Digital Commons Network^™

Elucidating The Mechanism Of Interleukin-17a Signaling In The Pathogenesis Of West Nile Virus, Farzana Nazneen

Dissertations

West Nile Virus (WNV), a neurotropic flavivirus transmitted by mosquitoes, is a leading cause of viral encephalitis in the United States and remains a significant public health concern. Unfortunately, no vaccine or therapeutic intervention is available against WNV infection. Previous studies, including ours, demonstrated that interleukin-17A (IL-17A) signaling increases the cytotoxic potential of CD8⁺ T cells to facilitate WNV and parasite clearance; however, the molecular mechanism is not understood. IL-17 receptor C (IL-17RC) is an obligatory co-receptor with IL-17 receptor A (IL-17RA) for signaling induced by IL-17A, IL-17A/F, and IL-17F. In this study, we found that IL-17RC deficient ( …

A Revolution Deferred: Polycrisis And The Failures Of Incremental Change In South Africa, Geoffrey Schneider

Working Papers

No abstract provided.

Creche Herald Vol. 28, No. 4, Rita B. Bocher

Creche Herald

The Winter 2024 publication features nativity sets and personal reflections from members in the organization; information about nativities and nativity exhibits; and information about the Friends of the Creche annual meeting.

Minimizing Take Of Threatened Rattlesnakes And Optimizing Project Review In Se Nebraska, Shaun Dunn, Dan Fogell, Colleen Rothe-Groleau

Nebraska Department of Transportation: Research Reports

The western massasauga (Sistrurus tergeminus) and the timber rattlesnake (Crotalus horridus) are protected under Nebraska Statute 37-801-811 and listed as threatened species. These species occur in the right-of-way (ROW) along several roads in Jefferson, Gage, Pawnee, and Richardson Counties which necessitates the need for added Environmental Review (ER) from Nebraska Department of Transportation (NDOT) staff and onsite surveys prior and during maintenance and construction to roadways. This project sought to minimize ER time, staff time, and increase the knowledge of these species in southeast Nebraska by:

1. Identifying precise locations of western massasauga brumation sites;
2. Mapping travel …

Low Public Awareness Opens Up New Opportunities For Highlighting Milk As An Iodine Dietary Source, Giovanni Niero, Simona Censi, Caterina Mian, Carmen L. Manuelian, Maristela Rovai, Eleni Tsiplakou, Luciana Da Costa, Et.Al

Dairy Science and Food Science Faculty Publications: 2022 to Present

No abstract provided.

The Guardian The Month Of December 2024, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of December 2024. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Epiphany - 7 January 2024, Joe Tedesco

Pastoral Liturgy

No abstract provided.

Full Journal

Pastoral Liturgy

No abstract provided.

Third Sunday Of Advent - 15 December 2024, Gerard Moore

Pastoral Liturgy

No abstract provided.

Mary, Mother Of God - 1 January 2025, Andrew Doohan

Pastoral Liturgy

No abstract provided.

Houge-Janssens Syndrome-1 Associated With Protein Phosphatase 2 Regulatory Subunit B’ Delta And Epilepsy: A Case Report, Dua Saleem, Fizza Akbar, Noor Zeeshan, Rabab Jafry, Salman Kirmani, Sidra Kaleem Jafri

Pakistan Journal of Neurological Sciences (PJNS)

Houge-Janssens syndrome 1 is a rare autosomal dominant disorder with approximately 100 case reports worldwide. Here, we present a case of a Pakistani toddler who presented with epilepsy and developmental delay. Family history was significant with reported and documented developmental delays in both father and elder sister, with subsequent improvement. Trio-whole-genome sequencing (WGS) and Sanger sequencing were performed, revealing a heterozygous LP variant NM_006245.4: c.626A>C, p.(His209Pro) in the girl. The same variant was also identified in her father and sister. This case sheds light on the variability of phenotypic expression amongst affected individuals and recommends the need for further …

Acute Flaccid Myelitis Caused By Enterovirus Infection- A Case Report, Ahmad Bilal, Tipu Sultan, Zia Ur Rehman, Arshad Mehmood, Amber Shabir, Javeria Raza

Pakistan Journal of Neurological Sciences (PJNS)

Enterovirus is a member of the Picornaviridae family, an enterovirus. It is suspected of causing a polio-like disorder called acute flaccid myelitis (AFM). This case report aims to present a 10-year-old boy who presented with neurological manifestations of weakness of lower limbs and urinary retention. He had reduced tone, absent reflexes, and palpable bladder. MRI spine revealed inflammation in grey matter of spinal cord. He was treated with high dose steroids and IVIG but no improvement was observed. Enterovirus was isolated from his stool sample. The patient received supportive care and physiotherapy with gradual improvement after months, having no evidence …

Connecticut Law Review Table Of Contents 57-1

Connecticut Law Review

No abstract provided.

Teaching Constitutional Law In A Crisis Of Judicial Legitimacy, William Baude

Chicago-Kent Law Review

No abstract provided.

From Constitutional Law To Constitutional Change, Steven D. Schwinn

Chicago-Kent Law Review

No abstract provided.

Whatcha Gonna Do When They Come For You? Assessing The Damage Associated With The Rise Of Reality Tv Policing And Proposing Avenues For Accountability And Reform, Danielle Taylor

Chicago-Kent Law Review

No abstract provided.

Energy Intensity Convergence Among Chinese Provinces: A Theil Index Decomposition Analysis, Yifan Wang, Wei Li, Nadia Doytch

Ateneo School of Government Publications

China, the world’s largest carbon emitter, has one of the most stringent provincial emissions reduction programs, incorporated into its Five-Year National Plan to reduce carbon emissions. However, the widening energy intensity gap between provinces poses a great challenge for carbon reduction. In this study, we analyze the convergence of Energy intensity (EIC), i.e., the time-dependent decrease of differences among regional energy intensity over time focusing on a data set of 30 Chinese provinces from 2000 to 2015. Our goal is to identify the provinces that are responsible for the observed divergence in energy intensity and identify the factors causing that …

Impossibility Of Artificial Inventors, Matt Blaszczyk

UC Law Science and Technology Journal

Recently, the United Kingdom Supreme Court decided that only natural persons can be considered inventors. A year before, the United States Court of Appeals for the Federal Circuit issued a similar decision. In fact, so have many of the courts all over the world. This Article analyzes these decisions, argues that the courts got it right, and finds that artificial inventorship is at odds with patent law doctrine, theory, and philosophy. This Article challenges the intellectual property (IP) post-humanists, exposing the analytical and normative perils of their argumentation, and recommends against getting rid of the nominally central place of humans …

Teaching Law Amidst Convulsive Doctrinal Change, Harold J. Krent

Chicago-Kent Law Review

No abstract provided.

Designing An Advanced Gui For A Laser Harp, Matthew Moran

2024 Fall Honors Capstone Projects - Archive

This project presents the design and development of a laser harp, an innovative digital instrument that combines music and technology to inspire interest in STEM education. The harp uses laser beams and phototransistors to simulate the strings of a traditional harp, producing sound when the beams are interrupted. The primary focus of the honors section of this work is a custom-built software interface developed with a graphical user interface (GUI) that allows users to easily adjust settings like note range, volume, and the central part of the show, looping notes. The GUI is designed to be intuitive, making it easy …

Effect Of Hyperbaric Oxygen Therapy (Hbot) On The Proportion Of Splenic Leukocytes During Skeletal Muscle Regeneration, Hetvi Patel

2024 Fall Honors Capstone Projects - Archive

Hyperbaric oxygen therapy (HBOT) can accelerate the regeneration of skeletal muscle after injury and improve overall recovery. Certain cells of the spleen are increased during muscle regeneration; however, the effect of HBOT on splenic cells during muscle regeneration is not well understood. In other experimental models, HBOT proliferates the proportion of splenic cells. In this study, eight male and nine female mice sustaining crush muscle injuries underwent HBOT at 1.5 atmospheres absolute for 60 min or normobaric hyperoxia (100% O₂) for 60 min within 2-6 hours of injury for 4 days. The mice were then euthanized at 4- …

Investigating The Acute Physiological Effects Of Effluent Crystal Violet On The Freshwater Bioindicator Daphnia Pulex, Hoang K. Ho

2024 Fall Honors Capstone Projects - Archive

This study examines the effects of acute exposure to crystal violet (CV) on the freshwater zooplankton Daphnia pulex in response to growing concerns over synthetic dyes from industrial runoff in aquatic ecosystems. The primary objective is to assess CV's impact on D. pulex's heart rate, mobility, morphology, and lethality via a series of acute exposure tests. 48-h acute toxicity (0-2000 μg/L), 48-h immobilization (0-180 μg/L), and 9-h heart rate (0-2,000 μg/L) tests were conducted using third-generation daphnids, followed by stereomicroscopic examination and statistical analysis. Results showed increasing mortality and decreasing mobility and heart rate with increasing CV concentration; the …

Determining Evolutionary Conservation Of Mhc-E And Vista Interaction, Julia Glenn

2024 Fall Honors Capstone Projects - Archive

Research in the Weidanz laboratory is focused on cellular molecules which inhibit immune activation, known as immune checkpoints. One example is HLA-E, which can modulate immune responses at homeostasis or in the context of cancer. HLA-E typically acts by presenting short canonical peptides (VL9s) and binding to CD94/NKG2A receptors on NK cells and T cells. The Weidanz laboratory’s research has found that in the absence of these VL9 peptides, HLA-E binds to another immune checkpoint, VISTA, instead of CD94/NKG2A. Therefore, the HLA-E/VISTA interaction is peptide-dependent. The current study aims to determine if this peptide-dependent interaction is evolutionarily conserved using the …

The Process Of Creating A Visual Identity System From Scratch, Daisy L. Macias

2024 Fall Honors Capstone Projects - Archive

A visual identity system is a collection of design elements that work together to maintain consistency through various applications. A study of iconic brands clarifies how a design is successfully executed. This creative project began with selecting an industry, writing a creative brief, curating mood boards for visual research, brainstorming a brand name, creating a set of graphics that aid the brand identity, and implementing these graphics together to create a successful visual identity system. For this project, an indie cinema was selected, and based on existing visual research for this industry, the design style referenced contemporary art. The final …

Forging A Niche: Preparing Models For The Animation Pipeline In A Changing Industry, Grayson Wiles

Master of Fine Arts in Digital Media Culminating Experience

This culminating experience shows a complete and comprehensive skill set in the animation pipeline using three diverse 3D models: Baba Yaga, the Orc, and the Roo Fighter. This work includes reposing, retopology, UV mapping, texturing, and rigging. Each model was selected for its unique attributes and challenges, showing versatility in anatomy, efficiency, and communication. Spurred on by a dubious job market and the improvement of AI tools, this project showcases the author's capabilities to fulfill multiple roles in the animation pipeline, providing an advantage for employment in the digital media industry.

The Role Of Eor-1/Plzf In Promoting Soma Compartment Specific Death In A Non-Canonical Cell Death Program In C. Elegans, Nathan Rather

2024 Fall Honors Capstone Projects - Archive

Programmed cell death (PCD) is an essential evolutionarily- conserved and genetically encoded program for normal development and homeostasis. A previous study identified a CED-3 dependent but mechanistically non-apoptotic and highly stereotyped elimination program called Compartmentalized Cell Elimination (CCE) in the C. elegans tail-spike epithelial cell (TSC). Here the transcription factor EOR-1/PLZF is found to promote CCE. The loss of which results in a persisting non-engulfed soma with enlarged nuclei in the first larval stage. This study finds that EOR-1 and its established partners function downstream of CED-3 Caspase protease activity, a role distinct from other PCD contexts where EOR-1 has …

Assessing The Potential For Soil-Mediated Transmission Of Symbiotic Bacteria In The Leaffooted Bug (Leptoglossus Phyllopus), Armeen Nasir

McNair Scholars Research Journal

Recent evidence suggests insects might indirectly provide symbionts to their offspring by releasing them into the soil via feces. We investigated whether this is occurring in the Eastern leaf-footed bug, Leptoglosuss phyllopus. We hypothesized that if adults release viable symbiont cells into their environment, then nymphs will have a higher survival rate, develop faster, and be larger at adulthood when exposed to soil that has been in contact with adult insects for longer. To measure the rate and whether the bugs acquired Caballeronia from the soil, insect nymphs were exposed to soil that had been exposed to a lab colony …

Analyzing Head Morphology Trends With Increasing Population Density In A Jamaican Lizard Species, Lillian Durand

2024 Fall Honors Capstone Projects - Archive

Anolis lizards are model organisms for studying natural selection and evolutionary processes. One trait that is hypothesized to be advantageous for males is head size, as larger heads lead to stronger bite forces and increased likelihood in outcompeting other males for mates. To better understand how linked head size and intraspecific competition are, the head morphology of male A. lineatopus was analyzed among Jamaican populations with varying levels of population density. Population densities were determined using standardized plot surveys and mark resight models. Head dimensions and body condition for individual lizards were measured at each site. My study found that …

Forced To Weather The Storm: Reforming The Livestock Indemnity Program To Improve Farm Animal Welfare, Cameron Krier Massey

Journal of Food Law & Policy

Each year, extreme weather events put the lives and wellbeing of millions of farm animals at risk. These events can lead to injury, suffering, acute and chronic stress, decreased productivity, and loss of life. As storms increase in frequency and intensity, efforts should be made to ensure livestock are protected. This paper proposes modifications to the Livestock Indemnity Program (LIP), a federally run disaster assistance program that compensates livestock owners and growers for animal deaths and reduced value caused by eligible conditions, including extreme weather. Surprisingly, the program does not require producers to show proof and use of a disaster …

Udder Confusion: An Almond Milk Case Study To Examine The Complex Interplay Of Consumer Choices, Social Media, And Regulation, Madeline Mcculloch

Journal of Food Law & Policy

The preference for plant-based diet options has steadily increased for the American public. This is all particularly true for alternative milks. By the end of 2020, plant-based milk alternatives (“PBMA”) accounted for approximately fifteen percent of the total milk market and thirty-five percent of the overall plant-based market, making alternative milks, particularly almond, one of the most popular ways for people to dabble in a plant-based diet. Almond milk holds the gold in the U.S. plant-based milk market. It is, first, essential to examine the comprehensive context surrounding almond milks’ status on grocery shelves. This writing will attempt to do …