Digital Commons Network^™

Field Prevalence Of Ring Nematodes In South Carolina And Its Potential To Predispose Peanut Pods To Aflatoxin Contamination, Sarala Giri

All Theses

Peanut ring nematode, Mesocriconema ornatum is a nematode pest of peanut which can cause necrotic lesions on pods, pegs, and roots. It has been reported to facilitate secondary infections in peanut and other crops resulting in more significant losses in yield and quality. Aspergillus flavus is a ubiquitous facultative saprophyte that produces aflatoxin, the most problematic mycotoxin for global health and economy. Experiments were conducted at the Edisto Research and Education Center of Clemson University to examine the relationship of ring nematode populations at pegging and harvest with aflatoxin concentration in peanut kernels due to infection by A. flavus …

Unraveling Phytosulfokine Trafficking In Arabidopsis Thaliana Using Fiber-Optic Fluorescence Microscopy, Issaka Obuaba

Electronic Theses and Dissertations

As sessile organisms, plants manage stress through complex signaling networks involving phytohormones such as phytosulfokine (PSK). PSK, a disulfated pentapeptide, regulates plant growth, development, and stress responses by interacting with specific PSK receptors (PSKRs). In this study, we explored the trafficking dynamics of PSK, its post-application fate, and the synthesis of an analog. We administered both native PSK and a fluorescent version tagged with TAMRA (5(6)-carboxytetramethylrhodamine) to various Arabidopsis thaliana genotypes, including wild type, a PSKR-deficient mutant, and a strain overexpressing PSKR1 tagged with green fluorescent protein (GFP) over the wild-type background. Fiber-optic fluorescence microscopy revealed that receptor presence influences …

College Student’S Learning Experiences During Covid-19 Among Traditional And Post-Traditional Students Enrolled In Institutions Affiliated With The Appalachian College Association, Jo Anne Smith

Electronic Theses and Dissertations

The purpose of this study was to determine the differences in the learning experiences, feelings and emotions, level of study support, and online learning during the COVID-19 pandemic between traditional and post-traditional college students enrolled in an institution affiliated with the Appalachian College Association.

A two-group comparison research design using a web-based survey was used for the study. Using the College Student’s Learning Experiences during COVID-19 among Traditional and Post-Traditional Students Enrolled in Institutions Affiliated with the Appalachian College Association survey, the research questions were analyzed with a sample size of N = 58, traditional college student group and N=33, …

Overcoming The Barrier To The Clinical Application Of Naloxone: Application Of Drug Delivery Technologies, Akeemat O. Tijani

Electronic Theses and Dissertations

Opioid overdose crisis continues to demand innovative solutions for rapid and effective drug administration. Naloxone (NAL), a critical opioid antagonist, has been the primary treatment for reversing opioid-induced respiratory depression. However, its current delivery methods, such as intravenous and intranasal formulations, are limited by their invasive nature, short half-life, and the need for repeated dosing. This dissertation investigates advanced drug delivery technologies aimed at overcoming these challenges and enhancing the clinical utility of NAL.

This research focused on improving the transdermal and transnasal delivery of NAL using minimally invasive techniques. Various approaches were evaluated, including sonophoresis, microneedles, laser ablation, dermaplaning …

Investigating Phytosulfokine Trafficking: Insights Into The Role Of Phytohormones In Plant Signaling, Martin Tindi

Electronic Theses and Dissertations

Phytosulfokine is a critical signaling peptide involved in plant growth, development, and stress responses. This thesis investigates the trafficking mechanisms of Phytosulfokine (PSK) in Arabidopsis thaliana, employing fluorescently labelled PSK for non-destructive imaging using a custom-built fiber-optic fluorescence microscope. The study aims to determine the mobility and fate of PSK in plant tissues. Experimental results reveal the short-range and long-range movement of PSK across leaves. Additionally, the project highlights the optimization of non-destructive imaging techniques and the synthesis of caged dexamethasone to facilitate optogenetic studies. These findings provide new insights into PSK trafficking mechanisms in plants, enhancing our understanding …

Rising Epidemiological Trends In Prevalence And Mortality Of Mpox: Global Insights And Analysis, Muhammad Os. Meo, Muhammad Zs. Meo, Isra M. Khan, Muhammad As. Butt, Adnan M. Usmani, Sultan A. Meo

Saudi Medical Journal

Objectives: To explore the global epidemiological trends in the prevalence and mortality due to mpox in various regions worldwide. Methods: In this cross-sectional study the data about mpox outbreak were recorded by the “World Health Organization, Centers for Disease Control and Prevention, and GSAID” from August 2023 to August 2024, analyzing the epidemiological trends from different countries worldwide. Results: The total number of mpox cases has reached 99,518 (95,196 cases from 115 countries that have not historically reported mpox; and 4,322 cases from 07 states that have traditionally reported mpox), from a total of 122 countries. The top 10 countries …

Assessing The Accuracy And Efficiency Of Chat Gpt-4 Omni (Gpt-4o) In Biomedical Statistics: Comparative Study With Traditional Tools, Anusha S. Meo, Narmeen Shaikh, Sultan A. Meo

Saudi Medical Journal

ABSTRACT Objectives: To assess the accuracy of ChatGPT-4 Omni (GPT-4o) in biomedical statistics. The recent novel inauguration of Artificial Intelligence ChatGPT-Omni (GPT-4o), has emerged with the potential to analyze sophisticated and extensive data sets, challenging the expertise of statisticians using traditional statistical tools for data analysis. Methods: This study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, in May 2024. Three datasets in a raw Excel file format were imported onto Statistical Package for the Social Sciences (SPSS) version 29 for data analysis. Based on this analysis, a script of 9 questions …

It's Only Unfair, Eleanor Davis

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Ellie is a Senior English Writing major with a minor in Hispanic Studies. She is a Bonner Scholar and volunteers at the Ullem Campus Farm and Greencastle Middle School. After graduation, she wants to go to graduate school for her MFA and become a teacher.

Investigating Nekton Response To Changing Salinities In The Mississippi Sound: An Experimental And Statistical Approach, Adam Murray

Master's Theses

The Mississippi Sound provides nursery habitats for many coastal species and is recognized for its commercial fisheries. Previous freshening events linked to the Bonnet Carré Spillway, a Mississippi River flood diversion structure, proved catastrophic for oyster populations in the Mississippi Sound, but effects on mobile fish and shellfish species are not well-defined. The planned Mid-Breton Sediment Diversion (MBSD), an initiative to combat wetland loss, is also forecasted to lower salinities in the region, increasing the need to better understand responses of commercially and ecologically important species to freshening events. The objective of this study was to characterize effects of salinity …

Understanding The Performance And Perception Of Odawa Warfare, 1615–1700, Eric P. Morningstar

Masters Theses

This research employs the ethnohistorical method to explore how the Odawa people perceived and carried out warfare from 1615 to 1700. While historians have examined the Odawa, these Native peoples have frequently not been the central focus in the secondary literature. Many primary sources also offer a vague answer as to how the Odawa conceived and carried out warfare. This study aims to clarify historiographical inconsistencies by quantitatively analyzing a database, constructed by the author, of specific primary references to known hostilities between the Odawa, other Native groups, and Europeans. The analysis includes specific variables germane to hostilities such as …

Do Horse Breed Association Youth Programs Promote Life Skills And Goaldevelopment For Youth With Attention Deficit Hyperactivity Disorder?, Julius Culwell, Makenna Foster, Molly Christine Nicodemus, Molly Friend, Holly Evans, Dean Jousan, Katherine Agbigail Holtcamp, Clay Cavinder, Toree Williams

Journal of Youth Development

Almost 10% of American youth are diagnosed with attention deficit hyperactivity disorder (ADHD). While not a learning disability, this diagnosis results in youth being labeled academically “at-risk.” While equine assisted services (EAS) promote an emotionally safe learning environment for at-risk youth, program availability is limited. Horse breed associations, however, offer programs nationwide for all youth, although these programs do not have a therapeutic intention. Therefore, the objectives of this study were to utilize a survey to determine program participation and associated development of life skills and goals for ADHD youth. A survey was developed with the following: 15 fixed-response multiple-choice …

Fournier's Gangrene Severity Index And Charlson Comorbidity Index Predict Mortality, Intensive Care Unit Admission, And Length Of Hospital Stay In Patients With Fournier's Gangrene: An Analysis Of 264 Consecutive Patients, Nicholas Hauser, Chenlin Huang, Girija Vaidya, Timothy Chrusciel, Krithika Narayana Kumarasan, John Culhane, Sameer Siddiqui

Faculty, Staff and Students Publications

Introduction

Fournier’s gangrene (FG) is a rapidly progressing necrotizing fasciitis. The Fournier's Gangrene Severity Index (FGSI), in conjunction with the Charlson Comorbidity Index (CCI), has been used as a mortality predictor during hospitalization. Patients with diabetes have also been shown to be at an increased risk for the development of FG. This study explores the potential of using FGSI, CCI, and patient diabetes status in predicting more extensive patient outcomes, including intensive care unit (ICU) admission and length of hospital stay.

Methods

From 2013 to 2023, inpatient admissions with the diagnosis of FG were selected from the EPIC Clarity database …

Chronic Β3-Ar Stimulation Activates Distinct Thermogenic Mechanisms In Brown And White Adipose Tissue And Improves Systemic Metabolism In Aged Mice, Duraipandy Natarajan, Bhuvana Plakkot, Kritika Tiwari, Shoba Ekambaram, Weidong Wang, Michael Rudolph, Mahmoud A Mohammad, Shaji K Chacko, Madhan Subramanian, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Ungvari, Anna Csiszar, Priya Balasubramanian

Faculty, Staff and Students Publications

Adipose thermogenesis has been actively investigated as a therapeutic target for improving metabolic dysfunction in obesity. However, its applicability to middle-aged and older populations, which bear the highest obesity prevalence in the United States (approximately 40%), remains uncertain due to age-related decline in thermogenic responses. In this study, we investigated the effects of chronic thermogenic stimulation using the β3-adrenergic (AR) agonist CL316,243 (CL) on systemic metabolism and adipose function in aged (18-month-old) C57BL/6JN mice. Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure, increased fatty acid oxidation and mitochondrial activity in adipose depots, improved glucose homeostasis, and a …

'Buy Me Some Peanuts And Cracker Jacks': How Peanuts, Chewing Gum, Hot Dogs, And Beer Became Icons Of Americana Through Baseball, Miles Houman Cipriano

Graduate Masters Theses

BUY ME SOME PEANUTS AND CRACKER JACKS’: HOW PEANUTS, CHEWING GUM, HOT DOGS, AND BEER BECAME ICONS OF AMERICANA THROUGH BASEBALL December 2024 Miles Houman Cipriano B.A., Westfield State University M.A., University of Massachusetts Boston Directed by Professor Bonnie Miller Peanuts, chewing gum, hot dogs, and beer are often closely associated with the game of baseball. Beginning in the mid to late nineteenth century, baseball was a rising form of entertainment in the United States of America, and part of the spectator experience was the purchase of concessions. The business of concessions in America has grown into a multi-billion-dollar industry …

The Application Of High-Resolution Mass Spectrometry For The Analysis Of Biopolymers, Metabolites, And Biologically Relevant Small Molecules, Christ Duc Tran

Graduate Doctoral Dissertations

High-resolution mass spectrometry (HRMS), as its name suggests, possesses high resolving power that enables the separation of ions with very close mass values. This is particularly beneficial for analyzing complex samples where numerous compounds may have similar masses, as it helps prevent signal overlaps and ensures an accurate spectral analysis. The current work explores the diverse applications of high-resolution mass spectrometry in oligonucleotide research, organic synthesis and medicinal chemistry. Oligonucleotide research: Chapters 2-5 present the research results from studies that employed ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) to understand the pharmacokinetics of RNA interference (RNAi) therapeutics. The …

“Go, Rebuild My House”: Empowering The Church Of The Poor Through The Eyes Of Saint Vincent De Paul, Daniel Franklin E. Pilario

Vincentian Studies

Daniel Franklin E. Pilario interprets the Vincentian charism by relating the concepts of mercy, mission, and synodality to Vincent de Paul’s teaching and ministry. Pope Francis has identified these as the keys to the Church’s reform, which is meant as the Christian response to suffering. Mercy (or compassion) is God’s defining characteristic. As Vincent de Paul taught, God was incarnated as a servant of the world to relieve its pain. We, who are made in God’s image, should therefore also be defined by compassion. If we are, then our most fundamental religious practice (mission) is service to the poor. Mission …

Beyond Charity: The Development Of The Mission Of The Daughters Of Charity In Sub-Saharan Africa, Theresa Eke

Vincentian Studies

Theresa Eke recounts the history of the Daughters of Charity’s service in Africa and explains the evolution of their approach to poverty alleviation there. The Daughters learned the importance of knowing the cultures and languages of those they served. At first, they addressed poverty with donations of material goods, but later they empowered the poor, teaching them skills and helping them establish farms and businesses, particularly through helping them to purchase equipment. They learned to listen to what the poor themselves said would help them. They supported high school and university education, especially for women and girls. The Daughters also …

Lack Of Inflammatory Response In Mouse Embryonic Cells To Listeria Infection, Damilola Oyebode

Master's Theses

Approximately 1 in 5 pregnancies in the United States results in miscarriage, with a significant percentage of these losses attributed to failed implantation due to immunological challenges encountered by the early embryo. Recent research has shown that key cell types within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα and IFNγ, both of which are known to hinder blastocyst development. However, the immune properties of the preimplantation stage embryo, specifically the blastocyst, remain poorly understood. Using mouse cell model, …

French Foreign Policy And Its Tendencies While Approaching International Relations Through Multilateralism, Dipin Subedi

Master's Theses

This paper studies the pattern of French foreign policy with respect to one objective: whether through the means available – namely economic, diplomatic, and military – it adheres to the principle of achieving multilateral goals or not. The multilateral institutions that are used in this study as a ground for comparison are NATO, the E.U., and the U.N. all of whom hold France as their member. Nine different categories with distinct characteristics are created that contain one primary case study. Certain expectations on how France could deal with the nation in a particular case study is gathered through hints contained …

A Study Of The Ceramics At The Ebert Canebrake Site (1mc25), Andrew Patterson

Master's Theses

The Ebert Canebrake site is a small multi-component village in Macon County, Alabama. The primary focus of this thesis is to explain the presence of two distinct ceramic traditions on-site during the Mississippi period (AD 1000-1450). Local Shine II ceramics are typified by sand tempering and are related to the Lamar culture of eastern Georgia and western Alabama. Big Eddy phase ceramics are typified by shell tempering and Moundville-like designs from the Black Warrior River Valley in western Alabama. The temporal and spatial relationship of these materials on site is examined through an artifact analysis based upon stratified samples recovered …

Recast, Reform, Reshape: Surreal Figurative Painting, Keely Wu

Theses

This thesis explores the use of surreal imagery and the reimagining of historical subjects as a means to discuss complex ideas of identity. In this exploration, I chose to use the human figure as a vessel for expressing my own intimate viewpoints and experiences. Through a series of paintings, I investigate how the juxtaposition of human forms with non-human elements challenges conventional notions of gender and sexuality to empower marginalized perspectives. My Master’s degree started with my transition from commercial illustration to fine art. The study examines my evolution of thematic and stylistic choices, emphasizing the creation of new works …

Shape Between Intimacy, Mackenzie Serwa

Theses

This thesis examines the parallel exploration of raw tactile materials and relationships to develop a personal dialogue of intimacy. It breaks down the materiality of glass, clay, and the impulse of collecting, aiming to communicate the human connections shared between each. By engaging with materials in this way, this study aims to foster a deeper understanding of the existence, influence, and expression of intimate relationships.

Unstable, Virginia Guerrero

Theses

Unstable is a film about a music-driven, psychedelic journey of reality slipping into a frenzy of madness. It explores bringing music to life with emphasis placed on music pacing, mood, and my own simultaneous, involuntary experience of color when listening to music. The film tells the story of a trapped, creepy, skeletal character escaping his shackles and causing mayhem. He bends reality and experiences several transformations as the music becomes increasingly aggressive. The story is primarily narrative with experimental features, including abstract backgrounds, varying art styles, and unexpected transitions. The main character goes through painful, physical changes and eventually reaches …

The Mythical Nexus: Illuminating The Rich Tapestry Of Global Folklore, Trishala Parmar

Theses

There is a lack of accessibility and exposure to global folklore for a wider audience. Despite the richness and diversity of folktales worldwide, many people may not have access to them due to limited resources, language barriers, cultural isolation, and a lack of exposure. I saw a need to preserve and celebrate cultural heritage through stories and make it fun. I created an interactive website called The Mythical Nexus which allows an audience to interact with different stories and cultures through a series of rotating cubes. This website connects stories and folklore from around the globe through the power of …

Robust And Efficient Active Inference For Perception, Action, And Learning, Zhizhuo Yang

Theses

Active Inference (AIF) is an emerging framework rooted in neuroscience aimed at elucidating human perception, action, and cognitive processes. Recent advances in machine learning have facilitated the non-invasive study of human cognition through the lens of this framework. This dissertation expands upon this theoretical foundation to address practical challenges in robotic control and human cognitive behavior analysis. We initiate our exploration with a review of the eye-tracking studies that underpin the motivation for AIF research. This provides a background for understanding how AIF can model cognitive processes. First, we present a minimal AIF model within a discrete state space, framed …

Clearing, Kaiser Kelly

Gandy Dancer Archives

No abstract provided.

Hot With The Bad Things: A Review, Mollie Mcmullan

Gandy Dancer Archives

No abstract provided.

Use Of Sea Buckthorn Oil In The Treatment Of Skin Disease: Anti-Inflammatory Benefits, Clinical Applications, And Formulary Challenges, Evadne Rodriguez, Justin Flores, Kathleen Click, Vivian Li, Alexandra Loperfito, Marissa Ruppe, Kelly M. Frasier

Student Publications

Skin diseases such as psoriasis, atopic dermatitis, burns, and other barrier insults pose ongoing therapeutic challenges, often requiring treatments that address both inflammation and skin barrier repair. The primary aim of this review is to provide a comprehensive overview of the potential benefits of sea buckthorn oil, derived from Hippophae rhamnoides, as a treatment for various skin diseases, detailing its anti-inflammatory properties, reporting benefits across several skin conditions, and highlighting challenges in formulation as well as preservation of the oil’s nutritional benefits. Drawing from a wide array of existing literature, this review investigates sea buckthorn oil’s rich composition of …

The Constitutional Limits To The Taxing Power, Ari Glogower

Fordham Law Review

The modern U.S. Supreme Court has elevated the apportionment requirement for direct taxes into the most important constitutional limitation to Congress’s taxing power. The U.S. Constitution requires that any “direct tax” must be apportioned among the states by population, which is impracticable or impossible for a tax today. The modern interpretative approach focuses on the formal categorization of the tax base, as either a “direct tax” or not. This approach could bar Congress from enacting certain taxes—such as a federal wealth tax or possibly even capital income tax reforms—simply through their formal labeling as direct taxes.

This interpretation inflates apportionment’s …

Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley

Theses and Dissertations

The heat shock response (HSR) is a cytoprotective stress response pathway that regulates cellular proteostasis. The HSR is an evolutionarily conserved pathway that is essential for normal cellular functioning. Here, we explore the broad ecological and pathological impacts of the HSR. In an ecological context, we perform gene level analysis of the transcriptomes of two closely related sunfish. We found that the more invasive bluegill sunfish has gene expansions in two HSR gene families, the HSP70 family and the HSP90 family compared to the redear sunfish. These gene expansions were also observed in several other teleost fish species and were …