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Sorgoleone (Lipophilic Benzoquinones) Levels In The Root Exudates Of Elite Sorghum [Sorghum Bicolor (L.) Moench] Cultivars, Suleica J. Lee

All Theses

Nitrogen loss from cropping systems is significant and is estimated at more than 50% of the amounts applied. Root exudates of certain plant species including sorghum [Sorghum bicolor (L.) Moench] contain sorgoleone which can reduce nitrification and nitrogen loss through biological nitrification inhibition (BNI). Therefore, the goal of this study was to screen selected elite sorghum germplasm comprising hybrids and parents to determine the best sorgoleone secreting cultivars. The hypothesis was that nitrogen loss from croplands could be curbed through exploring sorghum BNI traits. Screening of the cultivars selected was done using an established sorghum culture and extraction pipeline that …

The New Frontier Of Guidance Reviewability, Tomás Rios

Michigan Law Review

In the administrative context, agency actions must be “final” to trigger judicial review. The Supreme Court’s opinions in Sackett v. Environmental Protection Agency and U.S. Army Corps of Engineers v. Hawkes Co. marked an important shift in finality doctrine by emphasizing that the calculus of whether agency guidance is “final” may turn on its practical effects. For decades, agency guidance rarely warranted judicial review because it is not legally binding and, thus, not final. But the advent of the Sackett-Hawkes pragmatic analysis has changed the landscape, raising particular concerns for agencies relying on promulgating guidance documents to “softly” regulate. This …

Debunking Criminal Restitution, Lula A. Hagos

Michigan Law Review

Criminal restitution—the money paid by a defendant to a victim—is often overlooked amidst growing scholarly consensus about the adverse impact of criminal court fines and fees. Restitution receives less attention because it is perceived as a fair and unobjectionable sanction with legitimate goals, while fines and fees are now widely condemned as primarily serving as a funding source for local and state governments. Consequently, the animated and extensive discourse around financial punishment largely excludes criminal restitution.

Though criminal restitution may appear to have legitimate penological purposes, it serves to perpetually punish defendants who are poor—the vast majority of those in …

Marriage, Courts, And Substantive Equality: A Transformative Interpretation, Kushagr Bakshi

Michigan Law Review

Courts in various jurisdictions have relied on either the right to privacy or the right to equality to offer protections to the LGBTQ+ community. The use of different rights to achieve similar ends may seem like an empty distinction. But the differences in the nature and function of each right evince the differences in the construction of rights across jurisdictions. In the traditional liberal method of conceptualizing rights, privacy is typically a negative right, restricting the state from interfering in intimate relationships between individuals. Courts operating within a transformative framework of rights interpretation, however, rely on the positive right to …

The Reservoir Geomechanics And Production Effects On Permafrost Stability During Polymer Eor, Shane S. Namie

Theses and Dissertations

The North Slope of Alaska (ANS) contains an estimated 40 billion barrels of heavy oil in relatively shallow formations (984 to 1,969 ft / 304 to 600 m) within the Prudhoe Bay Unit (PBU), Milne Point Unit (MPU) and Kuparuk River Unit (KRU). Extracting this resource presents unique challenges, especially when hydrocarbon-bearing zones are near the permafrost. Research on tertiary recovery processes in these shallow zones is limited, with prior studies indicating minor permafrost thawing and subsidence over 30 to 40 years but lacking a numerical simulation model supported by laboratory data.This study investigates the feasibility of an enhanced oil …

The Role Of Disgust In Films: Disgust As An Aesthetically Appreciable Emotion That Enhances The Film’S Other Emotional Effects, Yunyi Zhu

Department of Philosophy: Dissertations, Theses, and Student Research

The goal of this paper is to address the questions: what is the role of disgust in films, or what makes people appreciate a film’s disgusting contents, given that disgust is unpleasant to experience? The films to which I am referring are audiovisual artworks, including both TV shows and movies, that arouse the emotion of disgust and typically have contents that are gory or gross, yet despite their disgusting contents, these films have as a primary goal to present a narrative or an experience rather than merely to disgust or disturb their audiences. This includes various genres of films, from …

Assessing Reproducibility Challenges In Clinical Metabolics, Darcy Lin Cochran

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Current metabolomics research is expanding to be multiplatform and interdisciplinary. Metabolomic analysis has the potential to provide detailed insight into any biological system of interest to analyze the underlying molecular mechanisms of variables like environment, disease, and genetics. Human clinical metabolomics is a major research area that is often focused on finding biomarkers or panels of biomarkers for different diseases. However, results are difficult to compare across different laboratories since the field of metabolomics has yet to widely adopt best practices for sample preparation, data acquisition and data processing, results are difficult to compare across different laboratories.

This thesis focuses …

Use Of Electrocardiogram To Evaluate Welfare Of Laying Hens And Chicks During Different Life Stages And Events, Ashley Elizabeth Bigge

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Three separate studies were conducted to evaluate the welfare of laying hens and chicks during different life stages. The stress responses of mature laying hens in two different scenarios were also investigated. All three studies utilized the electrocardiogram (ECG) as the chosen tool for data collection. Study 1 examined the startle response, prompted by an acute stressor that created sudden movement and noise, in White and Brown Leghorn hens housed in either cages or aviaries. The presence of a chronic stressor, a 23-hour feed failure, was also assessed as a factor. These hens had been surgically implanted with wireless ECG …

Examining Factors Of Variance In Energy Metabolism Of Dairy Cattle, Addison Lee Carroll

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Variation is thought to occur in the use of dietary energy for production in dairy cattle. First, variance can be observed when new methane mitigation strategies are fed resulting in increased H₂ output potentially resulting in downstream effects on estimates heat production via the Brouwer (1965) equation. Therefore, in chapter 3 a review was created to systematically describe the mathematics and theory behind the Brouwer equation, and rederive a heat production equation to integrate H₂ production. Results indicate heat production using the classical Brouwer equation (1965) relative to the rederived equation resulted in an overestimation of heat production …

Microbiome Variation In Production Phenotypes And The Role Of Colonization History In Microbiome Establishment, Seidu Adams

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Ruminant-based agriculture is expected to continue to be a major contributor to food security to feed the growing population. At the heart of nutrient degradation of complex organic matter within the rumen are its microbes. These microbes can convert otherwise unusable organic matter into usable protein and energy and can provide up to 50% of the animal’s protein needs and up to 70% of the energy needs. The microbial functional capacity within the rumen determines the nutrients utilized and the end products of fermentation. However, our understanding of microbial functional capacity within the rumen and factors that influence the rumen …

Domain-Specific Machine Learning Approaches For Geospatial Problems, Shine Bedi

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation explores novel algorithms for complex geospatial problems at the intersection of environmental, social, and computational sciences. Emphasizing the unique challenges of the geospatial domain, particularly the deviation from the independent and identical distribution (IID) assumption, the research spans various methodologies across different domains, demonstrating the benefits of specialized approaches in spatial analysis.

First, we show that machine learning techniques can be effectively used in environmental modeling, which often has severe class imbalance challenges. Using artificial neural networks (ANN), support vector machines (SVM), and extreme gradient boosting (XGB) and techniques to address class imbalance provides insights into groundwater quality …

Motivated By Hope: Why We Strive For The Improbable, Varkey K. Titus Jr.

Department of Philosophy: Dissertations, Theses, and Student Research

Some of the most rewarding actions we take in life are difficult. The outcomes of these actions are surrounded by uncertainty, and what relevant data is available indicates a high probability of failure. Current philosophical work proposes that hope can resolve the puzzle of how people can rationally choose to engage in difficult actions, but this work constrains hope’s motivational role to actions whose successful outcomes reside within the realm of an individual’s own agency. I expand the explanatory role of hope motivating action to include cases whose outcomes depend on some combination of factors internal and external to the …

December 2024 Table Of Contents Newsletter - Science Librarian / Google Lens, Kayla Birt Flegal

Table of Contents Newsletter

After many years of animal cams, unwavering support of all the science departments, and the best laugh on campus, the DePauw Libraries are saying merry retirement to Caroline Gilson! Caroline made an indelible mark on students and faculty through her work in science librarianship at DePauw. You can write a thank you to Caroline by stopping by TheDesk at Roy O. West. Join the celebration for Caroline on Thursday, December 5, 1:30-3pm in Roy O. West’s Laptop Lab (119).

Alfred Russel Wallace Notes 33. The Story In Evolution., Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823-1913) is best known for his independent formulation of the principle of natural selection. In this work I first review my understanding of Wallace’s intellectual development on this subject, including the notion that he had no model for the evolution of higher consciousness as of his first treatment of natural selection in 1858. This leads to some conclusions about his approach to the subject, and links to parallel ideas inherent in the philosophy of Baruch de Spinoza (1632-1677).

Heat Acclimated Algae Improves Heat Tolerance And Longevity In Daphnia, Ashit Dutta

Electronic Theses and Dissertations

Xenohormesis suggests that consuming stressed food provides physiological adaptation to the consumer for similar stresses. To evaluate this, Daphnia magna was provided with heat-stressed Nannochloropsis limnetica grown at 25℃ whereas the control group was provided Nannochloropsis limnetica grown at 12℃. In the heat tolerance experiment, Daphnia kept at 28℃ and 20℃ while consuming 25℃ algae had significantly higher heat tolerance compared to the control. Additionally, in stressed conditions, Daphnia consuming 25℃-grown food had significantly higher lifespan compared to the control. Next, Daphnia consuming 25℃-grown algae had significantly higher levels of antioxidants which could explain the lifespan extension. Finally, in fatty …

Epanorama December 2024, Southern Adventist University

Panorama Parent Newsletter

This electronic issue of Panorama includes information on campus holiday events, enrollment information, and awards won during the Society of Adventist Communicators competition in Chicago in October.

Metabolic Shifts In Ratio Of Ucocn To Cocn Toward Bone Resorption Contribute To Age-Dependent Bone Loss In Male Mice, Matthew Bernhard, Obinna Okorie, Wei-Ju Louis Tseng, Mengcun Chen, Julia Danon, Mingshu Cui, Elisabeth Lashbrooks, Yanmei Yang, Bin Wang

Center for Translational Medicine Faculty Papers

The study of the senile osteoporosis in men still lags significantly behind that in women. The changes of protein molecule levels and their relationships with bone loss remain poorly understood. In the present study, we used C57BL/6J male mice at ages from 3 to 24 mo to delineate the mechanisms of aging effects on bone loss. We used the microcomputed tomography, mechanical testing, histomorphometry assays, and detection of serum levels of undercarboxylated osteocalcin (ucOcn) and carboxylated osteocalcin (cOcn) to assess bone mass changes and their relationships with the ratios of ucOcn-to-cOcn in mice from different age groups. The results showed …

Bridging The Gap: Fostering Open Dialogue On Resource Access And Service Needs, Cameron Castillo

Capstone Projects and Master's Theses

This project investigates whether there are additional resources desired by clients or are needed to better support said clients in their recovery at the Interim, Inc. organization. This agency is a nonprofit organization whose sole purpose is to build community connections through providing services to individuals facing mental health and substance use challenges. While there is a wide range of programs available, there may still be clients with unmet needs. The purpose of this project was to identify any service gaps by conducting separate surveys of clients and staff members. Through the use of open-ended questions, the expectation of receiving …

Impact Of Place Based Learning On Community Engagement And Ownership, Alexis Mendez

Capstone Projects and Master's Theses

Place-based learning (PBL) offers an educational approach that emphasizes local history, environments, and communities, allowing students to engage with relevant content through the expertise gained from lived experiences. By utilizing their immediate surroundings, students are able to absorb educational material and foster a sense of place that can encourage civic engagement, environmental stewardship, and community ownership. This senior capstone research project explores the potential to enhance community ownership and engagement in Salinas, California through a Problem-Based Learning (PBL) approach. This project integrates the local geological and cultural history of California, Monterey Bay, and the Salinas Valley, alongside hands-on water quality …

Parenting With Grace, Eva Nelson Cole

Capstone Projects and Master's Theses

Parents are often caught off guard by the upheaval of adding children to their lives. Feelings of guilt, shame, isolation, and depression can arise when parents are faced with the demands and stressors that come along with having children. Studies have shown that children who have distressed parents endure lasting negative outcomes that can extend into the primary school years (Mihelic et al., 2018). Educating parents and giving them some awareness about what to expect can make a real difference. To have these conversations, I created a two-part parenting workshop for new parents at Parents’ Place in Pacific Grove, CA. …

Targeting The Glutamine-Arginine-Proline Metabolism Axis In Cancer, Di Wang, Jiang-Jie Duan, Yu-Feng Guo, Jun-Jie Chen, Tian-Qing Chen, Jun Wang, Shi-Cang Yu

Faculty, Staff and Student Publications

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism. This axis also acts as a scaffold for the synthesis of other nonessential amino acids and essential metabolites. In this paper, we briefly review (1) the glutamine addiction exhibited by tumour cells with accelerated glutamine transport and metabolism; (2) the methods regulating extracellular glutamine entry, intracellular glutamine synthesis and the fate of intracellular glutamine; (3) the glutamine, proline and arginine metabolic pathways and their interaction; and (4) the research progress in tumour therapy …

Genetic Ablation Of The Isoform Γ Of Pi3k Decreases Antidepressant Efficacy Of Ketamine In Male Mice, Gabriela N Vaz, Flávia C Turcato, Isabel A V Lima, Franciele F Scarante, Melissa R Araújo, Tamires A V Brigante, Livia C M Rodrigues, Francisco S Guimarães, Jaime E C Hallak, Jose A Crippa, Antonio L Teixeira, Antonio C P De Oliveira, Alline Cristina Campos

Faculty, Staff and Student Publications

About one-third of major depressive disorder (MDD) patients demonstrate unresponsiveness to classic antidepressants, and even the clinical efficacy of fast-acting drugs such as ketamine varies significantly among patients with treatment-resistant depression. Nevertheless, the lack of suitable animal models that mimic a possible ketamine-resistant phenotype challenges the understanding of resistance to drug treatment. In this study, we showed that PI3Kγ knock-out (KO) mice do not respond to classical doses of ketamine and classical antidepressants. PI3Kγ KO mice were unresponsive to both the rapid and sustained antidepressant-like effects of a single dose of ketamine in the forced swimming test. Additionally, they were …

A119: Intermittent Hypoxic Training Promotes Whole-Body Hif-1Α Expression To Improve Exercise Capacity, Yuepeng Li, Lan Zheng

International Journal of Physical Activity and Health

Research Context: It has been shown that a hypoxic environment induces up-regulation of HIF-1α and changes in its downstream gene sequences, and that exercising under hypoxic conditions improves athletes' sprint performance. However, there is more controversy regarding the effects of exercise under hypoxic conditions on exercise capacity, and the molecular mechanisms have been less well studied. Therefore, the aim of this study was to investigate the link between HIF-1α expression and exercise capacity under hypoxic conditions of exercise, and to provide a realistic theoretical basis for intermittent hypoxic training to improve exercise capacity.

Research Methodology: A total of 480 wild-type …

A150: Analysis Of The Mechanism Of Resveratrol's Action On Myocardial Energy Metabolism In Exercise-Induced Fatigue Rats, Shang Xu, Jinru Cai, Yulong Hu

International Journal of Physical Activity and Health

Background/Purpose: Promotional effects of resveratrol on myocardial mitochondrial energy metabolism in exercise-induced fatigue rats were investigated by network pharmacology and animal experiments.

Method: In the present study, the effects of resveratrol on myocardial energy metabolism were assessed using network pharmacology with enrichment analysis. Forty-eight healthy male SD rats of 6–8 weeks of age were selected and randomly divided into blank control group (C), resveratrol administration group (R), exercise fatigue group (E), and exercise fatigue + resveratrol administration group (ER) with 12 rats in each group. Rats in E group and the exercise fatigue + ER group were weight-bearing 5% swimming …

2024 Personal-Sized Seedless Watermelon Cultivar Evaluation In Indiana, Wenjing Guan

Midwest Vegetable Trial Reports

The annual watermelon cultivar evaluation trial is conducted at Southwest Purdue Agricultural Center (SWPAC) in Vincennes, Indiana. It evaluates yield, fruit quality, and overall plant performance of commercial watermelon cultivars and advanced breeding lines. Purdue Extension and seed companies financially support the trial. The 2024 personal-sized triploid watermelon cultivar trial evaluated 18 cultivars.

“A Frail Wish On Human Morality” Versus “A Life-And-Death Question For Humanity”, Yeomin Yoon

KAUPA Letters

No abstract provided.

Patterns In Gray Wolf Pup Survival And Recruitment In Northern Minnesota, Andrea Hynes

All NMU Master's Theses

Knowledge of how and why the vital rates of wildlife populations change through and over time is crucial for understanding wildlife population dynamics. Because estimating gray wolf pup survival is challenging, our understanding of pup survival and the factors influencing survival and recruitment is limited. I used a combination of litter counts and video observations from a large remote camera array to estimate annual wolf pup survival and recruitment and to evaluate intra-annual patterns in pup survival and recruitment within the Greater Voyageurs Ecosystem, MN, USA. Mean annual pup survival during 2019–2023 was 0.24, and the mean annual recruitment rate …

At Least, We Should Try, Semoon Chang

KAUPA Letters

No abstract provided.

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …

Pacific Rxtracts - December 2024, Pacific Rxtracts

Pacific RxTracts

Articles

• Attruby: A Promising Treatment for Transthyretin Amyloid Cardiomyopathy
• Triple Threat: GMRx2, An Emerging Low-Dose Triple Pill For Hypertension
• New Treatment for Hemophilia A or B
• Breaking the Placebo Barrier: FDA Review Challenges Effectiveness of Popular Decongestant
• Exploring Bempedoic Acid: Potential Benefits for Statin-Intolerant Patients and Liver Health
• The Flu Vaccine: Meeting You Where You Are
• Unique Application of Statins for Radiotherapy-Induced Cardiotoxicity
• One Shot, Two Solutions: How Semaglutide Combats Obesity and Knee Osteoarthritis