Digital Commons Network^™

Suma: A Lightweight Machine Learning Model Powered Shared Nearest Neighbour Based Clustering Application Interface Of Scrna-Seq, Hamza Umut Karakurt, Pınar Pir

Turkish Journal of Biology

Background/aim: Single-cell transcriptomics (scRNA-Seq) explores cellular diversity at the gene expression level. Due to the inherent sparsity and noise in scRNA-Seq data and the uncertainty on the types of sequenced cells, effective clustering and cell type annotation are essential. The graph-based clustering of scRNA-Seq data is a simple yet powerful approach which presents data as a “shared nearest neighbour” graph and clusters the cells using graph clustering algorithms. These algorithms are dependent on several user-defined parameters. Here we present SUMA, a lightweight tool that uses a random forest model to predict the optimum number of neighbours to have the optimum …

Federal Court Blocks Enforcement Of Idaho’S Ban On Gender-Affirming Care For Minors, Arthur S. Leonard

Other Publications

No abstract provided.

Career Transitioning Among Students With Visual Impairments: Educational And Public Policy Perspectives, Chiedu Eseadi, Shulamite E. Ogbuabor

Jurnal Kajian Bimbingan dan Konseling

The objective of this research is to examine the educational and public policy concerns pertaining to career transitioning among students with visual impair-ments. The authors conducted a narrative literature review. The conceptualization of policy, with a specific focus on educational and public policies, was provided. The article also discussed the roles and concerns of educational and public policies in facilitating career transitioning for these students. The study contributes to an increased understanding of the educational and policy implications of supporting students with visual impairments during career transitioning. The collaboration of career counsellors and policy actors is deemed necessary in order …

School Environment As Barrier To Effective Academic Performance Among Students With Physical Disabilities In Ilorin Metropolis, Florence Bosede Famolu

Jurnal Kajian Bimbingan dan Konseling

Insufficient infrastructural facilities make it difficult for a large number of students with visual and mobility impairment to walk around the campus and attend lectures. Also, fewer than ideal library facilities decrease the amount of study resources that are available to these students. This study investigated the school environment as barrier to effective academic performance among students with physical disabilities in the Ilorin metropolis, Kwara State. The descriptive survey of a correlational type was implemented using purposive sampling for this study. A purposive sampling technique was used to select 98 students in the Ilorin metropolis with physical disabilities, and the …

Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy

Blue Economy

In terms of focus, promising results obtained from extensive investigations showed that the biodiversity of marine invertebrates has been documented. This poses the marine ecosystem as a hopeful resource in the discovery of novel compounds, with an ideal starting point in scaffolding additional screening of marine natural products (MNPs), especially to face the rise in the burden of diseases and treatment failure. A wide range of antimicrobial, antiviral, anticancer, anti-inflammatory, antiparasitic, neuroprotective, analgesic, antimalarial and other agents of marine origin have been pursued in the control and management of diseases. In the current review, we will focus on figuring out …

In An Animal’S Shoes: Facing Animal Suffering As A Difficulty Of Reality, Konstantin Deininger

Between the Species

This paper examines the challenges posed by confronting the topic of animal suffering in animal husbandry. The predominant positions within animal ethics mainly focus on the moral status of humans and animals, arguing that killing farm animals is morally wrong due to specifiable intrinsic properties that grant farm animals significant moral status. Such positions are derived from a detached perspective that advocates for rational consistency. This paper opposes this detached perspective. By drawing on Cora Diamond’s concept of a difficulty of reality, it contends that facing animal suffering, including changing one’s habits and attitudes towards this suffering, is instead best …

Case Report And Literature Review Of An Atypical Polymyalgia Rheumatica And Its Management, Saad Bilal Ahmed, Saara Ahmad, Hanmei Pan

Department of Biological & Biomedical Sciences

Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of the elderly population that increases in incidence as age advances. It is characterised by the sudden or sub-acute onset of symptoms affecting the shoulder and pelvic girdles, often accompanied by constitutional symptoms. Due to the lack of consensual diagnostic criteria and specific laboratory or radiological investigations for PMR, its diagnosis can be very challenging, particularly because it can be mimicked or masked by other geriatric syndromes. PMR responds well to glucocorticoid treatment, but if left untreated, can lead to morbidity and poor quality of life. We present the case of an …

Credit Risk Modeling Using Interpreted Xgboost, Marcin Hernes, Jędrzej Adaszyński, Piotr Tutak

European Management Studies

Purpose: The aim of the paper is to develop a credit risk assessment model usingb the XGBoost classifier supported by interpretation issues. Design/methodology/approach: The risk modeling is based on Extreme Gradient Boosting (XGBoost) in the research. It is a method used for regression and classification problems. It is based on a sequence of decision trees using a gradient-based optimization method of the loss function to minimize the errors of weak estimators. We use also methods for performing local and global interpretability: ceteris paribus charts, SHAP and feature importance approach. Findings: Based on the research results, it can be concluded that …

Technology Intelligence As A One Of The Key Factors For Successful Strategic Management In The Smart World, Anna Adamik

European Management Studies

Purpose: Due to the poor recognition in the literature of the phenomenon of Technology Intelligence in contemporary organizations, the aim of the paper is to attempt to recognize the essence and significance of Technology Intelligence of organizations operating in a Smart World. Design/methodology/approach: The paper is conceptual-empirical in nature. The operationalization proposal is based on the identification and assessment of the Technology Intelligence of organizations as one of the key pillars of effective management in the Smart World. Findings: An organization’s Technology Intelligence significantly accelerates and improves the quality of many organizational processes, including smart strategic management. Unfortunately, it does …

Social Media Utilization Of Public Benefit Organizations During The Covid-19 Pandemic, Piotr Szamrowski, Marian Oliński

European Management Studies

Purpose: The main purpose of the research was twofold. First, it was to assess the impact of the COVID-19 pandemic on the publishing activity of Polish public benefit organizations on Facebook. Second, to determine the impact of content published in a crisis situation on the public reaction. Design/methodology/approach: During the investigation, the financial reports of public benefit organizations were analyzed. Farther the basic parameters of the organization’s Facebook profile and the content published on Facebook were analyzed (1025 organizations were covered by the research). From the reports, financial data of organizations has been collected. Both in 2020 and in 2021, …

Thrombotic And Hemorrhagic Complications Following Left Ventricular Assist Device Placement: An Emphasis On Gastrointestinal Bleeding, Stroke, And Pump Thrombosis, Joseph Phan, Kareem Elgendi, Masi Javeed, Juan M. Aranda, Mustafa M. Ahmed, Juan Vilaro, Mohammad Al-Ani, Alex M. Parker

HPD Articles

The left ventricular assist device (LVAD) is a mechanical circulatory support device that supports the heart failure patient as a bridge to transplant (BTT) or as a destination therapy for those who have other medical comorbidities or complications that disqualify them from meeting transplant criteria. In patients with severe heart failure, LVAD use has extended survival and improved signs and symptoms of cardiac congestion and low cardiac output, such as dyspnea, fatigue, and exercise intolerance. However, these devices are associated with specific hematologic and thrombotic complications. In this manuscript, we review the common hematologic complications of LVADs.

Ink 954 Llc V. Mann

All Decisions

No abstract provided.

Going Green To Sell, N'Dja D. N'Guessan

Student Theses and Dissertations

The following thesis project discusses green communication strategies that can be implemented across industries to improve sales while aligning with consumers’ environmental values. It incorporates practical ideas and techniques within the reach of for-profit organizations when creating, developing, and promoting green products. The environmental, social, and governance expectations have challenged organizations across industries for years. By producing and interpreting the results of a meta-analysis of green business strategies found in existing research, Going Green to Sell offers ideas to new and growing organizations on how to market their products, using functional communication strategies that have worked before, focusing on green …

Bill Of Rights Nondelegation, Eli Nachmany

BYU Law Review

Speculation about the “revival” of the nondelegation doctrine has reached a fever pitch. Although the Supreme Court apparently has not applied the nondelegation doctrine to declare a federal statute unconstitutional since 1935, the doctrine may be making a comeback. The common understanding is that the nondelegation doctrine prohibits Congress from “delegating” legislative power to the executive branch. While the nondelegation doctrine may appear to be about limiting Congress, its ultimate target is delegation. But if the nondelegation doctrine is about policing delegation, then the Court has been regularly — and rigorously — applying the doctrine in a different context: In …

Chronic Alcoholic Pancreatitis With Necrotising Exacerbation And Pseudocyst Treated With Homoeopathy: A Case Report, Bipin Sohanraj Jain, Tanvir Abdul Hamid Sheikh

Indian Journal of Research in Homoeopathy

Introduction: Chronic alcoholic pancreatitis with necrotising exacerbation and pseudocyst is a condition with a poor prognosis. The disease pathology, along with a history of trauma, and alcohol dependence, adds up to the severity making it more difficult to treat. The main surgical management is cyst drainage. Individualised homoeopathic medicine can resolve this without surgical intervention.

Case Summary: In a case with a combination of pathology, trauma and addiction, arriving at a homoeopathic similimum can be challenging. The present case study demonstrates the management of a patient in a semi-comatose state with abdominal rigidity and ultrasonographic evidence of pancreatic …

Tinea Capitis Treated With Homoeopathic Medicine Pulsatilla Nigricans: A Case Report, Khushboo Garg, Divya Bansal, Aayush Mittal

Indian Journal of Research in Homoeopathy

Introduction: Tinea infection is a common complaint encountered in day-to-day practice with increasing incidence, especially in countries such as India over the past decade. Tinea capitis is predominantly a disease of prepubertal children characterised by lesions of variable morphology on the scalp associated with itching, erythema, signs of inflammation and hair loss. Prompt recognition and treatment are necessary to prevent its spread due to its contagious nature, associated hair loss and the resultant psychological impact on social life. Individualised homoeopathic treatment has a significant scope in treating and combating such conditions cost-effectively through the totality of symptoms.

Case Summary …

Finding Objective Ways To Talk About Religion In The Classroom Is Tough − But The Cost Of Not Doing So Is Clear, Charles J. Russo

Materials from the University of Dayton Magazine Website

Finding objective ways to talk about religion in the classroom is tough − but the cost of not doing so is clear

Reacting To The Past As Education For Leadership, Javier S. Hidalgo

Interdisciplinary Journal of Leadership Studies

How can courses on leadership effectively cultivate students’ leadership skills? This reflective essay explores how one form of role-playing called Reacting to the Past can promote students’ leadership skills and deepen their understanding of leadership. Reacting to the Past is a series of immersive role-playing simulations that are set at key moments in history and that require students to play the part of historical actors over the course of several weeks. I argue that Reacting to the Past encourages students to practice leadership skills in an authentic context, improves students’ understanding of leadership by allowing them to observe and participate …

Ethnobotanical Study Of Antihemorrhagic Plants In The Skikda Region (North East Of Algeria), Nabila Souilah, Hamdi Bendif, Abdelkrim Benaradj, Abdelouaheb Belaid, Scherazad Mekious

Journal of Bioresource Management

Our survey was carried out at the level of 17 Municipalities of the Province of Skikda. Questionnaire sheets were distributed to 55 herbalists and 350 locale population (informants). The processing of survey data with the local population shows us that women (52 %) have more knowledge of phytotherapy compared to men (48 %) with a fairly high level of education. For the herbalists, we found that most are men (85.45 %) aged between 31-40 years (29.09 %) and 41-50 years (25.45 %), and with level of university study (36.36 %). On the other hand, 52.73 % of herbalists said they …

Structural Basis For Dna Proofreading, Gina Buchel, Ashok Nayak, Karl Herbine, Azadeh Sarfallah, Viktoriia Sokolova, Angelica Zamudio-Ochoa, Dmitry Temiakov

Department of Biochemistry and Molecular Biology Faculty Papers

DNA polymerase (DNAP) can correct errors in DNA during replication by proofreading, a process critical for cell viability. However, the mechanism by which an erroneously incorporated base translocates from the polymerase to the exonuclease site and the corrected DNA terminus returns has remained elusive. Here, we present an ensemble of nine high-resolution structures representing human mitochondrial DNA polymerase Gamma, Polγ, captured during consecutive proofreading steps. The structures reveal key events, including mismatched base recognition, its dissociation from the polymerase site, forward translocation of DNAP, alterations in DNA trajectory, repositioning and refolding of elements for primer separation, DNAP backtracking, and displacement …

Twenty-First Century Split: Partisan, Racial, And Gender Differences In Circuit Judges Following Earlier Opinions, Stuart Minor Benjamin, Kevin M. Quinn, Byungkoo Kim

BYU Law Review

Judges shape the law with their votes and the reasoning in their opinions. An important element of the latter is which opinions they follow, and thus elevate, and which they cast doubt on, and thus diminish. Using a unique and comprehensive dataset containing the substantive Shepard’s treatments of all circuit court published and unpublished majority opinions issued between 1974 and 2017, we examine the relationship between judges’ substantive treatments of earlier appellate cases and their party, race, and gender. Are judges more likely to follow opinions written by colleagues of the same party, race, or gender? What we find is …

Byte A Carrot For Change: Uprooting Problems In Data Privacy Regulations, Sarah Terry

BYU Law Review

There is a growing gap between technology advancement and a lagging regulatory system. This is particularly problematic in consumer data privacy regulating. Companies hold collected consumer data and determine its use largely without accountability. As a result, ethical questions that carry society-shaping impact are answered in-house, under the influence of groupthink, and are withheld from anyone else weighing in.

This Note poses a solution that would address multiple data privacy regulation issues. Namely, an incentive approach would help even out the information-imbalanced system. Incentives are used as tools throughout intellectual property law to foster commercial progress, discourage trade secrets, and …

’Tis The Season: Tale Of The Three Unwise Women, Jethro K. Lieberman

Other Publications

No abstract provided.

A Critical Computing Curriculum Design Case: Exploring Tribal Sovereignty For Middle School Students, Kristin A. Searle, Aubrey Rogowski, Colby Tofel-Grehl, Mengying Jiang

Journal of Computer Science Integration

We report on our efforts to design an integrated computing curriculum for middle school students in Montana that is in line with the Kapor Center’s focus on culturally sustaining-revitalizing pedagogies. Montana provides a unique context for doing this work because a state constitutional mandate requires all K-12 students to learn about tribal histories and cultures through Indian Education For All (IEFA). IEFA centers around seven essential understandings about Indigenous peoples in Montana that are integrated across content areas. In addition, implementation of Montana’s CS standards began in the 2021–2022 school year. In the curricular design, we sought to bring together …

Appealing Magna Carta, Thomas J. Mcsweeney

Faculty Publications

In 1999, Professor Richard Helmholz published Magna Carta and the Ius Commune, in which he argued that some of the ideas and language found in Magna Carta provide evidence that the early common law was engaging with the ius commune, the ancestor of modern civil law traditions. This Essay examines one piece of evidence highlighted by Helmholz and more recently by Professor Charles Donahue: that the Articles of the Barons, a preparatory document for Magna Carta, uses a phrase borrowed from canon law, appellatione remota (without possibility of appeal). Helmholz and Donahue pointed to its use as evidence that …

Neutrosophic Assessment Of Corporate Responsibility In Ecuador's Environmental Context, Carlos Gilberto Rosero Martínez, Ingrid Joselyne Díaz Basurto, Francisco Alejo Guanoluisa Almache, Jean Pierre Ramos Carpio

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Approaches To Emotional Intelligence Measurement, Gustavo Alvarez Gómez, Corona Gómez Armijos, Ariel Romero Fernández, Julio Cesar Dupotey Hernández

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Approaches To Environmental Law And Policy, Santiago Fernando Fiallos Bonilla, Diego Fernando Coka Flores, Janneth Ximena Iglesias Quintana, Víctor Raúl Reátegui Paredes

Neutrosophic Sets and Systems

No abstract provided.

Evaluation Of The Quality Of Care In Nursing Homes, Mónica Bustos Villarreal, Nairovys Gómez Martínez, Roberto Enrique Alvarado Chacón

Neutrosophic Sets and Systems

No abstract provided.

Ethics In Medical Research And Experimentation, Carlos Castañeda Guillot, Icler Sisalema Aguilar, Alex Valencia Herrera, Wilder Fabio Ramos Palacios

Neutrosophic Sets and Systems

No abstract provided.