Digital Commons Network^™

Preface, Anne Greene, Martin Lipa, Bill Paulson

Level 3

No abstract provided.

Regulators Are Exploring With Industry How To Strengthen Quality Risk Management Practices, With Revision Of Ich Q9 A Key Focal Point, ( Ipq )

Level 3

No abstract provided.

Links To Prst Past Monographs And Level 3 Special Editions

Level 3

No abstract provided.

Role Of Urban Parks In Carbon Sequestration– A Case Study Of Safari Park, Karachi, Pakistan, Amna Bano, Minzah Shehzad, Hasnain Kazmi, Jamshaid Iqbal

Journal of Bioresource Management

Urban parks besides their recreational use can be the potential source of climate mitigation through carbon sequestration. Present study aims to identify the carbon sequestration potential of Safari Park which is by far the largest public park of Karachi established in 1970 covering an area of 0.72 km². A total of 153 individual trees belonging to 25 species and 14 families were included in the study. Five dominant species with highest Important Value Index (IVI) were Cocos nucifera (14.62 %), Azadirachta indica (14.21 %), Guaiacum officinale (9.93 %), Washington robusta (9.31 %) and Delonix regia (7.11 %). The …

Antimicrobial Activity Of Crude Fractions Of Gossypium Barbadense Leaves And Isolation Of Stigmasterol, Maryam Saddiq, Ahmed Salisu, Kamaluddeen Kabir, Yusuf Hassan

Pharmaceutical Sciences and Research

Plants have been used in traditional medicine in different parts of the world to treat several diseases. Many studies have confirmed their medicinal values, which have led to the isolation and characterization of various potential drug candidates. This study focuses on the antimicrobial activity of crude fractions of Gossypium barbadense leaves and the isolation of active compound. The pulverized plant leave was soaked in ethanol (98% v/v), and a solvent-based fractionation was carried out using n-hexane, chloroform, ethyl acetate, and ethanol. The obtained crude fractions were screened for antimicrobial activity against four (4) clinical isolates: Escherichia coli, Pseudomonas …

The Three-Peat Challenge: Business As Usual, Responsible Agriculture, And Conservation And Restoration As Management Trajectories In Global Peatlands, Nicholas T. Girkin, Paul J. Burgess, Lydia Cole, Hannah V. Cooper, Coronado E Honorio, Scott J. Davidson, Jacqueline Hannam, Jim Harris, Ian Holman, Christopher S. Mccloskey, Michelle M. Mckeown, Alice M. Milner, Susan Page, Jo Smith, Dylan Young

School of Geography, Earth and Environmental Sciences

Peatlands are a globally important carbon store, but peatland ecosystems from high latitudes to the tropics are highly degraded due to increasingly intensive anthropogenic activity, making them significant greenhouse gas (GHG) sources. Peatland restoration and conservation have been proposed as a nature-based solution to climate change, by restoring the function of peatlands as a net carbon sink, but this may have implications for many local communities who rely on income from activities associated with transformed peatlands, particularly those drained for agriculture. However, without changing the way that humans interact with and exploit peatlands in most regions, peatlands will continue to …

2-Flavour $Su(2)$ Gauge Theory With Exponential Clover Wilson Fermions, Laurence Sebastian Bowes, Vincent Drach, Patrick Fritzsch, Antonio Rago, Fernando Romero-Lopez

School of Engineering, Computing and Mathematics

Composite Higgs models are a class of models proposed to address the hierarchy and naturalness problems associated with the Standard Model fundamental scalar Higgs. $SU(2)$ with two fundamental flavours is a minimal model for the composite Higgs sector which is not yet ruled out by experimental data. We present lattice results for $SU(2)$ with two fundamental mass degenerate flavours. For the fermion action we use the new exponential clover Wilson fermion action, which offers $O(a)$ improvement. We discuss tuning the $c_{\mathrm{SW}}$ parameter through Schr\"{o}dinger functional simulations, the scale setting of the ensembles using the Wilson gauge flow, and the low …

Supervised Physical Activity And The Incidence Of Gestational Diabetes Mellitus: A Systematic Review And Meta-Analysis, G. Bennett, N. King, K. Redfern, B. C. Breese

School of Biomedical Sciences

Background: Gestational diabetes mellitus (GDM) characterized by dysfunction in maintaining glucose homeostasis is recognized as the most common metabolic complication associated with pregnancy leading to adverse clinical outcomes for maternal and fetal health. Although previous analysis of the findings from randomized controlled trials (RCTs) support that regular physical activity reduces the incidence of GDM during pregnancy, less is known about the optimal timing of intervention with respect to trimester stage. Objectives: To examine the interaction between both the timing and volume of supervised physical activity interventions on reducing the incidence of GDM during pregnancy. Study design: Electronic databases including CINAHL, …

Smart Missions That Enable Innovation In High-Risk Environments., Ed Hoffman

Level 3

This article is a lightly edited version of Ed Hoffman’s talk on to the 01-June-2023 seminar hosted by the PRST entitled ICH Q9(R1): The Next Frontier – An audience with international thought leaders exploring how the effective use of knowledge can enhance QRM outcomes to benefit the patient. Ed’s remarks are focused on the future of work, and the needs for relationships, storytelling, and understanding the mission to get the best out of our collective intelligence and navigate the future of work.

Hpra’S Kevin O’Donnell On The Ich Q9 Revision And Considerations For Its Implementation, Kevin O'Donnell

Level 3

At the June 2023 PRST meeting on the ICH Q9 revision, HPRA Market Compliance Manager and Senior GMP Inspector Kevin O’Donnell, who has been serving as rapporteur for ICH Q9 (R1), addressed the changes introduced in the revision, the practicalities of implementation, and his “personal thoughts” on the implementation process. Click here for ICH Q9(R1) with the changes highlighted by O’Donnell, and here for the slides accompanying O’Donnell’s remarks. Formatting

changes and other minor edits have been made for clarity by IPQ. Expressions of thanks to the meeting organizers/attendees and disclaimers that the presentation represents the speaker’s views and not …

Introducing Research Collaboration And Gmp Human Resource Development At Three Universities With Gmp Laboratories In Japan, Shingou Sakurai, Osamu Hiruta, Ryoko Naruse

Level 3

This paper summarises initiatives presented on June 1^st 2023 at a seminar during a visit to Technological University Dublin. The authors travelled from 3 universities in Japan to share some of the collaborative research, education and training initiatives developed by them,

In their presentation the authors gave an overview of the current situation of Knowledge Management and Quality Culture in Japan, highlighting some recent issues and challenges, and presented some initiatives under development to specifically address these challenges.

Industry/Regulator Dialogue On Knowledge Management Is Intensifying In Wake Of Ich’S Q12 Initiative, ( Ipq )

Level 3

No abstract provided.

Agenda From June 1st Conference

Level 3

No abstract provided.

Ipq Descriptor

Level 3

No abstract provided.

Analysis Of Community-Based Pattern Of Water Demand And Supply, Ishaku Dibal Joshua, Abdullahi Chado Salihu, Ayuba Musa Mshelia, Nchedo Nnedinma Ubachukwu

Journal of Environmental Science and Sustainable Development

Gombi rural community of Adamawa state, Nigeria, has witnessed significant growth in human population, which has contributed to an increase in water demand. Thus, the study analyzed water demand and supply patterns in Gombi communities of Adamawa State, Nigeria. A structured questionnaire was used for data collection. Descriptive statistics such as mean and percentages and inferential statistics like Analysis of Variance (ANOVA), chi-square, and linear regression were adopted for the analysis. The results on socioeconomic characteristics showed that the majority were females, with low household income levels, large household sizes, and in their active ages. Hand-dug well water was the …

Roadside Greenbelt Effects On Thermal Comfort Of Pedestrian Corridors At A Busy Traffic Road, Nur Intan Simangunsong, Reza Fauzi, Dibyanti Danniswari, Rini Fitri

Journal of Environmental Science and Sustainable Development

The increasing number of motorized vehicles in Jakarta is causing environmental damage and can harm human health. In recent years, the Jakarta local government has the vision to focus on improving the human mobility network, including the pedestrian networks. As a heavily trafficked road, Jalan Kyai Tapa, West Jakarta, is used by many people. However, it may feel uncomfortable to walk there due to heat and sun exposure, which is compounded by extensive pavement coverage. The thermal condition of the pedestrian corridor is essential to create a comfortable walking experience. The objective of this study was to analyze the thermal …

Conversion Of Cellulose To 5-Hydroxymethylfurfural As Sustainable Energy: A Bibliometric Analysis By Vosviewer, Royyan Faradis, Ardiansyah Bagus Suryanto, Irmina Kris Murwani

Journal of Environmental Science and Sustainable Development

The developments of the global economy and society impact resources and the environment. This condition requires an alternative to find new, safe, and sustainable energy types. The conversion of cellulose to 5-hydroxymethylfurfural (5-HMF) has become a significant area of research interest. It has triggered the development of research directions related to biomass and energy because it can be an intermediary source for making polymers, solvents, pharmaceuticals, and biofuels. The primary objective of this study is to give a bibliometric analysis of 1753 reports on the development of research on cellulose conversion to 5-HMF from 1965 to 2021. The data were …

Faktor-Faktor Yang Mempengaruhi Personal Hygiene Pada Siswa Madrasah Aliyah (Ma) Boarding School, Atifah Nur Faizah, Wiwik Eko Pertiwi

Perilaku dan Promosi Kesehatan: Indonesian Journal of Health Promotion and Behavior

Background. Schools with a dormitory system allow disease transmission and students who live in dormitories are more susceptible to contracting disease. Objective. This research aims to analyze the factors that influence personal hygiene among Madrasah Aliyah (MA) boarding school students in Cilegon City in 2023. Method. The research was conducted in April – June 2023. This research used quantitative descriptive methods. Data analysis uses a cross-sectional approach with bivariate tests. The sample was 170 students taken by simple random sampling. Results. The research results showed mean score of respondents' personal hygiene was 52.7 (scale 100). Environmental hygiene is 68.2% in …

Interpol 90th General Assembly And The Securitisation Of Better Police Cooperation With National Central Bureau Jakarta, Marcellino L P Sirait, Ika R. Putranti, Hermini Susiatiningsih

Global: Jurnal Politik Internasional

In the modern age, the police institution is utilised as the primary spearhead to combat multiple sources of possible disruptions for the general safety of the public. The Indonesian National Police (INP) as a member of the INTERPOL takes part in multitude of activities conducted by the international organization. Currently, the Indonesian National Police is facing a rising number in the cases of missing persons, unidentified remains and crimes against children with casualties not only from Indonesian nationalities, but also international citizens. The current shortcoming of national technicalities and mechanism may open up a structured and tangible operational help from …

Foreword From Handling Editor - 11th Edition, Ahyahudin Sodri

Journal of Environmental Science and Sustainable Development

We are delighted to present the 11th edition of JESSD, published in December 2023. We have selected twelve of the best articles for this edition that related with topic of Environmental Science and Sustainable Development.

A Peculiar Natural Wonderland Of South China Sea: A Bird’S Eye View, Mohamad Nor Azra, Mohd Iqbal Mohd Noor, Juneta-Nor Abu Seman, Lee Seong Wei Dr

Journal of Environmental Science and Sustainable Development

The South China Sea research agenda has increased over the years. However, no scientometric studies have been performed on this topic, which has helped analyze the research on the South China Sea throughout many years. Thus, this study aimed to investigate the global findings of previous research on the South China Sea, development trends, and trending issues surrounding the sea. Literature was extracted from the Web of Science Core Collection (WOSCC) database, and the CiteSpace software was used to visualize the data analyzed. The survey included 12,755 articles. Overall, the number of publications increased annually. Acta Oceanologica Sinica and the …

The Role Of Live Streaming In Building Consumer Trust, Engagement, And Purchase Intention In Indonesian Social Commerce Thrift Clothes Sellers, Amyra Salsabela Yasser, Gita Gayatri

ASEAN Marketing Journal

Manuscript type: Research Article

Research Aims: Examine the relationship between shopping values consumers perceive during live streaming and their trust, engagement, and intention to purchase from Indonesian social commerce thrift clothes sellers.

Design/methodology/approach: Data was gathered through an online survey from consumers who have watched a live-streaming session of an online thrift clothes shop on Instagram. Data were analysed using covariance-based Structural Equation Modelling (SEM).

Research Findings: The output shows that only the utilitarian value of live stream positively affects trust in products and sellers. The variable engagement was only significantly affected by hedonic value. Additionally, the only …

The Effect Of Social Media Brand Engagement On Customer Brand Loyalty: A Study On Skincare Brands Customers In Indonesia, Dodi Ria Atmaja, Riska Ware Arum Sari

ASEAN Marketing Journal

Abstract

Manuscript type: Research Paper

Research Aims: This research aims to examine the impact of brand engagement on social media on consumer brand loyalty (BL), by investigating the moderating roles of brand co-creation, brand trust, and brand experience variables.

Design/methodology/approach: The study employed a purposive sampling method, involving 230 respondents. The data was analyzed using Structural Equation Modeling (SEM).

Research Findings: The results show that brand experience can moderate the impact of brand co-creation (BCC) on brand loyalty (BL). However, social media brand engagement does not always have a direct impact on brand loyalty (BL), suggesting that other factors may …

Effect Of Influencer Marketing Strategy On Consumer Behaviour In Fast Moving Consumer Goods Firms In Ghana, Pearl Fafa Bansah, Vanessa Gaffar, Disman Disman, Ayu Krishna Yuliawati

ASEAN Marketing Journal

Manuscript type: Research paper

Research Aims: This study examines the influence of influencer marketing strategies on consumer purchasing behaviour among fast-moving consumer goods (FMCG) companies in Ghana.

Design/methodology/approach: This study employs an explanatory (causal) research design. A 31-item questionnaire split into four categories was used to collect quantitative data. An online questionnaire was sent to FMCG consumers in Ghana's Greater Accra and Ashanti Regions, aged 18–48 years and older. Multiple regression analysis was performed to establish relationships between the study variables.

Research Findings: The findings showed that YouTube is the most popular social media platform among Ghanaian users, …

Multifactorial Analysis Of Work Accidents Among Transportation Sector Workers In Parepare City, Syamsiar S. Russeng, Lalu Muhammad Saleh, Nurul Mawaddah Syafitri, Naufal Hilmy Imran, Auliya Nurazizah, Andi Fatimah Mustovia Nurhidayah

Media Kesehatan Masyarakat Indonesia

Reports have shown that there has been a continuous annual increase in the number of traffic accidents in Indonesia. Parepare City, in particular, faces significant congestion in its public transportation system, leading to 167 cases and 144 cases of accidents in 2019 and 2020, respectively. Therefore, this study aims to analyze the influence of knowledge, attitude, personality, and safety riding practice on traffic accidents among transportation workers in Parepare City. This cross-sectional study comprised 100 respondents selected using the simple random sampling method. The study instrument was a questionnaire, which had previously been tested for its validity and reliability. The …

Spatial Analysis Of Diarrhea Incidences, Environmental Influences, And Behavioral Factors In An Ecological Study, Baby Putri Adria, Ririn Arminsih Wulandari, Fitri Kurniasari

Media Kesehatan Masyarakat Indonesia

Diarrhea is a global health problem that causes morbidity and death in all age groups. Among the cities in Indonesia, Depok has the second-highest incidence of diarrhea outbreaks. Although previous studies have shown the correlation between diarrhea and environmental and behavioral factors, the spatial analysis of these factors is still very limited. Therefore, in this study, we investigated the spatial analysis of the association between diarrhea incidence and environmental and behavioral factors using an ecological study. The secondary data from the Depok City Health Office were used in the analysis. Our results showed a significant relationship between proper drinking water …

Cost-Effectiveness Of Lifestyle Africa: An Adaptation Of The Diabetes Prevention Programme For Delivery By Community Health Workers In Urban South Africa, Melanie D. Whittington, Kathy Goggin, Lungiswa Tsolekile, Thandi Puoane, Andrew T. Fox, Ken Resnicow, Kandace K. Fleming, Joshua M. Smyth, Frank T. Materia, Emily A. Hurley, Mara Z. Vitolins, Estelle V. Lambert, Naomi S. Levitt, Delwyn Catley

Manuscripts, Articles, Book Chapters and Other Papers

Background: Lifestyle Africa is an adapted version of the Diabetes Prevention Program designed for delivery by community health workers to socioeconomically disadvantaged populations in low- and middle-income countries (LMICs). Results from the Lifestyle Africa trial conducted in an under-resourced community in South Africa indicated that the programme had a significant effect on reducing haemoglobin A1c (HbA1c).

Objective: To estimate the cost of implementation and the cost-effectiveness (in cost per point reduction in HbA1c) of the Lifestyle Africa programme to inform decision-makers of the resources required and the value of this intervention.

Methods: Interviews were held with project administrators to identify …

Covalent Inhibition Of Enzyme Sortase A As A New Pathway Against Bacterial Resistance Of Staphylococcus Aureus, Umyeena Bashir

Master's Theses

The continued rise of antibiotic-resistant bacteria, such as MRSA (methicillin-resistant Staphylococcus aureus), has made the discovery of novel antibiotics critical. While bacteriostatic and bactericidal antibiotics inevitably exert evolutionary pressure on bacteria to develop resistance, small molecules that target mechanisms of bacterial virulence present a promising alternative for treatment. Sortase A (Srt A), a cysteine protease of S. aureus, promotes bacterial virulence by covalently attaching proteins such as pilin to the bacterial surface, enabling bacterial adhesion to mammalian cells. Inhibitory studies of this enzyme have gained prominent interest as a new pathway for drug development since blocking this enzyme's ability to …

Fulfilling Urban Infrastructure Standards To Increase The Carrying Capacity Of Tourism Destination, Shana Fatina, Tri Edhi Budhi Soesilo, Rudy Parluhutan Tambunan

Journal of Environmental Science and Sustainable Development

Labuan Bajo is an emerging coastal tourism destination in Indonesia, which is also part of the United Nations Educational, Scientific and Cultural Organization (UNESCO) Komodo Biosphere Reserve located in the East Nusa Tenggara region. Recent tourism developments have transformed Labuan Bajo from a rural area into an urban area, and significant land use changes have followed. This new urban area development will attract tourists as well as population migration. The ongoing issue is to develop the urban infrastructure and facilities of Labuan Bajo in an integrated and sustainable way, considering the carrying capacity following the high demand for tourism and …

Community Structure Of Sea Urchin As An Indicator Of The Ecological Balance Of Coastal Areas, Abdul Wahab Radjab, Intan Rabiyanti, Fiqih Muharby

Journal of Environmental Science and Sustainable Development

Sea urchins, soft-shelled invertebrates (Echinoderms), crucially contribute to cleaning the ocean bottom. However, sea urchins in tropical waters like Indonesia have not yet been fully disclosed. This study was conducted at Hutumuri and Rutong waters, Ambon City. This study assessed physical-chemical parameters, sea urchin species composition, classification, and community structure. Employing the Line Transect method with 5x5 m quadrants and 50m transect spacing, data analysis included density, relative density, frequency of presence, diversity, uniformity, and dominance indices. Results indicated normal temperature and salinity at both stations, supporting sea urchin life, with rocky and sandy substrates deemed suitable. A total of …