Digital Commons Network^™

Do Age, Musical Training, And Multilingualism Contribute To Misophonia, Asmr, And Frisson Experiences?, Riley Ramos, Kayla Daugherty, Haley Yanez, Joseph Altamirano, David Vollweiler, Solena Mednicoff, Erin Hannon

Undergraduate Research Symposium Posters

Misophonia: intense negative reactions to sounds such as chewing or pen clicking. Autonomous Sensory Meridian Response (ASMR): positive tingling sensation to triggering auditory and visual stimuli. Frisson: Positive response (chills, teary eyes) to music or other emotionally charged experiences.

Third-Order Harmonic Generation In Few-Layer Graphene, Nicholas T. Pereira, Timothy Chung, Joshua O. Island

Undergraduate Research Symposium Posters

Optical harmonic generation is a phenomena that occurs in nonlinear materials and can be used to study the properties of those materials. For example, the nonlinear response of layered, two-dimensional (2D) materials can be used to characterize flake thickness, lattice and stacking symmetries, and crystal strain. Here, we study third harmonic generation (THG) in graphene and few-layer graphite as a precursor to investigating nonlinear optical properties of other 2D materials. We present a custom scanning setup for optical harmonic generation and present our results on few-layer flakes. These results provide a solid basis for future measurements of other new 2D …

Feasibility And Acceptability Of A Loving-Kindness Meditation Among Socio-Economically Diverse Older Adults, Carolyn Streb

Undergraduate Research Symposium Posters

In Psychology one of the first theories we learn is Maslow's Need Triangle. Within this theory we learn that love and belonging is one the basic human needs an individual needs to develop. This continues to be relevant later in age. The lack of compassionate love can result in increase feelings of loneliness and subsequent deterioration of mental health therefore making individuals, specifically older adults, more vulnerable to suicidal behavior. Loneliness is a public health epidemic affecting more the 40% of older adults. Theoretical and empirical evidence implies that human beings can cope with adversity when they possess a repertoire …

Lower Limb Revascularization Leads To Faster Walking But With Less Efficient Mechanics In Claudicating Patients, Alex Dzewaltowski, Iraklis Pipinos, Molly Schieber, Jason Johanning, George P. Casale, Sara A. Myers, Philippe Malcolm

Journal Articles

Peripheral artery disease (PAD) is characterized by reduced blood flow to the extremities due to atherosclerosis. Studies report impaired gait mechanics in patients with lower extremity PAD. We hypothesized that revascularization surgery would improve gait mechanics when quantified by net lower limb joint work across the stance phase of walking. We performed gait analyses in 35 patients with PAD and 35 healthy, older adults. Patients with PAD performed a walking protocol prior to and six months following revascularization surgery. Healthy adults only took part in a single walking session. Lower limb joint powers were calculated using inverse dynamics and …

Dynamic Segmental Kinematics Of The Lumbar Spine During Diagnostic Movements, Paul Mcmullin

Theses and Dissertations

While lumbar kinematics can be measured in vivo, most measurements are invasive (such as percutaneous bone pins), provide high doses of radiation (such as biplane fluoroscopy), or are taken with the patient in a static position (such as MRIs). Recent work suggests that lumbar kinematics can be determined by dynamic measurements of epidermal strain in the lower back. This work aims to develop and examine a method of examining lumbar kinematics via optoelectronic motion capture utilizing skin-mounted markers in the lumbar region. Two studies were performed. One study examined lumbar epidermal strain in 28 asymptomatic subjects during diagnostic movements, while …

Acs, George, Sophia Maier Garcia

Bronx Jewish History Project

George Acs was born in Hungary and was brought, as a three year old, to the United States in 1957, after his parents fled the Hungarian Revolution in 1956. His mother’s cousin, who survived Auschwitz with her, had an apartment in the Bronx and they moved in with her upon arriving in the United States. Eventually they would live on 174th Street and Southern Boulevard, which was a Jewish area but in the process of transitioning by the time they moved there in 1957 until they left in 1964 and moved to Lydig Avenue off Pelham Parkway, which was Jewish …

December 8, 2023 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

No abstract provided.

Decreasing Skin Infections In High School Wrestlers, Adrienne Villarreal Mathews

Doctor of Nursing Practice Final Project Abstract

Decreasing Skin Infections in High School Wrestlers

PURPOSE The purpose of this quality improvement project was to reduce the skin infection rates by implementing protocols designed to prevent infections by focusing on disinfection and screening practices. The project aims to reduce skin infection rates in wrestlers at a private boy’s high school. Long-term goals include enhancing awareness among high school wrestlers to maintain a healthy lifestyle and prevent sport-related skin infections.

BACKGROUND The project was implemented in a private boy’s high school wrestling team composed of 50 wrestlers in grades 9-12, located in Houston, Texas.

METHODOLOGY A daily log was …

Privacy Within Autonomous Vehicle Cameras, Joshua Montgomery

Honors Theses

In recent years, cameras have become ubiquitous in daily life, constantly surveilling, and taking in information. This leads to a potential security risk of the invasion in one’s privacy without their knowledge or any ability to prevent the privacy threat. While cameras alone are an issue, they are often only in locations where a user has some expectation of a loss of privacy, such as public locations with security systems. However, systems that rely on cameras to operate correctly, including autonomous vehicles, are becoming a more prominently used technology while often appearing in places where an average person has some …

Pedestrian-Friendly Streets: Assessing Overall Success On Well-Being With Post-Evaluations, Ariana Ordoñez

Student Works

Today, well-being has taken a central role in urban planning, emphasizing the significance of pedestrian-friendly streets for the overall welfare of a city's residents. Pedestrian-friendly streets are vital elements of urban design that enhance mobility and contribute significantly to people's quality of life. This study examines the impact of pedestrian-friendly streets on the well-being of individuals through a post-evaluation approach. The research focuses on two projects: the 12 Avenue South project, completed in April 2022, and the Madison Station Boulevard project, completed in August 2022. The study uses a well-being questionnaire encompassing physical, psychological, social, and environmental domains by conducting …

Identification Of Ct-Based Non-Invasive Radiomic Biomarkers For Overall Survival Prediction In Oral Cavity Squamous Cell Carcinoma, Xiao Ling, Gregory S. Alexander, Jason Molitoris, Jinhyuk Choi, Lisa Schumaker, Ranee Mehra, Daria A. Gaykalova, Lei Ren

Department of Radiation Oncology Faculty Papers

This study addresses the limited non-invasive tools for Oral Cavity Squamous Cell Carcinoma (OSCC) survival prediction by identifying Computed Tomography (CT)-based biomarkers to improve prognosis prediction. A retrospective analysis was conducted on data from 149 OSCC patients, including CT radiomics and clinical information. An ensemble approach involving correlation analysis, score screening, and the Sparse-L1 algorithm was used to select functional features, which were then used to build Cox Proportional Hazards models (CPH). Our CPH achieved a 0.70 concordance index in testing. The model identified two CT-based radiomics features, Gradient-Neighboring-Gray-Tone-Difference-Matrix-Strength (GNS) and normalized-Wavelet-LLL-Gray-Level-Dependence-Matrix-Large-Dependence-High-Gray-Level-Emphasis (HLE), as well as stage and alcohol usage, …

A Phenotypically Robust Model Of Spinal And Bulbar Muscular Atrophy In Drosophila, Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert Wessells, Diane E. Merry, Sokol V. Todi

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen-dependent manner. The precise molecular sequelae of SBMA are unclear. To assist with its investigation and the identification of therapeutic options, we report here a new model of SBMA in Drosophila melanogaster. We generated transgenic flies that express the full-length, human AR with a wild-type or pathogenic polyQ repeat. Each transgene is inserted into the same safe …

Engagement And Turnover In Registered Nurses Before And After The Covid-19 Pandemic, Laura Magstadt

Walden Dissertations and Doctoral Studies

No abstract provided.

Adaptive Social Distancing Strategies For Controlling Infection Inequality In Emerging Infectious Diseases, Asma Azizi, Caner Kazanci, Sunmi Lee

Faculty Articles

People fare in outbreaks of emerging infections based on social factors shaping their exposure and vulnerability to the virus. This different exposure cause a disproportionate share of prevalence among people with various socioeconomic statuses. Therefore, socioeconomic-based control strategies are needed to control the discrepancy in prevalence among socioeconomic groups. We propose and analyze a SIR mathematical model that is grouped based on individuals' income level (representing socioeconomic status). For the model's parameter, we use properties of a real-world social network of individuals residing in New Orleans, Louisiana. We then distribute the social distancing practice among different groups to minimize a …

Determining The Potential Of Sonic Bloom In Inducing Rice Resistance (Oryza Sativa) Against The Attack Of Bacterial Leaf Blight Disease Caused By Xanthomonas Oryzae, Azka Algina, Syifaa Yunita Yulianti, Rohimatus Syamsyiah, Veadora Yasminingrum, Bergas Frenli Nur Vendi, Vira Kusuma Dewi

Jurnal Kultivasi

Xanthomonas oryzae which causes bacterial leaf blight disease is one of the main pathogens that attack rice crops. The threat of losing rice yields due to X. oryzae needs to be avoided by implementing appropriate control strategies. Sonic bloom has the potential to induce plant immunity against diseases. Hence, this study aimed to examine the potential of sonic bloom in inducing rice resistance to bacterial leaf blight. The experiment was arranged in a Randomized Block Design (RBD) with five treatments and three replications. The treatments consisted of several frequencies, namely PR (0.5 - 1 kHz and inoculated with X. oryzae), …

The Application Of Florpyrauxifen-Benzyl 25 G/L, A New Auxin Synthetic Herbicide, To Control And Inhibit The Growth Of Water Hyacinth Weed (Eichhornia Crassipes (Mart). Solms), Nita Nur Rezkia, Denny Kurniadie, Dedi Widayat

Jurnal Kultivasi

Water hyacinth is an invasive species that spreads rapidly and causes several issues in aquatic habitats; therefore, efforts are required to eradicate weeds in aquatic ecosystems. Aquatic weed control in Indonesia using herbicide is very limited, so it can be an alternative for aquatic weed control management. This research goal was to examine the effectiveness of the herbicide with active agent Florpyrauxifen-benzyl 25 g/L in controlling and inhibiting the rapid growth of (E. crassipes). This research was carried out at the Ciparanje Greenhouse and Weed Science Laboratory, Faculty of Agriculture Universitas Padjadjaran, West Java, Indonesia, from August to October 2022. …

Evaluation Of Physiological Quality Of Seed On Yield Of Yellow And Black Soybean Treated With Biological Seed Coating, Muhamad Kadapi, Priscilla Olga Salim, Sumadi

Jurnal Kultivasi

The demand for soybeans as one of cereal commodities increases every year, however, to meet the production and demand level is still challenging in Indonesia. One of the causes of low soybean production is stress during cultivation, lack of nutrients, or poor quality of soybean seeds. One solution is to increase seed protection by coating the seeds with an environmentally friendly biological seed coating. This study aims to obtain the best biological seed coating for increasing soybean seed viability, vigor, and yield. The research was conducted at the Faculty of Agriculture Experimental Station of Universitas Padjadjaran, Jatinangor from August to …

Final 2023 Residential Metals Abatement Program (Rmap) Whitehall Borrow Submittal, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Optical Genome Mapping Helps To Identify Bcr::Jak2 Rearrangement Arising From Cryptic Complex Chromosomal Aberrations: A Case Report And Literature Review, Neelam Vanjari, Guilin Tang, Gokce A Toruner, Wei Wang, Beenu Thakral, Ming Zhao, Bhavana J Dave, Joseph D Khoury, L Jeffrey Medeiros, Zhenya Tang

Faculty, Staff and Student Publications

We report a case of myeloproliferative neoplasm, not otherwise specified (MPN-NOS)-transformed AML with BCR::JAK2 rearrangement. Chromosomal analysis indicated a simple abnormal karyotype 46,XY,t(7;17)(q21;q24),t(9;22)(p24;q11.2). Fluorescence in situ hybridization (FISH) using a BCR/ABL1/ASS1 probe set suggested a possible BCR rearrangement and a reflex JAK2 breakapart probe indicated JAK2 rearrangement, most likely partnered with BCR. Optical genome mapping (OGM) analysis confirmed BCR::JAK2 derived through an inv(9)(p24p13) after a t(9;22)(p13;q11.2) in this case. Due to the complexity of chromosomal aberrations, disruption and/or rearrangement of other genes such as KIF24::BCR, JAK2::KIF24/UBAP1, and CDK6:SOX9 were also identified by OGM. Although the functionality and clinical …

Rad54l2-Mediated Dna Damage Avoidance Pathway Specifically Preserves Genome Integrity In Response To Topoisomerase 2 Poisons, Huimin Zhang, Yun Xiong, Yilun Sun, Jeong-Min Park, Dan Su, Xu Feng, Sarah Keast, Mengfan Tang, Min Huang, Chao Wang, Mrinal Srivastava, Chang Yang, Dandan Zhu, Zhen Chen, Siting Li, Ling Yin, Yves Pommier, Junjie Chen

Faculty, Staff and Student Publications

Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA intermediates that are reversible but can be trapped by TOP2 poisons. Trapped TOP2ccs block transactions on DNA and generate genotoxic stress, which are the mechanisms of action of TOP2 poisons. How cells avoid TOP2cc accumulation remains largely unknown. In this study, we uncovered RAD54 like 2 (RAD54L2) as a key factor that mediates a TOP2-specific DNA damage avoidance pathway. RAD54L2 deficiency conferred unique sensitivity to treatment with TOP2 poisons. RAD54L2 interacted with TOP2A/TOP2B and ZATT/ZNF451 and promoted …

The Defined Tlr3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy And Potentiates Anti-Pd-1 Antibody Therapy By Enhancing Immune Cell Infiltration, Seung-Hwan Lee, Young-Ho Choi, Soon Myung Kang, Min-Gyu Lee, Arnaud Debin, Eric Perouzel, Seung-Beom Hong, Dong-Ho Kim

Faculty, Staff and Student Publications

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 …

Phenotyping Emt And Met Cellular States In Lung Cancer Patient Liquid Biopsies At A Personalized Level Using Mass Cytometry, Loukia G Karacosta, Danny Pancirer, Jordan S Preiss, Jalen A Benson, Winston Trope, Joseph B Shrager, Arthur Wai Sung, Joel W Neal, Sean C Bendall, Heather Wakelee, Sylvia K Plevritis

Faculty, Staff and Student Publications

Malignant pleural effusions (MPEs) can be utilized as liquid biopsy for phenotyping malignant cells and for precision immunotherapy, yet MPEs are inadequately studied at the single-cell proteomic level. Here we leverage mass cytometry to interrogate immune and epithelial cellular profiles of primary tumors and pleural effusions (PEs) from early and late-stage non-small cell lung cancer (NSCLC) patients, with the goal of assessing epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in patient specimens. By using the EMT-MET reference map PHENOSTAMP, we observe a variety of EMT states in cytokeratin positive (CK+) cells, and report for the first time MET-enriched CK+ …

Effects Of Independent Versus Dependent Stressful Life Events On Major Symptom Domains Of Schizophrenia, Yizhou Ma, Joshua Chiappelli, Mark D Kvarta, Heather Bruce, Andrew Van Der Vaart, Eric L Goldwaser, Xiaoming Du, Hemalatha Sampath, Samantha Lightner, Jane Endres, Akram Yusuf, Alexa Yuen, Samantha Narvaez, Danny Campos-Saravia, Peter Kochunov, L Elliot Hong

Faculty, Staff and Student Publications

We evaluated two models to link stressful life events (SLEs) with the psychopathology of schizophrenia spectrum disorders (SSD). We separated SLEs into independent (iSLEs, unlikely influenced by one's behavior) and dependent (dSLEs, likely influenced by one's behavior). Stress-diathesis and stress generation models were evaluated for the relationship between total, i- and d- SLEs and the severity of positive, negative, and depressive symptoms in participants with SSD. Participants with SSD (n = 286; 196 males; age = 37.5 ± 13.5 years) and community controls (n = 121; 83 males; 35.4 ± 13.9 years) completed self-report of lifetime negative total, i- and …

Novel Sox10 Indel Mutations Drive Schwannomas Through Impaired Transactivation Of Myelination Gene Programs, Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E Leboit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon

Faculty, Staff and Student Publications

BACKGROUND: Schwannomas are common peripheral nerve sheath tumors that can cause severe morbidity given their stereotypic intracranial and paraspinal locations. Similar to many solid tumors, schwannomas and other nerve sheath tumors are primarily thought to arise due to aberrant hyperactivation of the RAS growth factor signaling pathway. Here, we sought to further define the molecular pathogenesis of schwannomas.

METHODS: We performed comprehensive genomic profiling on a cohort of 96 human schwannomas, as well as DNA methylation profiling on a subset. Functional studies including RNA sequencing, chromatin immunoprecipitation-DNA sequencing, electrophoretic mobility shift assay, and luciferase reporter assays were performed in a …

A Finite-State Morphological Analyzer For Q'Eqchi' Using Helsinki Finite-State Technology (Hfst) And The Giellatekno Infrastructure, Cody Scott Christopherson

Theses and Dissertations

Finite-state morphological modeling has been used in natural language processing for many years particularly when dealing with lower resource languages. The present study details the development of an open-source finite-state morphological model for the Q'eqchi' Maya language using Helsinki Finite-State Technology (HFST) and the Giellatekno infrastructure. This project represents the first comprehensive morphological analyzer for Q'eqchi' and sets a foundation for future work in data annotation for this language. The resulting transducer consists of 4,439 lexemes, 2,610 states and 9,558 transitions and covers between 75% and 85% of tokens in a Q'eqchi' corpus. The success of this project lays the …

"Social" Movements: A Trend Analysis Of The Role Of Social Media In Social Movements, Courtney Nelson Stubbs

Theses and Dissertations

The gay rights movement has been very active on social media throughout the years. Using a trend analysis this study aimed to answer how social media is being used during a social movement, how a social movement evolves on social media, and how social media is being used by organizations as a public relations strategy to create change in social movements. Overall, the findings revealed 11 different ways social media is being used during a social movement, which shows how important opinion leaders are in helping a social movement gain traction and create the desired impact.

Soft Robot Trajectory Generation: Enabling Soft Robot Arms To Reliably And Effectively Perform Real World Tasks Through Optimization, Haley P. Sanders

Theses and Dissertations

The robotic platform presented in this thesis is underdamped with high inertia and can store potential energy in its compliant joints, making it ideal for many different types of real-world tasks for which traditional rigid-robots are ill-suited. Some real-world tasks suited to soft robots include high impact tasks like hammering a nail into a wall or moving heavy objects with other robot or human teammates while using relatively little power. Some of the same characteristics which make soft robots useful, such as their underdamped, highly compliant joints, also make motion planning and control for soft robots difficult. In this thesis, …

Perioperative Quality Initiative (Poqi) Consensus Statement On Perioperative Assessment Of Right Ventricular Function, Stephanie O Ibekwe, Jean Deschamps, Michael P W Grocott, Yafen Liang, Andrew Shaw, Tjorvi E Perry

Faculty, Staff and Student Publications

BACKGROUND: The right ventricle (RV) plays a central role in the maintenance of effective cardiac pump function. Despite overwhelming evidence that perioperative RV dysfunction (RVD) and failure (RVF) are associated with poor clinical outcomes, there are very few published recommendations or guidelines for comprehensive, evidence-based RV assessment on the risk of developing either during the perioperative period.

MAIN TEXT: To address this gap, the Perioperative Quality Initiative-IX (POQI-IX) investigators group, comprised of clinical experts in anesthesiology, cardiovascular surgery, internal medicine, critical care medicine, and advanced practice nursing, has developed a consensus statement based on current literature, published society recommendations, and …

Benzodioxane-Benzamides As Ftsz Inhibitors: Effects Of Linker's Functionalization On Gram-Positive Antimicrobial Activity, Lorenzo Suigo, William Margolin, Eugenia Ulzurrun, Martina Hrast Rambaher, Carlo Zanotto, Victor Sebastián-Pérez, Nuria E Campillo, Valentina Straniero, Ermanno Valoti

Faculty, Staff and Student Publications

FtsZ is an essential bacterial protein abundantly studied as a novel and promising target for antimicrobials. FtsZ is highly conserved among bacteria and mycobacteria, and it is crucial for the correct outcome of the cell division process, as it is responsible for the division of the parent bacterial cell into two daughter cells. In recent years, the benzodioxane-benzamide class has emerged as very promising and capable of targeting both Gram-positive and Gram-negative FtsZs. In this study, we explored the effect of including a substituent on the ethylenic linker between the two main moieties on the antimicrobial activity and pharmacokinetic properties. …

How A Study Abroad Program Supports Its Students Of Color: A Case Study, Hannah E. L. Bloom

Master's Theses

Students of Color study abroad at rates lower than their white peers, thus missing out on the academic, personal, and intercultural benefits one can gain from studying abroad. The purpose of this thesis was to conduct a qualitative case study to examine how a study abroad program supports its Students of Color during the pre-departure phase of study abroad. This case study uses Critical Race Theory as its theoretical lens. Research for this case study included interviews with four study abroad practitioners from one study abroad program, and a review of the study abroad program’s online spaces. This thesis endeavored …