Digital Commons Network^™

The Early Years Of Congress’S Anti-Removal Power, Aaron Nielson, Christopher J. Walker

Articles

Judges and scholars have long debated whether the Constitution provides the President with a power to remove executive officials. The Constitution, however, undoubtedly gives Congress tools to discourage the President’s use of such power. Perhaps most notably, the Appointments Clause makes it more difficult for the President to remove principal officers—even those whose views are out of the step with the President’s—because the President cannot know whether the Senate will consent to a preferred replacement. This is an example of what we dub Congress’s anti-removal power: Even if the President can remove, a motivated Congress can discourage the President’s use …

Reward Sensitivity Predicts The Response To Cognitive Behavioral Therapy For Children With Autism And Anxiety, Matthew J Hollocks, Jeffrey J Wood, Eric A Storch, An-Chuen Cho, Connor M Kerns, Philip C Kendall

Faculty, Staff and Students Publications

Objective: Cognitive-behavioral therapy (CBT) is an effective treatment for anxiety in youth with autism spectrum disorder (ASD). However, research has yet to examine what cognitive characteristics may influence treatment response. The current study investigated decision-making ability and social cognition as potential (a) predictors of differential treatment response to two versions of CBT and (b) moderators of the effect of treatment condition.

Method: The study included 148 children (mean age = 9.8 years) with interfering anxiety and a diagnosis of ASD who were enrolled in a randomized clinical trial comparing two versions of CBT for anxiety (standard and adapted for ASD). …

Novel Banana Lectin Car-T Cells To Target Pancreatic Tumors And Tumor-Associated Stroma, Mary K Mckenna, Ada Ozcan, Daniel Brenner, Norihiro Watanabe, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, Challice Bonifant, David M Markovitz, Malcolm K Brenner

Faculty, Staff and Students Publications

BACKGROUND: Cell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar residues that are a 'hallmark' of both malignant and associated stromal cells. We have expressed in T cells a modified lectin from banana, H84T BanLec, attached to a chimeric antigen receptor (H84T-CAR) that recognizes high-mannose (asparagine residue with five to nine mannoses). Here, we tested the efficacy of our novel H84T CAR in models of pancreatic ductal …

Emerging Challenges To Cellular Therapy Of Cancer, Premal D Lulla, Malcolm Brenner

Faculty, Staff and Students Publications

Cellular immunotherapy of cancer in the form of chimeric antigen receptor-modified T-cell therapy has become a standard treatment for lymphoid and more recently plasma cell malignancies. Although their successes in these cancers represent a breakthrough for adoptive cell therapy, there are several challenges to their continued growth in the field of cancer medicine. In this review, we discuss the progress made thus far toward achieving "off-the-shelf" accessibility of cell therapies that has the potential to greatly offset the costs associated with the current practice of making patient-specific products. We also review the innovations under investigation that attempt to make cellular …

Sphingolipids In Neurodegenerative Diseases, Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J Bellen

Faculty, Staff and Students Publications

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia (HSP), infantile neuroaxonal dystrophy (INAD), Friedreich’s ataxia (FRDA), as well as some forms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). Many of these diseases have been modeled in Drosophila melanogaster and are associated with elevated levels of ceramides. Similar changes have also been reported in vertebrate cells and mouse models. Here, we …

A Critical Evaluation Of Oral Baclofen In Pediatric Patients With Cerebral Palsy., Matthew J. Mclaughlin, Mark T. Fisher

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Burnout During The Covid-19 Pandemic: A Report On Pediatric Residents, Linessa M Zuniga, Abigail Schuh, Alan Schwartz, Patricia Seo-Mayer, Rachel Cramton, Kira Sieplinga, Ruchi Kaushik, Lauren Nassetta, Jason H Homme, Jessica Babal, John D Mahan, Maneesh Batra

Faculty, Staff and Students Publications

Background and objective: The Pediatric Resident Burnout and Resilience Consortium (PRB-RSC) has described the epidemiology of burnout in pediatric residents since 2016. We hypothesized burnout rates during the pandemic would increase. We explored resident burnout during the COVID-19 pandemic and its relationship to resident perception of workload, training, personal life, and local COVID burden.

Methods: Since 2016, PRB-RSC has sent an annual, confidential survey to over 30 pediatric and medicine-pediatrics residencies. In 2020 and 2021, seven questions were added to explore the relationship of COVID-19 and perceptions of workload, training, and personal life.

Results: In 2019, 46 programs participated, 22 …

Risk Stratification For Hepatocellular Cancer Among Patients With Cirrhosis Using A Hepatic Fat Polygenic Risk Score, Aaron P Thrift, Fasiha Kanwal, Yanhong Liu, Saira Khaderi, Amit G Singal, Jorge A Marrero, Nicole Loo, Sumeet K Asrani, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Spiridon Tsavachidis, Xiangjun Gu, Christopher I Amos, Hashem B El-Serag

Faculty, Staff and Students Publications

BACKGROUND: Polygenic risk scores (PRS) hold the promise to refine prognostication in hepatocellular cancer (HCC). The few available HCC PRS include germline risk variants identified among individuals of mostly European ancestry, but data are lacking on the transportability of these PRS in multiethnic U.S patients with cirrhosis from multiple etiologies.

METHODS: We used data from 1644 patients with cirrhosis enrolled in two prospective cohort studies in the U.S. Patients were followed until HCC diagnosis, death, liver transplantation, or last study visit through June 30, 2021. The high-risk variants in PNPLA3-MBOAT7-TM6SF2-GCKR were combined in a PRS and we evaluated its association …

Biting The Hand That Feeds: A Status-Based Model Of When And Why Receiving Help Motivates Social Undermining, Kenneth Tai, Katrina Jia Lin, Catherice K. Lam, Wu Liu

Research Collection Lee Kong Chian School Of Business

Social exchange theory suggests that after receiving help, people reciprocate by helping the original helpgiver. However, we propose that help recipients may respond negatively and harm the help giver when they perceive helping as a status threat and experience envy. Integrating the helping as status relations framework and the social functional perspective of envy, we examine when and why receiving help may prompt help recipients to undermine help givers. Across four studies, we find progressive support for our results, which show that when individuals receive task-related help from help givers who are perceived to be more, rather than less, competent …

Perspectives On The Mission, Value And Impact Of The Business School, Howard Thomas, Howard Thomas

Research Collection Lee Kong Chian School Of Business

The business school has been an important success story in the evolution of the modern university. Yet it is increasingly valued in that context “much more for its managerial expertise, cash generation ability and financial strength than its intellectual vigour and scholarship. Indeed … its legitimacy as a serious academic discipline is critically questioned by scholars in science, arts and the humanities” (Thomas, Lorange and Sheth, 2013, pp 52/3). Rakesh Khurana (2007) argues that business schools have become the ‘hired hands’ of business and have abandoned any pretence of fulfilling goals of developing a cadre of professional managers as proposed …

Understanding Human-Centred Artificial Intelligence In The Banking Sector, Krishnaraj Arul Obuchettiar, Alan @ Ali Madjelisi Megargel

Research Collection Lee Kong Chian School Of Business

The advent of smart digital devices and social media has shaped how consumers interact and transact with their financial institutions. Consumers increasingly want hyperpersonalised interactions that are more frequent and proactive, while financial institutions have a growing need to cater to consumers’ new demands. Financial institutions, such as banks, continuously adapt to the latest technologies to keep pace with evolving customer behaviours, needs, and experiences. One such emerging technology is artificial intelligence (AI). Many organisations realise the potential of AI; however, a human-centred AI system must be capable of understanding human characteristics and making decisions like humans. This paper presents …

Effect Of Air-Borne Abrasion Protocol On Micro-Tensile Bond Strength To Dentin Of Different Cad\ Cam Blocks (In-Vitro Study), Mohamed Fouad Haridy, Shereen Adel Gad, Radwa Nagy

Dentistry

No abstract provided.

Effect Of Overlay Material Type And Design On Fracture Resistance Of Mod Cavities In Molars.(In-Vitro Study), Mohamed Fouad Haridy, Shimaa Adel Gad, Sarah Adel Botros

Dentistry

No abstract provided.

Effect Of Different Surface Treatment Protocols On Micro-Tensile Bond Strength Of Cad/Cam Composite Blocks To Dentin, Mohamed Fouad Haridy, Ali Safwat, Shadwa Kabil

Dentistry

No abstract provided.

Effect Of Polishing Pressure And Surface Wetness On Surface Roughness Of Two Resin Composites Of Different Filler Types, Mohamed Fouad Haridy, Yara Habib Botros, Reham Salem, Khaled Aly Nour

Dentistry

No abstract provided.

Effect Of Different Digital Impression Techniques On The Trueness Of Post Space Scans With Fixed Cervical Diameter, Omar Elsergany

Dentistry

Objective: The aim of this study was to measure the trueness of post space impression by 2 digital impression techniques: Impression Scanning (IS) and Model Scanning (MS) with cervical diameter 3 millimeters. Materials and methods: Fourteen freshly extracted single rooted lower second premolars were endodontically treated using Wave-One single file technique. Then mounted in acrylic blocks parallel to long access using a dental surveyor 2mm above the CEJ, drills in sequence 1.4 and 1.6 millimeter then diamond stone with 3 millimeter diameter were used for teeth preparation with a standardized depth of 8mm. Teeth were scanned by reference scanner InEos5 …

Assessment Of The Effect Of Chin Augmentation With Hyaluronic Acid Filler On Facial Soft Tissues Using Lateral Cephalometric Radiograph, Noha Ibrahim Abdelrahman Professor, Islam Hassan Prof.

Dentistry

Aim: To assess the effect of chin augmentation using Hyaluronic acid filler on facial soft tissues using lateral cephalometric radiographs. Material and methods: Prospective case series. 10 adult female patients with mild chin deficiencies. Patients underwent chin augmentation using Restylane Defyne hyaluronic acid dermal filler. Each patient received 2ml Filler injected in the chin area. Lateral cephalometric radiographs were taken at three-time intervals for each patient. The first radiograph taken before augmentation procedure, second radiograph two weeks after filler injection and the third and final radiograph taken six months after the augmentation procedure. Two readings were used to assess the …

Evaluation Of The Effect Of Platelet-Rich Plasma Versus Platelet-Rich Fibrin On The Rate Of Tooth Movement Duringa Lignment Of Mandibular Anterior Crowding, Noha Ibrahim Abdelrahman Professor

Dentistry

Aim: To evaluate the efficiency of Platelet Rich Plasma vs. Platelet Rich Fibrin on overall leveling and alignment time of mandibular anterior crowding. Subjects and methods: Thirty-six females (18-25 years) with mandibular anterior crowding were randomly allocated into PRP, PRF, or control groups. The first molars on the right and left sides of the mandible were banded or bonded with Roth prescription tube. Mandibular teeth Second premolar to the second premolar were bonded using 0.022-inch pre-adjusted edgewise mini diamond brackets with Roth prescription. Immediately after bonding of the brackets, the initial wire used, the wire sequence was 0.014 Cu-Ni followed …

Deciphering The Salivary Microbiome In Crohn’S Disease Patients With Different Factors Contributing To Dysbiosis, Hala Elzayat

Theses

Crohn’s Disease (CD) is a chronic Inflammatory Bowel Disease (IBD), common in the UAE. Microbiota is necessary to maintain a balanced gut environment which is essential for good health. Dysbiosis can predispose to many diseases including CD. The oral cavity has the second largest and most diverse microbiota after the gut harboring over 700 species of bacteria. This study aims to investigate the alterations in the salivary microbiome in patients with CD compared to Healthy controls (HC). It also aims to compare CD patients for salivary microbiome complexity and diversity according to different factors that can contribute to dysbiosis, including …

Correlation Between Periodontal Disease And Covid-19: Systematic Review And Meta-Analysis, Dhihram Tenrisau, Mondastri K. Sudaryo, Erni Marlina, Nur R. Hasanuddin, Syafarudin Nur

Journal of Dentomaxillofacial Science

No abstract provided.

A Retrospective Institutional Study For Age Determination By The Root Length Of Mandibular Third Molar On Panoramic Radiograph In Deutero Malay Subject, Belly Sam, Ristaniah R. Effendy, Suhardjo Sitam, Ira Komara, Whildy A. Rifdah, Fahmi Oscandar

Journal of Dentomaxillofacial Science

No abstract provided.

Accuracy Of Mesiodistal Teeth And Dental Arch Width Measurement With Conventional Plaster And Digital Model Study, Zenia Adindaputri, Dyah Kurnia, Darmawan Sutantyo

Journal of Dentomaxillofacial Science

No abstract provided.

Risk Prevalence Of The Temporomandibular Disorder In Undergraduate Students Of Medicine Faculty, Mulawarman University, Indonesia, Imran Irsal, Nanda Pratiwi, Masyudi, Elliana Martalina, Portuna P. Kambaya, Alhawaris, Aziz Mohpul, Acing H. Mude

Journal of Dentomaxillofacial Science

No abstract provided.

Exploring Barriers To Oral Healthcare Experienced By Caregivers Living With Intellectual Disability: A Qualitative Study, Valendriyani Ningrum, Syamsiah Syam, Abu Bakar, Chung-Ming Liu

Journal of Dentomaxillofacial Science

No abstract provided.

Hydrophobicity Of The Biofunctionalized Scaffolds For Bone Tissue Engineering Application In Dentistry, Ridhayani Hatta, Beatriz Jc. Monteiro, Ilida O. Asencio

Journal of Dentomaxillofacial Science

No abstract provided.

Effect Of Local Anesthetic Lidocaine 2% With A Combination Of Adrenaline 1:80000 On Blood Sugar Levels Before And After Anesthesia Procedures At Department Of Oral And Maxillofacial Surgery, Faculty Of Dentistry, Universitas Sumatera Utara, Ahyar Riza, Ismi Anugrah

Journal of Dentomaxillofacial Science

No abstract provided.

Inhibition Of Cocoa Peel (Theobroma Cacao L.) Extract Gel On Growth Of Staphylococcus Aureus, Yani C. Rahayu, Ayu M. Prihanti, Tania P. Salsabila

Journal of Dentomaxillofacial Science

No abstract provided.

The Effect Of Immersing The Heat-Cured Acrylic Resin Plates Into Kitchen Vinegar And Star Fruit (Averrhoa Bilimbi Linn) Solution To Surface Roughness Base, Lenni Indriani, Rini I. Sitanya, Amelia Fitri

Journal of Dentomaxillofacial Science

No abstract provided.

Minimally Invasive Crown Lengthening With The Bone Reduction To Minimize Gingival Recession, Neira N. Sakinah, Shafira Kurnia

Journal of Dentomaxillofacial Science

No abstract provided.

The Effect Of Compression To Platelet Rich Fibrin Towards Fibroblast Proliferation Of Periodontal Ligament: An In Vitro Study, Vincensia M. Karina, Sri P. Lastianny, Soetomo Nawawi

Journal of Dentomaxillofacial Science

No abstract provided.