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Locus Specific Endogenous Retroviral Expression Associated With Alzheimer's Disease, Tyson Dawson, Uzma Rentia, Jessie Sanford, Carlos Cruchaga, John S K Kauwe, Keith A Crandall

2020-Current year OA Pubs

INTRODUCTION: Human endogenous retroviruses (HERVs) are transcriptionally-active remnants of ancient retroviral infections that may play a role in Alzheimer's disease.

METHODS: We combined two, publicly available RNA-Seq datasets with a third, novel dataset for a total cohort of 103 patients with Alzheimer's disease and 45 healthy controls. We use telescope to perform HERV quantification for these samples and simultaneously perform gene expression analysis.

RESULTS: We identify differentially expressed genes and differentially expressed HERVs in Alzheimer's disease patients. Differentially expressed HERVs are scattered throughout the genome; many of them are members of the HERV-K superfamily. A number of HERVs are correlated …

Hierarchy, Race & Gender In Legal Scholarly Networks, Nicholson W. Price, Keerthana Nunna, Jonathan Tietz

Articles

A potent myth of legal academic scholarship is that it is mostly meritocratic and mostly solitary. Reality is more complicated. In this Article, we plumb the networks of knowledge co-production in legal academia by analyzing the star footnotes that appear at the beginning of most law review articles. Acknowledgments paint a rich picture of both the currency of scholarly credit and the relationships among scholars. Building on others’ prior work characterizing the potent impact of hierarchy, race, and gender in legal academia more generally, we examine the patterns of scholarly networks and probe the effects of those factors. The landscape …

The Early Years Of Congress’S Anti-Removal Power, Aaron Nielson, Christopher J. Walker

Articles

Judges and scholars have long debated whether the Constitution provides the President with a power to remove executive officials. The Constitution, however, undoubtedly gives Congress tools to discourage the President’s use of such power. Perhaps most notably, the Appointments Clause makes it more difficult for the President to remove principal officers—even those whose views are out of the step with the President’s—because the President cannot know whether the Senate will consent to a preferred replacement. This is an example of what we dub Congress’s anti-removal power: Even if the President can remove, a motivated Congress can discourage the President’s use …

Averaged Behavior Model Of Current-Mode Buck Converters For Transient Power Noise Analysis, Anfeng Huang, Jingdong Sun, Hongseok Kim, Zhenxue Xu, Shuai Jin, Songping Wu, Zhiping Yang, Kelvin Qiu, Jun Fan, Chulsoon Hwang

Electrical and Computer Engineering Faculty Research & Creative Works

Accurate Evaluation and Simulation of Power Noise is Critical in the Development of Modern Electronic Devices. However, the Widely Used Target Impedance Fails to Predict the Low-Frequency Noise Generated in a Device Due to the Existence of the Dc–dc Converter, Whose Output Impedance Can Change under Different Loading Conditions. a Physical Circuit Model is Then Desired to Replicate the Behavior of a Voltage Regulator Module, and the Average Technique is an Efficient Method to Estimate the Noise of a Pulse Width-Modulated (PWM) Converter. with the Emergence of Converters with Adaptive On-Time (AOT) Controllers, More Complex Averaging Methods Are Required, But …

Factors Affecting The Decision Making To Use Thai Traditional Medical Postpartum Care Services Among Pregnant And Postpartum Women In Bangkok, Thailand, Lunlalin Sirichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

After giving birth, there will be changes in the body during the postpartum period to return to the normal state as before pregnancy. Postpartum women often have common problems, such as lower back pain, breast engorgement, plugged milk ducts, mastitis, and not having enough breast milk. In Thai traditional medicine, there has been postpartum care for a long time. Thai traditional medicine postpartum care services, also referred to as Yu-Fai, can assist in easing postpartum discomfort. But at present, the number of people receiving postpartum care services with Thai traditional medicine is still low. Therefore, this study aimed to determine …

Effects Of Crypto Bear Market On Mental Health Of Pakistani Crypto Traders, Muhammad Umar Iftikhar

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: The proliferation of Cryptocurrency trading has introduced significant volatility and stress into the lives of investors. With the high-pressure environment of trading, especially during bear markets, traders are frequently subjected to intense emotional strain. The psychological impact of trading, including anxiety, depression, and stress, has emerged as a growing concern, particularly in rapidly adopting markets such as Pakistan. Objective: The aim of this study is to investigate the prevalence and implications of depression, anxiety, and stress among Pakistani crypto traders in the context of a crypto bear market. Methods: A cross-sectional study design was adopted to collect quantitative data …

Association Between Oral Health Behavior,Oral Hygiene Status, And Oral Health Status Among Primary School Children In Bangkok, Thailand : A Latent Class Analysis, Pemmika Intato

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oral health affects both the overall health and quality of life of children. Dental caries and gingivitis are one of the most common global oral health problems among school children, including those in Thailand. Both problems are diet- and behavioral-related diseases, with various risk factors contribute to dental caries and gingivitis. This study aims to classify the clusters of oral health status among primary school children in Bangkok, Thailand, and identify association between the identified classes, oral health behavior, and oral hygiene status. The study utilized secondary data from dental chart records in the School Oral Health Promotion Program, Department …

The Effectiveness Of Using Facebook And Instant Communications Application (Line) To Reduce Alcohol Consumption Of Alcohol Promoters And Entertainers (Pretty Or Pr) In Bangkok, Thailand, Paladd Sakulthanit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The deleterious health consequences associated with alcohol consumption, ranging from addiction and liver disease to accidents and mental health disorders, have been extensively documented. This study aimed to assess the efficacy of an educational program utilizing Facebook and Line platforms in mitigating alcohol consumption intentions among such workers in Bangkok. Utilizing a randomized controlled trial methodology, the study focused in Bangkok. A total of forty-four participants were allocated into either the intervention (n=22) or control (n=22) groups. The intervention group received health education sessions and live video broadcasts on Facebook, while the control group received standard care messages. Outcome measures …

Influencing Factors On Chinese Tourists’ Health Behavior Prevention Toward Post Covid-19 In Beijing, China, Sihang Li

Chulalongkorn University Theses and Dissertations (Chula ETD)

The global travel and tourism landscape has been profoundly impacted by the COVID-19 pandemic, requiring precautionary measures to keep travelers and local communities safe. In this context, it is of great significance to understand the factors that influence the adoption of healthy behavioral prevention among Chinese tourists. This study delves into the complex connections between risk perceptions, knowledge, attitudes, social norms, accessibility, communication, and cultural factors that influence mask-wearing behavior among tourists in China post-COVID-19. This study aims to identify the prevalence of preventive health behaviors among Chinese tourists during post-COVID-19 and investigate the association between influencing factors and tourists’ …

Association Between Related Factors And Communication Channels Among Women With Abortion Service At Private Clinics In Thailand, Xiao Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2021, abortion was officially permitted in Thailand. In the delivery of abortion services, communication channel is a key factor in assisting clients to access services. Research on clients' choices of communication channels is important for increasing clients' access to legal abortion services. This secondary data cross-sectional study aims to identify the association between factors related to communication channels among the clients who receive abortion services at The Planned Parenthood Association of Thailand (PPAT)’s clinic. The study samples covered 3,734 clients who get abortion service at PPAT’s clinic from February 2021 to December 2022. The researcher employed socio-demographic characteristic, …

Development Of Probiotic Fermented Beverage From Gac Fruit (Momordica Cochinchinensis) And Its Functional Properties On Gut Health, Marisa Marnpae

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study aimed to develop a probiotic beverage using gac fruit and assess its characteristics and functional properties related to gut health through probiotic lactic acid fermentation. Gac juice (GJ) at 5–10 g/100 g was fermented with Lactobacillus paracasei subsp. paracasei (L. CASEI 431®), and various aspects were explored, including probiotic viability, physicochemical properties, phytochemicals, antioxidant activity, functional properties, volatile flavor compounds, and sensory acceptability of fermented GJ (FGJ). The results indicated a decrease in pH and sugar content, alongside an increase in lactic acid, acetic acid, and probiotic viability, up to 108 CFU/mL, post-fermentation. Notably, FGJ, particularly at 10 …

Effects Of Mckenzie’S Neck Exercise On Pain, Craniovertebral Angle, Strength And Endurance Of Deep Neck Flexor Muscles, And Disability In Individuals With Chronic Neck Pain, Sawita Chaiyawijit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To compare the effectiveness of McKenzie’s neck exercise and cranio-cervical flexion (CCF) exercise on strength and endurance of deep neck flexor (DNF) muscles, pain, disability, and craniovertebral angle (CVA) in individuals with chronic neck pain. Methods: Forty individuals with chronic neck pain were randomly allocated to the McKenzie’s neck or CCF exercise group. Each group performed exercises at home daily. The strength and endurance of DNF muscles were measured at baseline, immediately after the first exercise session, and each week follow-up for six weeks. Average pain over the past week was measured at baseline and each week follow-up for …

Probiotic Beverage From Different Cultivars Of Pomelo Juices (Citrus Grandis (L.) Osbeck) Fermented With Lactobacillus Spp., Vernabelle Balmori

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pomelo fruit contains prebiotic and bioactive components which makes it a promising substrate for non-dairy probiotic beverages. The study investigated the potential of fermenting five pomelo cultivars with Lactobacillus paracasei for non-dairy probiotic beverages. Fermentation enhanced lactic acid bacteria (8.80–9.28 log CFU/ml), organic acids, polyphenols, flavonoids, and antioxidant activity, disrupting cholesterol micellization and inhibiting pancreatic lipase. Some cultivars showed improved volatile compounds and sensory scores post-fermentation. Tubtim Siam exhibited the highest functionality and health benefits based on principal component analysis and hierarchical clustering and was used for further analysis for beneficial effects. The in-vitro colonic fermentation of fermented and non-fermented …

A Comparison Of Crestal Bone Loss Between Healing Abutment And Customized Abutment; 6 Months Clinical Observation, Adison Jirasuwannakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Adison Jirasuwannakul : A Comparison of crestal bone loss between healing abutment and customized abutment ; 6 months clinical observation. Advisor: Associate Professor Pravej Serichetaphongse, D.D.S., M.S . Co-advisor: Asst. Prof. Wareerat Chengprapakorn,, D.D.S., Ph.D. Objective : To compare the effect on marginal bone loss between using healing abutment and customized abutment (Definite abutment). Material and method : Thirdtyfour patients who required a single posterior implant-supported prosthesis were randomly divided into two groups which were healing abutment group (Control group)and customized titanium abutment group(Test group). Patients received one dental implant between 4.0 and 5.0 mm. diameter (Dentium Superline, Dentium, Seoul, …

Comparison Of Removal Torques Among Different Abutments In Single Implant Crowns After Cyclic Loading: An In Vitro Study, Suppanut Jongsiri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To evaluate the effect of different restoration designs on the removal torque loss of implant-supported maxillary first premolar crowns after cyclic loading and to measure the impact of cyclic loading on removal torque. Materials and Methods: Thirty-two dental implants (4.0*10 mm), embedded in resin blocks and their abutments, were divided into 4 groups (n=8) based on restoration design: screwmentable group, 2 cement-retained groups: cemented with adhesive resin cement (Panavia V5) or provisional cement (RelyX Temp NE), and screw-retained one-piece titanium group. Monolithic zirconia crowns were fabricated and cemented in the first three groups. Their removal torques were recorded using …

The Alleviating Effects Of Epidermal Growth Factor On An In Vitro Oral Mucositis Model In The Presence Of Fusobacterium Nucleatum, Tien Thi Trieu Truong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: 5-fluorouracil (5-FU) is commonly used as a chemotherapy drug for head and neck cancers. However, it often produces an adverse cytotoxic effect on the oral epithelia leading to oral mucositis (OM) in cancer patients. Thus, reversing this cytotoxic effect locally with novel bioactive drugs or factors is necessary. This study aimed to investigate the rescue effect of Nicotiana benthamiana plant-derived epidermal growth factor (P-EGF) on human normal oral keratinocytes (NOKs) exposed to 5-FU-induced cytotoxicity in the presence of Fusobacterium nucleatum (Fn). Materials and Methods: Cytotoxicity and ATP-dependent proliferation and metabolism of NOK monolayer cultures were assessed after 48 hours …

Factors Influencing Mode Choice Selection And Intention Of Public Transport Users : A Comparative Study Between Thailand And Indonesia During Pandemic, Aditya Mahatidanar Hidayat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The COVID-19 pandemic significantly impacted public transportation, causing a substantial decline in bus passengers. In 2021, Bangkok witnessed a 40-60% reduction compared to normal conditions, while Jakarta experienced a staggering 76% decline compared to June 2019. This study aims to assess passengers' intentions to use buses during the pandemic and analyze factors influencing mode choice. Two methodologies were employed: the Structural Equation Model (SEM) to identify factors impacting transportation intentions and the Hybrid Choice Model (HCM) to understand mode choice influencers. Data collection occurred in Bangkok and Jakarta, targeting bus users at central transportation hubs, with 392 and 387 respondents. …

Techno-Economic Analysis And Intensification Of Biosurfactant Production From Palm Fatty Acid For Oil Recovery Enhancement, Chanapol Charoentanaworakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Currently, Biosurfactants are receiving the interest as a substitute for surfactants synthesized from petroleum products due to their biodegradability. Palm oil derivatives are one of the interesting candidates of biosurfactant production because of the superior properties of hydrocarbon structure in the range of C16-C18. Thus, this research studied the economic and environmental impact analysis of production processes, and adsorption and oil recovery performance for different anionic biosurfactants synthesized from palm oil derivatives, i.e. palm fatty acid distillate (PFAD). Moreover, the optimal design and essential operating condition of batch reactive distillation column were also studied to intensify the equilibrium limitation of …

Biomarkers Of Mild Cognitive Impairment With And Without Depression In The Elderly, Gallayaporn Nantachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Amnestic Mild Cognitive Impairment (aMCI) is the deterioration of cognitive function, where those with the amnestic subtype have memory decline and may conversion to Alzheimer’s disease. This study is both a systematic review and meta-analysis on 3.798 MCI individuals and 6.063 healthy controls and a case-control study. The case-control study included 121 MCI and normal volunteers aged 60-75. Collectively, the dissertation aimed to explore the relationship between biomarkers, psychological symptoms, and neuropsychological assessment in MCI. Descriptive statistics were used to describe the general data set, while meta-statistics were used to review biomarkers. The predictive relationship of various factors in MCI …

Accuracy Of 177lu Quantification For Dosimetry Calculation Using 12-Swiveling Czt Detectors Spect/Ct Camera, Panattha Damthongsen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Recently, the 12-cadmium zinc telluride (CZT) based digital detectors SPECT/CT system has been introduced for advanced technology in nuclear medicine instrument, which outperforms conventional cameras. Moreover, the voxel S value-based dosimetry is important and offers more accurate in personalized dosimetry treatment using targeted radionuclide therapy. This study aimed to determine the accuracy of 177Lu quantification through an IEC/NEMA phantom study and to evaluate total-body dosimetry in patients undergoing 177Lu therapy using 12-swiveling digital CZT detectors SPECT/CT camera. The NEMA/IEC body phantom inserted with six fillable spheres (10-, 13-, 17-, 22-, 28-, and 37-mm inner diameter), filled with 177Lu solution of …

Self-Medication In Children Population: A Systematic Review And Meta-Analysis, Aye Chan Nyein Thinn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Self-medication is defined by the World Health Organization (WHO) as the use of medicines to treat self-recognized symptoms or ailments without consulting a physician. Self-medication practice was found among children either self-practice or with caregiver assistance. This study aimed to assess the prevalence and patterns of self-medication practice in children. This study utilized systematic review and meta-analysis by searching papers published during 2013 to 2022 in PubMed, ScienceDirect, Scopus, and Embase. The two sets of keywords “children” and “self-medication” or “non-prescription” were used. It was found that 4,333 articles were retrieved. After inclusion-exclusion screening, 83 articles were included in the …

Identification Of Active Region Of Colicin N Translocating Domain Involved In Its Antibacterial Activity, Wanassanan Lampromkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colicins are bacteriocins produced by Escherichia coli (E. coli) and toxified themselves. In general, colicins comprise three domains, including the N-terminal domain or translocation (T) domain, the Receptor binding (R) domain, and the Cytotoxic (C) domain. The combination of these domains produces different types and activities of colicin. Colicin N is the smallest colicin and functioned in pore-formation by the C-domain on the E. coli membrane. The antimicrobial activity is regulated by the specific binding between OmpF and TolA (as receptor and translocator) at region OBS (OmpF binding site) and TABs (TolA binding site), respectively. They are then inserting the …

Characteristics And Color Varieties Of Spinels From Main Deposits, Boonyapak Aksorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigates the characteristics and color variations of spinels from main deposits, including Liolava in Madagascar, Tunduru in Tanzania, Mogok in Myanmar, and three deposits in Vietnam (Minh Tien, Lang Chap, and An Phu). These spinel samples are categorized into four color varieties, i.e., red, orange, blue, and purple. All samples yielded the common properties of spinels. In addition, most red and orange spinels display strong red fluorescence under long wave ultraviolet (LWUV) and short wave ultraviolet (SWUV) lamps, however, some orange spinels exhibit non-fluorescence to red fluorescence under SWUV lamps. Blue spinel displays non-fluorescence under LWUV and SWUV …

Development Of Electrochemical Biosensor For Detection Of Thyroid–Stimulating Hormone, Kittirat Kitticharoenwiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation focused on the development of electrochemical paper-based immunosensor for determining thyroid-stimulating hormone (TSH) using a label-free immunoassay. Thyroid-stimulating hormone is a pituitary hormone that stimulates the thyroid gland to produce thyroid hormones for the body’s metabolism. The current electrochemiluminescence method for determining TSH as a specific biomarker indicating congenital hypothyroidism (CHT) onset is unfortunately restricted to laboratory settings, thereby resulting in limited practical utilization, delayed diagnosis, and severe outcomes. Herein, we proposed a simple, rapid, portable, and sensitive electrochemical biosensor with a label-free format based on bovine serum albumin (BSA)/graphene oxide (GO) nanocomposite for TSH determination. Caboxylated GO …

Bamboo Biochar For Bar Adsorptive Microextraction Of Parabens In Water, Maytinee Jantorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this research, bamboo biochar bar was prepared in the form of small-sized rods using starch as a binder and applied as a sorbent in bar adsorptive microextraction (BAµE) of parabens (methyl paraben, ethyl paraben, propyl paraben and butyl paraben) in water. The mixture of bamboo biochar which has a size of 60-80 mesh, a surface area of 102.6 m²g-1 and a pore size of 0.7 nm and starch in a weight ratio of 1:13 gave the good mechanical stability and high removal efficiency of parabens. When applied the bamboo biochar bar as a sorbent, the optimum conditions for BAµE …

Selective Photodegradation Of Food Contaminants Using Titania-Silica-Iron Oxide Nanocomposites With Molecularly Imprinted Technology, Mehak Un Nisa

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, magnetic imprinted photocatalysts (Fe3O4@SiO2@TiO2@MIP and Fe3O4@SiO2@MIP@TiO2) have been synthesized successfully by surface molecular imprinting technique. 5,7-dimethoxy-coumarin was used as a dummy template to give specific recognition ability to AFB1. A range of analytical techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), vibrating sample magnetometer (VSM), and Branauer-Emmett-Teller (BET) were employed to study the crystal structure, morphology, and chemical composition of the nanocomposites. The HPLC-DAD was used to quantify the photodegradation efficiency of imprinted photocatalysts under different factors such as the source of irradiation light, initial concentration of analyte, amount of photocatalyst, and …

Pea Protein Isolate As Emulsifier In Oil-In-Water Emulsion Model System, Mujahid Hassan Khan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Plant protein has been progressively demanded as a new-trend, healthier-choice and bioeconomic ingredient. However, the fundamental and technical knowledge of plant-based protein to understand and improve their structural functions are limited. In this study, pea protein isolate (PPI) were selected to be evaluated its emulsifying role on the formation, stability and tribology of model oil-in-water emulsions. Since PPI is a functional ingredient with hypoallergenic property. Firstly, the emulsifying property of PPI were investigated with corn oil-in-water emulsion systems. The results showed that 1% w/v PPI could stabilize the emulsion system of 5% w/v corn oil at pH7 using the high …

Crosslinking Enhancement Of Natural Rubber By Electron Beam, Mili Purbaya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vulcanization is a crucial process that transforms raw rubber into a durable and useful material. During vulcanization, crosslinking points are created between rubber molecules, which convert them into a thermosetting substance. The conventional vulcanization method is carried out by the addition of some chemicals accompanied by the application of thermal energy. This study explored the possibility of using electron beam irradiation which is an environmentally friendly and short-time method for vulcanizing natural rubber. The research was divided into two parts. In the first part, the efficacy of electron beam vulcanization was compared to that of thermal vulcanization. Natural rubber containing …

Cellulose Nanofiber/Poly(Acrylic Acid)-Based Hydrogel For Colorimetric Biomarker Sensors, Nichaphat Passornraprasit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This dissertation develops innovative CNF/PAA hydrogel-based colorimetric sensors for non-invasive biomarker detection, focusing on urea for chronic kidney disease (CKD) and sarcosine for prostate cancer (PCa). Hydrogels serve as a matrix for enzyme and indicator encapsulation due to their high absorption capacity and unique three-dimensional network, with CNF enhancing mechanical properties. The research is divided into two parts. Part I involves preparing a GO/CNF/PAA hydrogel via non-toxic radiation crosslinking, featuring high swelling capacity and enhanced laser absorptivity due to GO. This hydrogel, used as a patch for on-skin detection, shows vivid color changes to distinguish CKD patients from healthy individuals, …

Polyaniline/Cellulose Nanofiber/Polyvinyl Alcohol Hydrogel-Modified Screen-Printed Graphene Electrode For Cd2+ And Ni2+ Detection, Pichapon Boonkrong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Heavy metal contamination in wastewater has been an environmental issue, so the determination of heavy metals by an accurate and simple method is important. In this work, polyaniline/cellulose nanofiber/polyvinyl alcohol hydrogel-modified screen-printed graphene electrode (PANI/CNF/PVA hydrogel-modified SPGE) was fabricated by combining the advantages of graphene and conductive hydrogel to increase the conductivity and preconcentrate the metal ions to fabricate the modified electrode for the simultaneous detection of Cd2+ and Ni2+. First, PANI/CNF nanocomposite was synthesized by in situ chemical polymerization, and CNF was shown to prevented PANI aggregation and provided sufficient porous structure on the modified electrode. The PANI/CNF nanocomposite …