …


The Impact Of Prepartum Supplementation Strategy On Cow-Calf Performance In May-Calving Mature Cows, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks Jan 2024

The Impact Of Prepartum Supplementation Strategy On Cow-Calf Performance In May-Calving Mature Cows, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks

Nebraska Beef Cattle Reports

Implementation of minimal supplemental protein strategies during late gestation may have the potential to minimize any negative postweaning progeny performance while decreasing feed costs. A 3-yr study was conducted to evaluate the effects of mid- to late-gestation supplementation strategies on reproduction, cow body weight, and calf performance in May-calving mature range cows grazing upland native range. Supplementation was provided 2x weekly with treatments being 1) 05 lb per day of a 30% CP distillers-based supplement, 2) 1 lb per day of a 30% CP distillers-based supplement, 3) a negative control as a flexible supplementation strategy. The Flex strategy was developed …


The Effect Of Late Gestation Supplementation Strategy On Cow-Calf Performance In March-Calving Mature Cows, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks Jan 2024

The Effect Of Late Gestation Supplementation Strategy On Cow-Calf Performance In March-Calving Mature Cows, J. A. Musgrave, Kacie L. Mccathy, J. Travis Mulliniks

Nebraska Beef Cattle Reports

Implementation of supplemental protein strategies during late gestation has been shown to positively affect postweaning progeny performance. A 2-yr study was conducted to evaluate the effects of late gestation supplementation strategies on reproduction, cow body weight, and calf performance in March-calving mature range cows grazing dormant upland range. Supplementation was individually fed and provided daily with treatments being: 1) no supplementation, 2) 2 lb per day of a 30% CP distillers-based supplement, 3) 2 lb per day of a 30% CP distillers-based supplement with the inclusion of 160 mg/cow daily of monensin, 4) 2 lb per day of a 30% …


Effect Of Glucogenic Feed Additive On Reproductive Performance In Young Postpartum Range Cows, Tasha M. King, J. A. Musgrave, Nicole M. Woita, Shelby L. Boerman, J. C. Macdonald, J. Travis Mulliniks Jan 2024

Effect Of Glucogenic Feed Additive On Reproductive Performance In Young Postpartum Range Cows, Tasha M. King, J. A. Musgrave, Nicole M. Woita, Shelby L. Boerman, J. C. Macdonald, J. Travis Mulliniks

Nebraska Beef Cattle Reports

Performance of young March-Calving range cows receiving a protein supplement with the addition of either monensin or propionate salt were compared to evaluate the effect of feed additive on overall production in the postpartum stage. cow body weight and body condition were not impacted by postpartum supplementation throughout the study. Calf body weights were not impacted by type of feed additive at birth, weaning, or 205-d. Twenty-four-hour milk production was not impacted by the type of feed additive. Conception rates for cows receiving postpartum supplementation containing propionate salt were greater than cows receiving monsensin. This implies that the addition of …


Effect Of Heifer Percent Mature Body Weight At Breeding On Heifer Performance, Calf Production, And Subsequent Pregnancy Rates, Josie N. Crouch, J. Travis Mulliniks, J. A. Musgrave, Kathy J. Hanford, Kacie L. Mccathy Jan 2024

Effect Of Heifer Percent Mature Body Weight At Breeding On Heifer Performance, Calf Production, And Subsequent Pregnancy Rates, Josie N. Crouch, J. Travis Mulliniks, J. A. Musgrave, Kathy J. Hanford, Kacie L. Mccathy

Nebraska Beef Cattle Reports

A retrospective study was done utilizing 1,434 March- and May- calving Red Angus x Simmental crossbred cows and heifers from 2005 through 2019. Heifer weight as a percentage of mature body weight at breeding was used to conduct a regression analysis from 50 to 70% of mature body weight to determine the impact of body weight at breeding on reproductive performance. Heifer pregnancy rates and second pregnancy rates as 2-year-olds were greater for heifers at 60, 65, and 70% of mature body weight at breeding than heifers at 50 and 55%. However, heifer percent mature body weight at breeding did …


Impact Of Increasing Level Of Milk Production On Cow-Calf Performance In Nebraska Sandhills, Selby L. Boerman, Jacki A. Musgrave, Kathryn J. Hanford, Mitchell B. Stephenson, J. Travis Mulliniks Jan 2024

Impact Of Increasing Level Of Milk Production On Cow-Calf Performance In Nebraska Sandhills, Selby L. Boerman, Jacki A. Musgrave, Kathryn J. Hanford, Mitchell B. Stephenson, J. Travis Mulliniks

Nebraska Beef Cattle Reports

In a 2-yr study, data were collected on 118 crossbred cow-calf pairs from March and May-calving herds. On approximately 30, 60, 90, 120, and 210 d postpartum, individual cow 24-h bilk yield was estimated through weigh-suckle weigh techniques. Cow body weight (BW) and body condition score (BCS) were collected weekly through breeding. Calf BW was recorded at each milking. Individual cow milk area under the curve (AUC) values were calculated and data were analyzed using linear regression analysis. Results from this study illustrate that increasing total milk produced throughout the lactation period had minimal influence on the cow production parameters …


Clinical And Radiographical Assessment Of Platelet Rich Fibrin (Prf) Versus Placental Extract Gel On Delayed Implant Placement: Comparative Clinical Split Mouth Study, Eman Shawki Mira, Ayman Abdel Rahim Mohammed Elkashty, Ahmed Mohammed Saaduddin Sapri Jan 2024

Clinical And Radiographical Assessment Of Platelet Rich Fibrin (Prf) Versus Placental Extract Gel On Delayed Implant Placement: Comparative Clinical Split Mouth Study, Eman Shawki Mira, Ayman Abdel Rahim Mohammed Elkashty, Ahmed Mohammed Saaduddin Sapri

Mansoura Journal of Dentistry

Purpose: This study was established to compare Platelet Rich Fibrin (PRF) versus Placental Extract Gel on delayed implant placement.

Patient and Methods: Sixteen patients aged from 35-45 years were selected for that study. Split mouth design was performed, placing PFR on one side of the mouth while placing placental extract gel on the other side of the mouth during implant insertion. Follow -up was done for all the cases 6 months postoperatively both clinically and radiographically. When comparing two groups within the same timepoint, the student unpaired t-test was employed, and when comparing two timepoints within the same group in …


Comparative Study: Critical Thinking Skills Of Western Philosophy Versus Non-Western Philosophy Students, Jhansi Chagalakonda Jan 2024

Comparative Study: Critical Thinking Skills Of Western Philosophy Versus Non-Western Philosophy Students, Jhansi Chagalakonda

All-Inclusive List of Electronic Theses and Dissertations

The number of non-western students migrating to western countries for higher education is increasing every year. They suffer from stereotypes and often perceived as non-critical thinkers. However, it is not the lack of critical thinking skills, rather it is the lack of understanding of the different approaches and different styles of practicing critical thinking skills by non-western learners. The purpose of this qualitative study was to compare the perception of critical thinking skills of students who studied Indian philosophy with those who studied western philosophy, and to understand the commonalities and differences in students thinking processes and the approaches adopted …


The Loss Of Βι Spectrin Alters Synaptic Size And Composition In The, Michael C Stankewich, Luanne L. Peters, Jon S Morrow Jan 2024

The Loss Of Βι Spectrin Alters Synaptic Size And Composition In The, Michael C Stankewich, Luanne L. Peters, Jon S Morrow

Faculty Research 2024

Introduction: Deletion or mutation of members of the spectrin gene family contributes to many neurologic and neuropsychiatric disorders. While each spectrinopathy may generate distinct neuropathology, the study of βΙ spectrin’s role (Sptb) in the brain has been hampered by the hematologic consequences of its loss.

Methods: Jaundiced mice (ja/ja) that lack βΙ spectrin suffer a rapidly fatal hemolytic anemia. We have used exchange transfusion of newborn ja/ja mice to blunt their hemolytic pathology, enabling an examination of βΙ spectrin deficiency in the mature mouse brain by ultrastructural and biochemical analysis.

Results: βΙ spectrin is widely utilized throughout the brain as …


New Directions For Alzheimer's Disease Research From The Jackson Laboratory Center For Alzheimer's And Dementia Research 2022 Workshop., Maria Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael Maclean, Tain Luquez, Alexandra M Lish, Sarah Neuner, Amy R Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J Van Eldik, Paul R Territo, Gareth R Howell, Gregory W. Carter, Kristen M S O'Connell, Catherine Kaczorowski, The 2022 Jax Cadr Workshop Jan 2024

New Directions For Alzheimer's Disease Research From The Jackson Laboratory Center For Alzheimer's And Dementia Research 2022 Workshop., Maria Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael Maclean, Tain Luquez, Alexandra M Lish, Sarah Neuner, Amy R Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J Van Eldik, Paul R Territo, Gareth R Howell, Gregory W. Carter, Kristen M S O'Connell, Catherine Kaczorowski, The 2022 Jax Cadr Workshop

Faculty Research 2024

INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field.

METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic.

RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification …


Digitalization Of Toxicology: Improving Preclinical To Clinical Translation., Brian R Berridge, Szczepan W Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L Robertson Jan 2024

Digitalization Of Toxicology: Improving Preclinical To Clinical Translation., Brian R Berridge, Szczepan W Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L Robertson

Faculty Research 2024

Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development attrition where the costliest liabilities to both drug developers and patients emerge in late development or post-marketing. Animal studies are an important and influential contributor to the current drug discovery and development paradigm intending to provide evidence that a novel drug candidate can be used safely and effectively in human volunteers and patients. However, translational gaps-such as toxicity in patients not predicted by …


Phosphorus-Independent Role Of Fgf23 In Erythropoiesis And Iron Homeostasis., Min Young Park, Rafiou Agoro, Stanislovas S Jankauskas, Carole Le Henaff, Despina Sitara Jan 2024

Phosphorus-Independent Role Of Fgf23 In Erythropoiesis And Iron Homeostasis., Min Young Park, Rafiou Agoro, Stanislovas S Jankauskas, Carole Le Henaff, Despina Sitara

Faculty Research 2024

A number of studies have reported an association between phosphorus, red blood cell (RBC) production, and iron metabolism. However, it is difficult to distinguish whether the effect of phosphorus is direct or through the actions of FGF23, and it is not clear whether phosphorus is positively or negatively associated with RBC production. In the present study, we investigated the effects of a) increased phosphorus load and b) phosphorus deficiency on erythropoiesis and iron metabolism in association with FGF23. Mice were fed either a 1.2% or 1.65% phosphorus diet and compared to mice fed a control diet containing 0.6% of phosphorus. …


Apertures, Michael Schreyach Jan 2024

Apertures, Michael Schreyach

Art and Art History Faculty Research

No abstract provided.


Protecting Traditional Knowledge And Indigenous Peoples' Rights: The Key To Developing International Environmental Laws That Promote Harmonious Relationships With Nature, Melissa A. Padilla Jan 2024

Protecting Traditional Knowledge And Indigenous Peoples' Rights: The Key To Developing International Environmental Laws That Promote Harmonious Relationships With Nature, Melissa A. Padilla

California Western International Law Journal

No abstract provided.


The Digital "To Kill A Mockingbird": Artificial Intelligence Biases In Courts, Vera Lúcia Raposo Jan 2024

The Digital "To Kill A Mockingbird": Artificial Intelligence Biases In Courts, Vera Lúcia Raposo

California Western International Law Journal

No abstract provided.