Digital Commons Network^™

Facing Emergencies With Equity: Adopting Arpa's Emergency Rental Assistance Eligibility And Documentation Standards For Undocumented Individuals As A Model For Housing Stability, Gregory Zlotnick

Faculty Articles

Demand for federally funded housing programs vastly outpaces supply. Moreover, the supply of those programs has been limited in their scope: namely, to U.S. citizens and certain legal residents. A patchwork of federal statutes and regulations, stitched together over years, made clear that undocumented individuals-a group estimated to number around 11,000,000 in 2022-are ineligible for various kinds of federally subsidized housing.

As a result, undocumented individuals-an already-vulnerable class of residents-were even more vulnerable to housing instability when the COVID-19 pandemic reached the United States in 2020. Ineligible for short term resources, such as unemployment benefits, as well as longer-term supports, …

Addressing (In)Equality In Redress: Human Rights-Led Reform Of The Investor-State Dispute Settlement Mechanism, Surya Deva, Tara Van Ho

Faculty Articles

In the context of ongoing debates concerning the reform of the investor-State dispute settlement (ISDS) mechanism, this article critiques the widely-accepted approach that seeks to fit international human rights law (IHRL) into the existing structure of ISDS and argues that IHRL should at least be treated as ‘primus inter pares’ vis-à-vis international investment law. Testing ISDS on the touchstone of the human rights to equality, non-discrimination, and an effective remedy, the authors demonstrate that ISDS is incompatible with IHRL. Considering various structural and systemic problems, abolishing ISDS is perhaps the only normatively sound solution to address this incompatibility with IHRL. …

Dependence Among Order Statistics For Time-Transformed Exponential Models, Subhash C. Kochar, Fabio Spizzichino

Mathematics and Statistics Faculty Publications and Presentations

Let (X1, . . . ,Xn) be a random vector distributed according to a time-transformed exponential model. This is a special class of exchangeable models, which, in particular, includes multivariate distributions with Schur-constant survival functions and with identical marginals. Let for 1 ≤ i ≤ n, Xi:n denote the corresponding ith order statistic. We consider the problem of comparing the strength of dependence between any pair of Xi’s with that of the corresponding order statistics. It is proved that for m = 2, . . . , n, the dependence of X2:m on X1:m is more than that of X2 …

Chemical Reaction Networks In A Laplacian Framework, J.J.P. Veerman, T. Whalen-Wagner, Ewan Kummel

Mathematics and Statistics Faculty Publications and Presentations

The study of the dynamics of chemical reactions, and in particular phenomena such as oscillating reactions, has led to the recognition that many dynamical properties of a chemical reaction can be predicted from graph theoretical properties of a certain directed graph, called a Chemical Reaction Network (CRN). In this graph, the edges represent the reactions and the vertices the reacting combinations of chemical substances. In contrast with the classical treatment, in this work, we heavily rely on a recently developed theory of directed graph Laplacians to simplify the traditional treatment of the so-called defi- ciency zero systems of CRN theory. …

A Rare Case Of Pancreatic Actinomyces, Marguerite Poche, Kyle Liu, Codey Pham, Shilpa Jain, Robert Sealock

Faculty, Staff and Students Publications

Actinomyces israelii is a filamentous, gram-positive anaerobic bacterium commonly found in the upper gastrointestinal tract, colon, and female genital tract. Rarely, actinomycosis can infect the pancreas most commonly after pancreatic instrumentation, often mimicking malignancy. We describe a case of a 26-year-old woman who presented with epigastric abdominal pain and nausea without prior pancreatic instrumentation. Abdominal imaging demonstrated a mass in the pancreatic head with fine-needle biopsy revealing Actinomyces. The patient was successfully treated with long-term antibiotic therapy resulting in resolution of the mass. Our case emphasizes the importance of considering nonmalignant etiologies in the differential diagnosis of pancreatic masses.

Native Bk Polyomavirus Nephropathy In An Orthotopic Heart Transplant Patient, Zachary M Thompson, George Ajene, Prathit A Kulkarni, Nidhi Aggarwal, Savitri Fedson, Maulin K Shah

Faculty, Staff and Students Publications

BK polyomavirus nephropathy (BKVN) is a common cause of nephropathy in kidney transplant patients and is typically seen within the first year after transplantation. BK polyomavirus nephropathy can occur in the native kidneys of patients with nonrenal solid-organ transplants (NRSOT). However, this is rare, especially outside the early post-transplant period, and BKVN is not usually considered in the differential diagnosis for acute kidney injury in NRSOT patients. We present a case of a 75-year-old man who had undergone orthotopic heart transplant 13 years prior with stable allograft function who developed progressive renal dysfunction in the setting of recent unilateral obstructive …

Treatment Of Severe Covid-19 Infection With Remdesivir In Peritoneal Dialysis, Ryan Geffin, Shazia Raheem, Lavannya M Pandit, Andrew S Hunter, Michael W Holliday, Aditya V Rao, Maulin K Shah

Faculty, Staff and Students Publications

End-stage kidney disease (ESKD) has been shown to be correlated with an increased risk of COVID-19 infection and mortality. Remdesivir is an effective non-EUA U.S. Food and Drug Administration (FDA)-approved antiviral agent for the treatment of COVID-19 in hospitalized adult and pediatric patients, though a lack of data has prevented its use in patients with severe kidney disease including dialysis patients. Some observational studies report the use of remdesivir in hemodialysis patients, but there are no reports of patients treated with remdesivir on peritoneal dialysis. Dialysis modalities may affect drug pharmacokinetics, and safety and efficiency of remdesivir in peritoneal dialysis …

Trends And Outcomes In Patients With Coronary Artery Disease Undergoing Tavr: Insights From Va Cart, Khanjan B Shah, Colin O'Donnell, Dhruv Mahtta, Stephen W Waldo, Calvin Choi, Ki Park, Ali E Denktas, David Paniagua, Umair Khalid

Faculty, Staff and Students Publications

BACKGROUND: Obstructive coronary artery disease (CAD) is common in patients with severe symptomatic aortic stenosis. The management and impact of obstructive CAD in patients undergoing transcatheter aortic valve replacement (TAVR) have not been fully evaluated. We aimed to determine the patient characteristics and clinical outcomes among veterans undergoing TAVR with and without obstructive CAD and to determine temporal trends and association of pre-TAVR percutaneous coronary intervention (PCI) with clinical outcomes.

METHODS: We identified all patients who underwent TAVR from 2012 to 2021 in the VA Health Care System. The sample population was divided into patients with and without obstructive CAD …

Stealing From The Heart: A Rare Case Of Chest Pain Post-Coronary Artery Bypass Grafting, Prasanti A Kotta, Joshua R Hirsch, Umair Khalid, Ali E Denktas

Faculty, Staff and Students Publications

A 70-year-old veteran with prior triple vessel coronary artery bypass grafting (CABG) presented with exertional chest pain. His work-up revealed > 40 mm Hg bilateral upper extremity blood pressure difference. Chest computed tomography and invasive angiography revealed severe stenosis at the ostium of the left subclavian artery, proximal to the origin of the left internal mammary artery to left anterior descending artery graft (LIMA-LAD). A diagnosis of coronary subclavian steal syndrome (CSSS) was made, and carotid-subclavian bypass was performed. This case outlines when to suspect CSSS, an approach to its diagnosis, and the importance of its timely management.

Women's Empowerment Through Strength Sports—And Its Limits, Alison Clark Efford

History Faculty Research and Publications

This historical case study demonstrates that the purpose of a program of strength training affects whether it will empower women. The Turnverein or Turners was a German American organization that combined physical training, ethnic pride, and civic engagement. From the 1880s to the 1920s, it was at the forefront of promoting women’s exercise in the United States, including strength training with weighted clubs, dumbbells, and apparatuses. Woman Turners seized on physical training to challenge patriarchal power structures. They found joy in exertion, achievement, and comradery, while contesting the notion that to be feminine meant to be weak. Yet male Turners …

Advances In Prosthetic Technology: A Perspective On Ethical Considerations For Development And Clinical Translation, Hayden Gavette, Cody L Mcdonald, Kristin Kostick-Quenet, Ashley Mullen, Bijan Najafi, M G Finco

Faculty, Staff and Students Publications

Technological advancements of prostheses in recent years, such as haptic feedback, active power, and machine learning for prosthetic control, have opened new doors for improved functioning, satisfaction, and overall quality of life. However, little attention has been paid to ethical considerations surrounding the development and translation of prosthetic technologies into clinical practice. This article, based on current literature, presents perspectives surrounding ethical considerations from the authors' multidisciplinary views as prosthetists (HG, AM, CLM, MGF), as well as combined research experience working directly with people using prostheses (AM, CLM, MGF), wearable technologies for rehabilitation (MGF, BN), machine learning and artificial intelligence …

Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton

Faculty, Staff and Students Publications

Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. We hypothesized that inducing the expression of an ShK analog by hepatocytes would remove the requirement for frequent injections and lead to a …

Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang

Faculty, Staff and Students Publications

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac development and defects. Optical coherence tomography (OCT) plays an important role in embryonic heart imaging with its unique imaging scale and label-free contrasts. In particular, 4D (3D + time) OCT imaging enabled biomechanical analysis of the developing heart in various animal models. While ultrafast OCT systems allow for direct volumetric imaging of the beating heart, the imaging speed remains limited, leading to an image quality inferior to that produced by post-acquisition synchronization. As OCT systems become increasingly available to a wide range of biomedical researchers, a …

Building Belonging Into The System, Kristin Herman, Michelle Gill

STEMPS Faculty Publications

This design case documents how a K-12 district took steps to systemically support virtual student wellness and belonging. Plans for course design to support social-emotional-academic learning (SEAL) competencies, increase perception of belonging, and create safe, predictable learning environments characteristic of a trauma-informed approach to teaching and learning are shared. The assumption virtual learners are not looking to experience belonging and cannot be successful unless they already have strong SEAL skills is challenged. Rather, the positioning of SEAL competencies as learning objectives rather than necessary prerequisites to access online learning proved to contribute to more equitable learning opportunities.

How It Course Improves Digital Competencies: An Experimental Study In Science Education, Mustafa Tevfik Hebebci, Helen Crompton

STEMPS Faculty Publications

The rising significance of technology in society has caused a surge in the requirement of individuals possessing digital competencies. In the current era, digital skills are progressively vital for both personal and occupational growth. Governments have acknowledged the value of digital competencies and have incorporated them as part of fundamental proficiencies in numerous countries. Pre-service teachers have a paramount role in molding forthcoming generations, highlighting their necessity to possess robust digital competencies. This research centers on how an "Information Technologies in Science Education" course influences the digital competency progression in pre-service teachers. The study deployed a pre-test post-test experimental design …

Are Library And Information Science Educators Teaching Accessibility? Content Analysis Of Syllabi, Kevin J. Mallary, Rea N. Simons, Clayton A. Copeland, Jackie Nikiema, Evan J. Dorman

STEMPS Faculty Publications

Library and information science (LIS) graduates are expected to serve patrons from diverse backgrounds, including disabled patrons. While serving patrons with disabilities is a core value of librarianship, graduates often feel unprepared to serve disabled patrons, suggesting that programs inadequately train students to design accessible services. This study’s authors analyzed hundreds of course descriptions and 73 syllabi from 20 North American LIS programs to determine how often accessibility and disability topics are covered and how educators teach accessibility. Findings indicate that accessibility and disability topics are mostly covered in electives, meaning students may never develop accessibility competencies during their programs. …

Improving Reliability In Assessing Integrative Learning Using Rubrics: Does Group Norming Help?, Lanah Stafford, Erin Cousins, Linda Bol, Megan Mize

STEMPS Faculty Publications

Integrative learning is an important outcome for graduates of higher education. Therefore, it should be well-defined and assessed reliably. The American Association of Colleges & Universities has developed a rubric to define and assess integrative learning, but it has low reliability. This pilot study examines whether this rubric's reliability can be improved by training users on how to use the rubric in a group setting rather than individually. Twelve faculty were trained to score undergraduate ePortfolios using the Integrative and Applied Learning VALUE Rubric. Half of the faculty were trained in an individual setting and half in a group setting …

Malignant Insulinoma Arising From Nonfunctioning Pancreatic Neuroendocrine Tumor, Ritodhi Chatterjee, Basim Ali, Son H Nguyen, Rui Chen, Yvonne H Sada

Faculty, Staff and Students Publications

Pancreatic neuroendocrine tumors are rare neoplasms characterized into nonfunctioning (NF-PNET) and functioning (F-PNET) subtypes. F-PNETs typically involve overt symptoms related to excessive hormone secretion but may rarely present first as NF-PNETs with delayed transformation. We present a patient with known NF-PNET with liver metastases who developed hypoglycemia 2 years after initial diagnosis due to malignant insulinoma. Hypoglycemia was refractory to continuous dextrose but improved temporarily after diazoxide and hepatic artery embolization. Malignant insulinomas are usually metastatic at presentation and portend poor prognosis. Hypoglycemia may be medically managed with steroids, somatostatin analogues, and diazoxide, along with therapies to reduce tumor burden.

Lox Upregulates Fak Phosphorylation To Promote Metastasis In Osteosarcoma, Xiang Chen, Margaret Clement, M John Hicks, Poonam Sarkar, M Waleed Gaber, Tsz-Kwong Man

Faculty, Staff and Students Publications

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be the leading cause of death in patients with osteosarcoma. We have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in osteosarcoma. In this study, we further show that lysyl oxidase (LOX) expression was associated with p27 mislocalization. LOX is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter; however, its role in osteosarcoma is still unclear. Hence, we performed both

Coping During The Covid-19 Pandemic Among Young Adults Experiencing Homelessness And Unstable Housing: A Qualitative Study, Karen Divalerio Gibbs, Jennifer Torres Jones, Whitney Lamark, Sarah Abdulmooti, Lauren Bretz, Kelly D Kearney, Sarah Carter Narendorf, Diane M Santa Maria

Faculty, Staff and Students Publications

BACKGROUND: Young adults experiencing homelessness (YAEH) experience more stressors compared to housed peers, yet little is known about the impact of the COVID-19 pandemic on these youth. The purpose of this qualitative study was to explore how YAEH perceived the pandemic's impact on their well-being and coping.

METHODS: YAEH were recruited from those participating in an HIV prevention study. Semi-structured interviews were conducted and analysis was guided by Lazarus and Folkman's transactional theory of stress and coping.

RESULTS: Four major themes were identified from interviews with 40 youth: (1) ongoing harms, (2) COVID-19 as a stressor, (3) mental health impacts, …

The Mystery Of The Leavenworth Oaths, M H. Hoeflich, Stephen M. Sheppard

Faculty Articles

Lawyers have sworn an oath to be admitted to the Bar since the beginnings of the Anglo-American legal profession. The oath serves several extremely important purposes. First, it is the formal act that admits an individual into the Bar and confers upon the oath taker the right to perform the duties of an attorney in the jurisdiction in which the oath is given. Second, the oath admits the new attorney to the broader world of the legal profession and signifies that the new attorney has been judged by the oath giver as worthy of the right to practice law. Third, …

The Lawyer As Dream Enabler, Gerald S. Reamey

Faculty Articles

In law school and in law practice, the power of preparation is reinforced. Generations of law students have heard me extol the virtue of preparation above all others. While it is true, even the best preparation will never beat luck; luck is fickle and not subject to our control. On the other hand, we totally control the amount and quality of the preparation we put into any project. I discovered preparation is more important than good looks, nice clothes, a shiny leather briefcase, eloquence, experience, or even intelligence.

Ethical Lawyering: The Role Of Honor, Conscience, And Codes (Reviewing Michael S. Ariens, The Lawyer’S Conscience: A History Of American Lawyer Ethics), Vincent R. Johnson

Faculty Articles

Michael Ariens’ new book, The Lawyer’s Conscience: A History of American Lawyer Ethics, is a monumental work, rooted in his decades of excellent scholarship in the fields of attorney professional responsibility and legal history. The Lawyer’s Conscience captures the great sweep and key features of the roughly 250-year period in American legal ethics running from colonial times to the present day. Richly detailed and vividly presented, the story takes the reader on a grand tour of the landmark events and changing ideas that have defined the aspirations, responsibilities, and accountability of members of the American legal profession.

The Scholar: Twenty-Five Years Of Change, Catherine Casiano

Faculty Articles

Catherine Casiano, the Assistant Dean of Admissions at St. Mary's University School of Law, a former staff writer and editor for The Scholar, reflects on the journal's twenty-fifth anniversary and evolution.

Is, Ought, And The Limited Competence Of Experts, Adam J. Macleod

Faculty Articles

The moral innovators whom C. S. Lewis criticized in The Abolition of Man supposed that they could draw imperatives out of their superior understanding of sentiment and instinct. They assumed that to know what human beings want to do is to know what human beings should do. But people want to do all sorts of things that are irrational, pointless, harmful, and even downright evil. And people want inconsistent things. So the innovators are incoherent. As Lewis correctly affirmed, no amount of knowledge about nature or the world is sufficient by itself to direct us to do what is good …

In Silico Analyses Of Diversity And Dissemination Of Antimicrobial Resistance Genes And Mobile Genetics Elements, For Plasmids Of Enteric Pathogens, Suad Algarni, Jing Han, Dereje D. Gudeta, Bijay K. Khajanchi, Steven C. Ricke, Young Min Kwon, Douglas D. Rhoads, Steven L. Foley

Animal Science Faculty Publications and Presentations

Introduction: The antimicrobial resistance (AMR) mobilome plays a key role in the dissemination of resistance genes encoded by mobile genetics elements (MGEs) including plasmids, transposons (Tns), and insertion sequences (ISs). These MGEs contribute to the dissemination of multidrug resistance (MDR) in enteric bacterial pathogens which have been considered as a global public health risk.

Methods: To further understand the diversity and distribution of AMR genes and MGEs across different plasmid types, we utilized multiple sequence-based computational approaches to evaluate AMR-associated plasmid genetics. A collection of 1,309 complete plasmid sequences from Gammaproteobacterial species, including 100 plasmids from each of the following …

Mining For Sleep Data: An Investigation Into The Sleep Of Fly-In Fly-Out Shift Workers In The Mining Industry And Potential Solutions, Gemma Maisey

Theses: Doctorates and Masters

Shift work in the mining industry is a risk factor for sleep loss leading to impaired alertness, which may adversely impact health and safety risks. This risk is being increasingly recognised by leaders and shift workers in the mining industry, however, there is limited knowledge available on the extent of sleep loss and other potential contributing factors. Furthermore, knowledge of the efficacy of individual interventions to assist shift workers to improve their sleep, and the management of risk at an organisational level is scarce. This PhD thesis involved three studies. The first two studies involved the recruitment of 88 shift …

An Overview Of Blood-Based Biomarkers In Ad, Steve Pedrini

Theses: Doctorates and Masters

Alzheimer’s disease (AD) is the most common form of dementia in the elderly whose main neuropathological features are the presence of extracellular senile plaques in the brain and the intracellular accumulation of hyperphosphorylated tau filaments. However, a relatively cheap and non-invasive method for the diagnosis of AD remains elusive. Recent studies have indicated that cerebral biochemical changes take place decades before the clinical onset of the disease, but current methodologies, brain scan (PET amyloid imaging) and cerebrospinal fluid (CSF) analysis, are unsuited for community-wide screening. Brain scanning methods non-invasively assess amyloid load but are extremely expensive and cannot be used …

Explaining Organisational Business Process Adoption Mechanisms - A Critical Realist Perspective On Social Reflexivity And Process Affordances, Andreas Brönnimann

Theses: Doctorates and Masters

The implementation of new business processes can be problematic for organisations. Employees tend towards reluctant behaviour when confronted with organisational change that requires adoption of new workflows and work tasks. The crucial importance of people affected by change has been highlighted in past research. While the adoption of new processes is beneficial to the organisation, deviations from or rejections of new processes can lead to increased risks, missed process goals, increased waste leading to lost revenue, and other unforeseeable outcomes.

However, the adoption of proposed processes by individuals only is less desirable, because the collective nature of processes requires choreographed …

Exploring Demographic, Clinical And Exercise Prescription Moderators Of Resistance Exercise Effects On Objectively Measured And Patient-Reported Outcomes In Men With Prostate Cancer, Pedro Lopez Da Cruz

Theses: Doctorates and Masters

Information on specific prognostic factors such as the association of body composition with survival and tailored strategies considering demographic and clinical factors as well as the influence of exercise tolerance and compliance are required to establish targeted exercise prescription in men with prostate cancer. As a result, the purpose of this doctoral research is to: (i) investigate the role of body composition on overall survival in men with prostate cancer; (ii) determine which type of exercise/physical activity and/or dietary intervention is most effective for improving body composition outcomes in this population; (iii) examine the demographic and clinical characteristics of resistance …