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Advancing The Care Of Individuals With Cancer Through Innovation & Technology: Proceedings From The Cardiology Oncology Innovation Summit 2020 And 2021, Peter Mcgranaghan

All Publications

As cancer therapies increase in effectiveness and patients' life expectancies improve, balancing oncologic efficacy while reducing acute and long-term cardiovascular toxicities has become of paramount importance. To address this pressing need, the Cardiology Oncology Innovation Network (COIN) was formed to bring together domain experts with the overarching goal of collaboratively investigating, applying, and educating widely on various forms of innovation to improve the quality of life and cardiovascular healthcare of patients undergoing and surviving cancer therapies. The COIN mission pillars of innovation, collaboration, and education have been implemented with cross-collaboration among academic institutions, private and public establishments, and industry and …

Late-Onset Stiff-Person Syndrome: Challenges In Diagnosis And Management, Marinos Dalakas, Jessica Yi

Department of Neurology Faculty Papers

BACKGROUND: Stiff person syndrome (SPS) is a rare slowly progressive autoimmune neuronal hyperexcitability disease with very-high GAD-65 antibody titers that most commonly presents above the age of 20, with muscle stiffness, painful muscle spasms, slow gait, and falls leading to disability. In other autoimmune disorders, late-onset disease has different symptom-spectrum and outcomes, but there is no information regarding late-onset SPS (LOSPS).

OBJECTIVE: Highlight delayed diagnosis and poor tolerance or incomplete response to therapies of patients with LOSPS and outline how best to increase disease awareness early at onset.

DESIGN A RETROSPECTIVE CHART REVIEWMETHODS: We reviewed GAD-positive SPS patients with symptom …

Zirconia Implants: A Mapping Review, Steven J. Sadowsky

Pacific Faculty Work

The advent of zirconia ceramics with excellent mechanical, biomechanical, and optical properties has made them attractive metal-free substitutes for titanium implants. Both animal and human studies have documented shortcomings with titanium implants. A mapping review of the current literature on three iterations of zirconia implant designs has been challenging due to heterogeneous success data and limited follow-up. Zirconia implants hold promise for a new generation of dental implants, but technical developments are needed for design and material enhancements that will need to be validated by long-term rigorous studies.

The 2023 Orthopedic Research Society's International Consensus Meeting On Musculoskeletal Infection: Summary From The In Vitro Section, Noreen J. Hickok, Bingyun Li, Ebru Oral, Sebastian A.J. Zaat, David A. Armbruster, Gerald J. Atkins, Antonia F. Chen, Débora C. Coraça-Huber, Tianhong Dai, Edward M. Greenfield, Rajendra Kasinath, Matthew Libera, Cláudia N.H. Marques, T. Fintan Moriarty, K. Scott Phillips, Kapil Raghuraman, Dacheng Ren, Lia Rimondini, Kordo Saeed, Thomas P. Schaer, Edward M. Schwarz, Christopher Spiegel, Paul Stoodley, Vi Khanh Truong, Shao-Ting Jerry Tsang, Britt Wildemann, Anja R. Zelmer, Annelies S. Zinkernagel

Department of Orthopaedic Surgery Faculty Papers

Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of …

Advances In Research On Active Faults And Exploration Of Relevant Frontier Scientific Problems, Xu Xiwei, Li Feng, Cheng Jia, Liu Baojin, Chen Guihua, Li Kang, Ren Junjie, Jia Qichao

Coal Geology & Exploration

This study reviewed the approval and initiation processes and major research contents of China's active fault-related projects, such as the urban active fault survey projects, large-scale mapping programs of active faults, and the earthquake hazard assessment of active faults in key earthquake monitoring and prevention areas. By combining the scientific investigation results of the surface rupture zones induced by strong earthquakes over the past 20 years, this study elaborated on significant advances achieved in the following aspects: the survey and positioning techniques for concealed active faults under strong-noise and weak-signal conditions, the quantitative identification techniques for fault activity, theories and …

Optimization Of Data Acquisition Parameters For Deep Seismic Reflection Surveys In Complex Terrain, Yan Yunxiang, Li Pei, Zhi Min, Liu Jianda, Wang Zichen, Zhang Ying, Pei Gendi, Li Linyuan, Mou Qi, Jia Jin

Coal Geology & Exploration

Fujian, located in the orogen region of the coastal areas of southeast China, exhibits well-developed structures and complex surface conditions, which make deep seismic reflection surveys challenging. In response to the diversity and complexity of seismogeological conditions in Fujian, this study optimized the seismic excitation means based on previous deep seismic surveys. Specifically, the combination of large, medium, and small guns was transitioned into the layout of normal guns (spacing of shot points: 600 m) and large shots (spacing of shot points: 15 km), leading to enhanced folds of large shots. Through simulation analysis, this study calculated the spacing of …

Mechanical Behavior And Failure Response Characteristics Of Hard Sandstones Considering Bedding Dip Angles, Song Zhanping, Liu Hongke, Zheng Fang, Cheng Yun, Sun Yinhao, Song Wanxue

Coal Geology & Exploration

This study focuses on the mechanical behavior and failure responses of hard sandstones considering bedding dip angles. Through uniaxial compression tests of hard sandstones with different bedding dip angles, this study delved into the influence of bedding dip angles on the mechanical behavior of hard sandstones and the relationship between the bedding dip angles and fractal characteristics of hard sandstone fragments. The test results show that bedding dip angles produced negligible effects on the type of the stress-strain curves of hard sandstones. However, low dip angles (0°, 22.5°, and 45°) corresponded to unimodal curves, while high dip angles (67.5° and …

Comparison Of Edta And Boric Acid Irrigation In Terms Of Root Canal Dentin Microhardness And Sealer Penetration Depth, Selen İnce Yusufoğlu, Esma Saricam, Neslihan Bulak, Mustafa Güngörmüs, Fatih Tulumbacı, Suat Özcan

Journal of Dentistry Indonesia

Chemo mechanical preparation is one of the important stages for successful endodontic treatment, and Boric acid has been proposed as an alternative irrigation solution for root canal treatment. Objective: The purpose of this study was to evaluate the effect of irrigation with boric acid (BA) and EDTA on the mineral content and microhardness of dentin and penetration of the AH Plus root canal sealer. Methods: 63 single-rooted teeth were instrumented. Microhardness analysis, 45 teeth were cut longitudinally and then transversely to obtain dentin. Pre- and post-treatment microhardness values were measured. The samples were randomly assigned into 3 groups …

Management Of Ankyloglossia In A Non-Syndromic Patient Using A Super Pulsed Laser: A Life-Changing Treatment- A Case Report, Urfi Jawed, Afaf Zia, Ramniwas Kumawat, Afshan Bey, Maahin Mahmood

Journal of Dentistry Indonesia

Objective: Ankyloglossia affects a person’s overall well-being and life, from malnutrition due to poor feeding and mechanical problems to psychological stress and low self-esteem, thus affecting social life. This case reports the use of non-scalpel techniques, such as a super pulsed laser, to manage ankyloglossia in a non-syndromic patient suffering from speech incompetence and restricted tongue mobility and highlights its advantages over other conventional techniques. Case Report: A 17-year-old male patient presented with a complaint of restricted tongue mobility, due to which he could not pronounce certain words clearly. As the patient was apprehensive about the use of …

Prevalence And Clinical Characteristics Of Temporomandibular Disorders In Adults: An Epidemiological Study In The Mediterranean Region Of Türkiye, Esra Yavuz, Selmi Yardimci, Humeyra Tercanli

Journal of Dentistry Indonesia

The prevalence and clinical characteristics of temporomandibular disorders (TMD) in the Mediterranean region of Türkiye have not yet been thoroughly investigated. Objective: This study aimed to determine the prevalence and severity of TMD in a sample of the population in this region and to characterize the clinical findings related to TMD. Methods: Four hundred and one participants were included in this study. “Presence of TMD” in the participants was evaluated using the Fonseca Anamnestic Index. Through clinical examination, the findings in the participants were classified as limited mouth opening, deviation, temporomandibular joint (TMJ) sounds, TMJ pain, and muscle …

Case Report And X-Ray Microtomography And Scanning Electron Microscopy Analysis Of Teeth With Hypocalcified Amelogenesis Imperfecta, Rodrigo W. Marinoni, Thiago G. Silva, Leonardo S. Benato, Anelize M B Rumbelsperger, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Amelogenesis imperfecta (AI) is a genetic disease characterized by producing morphological and structural changes in tooth enamel. Objective: To highlight the morphological changes observed in teeth with hypocalcified AI based on scanning electron microscopy and microtomography analysis. Case report: An adult male had teeth seriously compromised by hypocalcified AI. The treatment plan involved removal of third molars followed by restorative and prosthetic treatment. After extraction, the teeth were analyzed by SEM and X-ray microtomography (microCT). Teeth with AI revealed the presence of microfractures arranged from the outer surface to the center of the enamel. Microfractures had a cracked or “cracked …

Surface Roughness Of Restorative Materials After Simulated Toothbrushing With Toothpastes Containing Theobromine And Arginine: An In Vitro Study, Fikri Öcal, Burak Dayi, Zeynep Küçükakçalı

Journal of Dentistry Indonesia

Objective: This study examined the effect of toothpastes containing theobromine and arginine on the roughness changes of microhybrid composite, nanohybrid composite, and giomer restorative materials. Methods: A total of 90 disc-shaped specimens were prepared using microhybrid composite (Arabesk-Ara), nanohybrid composite (Herculite-Her), and giomer (Beautifil II-Gio). The samples were divided into 3 subgroups (n = 10), and initial surface roughness was evaluated with a mechanical profilometer and scanning electron microscopy (SEM). All samples were then subjected to a 1-year brushing simulation via a toothbrushing simulator using toothpastes containing theobromine (Theodent Classic, Theodent) or arginine (Colgate PRO-Relief, Colgate Palmolive); a …

Comparison And Assessment Of Design, Handling Characteristics, And Efficacy Of Hand Instruments In Calculus Removal, Mohan Kumar Pasupuleti, Krishna Ganesh, Gautami S Penmetsa, Boddeda Anusha, Haripriya Narukurthi, Kommina Mouna Sahith

Journal of Dentistry Indonesia

Objective: primary objective of periodontal therapy is to remove supra and subgingival deposits from the tooth surface to stop disease progression. The purpose of the study is to address the instrument selection and its efficacy in calculus removal. Methods: A total of 50 subjects who fulfilled the criteria were included in the study. Participants were subjected to a complete periodontal examination, and the responses from 50 dental house surgeons were compared based on the instrument design, handling characteristics, and efficacy of calculus removal by using two sets of instruments. Results: The LM instrument was rated as best …

Factors Affecting The Preference Of Orthodontic Appliances Among Undergraduate Students In West Jakarta, Joko Kusnoto, Lia H. Andayani, Budi Kusnoto

Journal of Dentistry Indonesia

Malocclusion’s negative impact is not only limited to dentofacial appearance but also related to quality of life. Nowadays, orthodontic treatment can be done using conventional fixed appliances, or removable appliances called clear aligners. The preference for orthodontic appliances can be affected by several factors, including patient characteristics, self-perception, psychosocial, and oral-disorder factors. Objective: This study aims to evaluate the factors affecting the preference for orthodontic appliances among undergraduate students in West Jakarta. Methods: In this cross-sectional study, 244 undergraduate students were retrieved by purposive sampling from 7 universities located in West Jakarta. A self-administered questionnaire was used to …

Elastic Recovery Properties Of Alginate Impression Materials Based On Red Algae Kappaphycus Alvarezii, Didin Erma Indahyani, Izzata Barid, Nafisah Nafisah, Depi Praharani, Agus Sumono, Niken Probosari, Sulistiyani Sulistiyani

Journal of Dentistry Indonesia

Alginate impression materials in dentistry are used to form details of the oral cavity organs. The alginate content in the impression material functions to form a gel. One source of alginate is algae. Objective: This study aims to determine the recovery elasticity and setting time of alginate impression materials made from red algae K. alvarezii. Methods: The sodium alginate in the composition of this alginate impression material was extracted from red algae K. alvarezii. The alginate impression material was tested for setting time and recovery elasticity and compared with commercial impression material (Hygedent®). Results: The elastic …

Critical Links And Development Trends Of Research On Active Tectonics, Yuan Daoyang, Wang Youlin, Li Shuwu, Wang Wanhe, Li Linyuan, Zou Xiaobo, Wen Yameng

Coal Geology & Exploration

Following a brief introduction of the general characteristics of active tectonics in China, this study analyzed two new features of large earthquakes with M_s ≥ 7 that have struck continental China since the beginning of the 21st century: (1) Large earthquakes occur primarily in clusters along the boundary fault zone of the Bayanhar active tectonic block—part of the Qinghai-Tibet ateau active tectonic block. (2) Reverse fault-fold earthquakes have occurred multiple times within active basins or at basin-mountain boundaries. In response to the new seismic activity features and the new demand for disaster prevention and mitigation of engineering construction and …

New Evidence For Holocene Activity Of The Northern Segment Of The Puqian-Qinglan Fault In Northern Hainan Province, Liu Huaguo, Li Feng, Jia Qichao, Wang Zhicheng, Zhang Pan, Lin Zhen, Zhang Jiehan, Shi Chunhua, Zhang Yanbo, Jia Wei, Li Changlong

Coal Geology & Exploration

The Puqian-Qinglan fault, located in northern Hainan Province, is closely related to the judgment of the seismogenic structure of the Qiongshan M7½ earthquake in 1605. To accurately determine the latest activity characteristics of this fault, this study, adopting artificial shallow seismic exploration with large-tonnage seismic sources combined with small-spacing cross-well stratigraphic correlation, investigated the sedimentary geological conditions of the Quaternary basalt cover and significantly thick marine sand layers in northern Hainan Province through exploration at Qishantou and Dongzhai villages in the Sanjiang Town, Jiangdong New Area, Haikou. Key results are as follows: (1) the Puqian-Qinglan fault dislocates multiple marker …

Activity Of The Liyang-Nandu Fault In Southern Jiangsu, Zhang Shuo, Zhang Ping, Chen Huogen, Xu Shugang, Gong Xulong, Xu Hangang, Li Limei, Feng Wenli, He Zongnan

Coal Geology & Exploration

Located in the central part of the Sunan Modernization Construction Demonstration Area—one of the areas with the densest population and urban areas and the most developed economy in China, the Liyang-Nandu fault is an important concealed fault with a nearly E-W strike in the Yangtze River Delta in eastern China. This fault serves as an important regional geomorphic and neotectonic boundary. However, there is a lack of systematic research on this fault, and its latest activity era is yet to be ascertained. Using seismic exploration P-waves and S-waves and cross-well stratigraphic correlation, this study investigated the spatial distribution and Quaternary …

Application Of High-Precision Lidar Technology In Research On Active Fault-Induced Offset Geomorphic Features - A Case Study Of The Juxian-Tancheng Segment Of The Yishu Fault Zone, Yang Bin, Wang Hualin, Wu Hongbin, Ge Fugang, Zou Hao, Su Sili

Coal Geology & Exploration

The Tancheng-Lujiang fault zone (also referred to as the TanLu fault zone), one of the most significant large-scale active faults in eastern China, has great seismogenic potential while passing through several cities with the activities and accumulation of human beings. To investigate the geometric distribution and activity characteristics of the TanLu fault zone, this study focused on the Juxian-Tancheng segment of the Yishu fault zone—a part of the TanLu fault zone. Given the vegetation coverage in eastern China, airborne light detection and ranging (LiDAR) and terrestrial laser scanning were employed to collect high-precision topographic data of the Zuoshan (Yibujian), Zhonghuashan, …

Table Of Contents, The Editors

Coal Geology & Exploration

No abstract provided.

Theory And Application Of Setback Distance From Active Faults, Wei Leiming, Xu Xiwei, Li Feng, Cao Jun, Ren Junjie, Cheng Jia, Zhang Xianbing, Jia Qichao, Chen Guihua, Wu Xiyan

Coal Geology & Exploration

Determining setbacks from active faults is the “last 1 km” from active fault surveys to their application to seismic disaster mitigation. It is also a technique for blocking the risk sources of earthquake-induced chains of geologic hazards. Field investigations and experimental studies have demonstrated that buildings and structures can be free from catastrophic destruction caused by coseismic ruptures and offset of active faults provided they are kept at a certain finite distance from the active fault traces. Therefore, determining setbacks from active faults serves as an ultimate goal of the surveys and precise localization of active faults. Based on the …

Revealing The Upper Crustal Structure In The Fujian Region Using Deep Seismic Profiling, Li Pei, Ren Congrong, Li Haiyan, Wang Shanxiong

Coal Geology & Exploration

The Fujian region, located along the southeastern margin of the Chinese continent, constitutes an active tectonic belt along the coastal area in southeast China, with complex formation and evolution histories. To understand the characteristics of upper crustal structures and basement structures in the Fujian, this study collected the Pg travel time data from four NE-trending deep seismic sounding (DSS) survey lines in the region. Employing finite-difference tomography, this study obtained the fine-scale velocity structure of the upper crust along the four profiles, revealing the lateral variations in the upper crustal velocity structure, basement structures, and shallow fault characteristics in the …

Analogue Modeling Of Love-Type Channel Waves And Their Response To Faults, Liu Qiang, Hu Jiwu, Wang Pan, Shi Xianxin, Jia Qian

Coal Geology & Exploration

Owing to its high resolution and low energy attenuation, channel wave-based seismic exploration has been widely applied in the geophysical prospecting of hidden disaster-causing factors in underground coal mines. However, its accuracy fails to meet the requirements of intelligent mine mining presently. At present, the analogue modeling of channel waves mostly focuses on Rayleigh-type channel waves using 2D models, leading to a lack of research on Love-type channel waves. To explore the propagation law of Love-type channel waves, this study investigated the waves in the 3D analogue modeling of channel waves. Firstly, the wave and particle vibration characteristics of Love-type …

Multipoint Sources-Based High-Resolution Electrical Detection Of The Water-Rich Areas Near Mining Faces Of Coal Mine Roadways, Wu Rongxin, Xu Hui

Coal Geology & Exploration

To accurately explore the spatial distribution of water-rich areas near mining faces of mine roadways, this study proposed a multipoint sources-based high-resolution electrical detection technology. A multi-channel electrode observation system was arranged behind a roadway mining face, with electrodes at a distance of 1/4 measuring lines behind the mining face as point source electrodes sequentially. Data were collected using a monopole-dipole device, with the obtained apparent resistivity considered the sounding data of multipoint sources-based electrical detection. The images of multipoint sources-based electrical sounding allow for quickly determining the presence of water-rich areas and their locations relative to the mining faces …

Coal-Based Solid Waste From The Panyi Mine In The Huainan Mining Area: Fine-Scale Chemical Structure And Ecological Risk Assessment Of Heavy Metals, Yin Wenwen, Zhang Liqun, Ding Dan, Shan Shifeng, Chen Yongchun, An Shikai, Zheng Liugen

Coal Geology & Exploration

The utilization of clean coal-based solid waste is a pressing issue in the ecological construction of mining areas. To address this issue, the key is to ascertain the structures and morphology of heavy metals in coal-based solid waste. This study investigated the coal gangue and fly ash samples from the Panyi Mine in the Huainan mining area, Anhui Province. First, this study characterized the coal-based solid waste using microanalysis methods, such as X-ray fluorescence spectrometry (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR). Then, it examined the fine-scale chemical structure and heavy metal dissemination …

Current States , Prediction And Prevention Suggestions For Water Hazard Accidents In China’S Coal Mines, Sun Wenjie, Li Wenjie, Ning Dianyan, Ren Lingfeng

Coal Geology & Exploration

At present, the pattern of coal resource development in China has changed, but the water hazard accidents that restrict the safety production of coal mine still occur from time to time. In order to explore the characteristics and laws of water hazard accidents in coal mines in China and scientifically study and judge the evolution trend of water hazard accidents, study was performed in terms of the year, region, accident level and influencing factors of water hazard accidents, with the nationwide water hazard accidents from 2001 to 2022 as the statistical objects. Meanwhile, the Long Short-Term Memory (LSTM) model was …

Surface-Modified Pd/Ceo2 Single-Atom Catalyst Shows Increased Activity For Suzuki Cross-Coupling, Audrey Vice, Nicholas Langer, Benjamin J. Reinhart, Ofer Kedem

Chemistry Faculty Research and Publications

Single-atom catalysts (SACs) comprise catalytically active atoms dispersed on supports; they combine the high activity and site uniformity of homogeneous catalysts with the ease of separability of heterogeneous catalysts. However, SACs lack fine control over the active site, provided by ligands in homogeneous catalysts. In this work, we demonstrate that modification of the support with an organic monolayer is a viable approach to improving the catalytic performance. The addition of catechol-type monolayers to a Pd/CeO2 SAC increases its catalytic activity for Suzuki cross-coupling, a central reaction in the synthesis of fine chemicals and pharmaceuticals. Kinetic trials reveal that the coating …

Multi-Layer Strip Ionization Chamber For Proton Quality Assurance And Imaging, Shuang Zhou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Proton therapy is the most advanced radiation treatment modality. Proton treatment is delivered via pencil beam scanning (PBS) technique, in which a pencil beam scans the target spot-by-spot and layer-by-layer. An effective quality assurance (QA) device is needed to verify the quality of treatment dose delivery. Current clinical practice employs films or a two-dimensional (2D) detector to measure the dose at one or a few arbitrarily selected depths, which is insensitive to delivery error and time-consuming. A 3D dosimeter that can measure the 3D dose distribution is needed to improve the effectiveness and efficiency of proton QA. Furthermore, preclinical studies …

Exploration Of The Tumorigenic, Metabolic, And Cognitive Consequences Of Tau Protein Removal, Jennifer M. Erichsen, Valentina R. Garbarino, Anna Rodriguez, Jillian K. Lee, Justin C. Shayne, Timothy C. Orr, Miranda E. Orr

School of Medicine Publications

Background: Tau accumulation causes tauopathies and drives cellular senescence, which can lead to inflammation, neurodegeneration, and cognitive impairment. The association between intracellular tau deposition and pathogenesis has prompted therapeutic strategies that reduce tau expression. However, tau is also critical in microtubule stabilization, synaptic plasticity, and maintaining DNA integrity. We investigated the impact of tau removal on brain cell senescence and associated neurocognitive behaviors in aged tau knockout (Mapt^0/0) and wild type control (Mapt^+/+) mice. We also assessed physical, metabolic, histological, and biochemical outcomes in Mapt^0/0 and Mapt^+/+ mice and in response to …

Education For Primary Care Providers On Advance Care Planning: A Systematic Literature Review, Lindsey Ward

DNP Qualifying Manuscripts

Background: Healthcare providers in primary care treat patients at various stages of life. As patients age, it becomes necessary for providers to support their older patients throughout the aging process and address patient care even into life’s end stages. Primary care providers (PCPs) are well-positioned to provide this support and can do so through incorporating end-of-life (EOL) conversations in practice. Such discussions are called advance care planning (ACP). Though PCPs can play a crucial role in their patients’ EOL care decisions, providers report their limited knowledge of ACP as a barrier to its application.Consequently, further education for providers on utilizing …