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2024

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On Servant-Leadership And Quaker Influences, Paul W. Davis, Larry C. Spears Dec 2024

On Servant-Leadership And Quaker Influences, Paul W. Davis, Larry C. Spears

International Journal of Servant-Leadership

One important aspect of the Religious Society of Friends has to do with the nurturance of seekers. The very origins of the Religious Society of Friends had much to do with the fact that 17th-century English seekers were already present and listening when the prophetic visionary leadership of George Fox spoke to their hearts. Out of that union of seekers and prophet grew a powerful spiritual tradition that continues today


Interview With Executive President Fr. Peter Balleis, Sj, Shann Ray Ferch Dec 2024

Interview With Executive President Fr. Peter Balleis, Sj, Shann Ray Ferch

International Journal of Servant-Leadership

Fr. Peter Balleis, SJ, a leading advocate of refugee and forcibly displaced persons’ rights, has been fighting for human rights and social justice for more than 20 years. As executive president of Jesuit Worldwide Learning (JWL), Fr. Peter works toward a more peaceful world using the power of education.


A Collection Of Works Related To Greenleaf’S Distinction Between Persuasion And Coercion, Jiying Song Dec 2024

A Collection Of Works Related To Greenleaf’S Distinction Between Persuasion And Coercion, Jiying Song

International Journal of Servant-Leadership

Compiled by Jiying Song


Bridging The Tragic Gap With Servant-Leadership: An Exploration Of Stewardship And Healing, Jamie Noling-Auth Dec 2024

Bridging The Tragic Gap With Servant-Leadership: An Exploration Of Stewardship And Healing, Jamie Noling-Auth

International Journal of Servant-Leadership

This article utilizes servant-leadership theory to engage with the leadership predicament that theologian Parker Palmer calls “the tragic gap”—the disparity between a hopeful vision for good and the reality of humanity’s propensity for violence. Utilizing two of servant-leadership theory’s ten characteristics, this article explores how stewardship and healing might serve the servant-leader who wishes to bridge the tragic gap. Through a survey of interdisciplinary literature, this article concludes that essential actions of stewardship and healing include: honoring human dignity, care-giving, love, responsibility, and forgiveness.


Analysis Of Organoleptic Tests In Making Yoghurt Made From Three Different Types Of Date Milk, Awaliyatul Adawiyah, Eka Andriani, Milliyantri Elvandari Dec 2024

Analysis Of Organoleptic Tests In Making Yoghurt Made From Three Different Types Of Date Milk, Awaliyatul Adawiyah, Eka Andriani, Milliyantri Elvandari

Bulletin of Culinary Art and Hospitality

The purpose of this study was to determine the organoleptic quality of yoghurt from three different types of date milk, which includes characteristics of aroma, color, viscosity, sour taste, sweet taste, texture and viscosity. The research method used a completely randomized design (CRD). Data were processed using Analysis of Variant (ANOVA) method, and Duncan test was conducted if there was treatment effect. The results showed that there were significant differences (P < 0.05) in the characteristics of color, sweetness, and texture of yoghurt made from three different types of date milk.


Function Over Form: The Benefits Of Aspen As Surrogate Brood-Rearing Habitat For Greater Sage-Grouse, Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren Dec 2024

Function Over Form: The Benefits Of Aspen As Surrogate Brood-Rearing Habitat For Greater Sage-Grouse, Michel T. Kohl, Charles P. Sandford, Paul C. Rogers, Renee Chi, Terry A. Messmer, David K. Dahlgren

Aspen Bibliography

Species of conservation concern are often habitat specialists, posing significant risk to those species when specific plant communities are threatened. As a result, practitioners habitually focus conservation efforts on these communities while ignoring ecological mechanisms that explain the wildlife–plant relationships. In doing so, practitioners may overlook alternative vegetation communities that could maintain wildlife populations under alternative conditions (e.g., climate change). Here, we term these areas surrogate habitat, defined as vegetation communities or resource sites that provide similar critical resources as conventional sites, and assess their potential for conservation using a case study of greater sage-grouse (Centrocercus urophasianus) on …


Development Of Composite Flour And Its Potential As Functional Ingredient In Food Industry, Mansoor Abdul Hamid, Maryana Mohammad Nor, Mazarina Devi, Oslida Martony, Ita Rahmania Kusumawati, Mohamad Mustari, Ris Akril Nurimansjah Dec 2024

Development Of Composite Flour And Its Potential As Functional Ingredient In Food Industry, Mansoor Abdul Hamid, Maryana Mohammad Nor, Mazarina Devi, Oslida Martony, Ita Rahmania Kusumawati, Mohamad Mustari, Ris Akril Nurimansjah

Bulletin of Culinary Art and Hospitality

Composite flours are defined as a mixture of flours from tubers rich in starch and/or protein-rich flours and/or cereals with or without wheat flour and are used for the production of leavened or unleavened baked or snack products that are traditionally made from wheat flour and increase the essential nutrients in the human diet. The development of food products using composite flour has increased and is attracting much attention from researchers, especially in the bakery industry and many other food sectors, due to its benefits and functionality. Application composite flours in food industry sectors become most popular, especially on health …


End-To-End Autonomous Quadcopter Using Reinforcement Learning, Mohamed Marwan Chawa Dec 2024

End-To-End Autonomous Quadcopter Using Reinforcement Learning, Mohamed Marwan Chawa

Theses and Dissertations

This thesis investigates the potential of Reinforcement Learning (RL) for achieving robust and adaptable quadcopter control, focusing on trajectory and attitude stabilization. We compare state-of-the-art RL algorithms, specifically Proximal Policy Optimization (PPO), against traditional Proportional-Integral-Derivative (PID) controllers across three tasks: hovering, slow trajectory following, and fast trajectory following. To enhance realism, we employ a modified PyFlyt simulation environment with a high-fidelity Crazyflie 2.x model, accounting for motor dynamics, noise, wind disturbances, and aerodynamic drag.

The challenge of operating a quadcopter can be divided into two distinct parts: planning a flight path and actually following that path. Our focus is on …


Beyond Average Effects In Education Research Syntheses: Explaining Heterogeneity Of Concept Mapping Research In Science Education Through Meta-Regression Modeling, Aaron Wenger Dec 2024

Beyond Average Effects In Education Research Syntheses: Explaining Heterogeneity Of Concept Mapping Research In Science Education Through Meta-Regression Modeling, Aaron Wenger

Dissertations

Contemporary education research seeks causal inferences in order to guide policy and practice. Often well-controlled quasi-experimental and experimental designs are used as they are very useful for supporting and contextualizing causal inferences. Nevertheless, individual studies, even high-quality, resource-intensive randomized controlled trials, are not able to establish generalized claims. Because primary studies vary over dozens of variables (e.g., grade, subject, duration) simply conducting additional primary studies cannot change this. Furthermore, the informal assessments of primary studies common in literature reviews are unable to resolve certain challenges (e.g., publication bias) that are described in the emerging field of meta-research. These challenges require …


Diagnosis And Treatment Of Crop Inflammation Of Rough-Legged Buzzard (Buteo Lagopus) In Daqing Wildlife Nature Reserve, Heilongjiang Province, China, Wang Zheng, Ding Ruxin, Ge Yansong, Xu Enshuang, Zheng Jiasan Dec 2024

Diagnosis And Treatment Of Crop Inflammation Of Rough-Legged Buzzard (Buteo Lagopus) In Daqing Wildlife Nature Reserve, Heilongjiang Province, China, Wang Zheng, Ding Ruxin, Ge Yansong, Xu Enshuang, Zheng Jiasan

The Thai Journal of Veterinary Medicine

This article describes a Rough-legged Buzzard (Buteo lagopus) from the Wildlife Nature Reserve in Daqing, China. According to the staff of Daqing Wildlife Nature Reserve, the Rough-legged Buzzard was found to have impaired flight ability, depression, and loss of aggression, but its feathers were full and there were no obvious external injuries, so it was sent to the Wildlife Rehabilitation Center of the Teaching Animal Hospital of Heilongjiang Bayi Agricultural University for treatment. After the vet conducted X-ray and blood tests, he diagnosed the bird with a foreign body in the crop and crop inflammation. He finally treated …


Hematology, Blood Biochemistry And Cytochemical Characteristics Of Blood Cells Of Captive Aldabra Giant Tortoise (Aldabrachelys Gigantea) In Thailand, Thanida Haetrakul, Nitiwadee Keschumras, Sirawich Srisiri, Narinthip Chaiyanont, Nisama Wongnitipat, Phatcharaporn Phuasombatcharoen, Praewa Sirichitr, Nantarika Chansue Dec 2024

Hematology, Blood Biochemistry And Cytochemical Characteristics Of Blood Cells Of Captive Aldabra Giant Tortoise (Aldabrachelys Gigantea) In Thailand, Thanida Haetrakul, Nitiwadee Keschumras, Sirawich Srisiri, Narinthip Chaiyanont, Nisama Wongnitipat, Phatcharaporn Phuasombatcharoen, Praewa Sirichitr, Nantarika Chansue

The Thai Journal of Veterinary Medicine

Aldabra giant tortoises (Aldabrachelys gigantea), well-known pet tortoises worldwide, were classified as Appendix II by The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). This study aims to investigate the hematological, blood biochemical, and cytochemical characteristics of blood cells in healthy Aldabra giant tortoises in captivity. Blood samples were collected from the dorsal tail vein of 12 tortoises (6 males and 6 females) during May and October 2022. The hematological values showed no statistically significant differences between male and female tortoises. However, in female tortoises, calcium and phosphorus levels were significantly higher than …


The Effects Of Propofol On Doppler Echocardiographic Values Of The Aorta, Main Pulmonary Artery, And Mitral E Wave In New Zealand White Rabbits, Mehmet Alper Çetinkaya, Mahir Kaya Dec 2024

The Effects Of Propofol On Doppler Echocardiographic Values Of The Aorta, Main Pulmonary Artery, And Mitral E Wave In New Zealand White Rabbits, Mehmet Alper Çetinkaya, Mahir Kaya

The Thai Journal of Veterinary Medicine

The aim of this study was to determine the effects of propofol on acceleration time (AT), ejection time (ET), AT / ET ratio obtained from the aorta (Ao) and main pulmonary artery (MPA) and Doppler echocardiographic values of mitral E wave (E) in New Zealand white rabbits. Echocardiographic evaluation was performed in 40 conscious rabbits and repeated after propofol administration. The baseline mean values were 0.028±0.006 second (s) for Ao-AT, 0.116±0.017 s for Ao-ET, 0.24±0.036 for Ao-AT / ET, 0.05±0.01 s for MPA- AT, 0.137±0.018 s for MPA-ET, 0.38±0.037 s for MPA-AT/ET, 84.13±18.26 cm/s for E peak velocity, 3.06±1.38 mmHg …


Electoral College Subversion, The Vice President & The Federal Writ Of Mandamus, Benjamin Sevart Dec 2024

Electoral College Subversion, The Vice President & The Federal Writ Of Mandamus, Benjamin Sevart

Tennessee Journal of Law and Policy

No abstract provided.


Indeterminate Stepper User Interface For Complex Data Entry Tasks, Neha Karve, Ramprasad Sedouram, Yun Theng Kwok Dec 2024

Indeterminate Stepper User Interface For Complex Data Entry Tasks, Neha Karve, Ramprasad Sedouram, Yun Theng Kwok

Defensive Publications Series

In many contexts, users are required to fill in forms to provide their information. When a large amount of data is to be entered, the forms can be complex, multi-step data entry tasks. It is difficult for users to determine their overall progress through such a form as well as portions of the form that are still incomplete. This disclosure describes a user interface that divides the data entry task into multiple sections. Each section is configurable and includes a small, manageable set of steps. Progress in each section is indicated visually via a section-specific progress bar. Overall progress is …


Changes In Climate And Their Implications For Cattle Nutrition And Management, Bashiri Iddy Muzzo, R. Douglas Ramsey, Juan J. Villalba Dec 2024

Changes In Climate And Their Implications For Cattle Nutrition And Management, Bashiri Iddy Muzzo, R. Douglas Ramsey, Juan J. Villalba

Wildland Resources Faculty Publications

Climate change is a global challenge that impacts rangeland and pastureland landscapes by inducing shifts in temperature variability, precipitation patterns, and extreme weather events. These changes alter soil and plant conditions, reducing forage availability and chemical composition and leading to nutritional stress in cattle. This stress occurs when animals lack adequate water and feed sources or when these resources are insufficient in quantity, composition, or nutrient balance. Several strategies are essential to address these impacts. Genetic selection, epigenetic biomarkers, and exploration of epigenetic memories present promising avenues for enhancing the resilience of cattle populations and improving adaptation to environmental stresses. …


Laudate Deum: A Framework For Environmental Stewardship And Social Justice In The Philippines And Southeast Asia, Antonio Levy S. Ingles Jr. Dec 2024

Laudate Deum: A Framework For Environmental Stewardship And Social Justice In The Philippines And Southeast Asia, Antonio Levy S. Ingles Jr.

CSID Journal of Infrastructure Development

This study explores the intersection of environmental initiatives and social justice movements in the Philippines, a nation rich in biodiversity but acutely vulnerable to climate change and ecological degradation. Using Laudate Deum as a guiding framework, the research examines how the principles of Immediate Action, Collective Responsibility, and Social Justice can inform collaborative strategies to address these challenges. Through an analysis of case studies, this paper highlights the socio-economic impacts of environmental crises, such as deforestation and pollution, and evaluates initiatives like mangrove reforestation and community-based waste management for their ecological and social benefits. The findings reveal that integrating Laudate …


From The Ocean To Our Kitchen Table: Anthropogenic Particles In The Edible Tissue Of U.S.. West Coast Seafood Species, Summer D. Traylor, Elise F. Granek, Marilyn Duncan, Susanne Brander Dec 2024

From The Ocean To Our Kitchen Table: Anthropogenic Particles In The Edible Tissue Of U.S.. West Coast Seafood Species, Summer D. Traylor, Elise F. Granek, Marilyn Duncan, Susanne Brander

Environmental Science and Management Faculty Publications and Presentations

Microplastics (MPs) and other anthropogenic particles (APs) are pervasive environmental contaminants found throughout marine and aquatic environments. We quantified APs in the edible tissue of black rockfish, lingcod, Chinook salmon, Pacific herring, Pacific lamprey, and pink shrimp, comparing AP burdens across trophic levels and between vessel-retrieved and retail-purchased individuals. Edible tissue was digested and analyzed under a microscope, and a subset of suspected APs was identified using spectroscopy (μFTIR). Anthropogenic particles were found in 180 of 182 individuals. Finfish contained 0.02–1.08 AP/g of muscle tissue. In pink shrimp (Pandalus jordani), the average AP/g was 10.68 for vessel-retrieved and …


Digital Twin And Cybersecurity In Additive Manufacturing, Lidong Wang Dec 2024

Digital Twin And Cybersecurity In Additive Manufacturing, Lidong Wang

Journal of Cybersecurity Education, Research and Practice

Additive manufacturing (AM) has been applied to automotive, aerospace, medical sectors, etc., but there are still challenges such as parts’ porosity, cracks, surface roughness, intrinsic anisotropy, and residual stress because of the high level of thermal gradient. It is significant to conduct the modeling and simulation of the AM process and achieve quality products. Digital Twin (DT) can help AM with forecasting defects/errors through simulation and real-time process monitoring. DT is a concept of Industry 4.0, and its digital structure reflects the real-time behaviors of a cyber-physical or physical system. This paper introduces the progress of DT applications in AM, …


3d Printed Heart Model With Simulated Cardiac Stroke Volumes, Fadi Matar, Jonathan Michael Ford, Summer Joy Decker Dec 2024

3d Printed Heart Model With Simulated Cardiac Stroke Volumes, Fadi Matar, Jonathan Michael Ford, Summer Joy Decker

USF Patents

Disclosed herein is a 3D printed heart model with simulated cardiac stroke volumes. It involves an inner membrane conforming to the shape of the inner lining of the ventricle. This results in the creation of a compression pouch with a potential space (compression sac) bordered by the inner surface of the simulated ventricle and the outer surface of the inner membrane. The inner membrane also defines a neo-ventricular chamber that is in contact with blood simulating fluid. A pulsatile flow pump can serve as a hydrodynamic driver for inflow and outflow into and out of the compression sac. This can …


Regulated Drug Delivery Via Controlled Degradable Chondroitin Sulfate Particles, Nurettin Sahiner, Ramesh Ayyala Dec 2024

Regulated Drug Delivery Via Controlled Degradable Chondroitin Sulfate Particles, Nurettin Sahiner, Ramesh Ayyala

USF Patents

Disclosed herein are crosslinked chondroitin sulfate particles crosslinked chondroitin sulfate particle polyelectrolytes. The particles are useful in drug delivery applications. The particles may be used to treat various conditions, including bacterial and fungal infections.


Device For Targeted Feature-Specific Sensory Therapy, David Eddins, Joseph Walton Dec 2024

Device For Targeted Feature-Specific Sensory Therapy, David Eddins, Joseph Walton

USF Patents

A device and method that supplements sensory input, thereby providing a supplemented sensory environment, to induce plasticity within the central nervous system that effectively overcomes sensory-neural processing deficits or strengthens specific sensory-neural abilities. In one implementation, ear-level hearing devices are used to deliver therapeutic sound with specific acoustic features that serve as archetypes of stimulus features for which sensory-neural processing is compromised by a sensory-neural deficit.


Gender Equity And Coffee Agroforestry: The Environmental And Social Impacts Of Commodity Production In Latin America, Suzanna Lloyd Dec 2024

Gender Equity And Coffee Agroforestry: The Environmental And Social Impacts Of Commodity Production In Latin America, Suzanna Lloyd

Student Theses 2015-Present

This paper addresses the environmental and social implications of coffee growth and production in Latin America. Women contribute significantly to the ownership of coffee farms and labor of coffee production; however, there is a lack of resources and financial compensation for their work. Chapter One provides both quantitative and qualitative data on the environmental impacts of coffee plantations compared to agroforestry methods of coffee production in Latin America. This chapter defines basic terms, differentiates coffee species and mode of production, and explains the ecosystem services of biodiverse, tropical farms. Chapter Two highlights the patriarchal nature of Latin American agriculture systems …


Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey Dec 2024

Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey

2020-Current year OA Pubs

Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding, leading to the accumulation of misfolded COMP in chondrocytes. The MT-COMP mouse is a murine model of PSACH that expresses D469del human COMP in response to doxycycline and replicates the PSACH chondrocyte and clinical pathology. The basis for the mutant-COMP pathology involves endoplasmic reticulum (ER) stress signaling through the PERK/eIF2α/CHOP pathway. C/EBP homologous protein (CHOP), in conjunction with a TNFα inflammatory process, upregulates mTORC1, hindering autophagy clearance of mutant COMP …


Determination Of The Kinetic Parameters Of Cholesterol Oxidation Using Cholesterol Oxidase From Streptomyces Sp., Meka Saima Perdani, Heri Hermansyah, Muhamad Sahlan, Dwini Normayulisa Putri, Teguh Pambudi, Anggi Khairina Hanum Hasibuan Dec 2024

Determination Of The Kinetic Parameters Of Cholesterol Oxidation Using Cholesterol Oxidase From Streptomyces Sp., Meka Saima Perdani, Heri Hermansyah, Muhamad Sahlan, Dwini Normayulisa Putri, Teguh Pambudi, Anggi Khairina Hanum Hasibuan

Makara Journal of Technology

Cholesterol oxidase (CO) was successfully produced from Streptomyces sp. via the submerged fermentation method, and 69 U/mL enzyme activity was obtained. This study aimed to determine cholesterol oxidation kinetics and the production of CO as a catalyst. The enzyme was diluted to 0.15, 0.075, and 0.00375 U/mL for the oxidation reaction. The substrate was also prepared in three concentrations: 3.23, 6.46, and 12.93 mM. The optimization of conditions for enzymatic cholesterol oxidation was investigated through measurement of the effect of initial cholesterol and enzyme concentrations. Cholesterol concentration was rapidly measured via high-performance liquid chromatography (HPLC). The kinetics of CO were …


Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey Dec 2024

Loss Of Chop Prevents Joint Degeneration And Pain In A Mouse Model Of Pseudoachondroplasia, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Michele Carrer, Frankie Chiu, Dorde Relic, Paymaan Jafar-Nejad, Karen L Posey

Faculty, Staff and Student Publications

Pseudoachondroplasia (PSACH), a severe dwarfing condition characterized by impaired skeletal growth and early joint degeneration, results from mutations in cartilage oligomeric matrix protein (COMP). These mutations disrupt normal protein folding, leading to the accumulation of misfolded COMP in chondrocytes. The MT-COMP mouse is a murine model of PSACH that expresses D469del human COMP in response to doxycycline and replicates the PSACH chondrocyte and clinical pathology. The basis for the mutant-COMP pathology involves endoplasmic reticulum (ER) stress signaling through the PERK/eIF2α/CHOP pathway. C/EBP homologous protein (CHOP), in conjunction with a TNFα inflammatory process, upregulates mTORC1, hindering autophagy clearance of mutant COMP …


Targeted Degradation Of Oncogenic Krasg12v Triggers Antitumor Immunity In Lung Cancer Models, Dezhi Li, Ke Geng, Yuan Hao, Jiajia Gu, Saurav Kumar, Annabel T Olson, Christina C Kuismi, Hye Mi Kim, Yuanwang Pan, Fiona Sherman, Asia M Williams, Yiting Li, Fei Li, Ting Chen, Cassandra Thakurdin, Michela Ranieri, Mary Meynardie, Daniel S Levin, Janaye Stephens, Alison Chafitz, Joy Chen, Mia S Donald-Paladino, Jaylen M Powell, Ze-Yan Zhang, Wei Chen, Magdalena Ploszaj, Han Han, Shengqing Stan Gu, Tinghu Zhang, Baoli Hu, Benjamin A Nacev, Medard Ernest Kaiza, Alice H Berger, Xuerui Wang, Jing Li, Xuejiao Sun, Yang Liu, Xiaoyang Zhang, Tullia C Bruno, Nathanael S Gray, Behnam Nabet, Kwok-Kin Wong, Hua Zhang Dec 2024

Targeted Degradation Of Oncogenic Krasg12v Triggers Antitumor Immunity In Lung Cancer Models, Dezhi Li, Ke Geng, Yuan Hao, Jiajia Gu, Saurav Kumar, Annabel T Olson, Christina C Kuismi, Hye Mi Kim, Yuanwang Pan, Fiona Sherman, Asia M Williams, Yiting Li, Fei Li, Ting Chen, Cassandra Thakurdin, Michela Ranieri, Mary Meynardie, Daniel S Levin, Janaye Stephens, Alison Chafitz, Joy Chen, Mia S Donald-Paladino, Jaylen M Powell, Ze-Yan Zhang, Wei Chen, Magdalena Ploszaj, Han Han, Shengqing Stan Gu, Tinghu Zhang, Baoli Hu, Benjamin A Nacev, Medard Ernest Kaiza, Alice H Berger, Xuerui Wang, Jing Li, Xuejiao Sun, Yang Liu, Xiaoyang Zhang, Tullia C Bruno, Nathanael S Gray, Behnam Nabet, Kwok-Kin Wong, Hua Zhang

Faculty, Staff and Student Publications

Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the clinical management of patients with the G12C mutation and advanced our understanding of the function of this mutation. However, little is known about the targeted disruption of KRASG12V, partly due to a lack of specific inhibitors. Here, we leverage the degradation tag (dTAG) system to develop a KRASG12V-transgenic mouse model. We explored the therapeutic potential of KRASG12V degradation and characterized its effect on the tumor microenvironment (TME). …


Muqarnas In Damascus: A Forgotten Treasure’S History, Inception And Geometry, Nahed Jawad Chakouf Dec 2024

Muqarnas In Damascus: A Forgotten Treasure’S History, Inception And Geometry, Nahed Jawad Chakouf

All Works

The architecture of the Islamic world encompasses both religious and secular buildings that are unified by the use of a common architectural language, which includes architectural elements such as minarets, domes and arches, ornamental details, and vaulting with the use of muqarnas. The study provides a broad overview of the development of Islamic architecture, focusing on Damascus, the early Islamic period, the mid-Islamic period and the late Islamic period. The late Islamic period includes Ottoman art, with architecture influenced by Byzantine, Persian, Armenian, and Mamluk artefacts, but differs from their predecessors. The researcher undertook a geometric analysis of the muqarnas …


Nappy, Loc’D Or Straight, It Still Gets Hate: A Collaborative Autoethnography Examining Black Hair In K-12 Education And Beyond, Maiya Turner, Janae Alexander-Bady, Virginia Redwine Johnson, Salandra Grice, Tyra Montour Dec 2024

Nappy, Loc’D Or Straight, It Still Gets Hate: A Collaborative Autoethnography Examining Black Hair In K-12 Education And Beyond, Maiya Turner, Janae Alexander-Bady, Virginia Redwine Johnson, Salandra Grice, Tyra Montour

Journal of Multicultural Affairs

The purpose of this study is to examine the impact that Black hair discrimination has on Black girls in K-12 educational settings. Black hair has long been tied to Black girls and women’s cultural identities. However, Black girls often fall victim to discrimination based on their hair texture and style, which can often impact their relationship with their hair through adulthood. Utilizing collaborative autoethnography, we provide our hair experiences during our K-12 educational experiences and how this has impacted our current relationships with our hair. Additionally, within the findings, we identify three themes common among our experiences: dress codes as …


Estha And Trans Identity In The God Of Small Things, Clara Reid Dec 2024

Estha And Trans Identity In The God Of Small Things, Clara Reid

Critical Humanities

Gender relationships in The God of Small Things by Arundhati Roy change over the course of the book. In many ways, gender and caste are inseparable from one another in how they interact; it is Estha who bridges the gap between both. Whether consciously or subconsciously, he engages in this transgressive behavior in order to become his sister Rahel. This essay positions Estha as a trans woman longing for a becoming, and it is through his successful pursuit of Rahel in both a queer and psychoanalytic sense that he becomes a woman. This pursuit manifests through transgressive behavior, putting him …


Homelessness And Uncertain Belonging Of The Bhutanese Nepali Diaspora, Ramji Timalsina Dec 2024

Homelessness And Uncertain Belonging Of The Bhutanese Nepali Diaspora, Ramji Timalsina

Critical Humanities

Bhutanese Nepali Diaspora is a classic example of Nepali transnational community. Started centuries ago, it was massively developed in the 19th and 20th centuries before it was dispersed in the 21st century. Living in Bhutan as an agricultural and free-of-cost-labour community for the Bhutanese regime, they always believed that Nepali culture, language and king were their own. When Bhutan brought the ‘one culture, one nation’ policy in the 1980s, about a hundred thousand Bhutanese Nepalis were expelled and they returned to Nepal with the belief that Nepal as their ancestor’s land would accept them. But, as the …