Digital Commons Network^™

3pnmf-Mkl: A Non-Negative Matrix Factorization-Based Multiple Kernel Learning Method For Multi-Modal Data Integration And Its Application To Gene Signature Detection\, Saurav Mallik, Anasua Sarkar, Sagnik Nath, Ujjwal Maulik, Supantha Das, Soumen Kumar Pati, Soumadip Ghosh, Zhongming Zhao

Faculty, Staff and Student Publications

In this current era, biomedical big data handling is a challenging task. Interestingly, the integration of multi-modal data, followed by significant feature mining (gene signature detection), becomes a daunting task. Remembering this, here, we proposed a novel framework, namely, three-factor penalized, non-negative matrix factorization-based multiple kernel learning with soft margin hinge loss (3PNMF-MKL) for multi-modal data integration, followed by gene signature detection. In brief, limma, employing the empirical Bayes statistics, was initially applied to each individual molecular profile, and the statistically significant features were extracted, which was followed by the three-factor penalized non-negative matrix factorization method used for data/matrix fusion …

Predictive Modeling Using Shape Statistics For Interpretable And Robust Quality Assurance Of Automated Contours In Radiation Treatment Planning, Zachary T Wooten, Cenji Yu, Laurence E Court, Christine B Peterson

Faculty, Staff and Student Publications

Deep learning methods for image segmentation and contouring are gaining prominence as an automated approach for delineating anatomical structures in medical images during radiation treatment planning. These contours are used to guide radiotherapy treatment planning, so it is important that contouring errors are flagged before they are used for planning. This creates a need for effective quality assurance methods to enable the clinical use of automated contours in radiotherapy. We propose a novel method for contour quality assurance that requires only shape features, making it independent of the platform used to obtain the images. Our method uses a random forest …

Grid Cells, Border Cells, And Discrete Complex Analysis, Yuri Dabaghian

Faculty, Staff and Student Publications

We propose a mechanism enabling the appearance of border cells-neurons firing at the boundaries of the navigated enclosures. The approach is based on the recent discovery of discrete complex analysis on a triangular lattice, which allows constructing discrete epitomes of complex-analytic functions and making use of their inherent ability to attain maximal values at the boundaries of generic lattice domains. As it turns out, certain elements of the discrete-complex framework readily appear in the oscillatory models of grid cells. We demonstrate that these models can extend further, producing cells that increase their activity toward the frontiers of the navigated environments. …

Pediatric Diarrhea Patients Living In Urban Areas Have A Higher Incidence Of Clostridioides Difficile Infection, Ayodele T Adesoji, Osaro Mgbere, Charles Darkoh

Faculty, Staff and Student Publications

Clostridioides difficile infection (CDI) is a major cause of antibiotic-associated diarrhea and an unappreciated contributor to child mortality in low- and middle-income countries where the diagnosis may be difficult. There is little information about the prevalence of CDI among infants, children, and adolescents in Africa. Using a cross-sectional design, seventy-six samples were collected from pediatric patients presenting with diarrhea, including infants (≤ 2 years old), children (2-12 years), and adolescents (13 ≤17 years) from three hospitals between January and December 2019. Demographic data, medical history, and prior antibiotic use were recorded. Toxigenic culture and PCR were used to detect and …

Population-Based Assessment Of The Burden Of Covid-19 Infection In African Countries: A First-Year Report Card And Public Health Implications, Osaro Mgbere, Ogbonna Collins Nwabuko, Olajumoke A Olateju, Omolola E Adepoju, Winston Liaw, Charles Darkoh, Ekere James Essien

Faculty, Staff and Student Publications

BACKGROUND: The COVID-19 pandemic constitutes a global health threat and poses a major burden on the African continent. We assessed the real-world burden of COVID-19 infection in African Union (AU) member states to determine the distributional patterns of epidemiological measures during the first 1 year of the pandemic.

METHODS: This retrospective cross-sectional study utilized COVID-19 data from publicly available data repositories of the African Center for Disease Control and Prevention and

RESULTS: A total of 3.21 million cases were reported during the 1-year period, with 2.6 million recoveries, 536,784 cases remaining active, and 77,486 deaths. Most countries (49.1%,

CONCLUSION: Understanding …

Evolutionary Aspects Of Infections: Inflammation And Sickness Behaviors, Robert Dantzer

Faculty, Staff and Student Publications

Sickness behavior was conceptualized initially as the behavioral counterpart of the fever response to infectious pathogens. It helps to raise body temperature to its higher setpoint and to maintain it at this new level and it has the additional benefit of enabling a weakened organism to protect itself from other dangers. The discovery of the behavioral effects of proinflammatory cytokines produced by activated immune cells provided a cellular and molecular basis to this phenomenon. The administration of cytokines or cytokine inducers like lipopolysaccharide to healthy rodents allowed to reveal the similarities and differences between inflammation-induced sickness behavior and the fever …

Inhibition Of Nox2 Or Nlrp3 Inflammasome Prevents Cardiac Remote Ischemic Preconditioning, Sandra Benavides, Rodrigo Palavecino, Jaime A Riquelme, Luis Montecinos, José Pablo Finkelstein, Paulina Donoso, Gina Sánchez

Faculty, Staff and Student Publications

Introduction: Short episodes of ischemia-reperfusion (IR) in the heart (classical ischemic preconditioning, IPC) or in a limb (remote ischemic preconditioning, RIPC) before a prolonged ischemic episode, reduce the size of the infarct. It is unknown whether IPC and RIPC share common mechanisms of protection. Animals KO for NOX2, a superoxide-producing enzyme, or KO for NLRP3, a protein component of inflammasome, are not protected by IPC. The aim of this study was to investigate if NOX2 or NLRP3 inflammasome are involved in the protection induced by RIPC. Methods: We preconditioned rats using 4 × 5 min periods of IR in the …

Endothelial Activation Impairs The Function Of Small Extracellular Vesicles, Nicolas Herrera-Zelada, Úrsula Zúñiga-Cuevas, Andrés Ramírez-Reyes, Ignacio Norambuena-Soto, Leslye Venegas-Zamora, Mayarling F Troncoso, Alejandra Hernández, Gina Sánchez, Zully Pedrozo, Sergio Lavandero, Jaime A Riquelme

Faculty, Staff and Student Publications

Small extracellular vesicles are nanosized vesicles (30-200 nm) that can ferry proteins, nucleic acids, and lipids between cells and therefore, have significant potential as biomarkers, drug delivery tools or therapeutic agents. SEVs of endothelial origin have been shown to -among other functions-reduce in vitro ischemia/reperfusion (I/R) injury in cardiomyocytes, but whether a pro-inflammatory state of the endothelium impairs the functionality of these SEVs remains to be elucidated. To test this, human umbilical vein endothelial cells cells were treated with TNF-α 10 ng/mL and the expression of the pro-inflammatory parameters VCAM-1, ICAM-1 and eNOS were determined by Western blot. SEVs were …

Targeting Mcl-1 Protein To Treat Cancer: Opportunities And Challenges, Shady I Tantawy, Natalia Timofeeva, Aloke Sarkar, Varsha Gandhi

Faculty, Staff and Student Publications

Evading apoptosis has been linked to tumor development and chemoresistance. One mechanism for this evasion is the overexpression of prosurvival B-cell lymphoma-2 (BCL-2) family proteins, which gives cancer cells a survival advantage. Mcl-1, a member of the BCL-2 family, is among the most frequently amplified genes in cancer. Targeting myeloid cell leukemia-1 (MCL-1) protein is a successful strategy to induce apoptosis and overcome tumor resistance to chemotherapy and targeted therapy. Various strategies to inhibit the antiapoptotic activity of MCL-1 protein, including transcription, translation, and the degradation of MCL-1 protein, have been tested. Neutralizing MCL-1's function by targeting its interactions …

Turning The Page On Breast Cancer In Ohio: Lessons Learned From Implementing A Multilevel Intervention To Reduce Breast Cancer Mortality Among Black Women, Tasleem J. Padamsee, Daniel G. Stover, Willi L. Tarver, Chasity M. Washington, Ryan D. Baltic, Cecilia R. Degraffinreid, Clarissa R.B. Whiting, Ruvarashe Rumano, Clara N. Lee, Timiya Nolan, Bridget Oppong, Samilia Obeng‐Gyasi, Amanda E. Toland, Brittany Bernardo, Heather Hampel, Electra D. Paskett

Faculty Publications

No abstract provided.

Preparedness Behavior And The Apocalypse: Religion And Politics In The Post 2020 Election Era, Jason Adkins, Paul Djupe, Jacob R. Neiheisel

Faculty Publications

No abstract provided.

An Analysis Of Protesting Activity And Trauma Through Mathematical And Statistical Models, Nancy Rodríguez, David White

Faculty Publications

No abstract provided.

College Transition Fall 2020 And 2021: Understanding The Relationship Of Covid-19 Experiences And Psychosocial Correlates With Anxiety And Depression, Andrea Lourie, Susan Kennedy, Erin J. Henshaw, Drexler James

Faculty Publications

Rates of mental health symptoms, particularly anxiety and depression, have increased significantly in college students in the past decade along with utilization of mental health resources. The COVID-19 pandemic created an additional source of stressors to an already challenging landscape of college transition. COVID-19 has been associated with an increase of anxiety among college students, particularly first year students, entering college in Fall 2020. The shifts in policy (e.g., federal, state, and college) accruing medical data, and vaccine availability between Fall 2020 and Fall 2021 provide an opportunity to examine the role of COVID-19 experiences in the transition to college …

Historical Records: Reissuing As Curatorial Practice In Harry Smith's Anthology Of American Folk Music, Dan Blim

Faculty Publications

No abstract provided.

Black Women's Relational Competencies And Ethical Leadership In The Workplace, S. Alease Ferguson, Toni C. King

Faculty Publications

Three qualitative case vignettes illustrate Black women leaders’ application of relational competencies to assert culturally informed ethical values in organizational life. Theoretical frameworks of Patricia Hill Collins’ (1994) theory of motherwork and Wilfred Bion’s (1991) psycho-dynamics theory of group development guide the analysis of Black women’s relational competencies. Methodologically, the data derive from the authors’ use of phenomenological review of over three decades of corporate and non-profit consultancies. This methodology entailed uncensored story genera- tion relative to the topic and culling of the story set guided by a rubric to screen for story features that exemplify group and relational competencies …

Survival In Common Snapping Turtles, Chelydra Serpentina (Testudines: Chelydridae), In Western Nebraska, John B. Iverson, Geoffrey R. Smith

Faculty Publications

Annual estimates of survival for Common Snapping Turtles (Chelydra serpentina) in western Nebraska USA were generated from mark-recapture data from nesting females encountered in 2005–2017. Our population models suggested no annual variation in either adult annual survival (0.947 ± 0.017 SE) or annual capture probability (0.294 ± 0.027 SE). However, there was a tendency toward higher survival in larger females. High annual survival (e.g. > 90%) characterises populations of Chelydra from Ontario to Texas.

Realms Unseen: Albinism And Epistemic Decoloniality In Tanzania, Jane L. Saffitz

Faculty Publications

No abstract provided.

Mundane Desires, Aileen Schretzmayer

Student Scholarship

No abstract provided.

The Language Of Riot: Examining The Legibility Of Unrest, Peter L. Macchiarulo

Student Scholarship

No abstract provided.

The Body: Human Remains And Gender Relationships Throughout Medieval Ireland, Danielle Norris

Student Scholarship

No abstract provided.

Neuralink Must Think: Elon Musk’S Questionable Treatment Of Animal Test Subjects, Caleb Rader

The Synapse: Intercollegiate science magazine

No abstract provided.

Your Brain On Meditation: Benefits Of Meditation For Spiritual & Physical Health, Ava Lausch

The Synapse: Intercollegiate science magazine

No abstract provided.

Bohemian Rat-Sod:Y Rats Can Bop To The Beat Like Humans, Andrea Nyugen

The Synapse: Intercollegiate science magazine

No abstract provided.

Did Trees Cause The Devonian Mass Extinction? Root Evolution And Hypoxia, Isabelle Small

The Synapse: Intercollegiate science magazine

No abstract provided.

Are Jellyfish Actually Apex Predators? The Potential Of A Jellyfish-Dominated Ocean Ecosystem, Jackie Brick

The Synapse: Intercollegiate science magazine

No abstract provided.

The Sounds Of The Deep Sea: Is There A Monster In Our Depths?, Tanisha Shende

The Synapse: Intercollegiate science magazine

No abstract provided.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

Strategies To Secure Water For Great Salt Lake, Lisa W. Welsh, Joanna Endter-Wada, Karin M. Kettenring

Environment and Society Faculty Publications

Great Salt Lake is the largest saline lake in the Western Hemisphere (Wilsey et al. 2017) and plays an important role in Utah’s economy, environment, and ecology (Baxter and Butler 2020; Great Salt Lake Advisory Committee 2021). It has a long history of commercial and recreational activities including mineral production, brine shrimp harvesting, waterfowl hunting, boating, and sightseeing (Utah Department of Natural Resources 2013a, 2013b). The Great Salt Lake ecosystem supports over 10 million birds representing 338 species and acts as an important stopover for migratory birds between North and South America (Great Salt Lake Ecosystem Program; Wilsey et al. …

The Impact Of The Covid-19 Pandemic On Employee Engagement And Performance In The Teleworking Context In The U.S. Public Sector: A Phenomenological Case Study, Elizabeth Nesuda

Human Resource Development Theses and Dissertations

The global shift to telework during the COVID-19 pandemic has redefined work environments and created challenges and opportunities for the public sector. This study addressed a significant gap in the existing literature by exploring the relationship between employee engagement and performance in the context of COVID-19. This study explores employee engagement and performance in teleworking environments within the federal public sector. This study adopted a phenomenological case study design focused on understanding the experiences of public sector employees who shifted to telework during the COVID-19 pandemic. Research and interview questions were developed to uncover employee engagement and performance experiences in …

Evaluating Healthcare Student Learning Performance During The Initial Year Of The Covid-19 Pandemic: A Case Study, Maria D. Garcia-Villarreal

Human Resource Development Theses and Dissertations

The COVID-19 pandemic caused a mass interruption to daily life lasting almost an entire academic year. Return to normalcy was hard won and phased over the following academic year. Neither time-period offered “traditional” learning experiences in academic institutions. The extent to which the operational shut-down affected academic institutions and their learners is just now beginning to be elucidated. Human resource development (HRD) is uniquely positioned to apply established and newly developed theories and applications to the study of this phenomenon. One particular case lends itself to observation. A major academic medical center launched a technology-driven state-of-the-art simulation education center mere …